EKS-DAR-00085

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00085

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	345.2	5.5E-103	84	369	286

Status

Reviewed

Ensembl Protein

ENSDARP00000075572

UniProt Accession

Q1RLU9;

Protein Name

Cyclin-dependent kinase 15

Protein Synonyms/Alias

Cell division protein kinase 15;

Gene Name

cdk15

Gene Synonyms/Alias

cdk15; pftk2; zgc:136819;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000006093	ENSDARP00000075572	ENSDART00000081129

Organism

Danio rerio

Functional Description

Serine/threonine-protein kinase involved in the controlof the eukaryotic cell cycle, whose activity is controlled by an associated cyclin (By similarity).

Protein Length

418

Protein Sequence
(FASTA)

MQNLRHAASE AFQRLGLKQR HLGYEELGEL DGVEKPQPHW FHTLQVRRLR VQRGRSNSDP 60

MGGKSFQQEF QWKTGLQFGN ATSYLNLEKL GEGTYATVYK GISRINGHLV ALKVIHMKTE 120

EGIPFTAIRE ASLLKGLKHA NIVLLHDIIH TRESLTFVFE YVQTDLAQYM IQHPGGLHSY 180

NIRLFMFQLL RGLSYIHGRR ILHRDLKPQN LLISYLGELK LADFGLARSK SIPCQTYSAE 240

VVTLWYRPPD VLMGSTDYST ALDIWGAGCI FIEMLQGSPA FPGVADVFEQ LLKIWTVIGV 300

PTEEIWPGVS DLPNYKPEWF LPCKPQQFRD VWKRLSQLPY KTEDLAQQML MMNPKDRISA 360

QDALLHPYFN TLPPPLMHLR DTVSIFKVPG VRLESEARDI FSPSRRTKTP LAPLAKCW 418

Nucleotide Sequence
(FASTA)

ATGCAGAACC TCCGGCATGC AGCTTCAGAG GCTTTCCAGC GTCTGGGGCT AAAGCAAAGA 60

CATCTGGGCT ATGAGGAGCT GGGTGAGCTG GACGGGGTGG AGAAACCACA GCCGCACTGG 120

TTTCACACAC TGCAGGTGCG GCGGCTCAGA GTTCAGAGAG GCCGCAGTAA CAGCGATCCA 180

ATGGGAGGAA AGAGCTTCCA GCAAGAGTTT CAGTGGAAAA CTGGCCTACA ATTTGGGAAC 240

GCAACATCTT ATCTGAATCT GGAAAAACTC GGAGAGGGCA CATATGCCAC AGTTTACAAA 300

GGAATCAGCA GGATAAATGG TCATCTTGTG GCTTTAAAGG TGATTCACAT GAAAACTGAA 360

GAGGGAATTC CATTCACAGC TATCAGAGAA GCCTCCTTGT TAAAAGGCCT TAAACATGCC 420

AACATAGTCT TGCTTCATGA CATCATCCAC ACGAGAGAGT CCCTCACCTT TGTCTTCGAG 480

TATGTGCAAA CAGATTTGGC TCAGTATATG ATTCAGCATC CTGGTGGACT TCACTCCTAT 540

AACATCAGGC TCTTCATGTT TCAGCTGCTG CGAGGATTGT CTTACATTCA CGGCAGAAGG 600

ATTCTGCACC GAGACCTCAA ACCTCAGAAT TTGCTCATCA GCTATCTGGG AGAACTCAAA 660

CTAGCTGATT TTGGACTGGC TCGATCGAAG TCCATACCAT GTCAAACGTA CTCTGCTGAG 720

GTGGTGACTT TATGGTACCG TCCACCAGAT GTTCTCATGG GCTCCACAGA TTACTCCACA 780

GCCCTGGACA TCTGGGGAGC TGGCTGCATT TTCATAGAGA TGCTACAGGG GTCACCAGCG 840

TTTCCTGGAG TCGCTGATGT CTTTGAGCAG CTGCTGAAGA TTTGGACAGT CATTGGTGTC 900

CCGACTGAGG AGATCTGGCC AGGTGTCAGT GATCTGCCAA ACTACAAACC AGAGTGGTTC 960

CTGCCCTGCA AGCCCCAGCA ATTCCGAGAT GTCTGGAAAA GGCTCTCTCA GTTACCTTAT 1020

AAGACGGAGG ATCTGGCCCA GCAGATGCTG ATGATGAATC CAAAGGACAG GATTTCAGCC 1080

CAGGATGCAT TGCTGCACCC ATATTTCAAC ACTCTTCCAC CTCCGTTAAT GCATCTAAGG 1140

GACACTGTGT CCATCTTTAA GGTGCCGGGC GTGAGGTTGG AGTCGGAAGC GAGGGATATC 1200

TTCAGCCCCA GCAGACGAAC GAAGACGCCT CTCGCTCCAC TGGCCAAATG CTGGTGA 1257

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y +lek+geGty++vyk+ ++ +g++vAlK i++++e eg+p+ta+rE sllk lkh+ni

Q: 84    YLNLEKLGEGTYATVYKGISRINGHLVALKVIHMKTE-EGIPFTAIREASLLKGLKHANI  142

         6789******************************999.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v L+++++ ++++l++vfe++++dL++++ +++  +l++ +++ +++qll+gl+y+H ++

Q: 143   VLLHDIIH-TRESLTFVFEYVQTDLAQYMIQHPG-GLHSYNIRLFMFQLLRGLSYIHGRR  200

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         ilHRDlKpqNlLis  g+lklaDfGlar+ s p +ty+ evvTlwYr+P++L+g+++Yst

Q: 201   ILHRDLKPQNLLISYLGELKLADFGLARSKSIPCQTYSAEVVTLWYRPPDVLMGSTDYST  260

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkse.idqlerifkllgtpsekvwpevsklpeyk.ksf  238

         a+DiW++gci+ e+l+ +p f+g  +  +ql +i++++g p+e++wp+vs+lp+yk + f

Q: 261   ALDIWGAGCIFIEMLQGSPAFPGVADvFEQLLKIWTVIGVPTEEIWPGVSDLPNYKpEWF  320

         ***********************99867****************************8899

S: 239   pkkkkkklkekvkklk...ekaldllekllaldpkkRisakealqhkyf  284

          + k++++++++k+l+    k+ dl +++l+++pk+Risa++al h+yf

Q: 321   LPCKPQQFRDVWKRLSqlpYKTEDLAQQMLMMNPKDRISAQDALLHPYF  369

         9999999999998887443579**************************9

Domain Sequence
(FASTA)

YLNLEKLGEG TYATVYKGIS RINGHLVALK VIHMKTEEGI PFTAIREASL LKGLKHANIV 60

LLHDIIHTRE SLTFVFEYVQ TDLAQYMIQH PGGLHSYNIR LFMFQLLRGL SYIHGRRILH 120

RDLKPQNLLI SYLGELKLAD FGLARSKSIP CQTYSAEVVT LWYRPPDVLM GSTDYSTALD 180

IWGAGCIFIE MLQGSPAFPG VADVFEQLLK IWTVIGVPTE EIWPGVSDLP NYKPEWFLPC 240

KPQQFRDVWK RLSQLPYKTE DLAQQMLMMN PKDRISAQDA LLHPYF 286

Keyword

ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0046872	; F:metal ion binding
GO:0007049	; P:cell cycle

KEGG

dre:791619

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013