EKS-DAR-00777

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00777

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	479.0	7.7E-144	491	755	265

Status

Unreviewed

Ensembl Protein

ENSDARP00000116623

UniProt Accession

B3DGN7;

Protein Name

Protein Synonyms/Alias

Dtk protein; Tyrosine-protein kinase receptor TYRO3;

Gene Name

tyro3

Gene Synonyms/Alias

tyro3; dtk;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000005356	ENSDARP00000116623	ENSDART00000140391
ENSDARG00000005356	ENSDARP00000076100	ENSDART00000081659

Organism

Danio rerio

Functional Description

Protein Length

868

Protein Sequence
(FASTA)

MEVSLCILLF LLHFNEGIHG VRFTKNPSNQ TVTQGNMVRL GCAFEGLSEP EIIWMKDGEK 60

LFSTDQMYIT LDPYHWETFH SVKSVQQQDA GKYWCEVEYH GAIISSEPAW ITVAGVPHFG 120

VEPEDVAAFA GESFNLTCAA SGPPEPVEVL WWLGGEQNGD FTPSPSVLFV KGVNESIKFH 180

CEAKNARGIS VSRTGTVHIK ARPDSPRDVQ VHHVSDFNIT LTWSPGFTGH SQLSTCTIQL 240

SRGPGKKVKL PDVVVEVPPF QHVFEGLRSY SNYSVRVRCD NEVGSSPFSP WVDFHTPQAA 300

PSAAPKNFTF DLSEQQLTLS WATLEQEELR GRLLAYKLQW NQGGESQDPL LFKENVAHLS 360

GAGRFFNATF QVAACTMAGC GPWSQPVLVM PVSAMQAQTQ RGHMWVGLLF GLLVATMVGL 420

LLIVLIRNRG KETQFGSAFA AQGAEVPVSF TAARSFNRQF PELPESTLDS LGINSDLKAK 480

LQDVLISERL LTLGRMLGKG EFGSVREAFL KSENNSGQKV AVKVLKTDIN SSSDIEQCLK 540

EAAYMKDFHH PNVIQLIGVS LHRRAQQRLP VPMVILPFMK HGDLHTFLLM SRLGDEPFTV 600

SQQILIQFML DIARGMEYLS NKNIIHRDLA ARNCMLNENM SVCVADFGLS KKIYSGDYYR 660

QGSVSKLPVK WIALESLADN VYTTQSDVWA FGVTMWEIMT RGQTPYPGVE NSEIYEYLIK 720

GERLKQPPDC PADIYEIMHS CWSPVPKCRP SFQHLIDQLE LLWAKLNPAP VKEPLLYVNL 780

EEEDGEQANS GTRSSEEPSW GVPWQCAGIE EDEKDWLMVS SGAALAIGGD YRYIIGPSVS 840

AIDEESRHSD DGLSEDIREE EEDVIINV 868

Nucleotide Sequence
(FASTA)

ATGGAGGTTT CTCTTTGTAT CCTGCTCTTT TTACTGCACT TCAATGAGGG AATTCATGGG 60

GTACGCTTCA CCAAAAACCC TTCCAACCAA ACGGTGACTC AGGGTAACAT GGTCCGGCTG 120

GGCTGTGCCT TTGAGGGTTT GAGTGAACCA GAGATTATCT GGATGAAGGA TGGAGAGAAG 180

CTCTTCAGCA CTGATCAGAT GTACATCACA CTGGATCCAT ATCACTGGGA AACCTTTCAC 240

AGTGTTAAAT CTGTGCAGCA ACAAGACGCT GGAAAGTACT GGTGTGAAGT TGAATATCAC 300

GGCGCAATCA TTTCCTCTGA GCCTGCTTGG ATTACAGTAG CAGGTGTGCC TCATTTTGGC 360

GTAGAACCTG AGGATGTGGC TGCATTTGCA GGGGAGTCGT TCAATCTGAC GTGTGCTGCT 420

TCAGGCCCTC CAGAGCCTGT GGAGGTGCTG TGGTGGCTGG GGGGTGAACA GAATGGCGAT 480

TTTACACCCT CCCCATCAGT TCTCTTTGTT AAAGGTGTGA ATGAGAGTAT AAAGTTTCAC 540

TGCGAGGCCA AGAACGCTCG AGGCATCTCC GTGTCCCGCA CAGGCACTGT GCACATTAAA 600

GCCCGGCCTG ATTCCCCTCG GGACGTACAG GTTCATCATG TGTCGGATTT TAACATAACT 660

TTAACATGGA GTCCAGGTTT CACTGGGCAT TCGCAGCTTT CCACCTGCAC TATACAGTTG 720

TCAAGGGGAC CTGGAAAGAA GGTCAAGCTT CCTGATGTGG TTGTGGAAGT TCCTCCATTC 780

CAGCACGTGT TTGAAGGGCT TCGCAGCTAC TCGAATTACA GTGTGAGAGT CCGGTGTGAT 840

AATGAGGTGG GCTCTTCCCC CTTCTCTCCC TGGGTGGACT TTCACACTCC ACAGGCAGCA 900

CCGTCAGCAG CTCCAAAGAA CTTTACCTTT GACCTCAGCG AGCAGCAGCT CACTCTGTCC 960

TGGGCGACGC TGGAACAGGA GGAGCTTCGA GGAAGATTAC TGGCTTATAA ACTGCAGTGG 1020

AACCAAGGAG GAGAGAGTCA GGATCCCTTA CTGTTTAAGG AGAATGTTGC CCATCTTTCG 1080

GGTGCAGGGC GCTTCTTTAA CGCCACCTTC CAGGTTGCAG CGTGCACAAT GGCAGGATGT 1140

GGCCCGTGGA GTCAGCCTGT TCTTGTTATG CCTGTGTCAG CCATGCAGGC TCAGACACAG 1200

AGGGGCCACA TGTGGGTGGG CCTGCTTTTC GGGCTTCTTG TGGCCACCAT GGTGGGACTC 1260

TTGTTGATTG TATTGATACG AAACCGAGGC AAAGAGACAC AGTTTGGGTC TGCATTCGCA 1320

GCTCAAGGAG CGGAAGTACC GGTTTCCTTC ACAGCTGCAA GGTCCTTCAA CAGGCAGTTC 1380

CCCGAGCTCC CAGAATCCAC ATTGGACAGT CTGGGAATCA ACAGTGATTT GAAGGCCAAG 1440

TTACAGGATG TTCTCATCTC CGAAAGGCTC TTAACTCTGG GACGCATGCT AGGAAAAGGG 1500

GAGTTTGGCT CTGTGAGAGA AGCTTTCCTC AAATCCGAGA ACAACTCTGG GCAGAAGGTT 1560

GCTGTGAAAG TCCTAAAAAC GGACATTAAT TCATCCAGTG ACATTGAGCA ATGCCTGAAA 1620

GAAGCTGCCT ATATGAAGGA CTTCCACCAT CCCAATGTCA TTCAGCTTAT AGGTGTGAGT 1680

TTGCACAGAA GAGCCCAGCA GCGTCTGCCT GTTCCTATGG TCATCCTGCC CTTCATGAAA 1740

CATGGAGATC TCCACACGTT TCTTCTCATG TCTCGTCTCG GAGATGAACC TTTTACTGTT 1800

TCTCAGCAAA TTCTCATCCA GTTCATGCTG GATATCGCTC GAGGGATGGA GTATCTAAGC 1860

AACAAAAACA TCATCCATCG GGATTTGGCT GCGCGCAACT GCATGTTGAA TGAAAACATG 1920

AGCGTATGTG TAGCAGATTT TGGTCTCTCG AAGAAAATCT ACAGCGGTGA CTACTATAGG 1980

CAAGGCTCTG TCTCCAAATT GCCTGTAAAG TGGATTGCTT TGGAAAGCCT GGCTGATAAT 2040

GTCTACACAA CACAGAGTGA TGTGTGGGCG TTTGGTGTGA CTATGTGGGA GATCATGACT 2100

AGAGGTCAAA CACCTTACCC AGGAGTGGAG AACTCTGAGA TCTACGAGTA TCTTATCAAG 2160

GGAGAAAGAC TAAAGCAGCC GCCGGACTGC CCTGCTGACA TTTACGAAAT CATGCACAGC 2220

TGTTGGTCTC CAGTGCCTAA ATGCCGCCCC AGTTTCCAGC ACCTCATTGA CCAATTGGAG 2280

CTCCTGTGGG CGAAGTTGAA TCCTGCTCCT GTAAAAGAGC CATTGCTGTA TGTCAACCTT 2340

GAGGAGGAAG ATGGAGAACA GGCTAATAGC GGGACCCGGA GCAGTGAGGA GCCCTCATGG 2400

GGCGTCCCGT GGCAGTGTGC AGGTATTGAG GAAGACGAAA AAGATTGGTT AATGGTGTCA 2460

TCGGGAGCTG CTCTTGCTAT TGGTGGAGAT TACCGGTACA TCATTGGCCC GTCTGTTAGC 2520

GCCATTGATG AAGAGAGCAG ACATTCTGAC GACGGACTAT CGGAGGATAT CAGGGAAGAA 2580

GAAGAGGATG TTATTATTAA TGTGTGA 2607

Domain Profile

S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60

         l+lg++lg+gefgsv+e+ lk e+ s +kvavk+lk di ++s+ie+ l+eaa mk+f+h

Q: 491   LTLGRMLGKGEFGSVREAFLKSENNSGQKVAVKVLKTDINSSSDIEQCLKEAAYMKDFHH  550

         68**********************************************************

S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120

         pnvi+l+gvsl+ ++++rlp p+vilpfmk+gdlh+fll+srlg++p+ +  q+l++fm+

Q: 551   PNVIQLIGVSLHRRAQQRLPVPMVILPFMKHGDLHTFLLMSRLGDEPFTVSQQILIQFML  610

         ************************************************************

S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180

         dia gmeyls++n+ihrdlaarncml+e+m+vcvadfglskkiysgdyyrqg ++klpvk

Q: 611   DIARGMEYLSNKNIIHRDLAARNCMLNENMSVCVADFGLSKKIYSGDYYRQGSVSKLPVK  670

         ************************************************************

S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240

         wia+eslad+vyt++sdvwafgvtmwei+trgqtpy+gven+eiy+yl++g+rlkqp+dc

Q: 671   WIALESLADNVYTTQSDVWAFGVTMWEIMTRGQTPYPGVENSEIYEYLIKGERLKQPPDC  730

         ************************************************************

S: 241   ldelydlmyrcweadpkdrpsfsvl  265

           ++y++m++cw+  pk rpsf  l

Q: 731   PADIYEIMHSCWSPVPKCRPSFQHL  755

         **********************876

Domain Sequence
(FASTA)

LTLGRMLGKG EFGSVREAFL KSENNSGQKV AVKVLKTDIN SSSDIEQCLK EAAYMKDFHH 60

PNVIQLIGVS LHRRAQQRLP VPMVILPFMK HGDLHTFLLM SRLGDEPFTV SQQILIQFML 120

DIARGMEYLS NKNIIHRDLA ARNCMLNENM SVCVADFGLS KKIYSGDYYR QGSVSKLPVK 180

WIALESLADN VYTTQSDVWA FGVTMWEIMT RGQTPYPGVE NSEIYEYLIK GERLKQPPDC 240

PADIYEIMHS CWSPVPKCRP SFQHL 265

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 1.
PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 2.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013