EKS-DAR-00541

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00541

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	375.8	2.3E-112	70	366	297

Status

Unreviewed

Ensembl Protein

ENSDARP00000014914

UniProt Accession

Q1LY62;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase 2; Novel protein similar to vertebrate mitogen-activated protein kinase kinase 1 (MAP2K1);

Gene Name

map2k2a

Gene Synonyms/Alias

map2k2a; map2k2; CH211-195M2.7-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000006609	ENSDARP00000014914	ENSDART00000010048
ENSDARG00000006609	ENSDARP00000105838	ENSDART00000129402

Organism

Danio rerio

Functional Description

Protein Length

397

Protein Sequence
(FASTA)

MAPKRRPVPL IITPTGEGQS TNIDAAAEAN LEALQRKLGE LDLDEQQRKR LEAFLTQKAQ 60

VGELKDEDFE PICELGAGNG GVVHKVRHKP SRLVMARKLI HLEIKPAIRN QIIRELQVLH 120

ECNSPYIVGF YGAFYSDGEI SICMEHMDGG SLDQVLKEAR RIPEEILGKV SIAVLRGLAY 180

LREKHQIMHR DVKPSNILVN SRGEIKLCDF GVSGQLIDSM ANSFVGTRSY MSPERLQGTH 240

YSVQSDVWSM GLSLVELAIG RYPIPPPDAK ELEAIFGRPV LDAGGAEGHS MSPRPRPPGR 300

PVSGHGMDSR PAMAIFELLD YIVNEPPPKL PHGVFTTDFE EFVTKCLIKN PADRADLKML 360

MGHTFIKRAE VEEVDFAGWL CKTMGLHQPS TPTHSAE 397

Nucleotide Sequence
(FASTA)

ATGGCACCAA AAAGAAGACC AGTCCCCTTG ATTATAACCC CCACTGGAGA GGGACAGTCA 60

ACCAACATTG ATGCAGCAGC AGAGGCCAAC CTGGAGGCCT TGCAGAGGAA GTTAGGTGAG 120

CTGGATTTGG ATGAACAGCA GAGGAAGCGC CTCGAAGCTT TCCTCACCCA GAAAGCCCAG 180

GTGGGCGAGC TCAAGGATGA AGATTTCGAA CCCATATGTG AACTTGGCGC TGGTAATGGT 240

GGAGTGGTTC ATAAAGTCCG TCACAAACCC TCGAGACTGG TTATGGCCAG GAAGCTTATA 300

CACTTGGAAA TCAAACCAGC CATCAGGAAC CAGATTATTC GAGAGCTGCA GGTTCTACAC 360

GAGTGTAACT CACCGTACAT TGTAGGGTTT TACGGCGCCT TCTACAGTGA TGGAGAAATC 420

AGCATCTGTA TGGAGCACAT GGATGGAGGC TCTTTGGATC AAGTGCTCAA AGAAGCCAGA 480

AGAATCCCTG AGGAAATTTT GGGCAAAGTT AGCATAGCTG TACTCAGAGG TTTGGCGTAT 540

CTTCGGGAGA AGCACCAAAT AATGCACAGA GACGTTAAGC CCTCCAACAT CCTGGTGAAC 600

TCGCGCGGTG AGATCAAACT GTGCGACTTT GGTGTGAGTG GCCAGCTCAT CGACTCTATG 660

GCCAACTCCT TCGTTGGAAC ACGGTCGTAC ATGTCGCCGG AGAGACTCCA GGGCACGCAC 720

TACTCGGTTC AGTCGGATGT GTGGAGCATG GGCCTATCAC TGGTTGAGCT TGCTATTGGA 780

CGCTACCCCA TCCCCCCTCC CGATGCTAAG GAACTGGAGG CCATATTTGG CCGGCCAGTG 840

CTGGATGCAG GTGGGGCAGA AGGTCACAGC ATGTCTCCAA GACCCAGGCC TCCAGGACGA 900

CCAGTTAGTG GACACGGAAT GGACAGCAGG CCAGCAATGG CTATATTTGA GCTACTGGAC 960

TACATTGTCA ATGAGCCTCC ACCCAAGCTC CCCCATGGCG TCTTCACCAC AGACTTTGAG 1020

GAGTTTGTGA CAAAATGCCT CATAAAGAAC CCTGCTGACA GAGCTGACCT CAAGATGCTA 1080

ATGGGTCACA CGTTCATCAA GCGGGCTGAG GTTGAGGAGG TGGATTTTGC TGGATGGTTG 1140

TGTAAAACCA TGGGCCTTCA CCAGCCTAGC ACACCCACTC ATAGCGCTGA ATGA 1194

Domain Profile

S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv  61

         e + elGaGnggvV+kv+hk+s  ++a+K i+leik+++++qi+rel+vl+++ nspyiv

Q: 70    EPICELGAGNGGVVHKVRHKPSRLVMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIV  128

         56789************************************************.******

S: 62    kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek  121

         +fyGaf+s+g++sicme+mdg+sld+vlk+    ++ripe++lgk+++av+++l+yl+ek

Q: 129   GFYGAFYSDGEISICMEHMDGGSLDQVLKE----ARRIPEEILGKVSIAVLRGLAYLREK  184

         *****************************9....79************************

S: 122   lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv  181

         ++i+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++Ysv

Q: 185   HQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYSV  243

         ******************************************************.*****

S: 182   ksdvWslGltlvelatgrypyeklke..................................  207

         +sdvWs+Gl+lvela+gryp++++++

Q: 244   QSDVWSMGLSLVELAIGRYPIPPPDAkeleaifgrpvldaggaeghsmsprprppgrpvs  303

         ************************999*********************************

S: 208   ...........ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellkh  256

                    i+ell++ivne+ppklp+  f+++f+efv+kCl+k++++R++lk+l+ h

Q: 304   ghgmdsrpamaIFELLDYIVNEPPPKLPHGVFTTDFEEFVTKCLIKNPADRADLKMLMGH  363

         ************************************************************

S: 257   afi  259

+fi

Q: 364   TFI  366

*97

Domain Sequence
(FASTA)

EPICELGAGN GGVVHKVRHK PSRLVMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG 60

FYGAFYSDGE ISICMEHMDG GSLDQVLKEA RRIPEEILGK VSIAVLRGLA YLREKHQIMH 120

RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDVWS 180

MGLSLVELAI GRYPIPPPDA KELEAIFGRP VLDAGGAEGH SMSPRPRPPG RPVSGHGMDS 240

RPAMAIFELL DYIVNEPPPK LPHGVFTTDF EEFVTKCLIK NPADRADLKM LMGHTFI 297

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

dre:563181

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013