EKS-DAR-00745
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00745
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src446.16.8E-134280529250
StatusReviewed
Ensembl ProteinENSDARP00000009659
UniProt AccessionA1A5H8; Q6EWH1; Q8AXW6;
Protein NameTyrosine-protein kinase yes
Protein Synonyms/Alias p61-Yes;
Gene Nameyes1
Gene Synonyms/Alias yes1; yes;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000005941ENSDARP00000009659ENSDART00000027090
OrganismDanio rerio
Functional DescriptionNon-receptor protein tyrosine kinase that is involved inthe regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, differentiation, G2/M progression and cytokinesis (By similarity). Required for convergent extension cell movements during gastrulation, acting with fyna via rhoa. May be required for epiboly to occur, possibly through its effects in calcium signaling. During embryonic development, phosphorylates ptk2.1/fak.
Protein Length546
Protein Sequence
(FASTA)
MGCVKSKEDK GPTQKYRPDP TNPTPGSHMG LYGPDPTQMG QSPALKGPTN NYNSRSSGLT 60
PFGGSSSVIT PFGGASSSFS TVAVNNPFPG VVTGGVTFFV ALYDYEARTS DDLSFSKGDR 120
FQIINNTEGD WWEARSINTG QKGYIPSNYV APADSIQAEE WYFGKMGRKD AERLLLLPGN 180
QRGTFLVRES ETTKGAYSLS IRDWDEMKGD NVKHYKIRKL DSGGYYITTR AQFDTLQKLV 240
KHYTEHADGL CYRLTTVCPT VKPQTQGLAK DAWEIPRESL RLELKLGQGC FGEVWMGTWN 300
GTTKVAIKTL KPGTMSPEAF LQEAQIMKKL RHDKLVPLYA VVSEEPIYIV TEYMGKGSLL 360
DFLKEGEGKY LKLPQLVDMA AQIADGMAFI ERMNYIHRDL RAANILVGDN LVCKIADFGL 420
ARLIEDNEYT ARQGAKFPIK WTAPEAALYG RFTIKSDVWS FGILLTELVT KGRVPYPGMV 480
NREVLEQVER GYRMPCPQGC PESLHEMMRL CWKKEPDERP TFEYIQSFLE DYFTATEPQY 540
QPGDNL 546
Nucleotide Sequence
(FASTA)
ATGGGCTGTG TCAAGAGTAA AGAGGACAAG GGTCCCACAC AGAAGTACCG ACCAGATCCC 60
ACCAATCCCA CCCCTGGGTC ACACATGGGC CTCTATGGAC CAGACCCTAC TCAGATGGGT 120
CAGTCACCAG CCCTGAAGGG TCCCACCAAC AACTATAACA GCCGCTCCTC TGGTCTCACC 180
CCATTCGGTG GCTCTTCCTC TGTCATCACA CCCTTCGGTG GAGCCTCGTC CTCCTTCTCC 240
ACGGTGGCAG TGAACAACCC TTTTCCTGGT GTCGTCACAG GTGGCGTAAC ATTCTTTGTG 300
GCCTTATATG ATTATGAAGC CAGGACATCA GATGACCTCT CCTTCAGTAA AGGCGATAGA 360
TTTCAAATCA TCAACAACAC AGAGGGTGAC TGGTGGGAGG CTCGCTCCAT CAACACGGGC 420
CAGAAGGGCT ACATTCCCAG CAATTACGTG GCCCCTGCAG ACTCCATCCA GGCGGAAGAA 480
TGGTACTTTG GGAAAATGGG TCGTAAAGAT GCTGAGCGAC TGCTGCTTCT TCCCGGAAAC 540
CAACGGGGCA CCTTTTTAGT CCGAGAAAGT GAGACCACTA AAGGAGCTTA CTCTCTCTCA 600
ATACGAGACT GGGATGAGAT GAAGGGAGAC AACGTGAAAC ACTACAAAAT CCGAAAGCTT 660
GACAGCGGAG GCTATTACAT CACCACAAGG GCTCAGTTTG ACACCCTACA GAAACTGGTG 720
AAGCATTACA CAGAGCATGC AGATGGGCTG TGTTATCGAC TCACTACAGT GTGTCCGACG 780
GTGAAGCCCC AAACTCAGGG TCTGGCTAAA GATGCATGGG AAATACCTCG AGAGTCACTG 840
CGTCTGGAGC TTAAGCTGGG TCAGGGCTGC TTCGGAGAGG TTTGGATGGG CACTTGGAAT 900
GGCACGACTA AGGTAGCTAT TAAGACCCTG AAGCCGGGCA CCATGTCTCC CGAAGCCTTC 960
CTGCAGGAGG CCCAGATCAT GAAGAAGCTC CGGCATGATA AGCTCGTTCC GCTGTATGCT 1020
GTTGTGTCTG AAGAGCCAAT TTACATTGTC ACTGAATACA TGGGCAAAGG GAGCTTGCTG 1080
GACTTTTTGA AGGAGGGTGA GGGTAAATAC CTCAAATTGC CCCAGCTGGT TGACATGGCT 1140
GCCCAGATTG CAGATGGCAT GGCCTTCATC GAGAGGATGA ACTACATCCA TAGAGACCTG 1200
AGGGCTGCTA ACATCCTGGT GGGAGACAAT CTGGTTTGCA AGATTGCTGA CTTTGGCCTG 1260
GCTAGACTAA TCGAAGACAA CGAATACACT GCTAGACAAG GAGCCAAGTT TCCCATTAAG 1320
TGGACTGCGC CAGAAGCAGC TCTGTACGGC CGATTCACTA TTAAATCTGA CGTCTGGTCC 1380
TTCGGGATTC TGCTGACAGA GCTGGTCACC AAGGGCAGAG TGCCATATCC AGGCATGGTG 1440
AACCGCGAGG TGTTGGAGCA GGTGGAGCGG GGCTACAGAA TGCCATGTCC TCAGGGCTGC 1500
CCAGAGTCGC TGCACGAAAT GATGCGGCTC TGCTGGAAGA AGGAGCCCGA CGAGCGGCCC 1560
ACATTCGAAT ACATCCAGTC CTTCCTAGAG GACTATTTCA CCGCCACTGA GCCACAGTAT 1620
CAGCCCGGAG ACAACCTGTA G 1641
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         l+l+ klG+G+fGevw+g+w+g++kva+ktlk+gt+speafl+eaqi+kklrh+klv ly
Q: 280   LRLELKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLQEAQIMKKLRHDKLVPLY  339
         57899*******************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvse ePiyivte+m kGslldflke egk+lklp+lvd+aaq+a+Gma++e++n+ihr
Q: 340   AVVSE-EPIYIVTEYMGKGSLLDFLKEGEGKYLKLPQLVDMAAQIADGMAFIERMNYIHR  398
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lvg++lv+k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv
Q: 399   DLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  458
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillte+vtkG+vPypGm n+evleqvergyr+p+p+ cpe+l+e++  cwkk+p+e
Q: 459   WSFGILLTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHEMMRLCWKKEPDE  518
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe++q++l
Q: 519   RPTFEYIQSFL  529
         *******9986
Domain Sequence
(FASTA)
LRLELKLGQG CFGEVWMGTW NGTTKVAIKT LKPGTMSPEA FLQEAQIMKK LRHDKLVPLY 60
AVVSEEPIYI VTEYMGKGSL LDFLKEGEGK YLKLPQLVDM AAQIADGMAF IERMNYIHRD 120
LRAANILVGD NLVCKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180
SFGILLTELV TKGRVPYPGM VNREVLEQVE RGYRMPCPQG CPESLHEMMR LCWKKEPDER 240
PTFEYIQSFL 250
KeywordATP-binding; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Kinase; Lipoprotein; Membrane; Myristate; Nucleotide-binding; Palmitate; Phosphoprotein; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00341
EKS-ANC-00355
EKS-BOT-00367
EKS-CAJ-00370
EKS-CAF-00368
EKS-CAP-00400
EKS-DIO-00055
EKS-EQC-00358
EKS-FEC-00355
EKS-GAM-00221
EKS-GAG-00311
EKS-GAA-00448
EKS-HOS-00373
EKS-LAC-00381
EKS-LOA-00376
EKS-MAM-00367
EKS-MEG-00301
EKS-MOD-00356
EKS-MUM-00399
EKS-MUP-00361
EKS-MYL-00365
EKS-ORN-00472
EKS-ORA-00321
EKS-ORC-00345
EKS-ORL-00437
EKS-OTG-00368
EKS-PAT-00347
EKS-PES-00324
EKS-PEM-00192
EKS-POA-00357
EKS-RAN-00381
EKS-TAG-00438
EKS-TAR-00469
EKS-TEN-00464
EKS-TUT-00098
EKS-VIP-00050
EKS-XET-00481
EKS-XIM-00462
Gene Ontology
GO:0005829; C:cytosol
GO:0005815; C:microtubule organizing center
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0060027; P:convergent extension involved in gastrulation
GO:0046777; P:protein autophosphorylation
GO:0045859; P:regulation of protein kinase activity
KEGG
dre:407620;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013