EKS-DAR-00859

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00859

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/CK1	489.1	5.4E-147	9	269	261

Status

Reviewed

Ensembl Protein

ENSDARP00000014900

UniProt Accession

Q6P3K7; Q4V962;

Protein Name

Casein kinase I isoform delta-B

Protein Synonyms/Alias

CKI-delta-B; CKId-B;

Gene Name

csnk1db

Gene Synonyms/Alias

csnk1db;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000006125	ENSDARP00000014900	ENSDART00000021491

Organism

Danio rerio

Functional Description

Casein kinases are operationally defined by theirpreferential utilization of acidic proteins such as caseins as substrates. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling (By similarity).

Protein Length

409

Protein Sequence
(FASTA)

MELRVGNRYR LGRKIGSGSF GDIYLGTDIS VGEEVAIKLE CVKTKHPQLH IESKIYKMMQ 60

GGVGIPTIKW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH 120

SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA 180

SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL 240

CKGYPSEFAT YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGANRT 300

AEEADRERRE RDERMRHSRN PAARGIPAAS GRPRPTQDGA PPTPLTPTSH TANTSSPRPV 360

TGMERERKVS MRLHRGAPVN VSSSDLTGRQ DTSRMSTSQN SIPFDHHGK 409

Nucleotide Sequence
(FASTA)

ATGGAGCTAC GAGTTGGAAA CAGATACAGA CTGGGCAGAA AAATTGGAAG TGGATCGTTT 60

GGTGACATTT ATTTAGGCAC AGACATTTCA GTTGGAGAGG AAGTGGCCAT CAAACTGGAA 120

TGTGTGAAGA CAAAGCATCC ACAGCTCCAT ATCGAGAGCA AGATTTACAA GATGATGCAG 180

GGTGGAGTTG GCATCCCTAC CATAAAGTGG TGTGGTGCAG AAGGAGATTA TAACGTGATG 240

GTGATGGAGT TGCTCGGCCC CAGTCTGGAG GATCTCTTCA ATTTCTGCTC CAGAAAATTC 300

AGCCTGAAAA CTGTCCTCCT GTTGGCCGAT CAGATGATTA GCCGCATAGA GTACATCCAC 360

TCCAAGAACT TCATTCACAG AGACGTGAAG CCTGATAACT TTCTGATGGG CTTGGGAAAG 420

AAAGGCAACC TTGTCTACAT AATTGACTTC GGTTTGGCAA AGAAATACCG TGATGCCCGA 480

ACACACCAGC ACATTCCCTA TCGTGAGAAC AAGAACCTCA CAGGCACTGC GCGCTATGCA 540

TCCATCAACA CACATCTTGG CATTGAGCAA TCTCGGAGAG ATGACCTGGA GTCTCTTGGT 600

TATGTGCTGA TGTACTTCAA CTTGGGCTCA CTGCCTTGGC AGGGACTGAA AGCCGCCACC 660

AAGAGACAGA AGTATGAGCG TATCAGTGAA AAGAAAATGT CCACTCCCAT TGAAGTTCTC 720

TGCAAGGGCT ACCCATCTGA ATTTGCCACA TACCTCAACT TCTGCCGGTC ACTGCGATTT 780

GATGATAAGC CAGACTACTC GTATTTGAGG CAGCTCTTCA GGAATCTGTT CCACAGACAG 840

GGCTTTTCCT ATGACTACGT GTTTGATTGG AACATGCTCA AATTTGGCGC TAACCGTACA 900

GCAGAGGAAG CAGATCGTGA GAGGAGAGAG CGGGATGAGC GAATGAGGCA CAGCAGGAAT 960

CCTGCTGCTC GAGGGATCCC AGCAGCATCA GGCAGACCCC GGCCTACACA GGACGGTGCT 1020

CCACCCACCC CACTCACACC CACCTCTCAC ACAGCAAACA CATCCTCACC GAGACCAGTC 1080

ACTGGGATGG AGCGTGAACG CAAGGTCAGC ATGCGGCTTC ATCGTGGCGC CCCAGTAAAC 1140

GTGTCATCCT CAGACCTGAC GGGGCGACAA GACACTTCCC GCATGTCCAC ATCACAGAAT 1200

AGCATTCCTT TCGATCACCA CGGCAAGTAG 1230

Domain Profile

S: 1     yrvvkkiGsGsfGdiylgknlasgeevaikleskkskapqlklesrvykilqggvgiPev  60

         yr+++kiGsGsfGdiylg+++  geevaikle++k+k+pql++es++yk++qggvgiP++

Q: 9     YRLGRKIGSGSFGDIYLGTDISVGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTI  68

         89**********************************************************

S: 61    ryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyrd  120

         +++g+e++ynv+v++llGpsledlf++c+rkfslktvllladq+isriey+hsk++i+rd

Q: 69    KWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRD  128

         ************************************************************

S: 121   ikPdnfllgigrkgkkvylidfGlakkyrdaktkkhipyreeksltGtaryasinthlgk  180

         +kPdnfl+g+g+kg+ vy+idfGlakkyrda+t++hipyre+k+ltGtaryasinthlg+

Q: 129   VKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGI  188

         ************************************************************

S: 181   eqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlcegfPeef  240

         eqsrrddleslgyvl+yf+ gslPWqglkaatk+qkye+isekk+st+ievlc+g+P+ef

Q: 189   EQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEF  248

         ************************************************************

S: 241   atylkyvrklkfeekPdyeyl  261

         atyl+++r+l+f++kPdy+yl

Q: 249   ATYLNFCRSLRFDDKPDYSYL  269

         *******************97

Domain Sequence
(FASTA)

YRLGRKIGSG SFGDIYLGTD ISVGEEVAIK LECVKTKHPQ LHIESKIYKM MQGGVGIPTI 60

KWCGAEGDYN VMVMELLGPS LEDLFNFCSR KFSLKTVLLL ADQMISRIEY IHSKNFIHRD 120

VKPDNFLMGL GKKGNLVYII DFGLAKKYRD ARTHQHIPYR ENKNLTGTAR YASINTHLGI 180

EQSRRDDLES LGYVLMYFNL GSLPWQGLKA ATKRQKYERI SEKKMSTPIE VLCKGYPSEF 240

ATYLNFCRSL RFDDKPDYSY L 261

Keyword

ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0016055	; P:Wnt receptor signaling pathway

KEGG

dre:406533

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013