EKS-DAR-00875
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00875
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK410.66.3E-12325307283
StatusUnreviewed
Ensembl ProteinENSDARP00000020408
UniProt AccessionQ5RHW0;
Protein Name
Protein Synonyms/Alias Novel protein similar to vertebrate mitogen-activated protein kinase-activated protein kinase family; Si:dkey-14d8.5;
Gene Namemapk12b
Gene Synonyms/Alias mapk12b; si:dkey-14d8.5; DKEY-14D8.5-001;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000006409ENSDARP00000020408ENSDART00000027304
OrganismDanio rerio
Functional Description
Protein Length364
Protein Sequence
(FASTA)
MSLRSRAGFY RQEINRTVWD VPERYRDLIQ IGTGAYGTVC SAIDRKTGVR VAIKKLHRPF 60
QSRLFAKRAY RELRLLKHMK HENVIGLLDV FTSEILLDRF HDFYLVMPFM GTDLGKLMKM 120
ERLCEDRVQF LVYQILRGLK YIHSAGIIHR DLKPGNLAVN QNCELKILDF GLARQADSEM 180
TGYVVTRWYR APEVILNWMH YSQTVDIWSV GCIMAEMLLG RTLFKGNDHL DQLREIMKIT 240
GTPAPDFITK LQSQDAKNYI RGLPKVPKKD LNTIFFKASS EAVSALELML VLDPDKRVSA 300
AEALELPLFT EFREPEEETE ALPYDHSMDN TELPLDQWKR HTFTEILSFQ PPVTEIRDSK 360
ETSL 364
Nucleotide Sequence
(FASTA)
ATGTCACTTC GAAGCAGGGC AGGATTTTAT CGCCAGGAGA TAAACAGAAC CGTTTGGGAC 60
GTTCCAGAGA GATACAGAGA TCTAATCCAG ATCGGAACCG GAGCGTATGG AACAGTCTGT 120
TCAGCCATTG ACCGCAAGAC AGGAGTTCGA GTGGCCATCA AGAAGCTCCA CAGACCGTTC 180
CAGTCCAGAC TGTTCGCCAA GCGCGCTTAC AGAGAGCTAC GACTTCTCAA GCACATGAAA 240
CATGAGAATG TTATCGGGCT GCTGGATGTT TTTACCTCAG AAATCTTGTT GGACAGATTT 300
CATGATTTTT ACCTGGTGAT GCCGTTTATG GGCACTGATC TGGGAAAGCT GATGAAAATG 360
GAGAGACTGT GTGAGGACAG AGTGCAGTTT CTGGTCTATC AGATACTGCG GGGTCTGAAG 420
TATATTCATT CAGCCGGGAT CATTCACAGG GATCTCAAAC CAGGAAATCT GGCAGTGAAT 480
CAAAACTGTG AACTTAAGAT CCTGGACTTT GGACTTGCGC GTCAGGCGGA TTCAGAAATG 540
ACGGGTTATG TGGTGACCCG CTGGTACAGA GCACCAGAGG TTATCCTCAA CTGGATGCAC 600
TACTCACAAA CAGTTGATAT CTGGTCAGTG GGCTGCATCA TGGCGGAGAT GTTACTTGGA 660
AGGACACTTT TTAAAGGCAA TGACCACCTA GACCAGCTGA GAGAGATCAT GAAAATCACA 720
GGAACTCCAG CTCCGGATTT CATCACCAAG CTACAAAGCC AAGATGCCAA AAACTACATC 780
AGAGGTCTAC CTAAAGTCCC AAAGAAAGAC TTAAACACTA TTTTCTTCAA AGCCAGCTCA 840
GAAGCGGTGA GTGCTCTGGA GCTAATGCTG GTTCTGGATC CAGATAAACG TGTAAGCGCT 900
GCAGAGGCGC TCGAACTTCC CCTTTTTACA GAGTTCAGAG AACCTGAAGA AGAGACGGAG 960
GCCCTGCCTT ATGACCACTC CATGGACAAC ACAGAACTGC CTCTGGATCA GTGGAAACGT 1020
CACACTTTTA CAGAGATCCT GTCATTCCAG CCGCCCGTCA CAGAGATCAG AGACTCCAAA 1080
GAAACATCAC TTTGA 1095
Domain Profile
S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60
         y++l ++g+Gayg+v+sa+d++t+ rvaikkl rpfq++  akr++REl+llk++kheN+
Q: 25    YRDLIQIGTGAYGTVCSAIDRKTGVRVAIKKLHRPFQSRLFAKRAYRELRLLKHMKHENV  84
         677889******************************************************
S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120
         i lldvft+e  l++++d+Ylv+ +m+tdL k++k+++l ++++++l+yqilrglky+Hs
Q: 85    IGLLDVFTSEILLDRFHDFYLVMPFMGTDLGKLMKMERLCEDRVQFLVYQILRGLKYIHS  144
         ************************************************************
S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180
         a++iHrDlKP+Nl+vn++celkildFGlar+ad+e    +t+yv+trwYraPe++l++++
Q: 145   AGIIHRDLKPGNLAVNQNCELKILDFGLARQADSE----MTGYVVTRWYRAPEVILNWMH  200
         **********************************9....*********************
S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240
         y+++vDiWsvGCI+aE+l g++lf+g+d++dql++i++++gtp  +f++k++s+ a+nyi
Q: 201   YSQTVDIWSVGCIMAEMLLGRTLFKGNDHLDQLREIMKITGTPAPDFITKLQSQDAKNYI  260
         ************************************************************
S: 241   kslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehp  287
         + lpk +kkd++++f kas+ea+  le +LvldpdkR+s++eaLe p
Q: 261   RGLPKVPKKDLNTIFFKASSEAVSALELMLVLDPDKRVSAAEALELP  307
         ********************************************876
Domain Sequence
(FASTA)
YRDLIQIGTG AYGTVCSAID RKTGVRVAIK KLHRPFQSRL FAKRAYRELR LLKHMKHENV 60
IGLLDVFTSE ILLDRFHDFY LVMPFMGTDL GKLMKMERLC EDRVQFLVYQ ILRGLKYIHS 120
AGIIHRDLKP GNLAVNQNCE LKILDFGLAR QADSEMTGYV VTRWYRAPEV ILNWMHYSQT 180
VDIWSVGCIM AEMLLGRTLF KGNDHLDQLR EIMKITGTPA PDFITKLQSQ DAKNYIRGLP 240
KVPKKDLNTI FFKASSEAVS ALELMLVLDP DKRVSAAEAL ELP 283
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00447
EKS-CAF-00462
EKS-CAP-00495
EKS-EQC-00455
EKS-GAA-00569
EKS-ORN-00585
EKS-ORC-00436
EKS-ORL-00532
EKS-OTG-00468
EKS-PES-00404
EKS-TAG-00528
EKS-TAR-00578
EKS-TEN-00581
EKS-XET-00611
EKS-XIM-00575
Gene Ontology
GO:0005524; F:ATP binding
GO:0004707; F:MAP kinase activity
GO:0000165; P:MAPK cascade
KEGG
dre:557810;
InterPros
IPR011009; Kinase-like_dom.
IPR003527; MAP_kinase_CS.
IPR008352; MAPK_p38.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS01351; MAPK; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR01773; P38MAPKINASE.
Created Date20-Feb-2013