EKS-DAR-00647
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00647
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR429.39.5E-129659915257
StatusUnreviewed
Ensembl ProteinENSDARP00000002603
UniProt AccessionF8W3W7;
Protein Name
Protein Synonyms/Alias
Gene Nameerbb3a
Gene Synonyms/Alias erbb3a;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000006202ENSDARP00000002603ENSDART00000014892
ENSDARG00000006202ENSDARP00000124619ENSDART00000149285
ENSDARG00000006202ENSDARP00000124007ENSDART00000148908
OrganismDanio rerio
Functional Description
Protein Length1305
Protein Sequence
(FASTA)
MYKCMCICVN KFTLSLSLSA VGVCTGTQNL LSVTGSSEVQ YKLMKEMYTG CQIVIGNLEI 60
TQMEHNRDFS FLQSIREVTG YILIAINQFR RLPLEQLRVI RGTSLYEDKF ALAVLVNYQK 120
DGVYGLRELG LTHLTEILEG GVQIIQNKFL SYAPQINWQD IVKNSGAEVI IQDNGPEVPC 180
HESCGGPCWG PGNDTCQILT KTVCALQCNV RCFGRSPSEC CHNECAGGCT GPLDTDCFAC 240
RNFNNSGSCV SQCPRADIYN KVTFKMEPNP NAKYQFGSMC VSHCPPNFVV DGSSCVSSCP 300
ADKMEVDKTG VKRCEKCEGL CPKACVGTGT GTASRQTVDS QNIDSFINCT KIQGSLHFLV 360
TGIKGDSYNN ISALDPKKLK IFNTVREITD ILSIQSWPEE LEDLSVFSNL ATIQGRTLYR 420
GYSLLVMKIP TLKSLGLRSL KRISDGGIYI TGNTQLCYHH TVNWTRLFGS GPRALRRQKS 480
LDIKENRPQE QCRMLGSGTR SVFVLQELQK RRNMCTRLQL HVRGSDECKA CAHLQDGPYC 540
VSSCPEGVQG ENGLIIYKFP NRQNKCQPCH ANCTLGSAHY GVNIVRYRLP VTAIVLSVIF 600
CVLLAFSVFV LSVLYRRSLS IRRKRAMRRY LQSGESFEPL EPGEKGVKVH ARILRTSELK 660
KIKLLGSGVF GTVHKGIWIP EGDTVKIPVA IKTIQDRTGR QTFQEITDHM LAMGSLDHAY 720
IVRILGICPG ASLQLVTQLS PQGSLLDHIR QRRDNLNPQR LLNWCVQIAK GMYYLEEQRM 780
VHRNLAARNI LLKSDLIVQI ADYGIADLLY PDEKKYFFNE IKTPIKWMAL ESILFRRYTH 840
QSDVWSYGVT VWEMMSYGAE PYSAMRPQDV PDLLEKGERL SQPQICTIDV YMVMVKCWMI 900
DENVRPTFKE LANEFTRMAR DPHRYLVIKE EDRAPDSASD ETHQNGTEID ILGVALEDQD 960
DEVLEDAIDA PRYITPSRSF SRLRIDSHRS SLTPSTTAGY LPMTPGLESS VQTGWASRSR 1020
LDSACTVSES SEGRGALELE MNDDFSSVGS LRRVRHREDS AYMSQRDSLS GPPETTSTGT 1080
QGEEDQNEYV LPGFGESPEK ETLLFTSSRS TLSQKRLSRG HSGDFLEANR GAGEEYEYMN 1140
NQTLSLSHIP GQLKEYNQRA PRNRSASFNP GGMYSNHKPS RPSKRSSIEG SESSGGLSQS 1200
STDQRSHSDG DFLSSEAEYT DGDLEGGGGE AYEYEDMDSL AAGGASGAEY QNLDGEDEER 1260
DEDWSGGPRS PGPYVQVHAG TNHNAFDNPD YWHSRSFHKT KAVRT 1305
Nucleotide Sequence
(FASTA)
ATGTATAAAT GCATGTGTAT TTGTGTTAAT AAATTCACTC TTTCTCTGTC TCTCTCTGCA 60
GTTGGAGTGT GTACAGGCAC TCAGAATTTG CTGAGTGTGA CGGGAAGCTC TGAGGTCCAA 120
TACAAACTCA TGAAGGAAAT GTACACAGGT TGCCAGATTG TCATAGGAAA CCTGGAGATC 180
ACACAGATGG AGCACAACCG CGATTTCTCA TTCCTACAGT CTATCCGTGA GGTAACCGGC 240
TACATCCTCA TCGCTATAAA CCAGTTCAGA CGTTTACCGC TGGAGCAGCT GCGGGTTATA 300
CGGGGAACGT CTCTGTATGA AGATAAATTC GCCCTCGCTG TCCTTGTCAA CTATCAGAAA 360
GACGGAGTGT ATGGACTGAG GGAGCTGGGC CTCACACACT TGACAGAGAT CCTGGAGGGT 420
GGCGTGCAGA TCATCCAGAA TAAATTCTTG AGCTACGCAC CGCAGATTAA CTGGCAAGAC 480
ATTGTGAAAA ACAGTGGAGC AGAAGTCATC ATACAAGACA ATGGACCAGA AGTTCCCTGT 540
CATGAGTCTT GCGGGGGTCC ATGTTGGGGT CCAGGAAATG ACACCTGTCA AATCTTGACT 600
AAGACAGTGT GCGCACTGCA ATGTAACGTG CGCTGTTTTG GACGCAGCCC GAGTGAGTGT 660
TGCCATAATG AGTGTGCCGG CGGCTGCACC GGACCCCTCG ACACCGACTG CTTTGCCTGC 720
AGAAACTTCA ACAACTCGGG CTCGTGTGTG TCGCAGTGTC CAAGGGCTGA TATTTACAAC 780
AAAGTGACAT TCAAAATGGA GCCCAATCCT AACGCCAAAT ACCAGTTTGG CTCCATGTGT 840
GTGTCACATT GCCCTCCTAA TTTTGTTGTA GATGGCAGTT CGTGTGTTAG CAGCTGTCCA 900
GCAGACAAGA TGGAGGTGGA TAAAACAGGG GTGAAAAGGT GTGAGAAGTG TGAAGGCCTC 960
TGTCCTAAAG CCTGTGTTGG CACCGGCACC GGCACCGCCT CCAGACAGAC AGTAGATTCC 1020
CAAAACATCG ACAGCTTCAT AAACTGCACC AAGATTCAGG GCAGCCTGCA CTTCCTTGTC 1080
ACAGGAATTA AAGGAGACAG TTATAATAAC ATCAGTGCTC TGGATCCAAA GAAACTTAAG 1140
ATCTTCAACA CTGTCCGAGA GATCACAGAC ATTCTGAGTA TTCAATCTTG GCCTGAAGAG 1200
CTGGAAGATC TTTCTGTTTT CTCCAATCTA GCAACAATAC AGGGAAGAAC ACTGTATAGG 1260
GGTTATTCTC TTTTGGTAAT GAAGATCCCA ACGCTGAAGT CTCTGGGCCT TCGCTCTCTG 1320
AAGCGAATCA GTGATGGAGG GATCTACATC ACAGGAAACA CACAGCTCTG TTATCATCAC 1380
ACTGTGAACT GGACGCGTTT GTTCGGCAGC GGTCCGCGAG CCCTGCGCCG CCAAAAATCA 1440
CTGGACATCA AGGAGAATCG CCCTCAGGAG CAATGCAGGA TGCTGGGGTC CGGGACCCGA 1500
TCAGTGTTTG TCCTGCAAGA ACTTCAGAAG AGGAGGAACA TGTGTACCAG ACTGCAACTT 1560
CATGTCCGGG GCTCTGATGA GTGCAAAGCG TGTGCTCATC TGCAGGACGG CCCGTACTGT 1620
GTGTCCTCCT GTCCAGAGGG AGTTCAGGGG GAAAATGGAC TCATCATTTA TAAGTTCCCT 1680
AATAGACAAA ACAAATGCCA ACCTTGTCAT GCCAACTGCA CCTTGGGCTC AGCTCATTAT 1740
GGTGTTAATA TTGTGCGTTA CAGGCTGCCG GTCACCGCCA TCGTGCTGAG CGTCATATTC 1800
TGTGTCCTGC TCGCGTTTTC GGTGTTTGTG CTGAGTGTGC TTTACCGCAG GAGTCTCTCC 1860
ATCCGCAGAA AACGAGCCAT GAGGAGATAC CTGCAGAGCG GAGAGAGCTT TGAACCGCTG 1920
GAACCCGGAG AGAAAGGTGT GAAAGTTCAT GCTCGGATTC TGAGAACTTC TGAATTGAAG 1980
AAGATCAAGC TTCTGGGCTC TGGAGTGTTC GGGACGGTTC ACAAGGGCAT CTGGATACCA 2040
GAGGGAGACA CGGTGAAGAT TCCCGTGGCC ATCAAGACTA TTCAGGACCG CACGGGGCGA 2100
CAGACCTTTC AGGAAATTAC TGATCACATG TTGGCAATGG GTAGTCTGGA TCACGCGTAT 2160
ATTGTCCGCA TCCTGGGCAT CTGTCCGGGT GCCAGTCTGC AGCTGGTCAC TCAGCTCAGT 2220
CCACAGGGCT CTTTACTGGA TCACATCCGC CAGCGCAGGG ACAACCTGAA CCCGCAGAGG 2280
CTGCTGAACT GGTGTGTGCA GATCGCCAAG GGCATGTACT ATCTGGAGGA GCAGAGGATG 2340
GTGCACAGAA ACCTGGCTGC CCGAAATATT CTGCTCAAGA GTGATTTAAT TGTTCAGATA 2400
GCCGATTATG GCATCGCTGA CCTGCTCTAT CCTGATGAAA AGAAATACTT CTTCAATGAA 2460
ATTAAGACTC CTATAAAGTG GATGGCCCTT GAGAGCATCT TGTTCCGCAG ATACACTCAT 2520
CAGAGTGATG TATGGAGCTA CGGTGTGACG GTCTGGGAAA TGATGTCATA CGGGGCAGAG 2580
CCTTACTCTG CGATGCGACC GCAGGATGTT CCTGATCTGT TAGAGAAAGG AGAACGACTC 2640
TCTCAGCCTC AAATCTGCAC CATTGACGTC TACATGGTCA TGGTCAAATG CTGGATGATT 2700
GATGAAAATG TACGTCCAAC TTTTAAAGAG CTGGCCAATG AATTCACCCG AATGGCTCGA 2760
GACCCACACC GTTACCTGGT CATCAAAGAG GAAGACAGAG CCCCAGACTC AGCCTCAGAT 2820
GAGACTCATC AGAATGGTAC TGAAATAGAC ATTCTCGGGG TGGCACTGGA GGACCAGGAT 2880
GATGAAGTCT TGGAGGATGC CATAGATGCT CCACGCTATA TAACACCATC TAGAAGCTTC 2940
TCTAGACTGC GTATAGATTC TCATCGGTCA AGTTTGACTC CATCCACTAC TGCTGGATAT 3000
CTACCTATGA CTCCGGGTCT GGAGAGCTCT GTACAGACTG GATGGGCGTC TCGGTCCCGT 3060
CTGGACTCAG CGTGCACTGT TTCTGAGAGC TCGGAGGGAC GAGGAGCGCT GGAACTGGAA 3120
ATGAATGACG ACTTCTCATC CGTTGGCAGT CTAAGGAGGG TCAGACATCG TGAAGACAGT 3180
GCTTACATGT CACAGCGGGA CAGTCTTTCA GGACCACCAG AAACAACCTC CACAGGAACT 3240
CAAGGAGAAG AAGACCAGAA TGAATATGTG CTGCCTGGAT TCGGTGAAAG CCCAGAGAAA 3300
GAAACTCTTC TGTTCACATC ATCACGTTCA ACGCTTTCTC AAAAGAGACT CTCGAGAGGT 3360
CATTCTGGAG ACTTTCTGGA AGCCAACAGA GGTGCTGGTG AAGAATACGA GTACATGAAC 3420
AACCAGACGC TCTCTCTCAG CCACATACCA GGACAGCTAA AAGAGTACAA TCAACGAGCG 3480
CCACGAAACC GCAGCGCCTC CTTTAACCCT GGCGGGATGT ACAGCAACCA CAAACCCAGC 3540
AGACCTAGTA AGAGGTCATC GATCGAGGGC TCGGAAAGCA GCGGAGGACT CTCTCAATCC 3600
TCAACTGACC AGAGGAGTCA CAGCGATGGA GATTTCCTCT CCAGTGAAGC AGAATACACA 3660
GATGGGGATC TGGAGGGCGG TGGAGGAGAA GCGTATGAAT ATGAGGATAT GGACTCACTG 3720
GCTGCAGGCG GAGCTTCGGG AGCTGAATAT CAGAATCTGG ATGGAGAAGA TGAGGAAAGG 3780
GATGAAGATT GGTCTGGAGG ACCTCGTAGC CCGGGACCGT ATGTACAGGT GCACGCTGGG 3840
ACCAATCATA ATGCTTTTGA TAACCCTGAT TATTGGCACA GCAGATCATT TCATAAAACT 3900
AAAGCTGTCC GCACGTAG 3918
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lkk+k lGsG+fGtv+kGiwipeg++vkipvaik ++++tg+++++e++d++l+++sldh
Q: 659   LKKIKLLGSGVFGTVHKGIWIPEGDTVKIPVAIKTIQDRTGRQTFQEITDHMLAMGSLDH  718
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         a++vr+lg+c   +lqlvtql p G+lld++r+++d+l +q llnwcvqiakGm+ylee+
Q: 719   AYIVRILGICPGASLQLVTQLSPQGSLLDHIRQRRDNLNPQRLLNWCVQIAKGMYYLEEQ  778
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         r+vhr+laarn+l+ks   v+i+d+G+a+ll  dek++  ++ k+pikw+alesil+r+y
Q: 779   RMVHRNLAARNILLKSDLIVQIADYGIADLLYPDEKKYFFNEIKTPIKWMALESILFRRY  838
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwe++++Ga+py +++ +++pdllekGerl+qp+ictidvymv+vkcw
Q: 839   THQSDVWSYGVTVWEMMSYGAEPYSAMRPQDVPDLLEKGERLSQPQICTIDVYMVMVKCW  898
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mid+++rp+fkela+ef
Q: 899   MIDENVRPTFKELANEF  915
         ****************9
Domain Sequence
(FASTA)
LKKIKLLGSG VFGTVHKGIW IPEGDTVKIP VAIKTIQDRT GRQTFQEITD HMLAMGSLDH 60
AYIVRILGIC PGASLQLVTQ LSPQGSLLDH IRQRRDNLNP QRLLNWCVQI AKGMYYLEEQ 120
RMVHRNLAAR NILLKSDLIV QIADYGIADL LYPDEKKYFF NEIKTPIKWM ALESILFRRY 180
THQSDVWSYG VTVWEMMSYG AEPYSAMRPQ DVPDLLEKGE RLSQPQICTI DVYMVMVKCW 240
MIDENVRPTF KELANEF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-GAA-00373
EKS-ORN-00391
EKS-ORL-00362
EKS-PES-00266
EKS-TAR-00394
EKS-TEN-00390
EKS-XIM-00382
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 3.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013