EKS-DAR-00763

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00763

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	305.0	8.5E-91	18	259	242

Status

Unreviewed

Ensembl Protein

ENSDARP00000093598

UniProt Accession

B0S4Y7;

Protein Name

Protein Synonyms/Alias

Novel protein similar to vertebrate sterile alpha motif and leucine zipper containing kinase AZK (ZAK);

Gene Name

zak

Gene Synonyms/Alias

zak; DKEY-15I8.3-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000006978	ENSDARP00000093598	ENSDART00000102823

Organism

Danio rerio

Functional Description

Protein Length

789

Protein Sequence
(FASTA)

MASLGSSFVQ IKFDDIHFYE NCGGGSFGSV YRARWLSQDR EVAVKKLLKI EKEAEILSVL 60

SHRNIIKFYG AILEAPNYGI VTEYASGGSL FDYLSSDDSE DISMQQIMTW AMDIAKGMHY 120

LHSEAPVKVI HRDLKSRNVV LSSDSVLKIC DFGASKFHSH TTHMSLVGTF PWMAPEVIQS 180

LPVSETCDTF SYGVVLWEML TQEIPFKGLE GLQVAWLVVE KHERLTIPSS CPASFACLMR 240

SCWATEPKER PLFKHILSTL ESMWSDTQLP DKCNTFLQNK AEWRCEIEAT LERLKRLERD 300

LSTKEQALKE RERRLKMWER KLIEQSNTPL LPNLAIHSWT EEHVHFWMEQ IFEGDGELQQ 360

YANVFRQNHI TGQRLLLLSE SDMRDLGVTS KGHIIHLKTE IEKLTHDYLN LFHFPPLIKD 420

GSASEEADED WSKTVNLELV FGYHWKAGTG QKDCKWKMYM ELDGDEVAIA YIKDVTFNAN 480

RPDVDVLKMT KPPFVMDKWI VGISGTHTVD YIVNYEGNVK SPKCTRHVHT VQWSADSGKD 540

VIKPVELVIE TAPGIREAHN RSRSNSGVDP KWIYSLRMKQ MKEQAAQESP SKMSLPQFLS 600

VISNQSSYAA AVRRSPNRSP LSPWTDSRSS SPTLSVKLSN MHLGSKGSSP SSTTSESASE 660

RERPPSAGAK HNYNKKPYYD HHTLKMSSRG DGEPRRFLPQ RGSRGFQHAG RPRNAHSYAT 720

PPHYQRPIPG MSMAAEGPKQ KVASEEPGDG DWIKVERKKT NKQECKYQEV RPVRGRSRRG 780

GRGGGRGRN 789

Nucleotide Sequence
(FASTA)

ATGGCATCTC TGGGCAGCTC CTTTGTGCAG ATCAAGTTTG ATGACATCCA CTTCTATGAG 60

AACTGCGGCG GCGGCAGCTT CGGGAGTGTG TATCGCGCCC GCTGGCTCTC GCAGGACAGA 120

GAGGTGGCGG TGAAAAAACT GCTGAAGATC GAGAAAGAGG CTGAGATTTT GAGCGTTCTC 180

AGTCATCGGA ACATTATCAA GTTTTATGGA GCGATTCTGG AAGCGCCCAA TTATGGGATT 240

GTTACAGAGT ATGCCAGTGG CGGGTCTCTG TTTGACTATC TGTCCAGCGA CGACAGCGAG 300

GACATCAGTA TGCAGCAGAT CATGACCTGG GCCATGGACA TCGCTAAAGG CATGCATTAT 360

CTGCACTCTG AGGCCCCGGT TAAAGTCATT CACAGAGACC TCAAGTCCCG AAATGTTGTG 420

TTAAGCTCAG ATTCAGTACT CAAGATCTGT GATTTCGGGG CGTCCAAGTT TCATTCACAC 480

ACCACACACA TGTCTCTGGT GGGCACGTTT CCCTGGATGG CCCCTGAGGT CATTCAGAGC 540

CTCCCGGTGT CTGAGACCTG CGACACCTTC TCCTACGGCG TGGTCCTGTG GGAGATGCTG 600

ACTCAGGAGA TTCCCTTCAA AGGTCTGGAG GGGCTTCAGG TGGCCTGGCT GGTGGTGGAG 660

AAACATGAGA GGTTGACGAT CCCCAGCAGC TGCCCAGCAA GTTTCGCCTG TTTGATGAGA 720

AGCTGCTGGG CGACTGAACC AAAAGAGCGG CCGCTGTTTA AACACATCCT GTCCACACTG 780

GAGTCCATGT GGAGCGACAC TCAGCTGCCT GACAAGTGCA ACACTTTCCT GCAGAATAAA 840

GCCGAGTGGA GGTGTGAGAT CGAGGCGACT CTGGAGCGTC TGAAGCGTTT GGAAAGAGAT 900

CTGAGCACCA AAGAACAAGC GCTGAAGGAG CGAGAGAGAC GCTTGAAGAT GTGGGAGAGG 960

AAACTGATCG AGCAGTCAAA CACACCGCTT CTTCCAAACC TGGCCATTCA CTCCTGGACA 1020

GAAGAGCATG TGCATTTCTG GATGGAGCAG ATCTTTGAAG GTGACGGAGA GCTGCAGCAG 1080

TACGCCAATG TCTTCAGACA GAACCACATC ACAGGACAGA GACTGCTGCT GCTGTCCGAG 1140

TCTGACATGA GAGATCTGGG TGTGACGTCT AAAGGACACA TCATACACCT GAAGACTGAA 1200

ATCGAGAAAC TGACCCACGA CTACCTGAAT CTGTTTCACT TTCCTCCGCT GATCAAGGAC 1260

GGTTCGGCCT CTGAGGAAGC AGACGAGGAC TGGAGCAAGA CAGTGAACCT GGAGCTGGTG 1320

TTTGGGTATC ACTGGAAAGC AGGCACAGGA CAAAAGGACT GCAAATGGAA AATGTACATG 1380

GAGCTGGACG GGGACGAGGT GGCGATAGCG TACATCAAAG ACGTGACCTT TAACGCCAAC 1440

AGACCAGATG TAGATGTTTT AAAGATGACC AAGCCTCCTT TCGTGATGGA TAAATGGATA 1500

GTGGGAATAT CTGGCACACA TACTGTTGAC TACATAGTGA ACTATGAGGG TAACGTGAAA 1560

TCTCCGAAGT GTACAAGACA CGTTCACACA GTGCAGTGGA GTGCAGACAG CGGAAAAGAC 1620

GTGATCAAAC CTGTGGAGCT GGTCATCGAG ACGGCGCCGG GCATCAGGGA GGCGCACAAC 1680

AGGAGCAGGT CCAACTCAGG TGTGGATCCC AAATGGATTT ACAGTCTGAG AATGAAGCAG 1740

ATGAAAGAGC AGGCGGCCCA GGAGTCCCCC AGCAAAATGA GCCTCCCTCA GTTCCTGTCC 1800

GTCATCAGCA ACCAGTCTTC ATATGCGGCA GCTGTAAGAA GATCTCCAAA CCGCAGTCCT 1860

CTCAGTCCCT GGACCGACTC CCGCAGCTCC TCTCCAACTC TCTCCGTCAA ACTCTCCAAC 1920

ATGCACCTGG GCTCCAAAGG CAGCAGTCCG TCCAGCACCA CCTCCGAGAG CGCATCCGAA 1980

CGCGAGCGGC CCCCGAGCGC TGGAGCCAAA CACAACTACA ACAAAAAACC CTACTACGAT 2040

CACCACACAC TGAAGATGAG CAGTAGAGGA GATGGAGAAC CCAGGAGGTT TCTGCCGCAG 2100

AGAGGATCTA GAGGCTTCCA ACATGCTGGA CGACCACGAA ACGCACACTC ATACGCAACG 2160

CCACCGCACT ACCAAAGGCC CATACCGGGG ATGTCAATGG CCGCTGAAGG GCCGAAGCAG 2220

AAAGTGGCGT CTGAGGAACC AGGGGATGGG GACTGGATTA AAGTAGAGAG GAAAAAGACA 2280

AACAAACAGG AGTGTAAATA TCAGGAAGTG AGGCCGGTCA GAGGTCGGTC GCGTAGAGGT 2340

GGGAGAGGCG GTGGACGGGG GCGTAACTGA 2370

Domain Profile

S: 3     leeligsgafgkvykakwrkke..vavKklreeaeekekleklereakllsklshpniie  60

         + e +g g+fg+vy+a+w +++  vavKkl +          +e+ea++ls lsh+nii+

Q: 18    FYENCGGGSFGSVYRARWLSQDreVAVKKLLK----------IEKEAEILSVLSHRNIIK  67

         67899*************665555****9987..........899***************

S: 61    llGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapk  120

         ++G++le pn+++v+ey++ggsL+++l++++++ i+++++++wa++iA+Gm+YLhseap+

Q: 68    FYGAILEAPNYGIVTEYASGGSLFDYLSSDDSEDISMQQIMTWAMDIAKGMHYLHSEAPV  127

         ************************************************************

S: 121   kiihrdLksknvLlseekktlkicdFGtarelskstkmsaagtlawmaPEvlkeekvsek  180

         k+ihrdLks+nv+l +++ +lkicdFG ++++s++t+ms  gt+ wmaPEv+++ +vse+

Q: 128   KVIHRDLKSRNVVL-SSDSVLKICDFGASKFHSHTTHMSLVGTFPWMAPEVIQSLPVSET  186

         **************.*********************************************

S: 181   sDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwned  240

         +D +SygvvLWe+lt+e+P+k+l+ l++a+ v++k++rl+ipsscp++++ Lm++cw+++

Q: 187   CDTFSYGVVLWEMLTQEIPFKGLEGLQVAWLVVEKHERLTIPSSCPASFACLMRSCWATE  246

         ************************************************************

S: 241   pekRpsfseivks  253

         p++Rp f++i+++

Q: 247   PKERPLFKHILST  259

         **********976

Domain Sequence
(FASTA)

FYENCGGGSF GSVYRARWLS QDREVAVKKL LKIEKEAEIL SVLSHRNIIK FYGAILEAPN 60

YGIVTEYASG GSLFDYLSSD DSEDISMQQI MTWAMDIAKG MHYLHSEAPV KVIHRDLKSR 120

NVVLSSDSVL KICDFGASKF HSHTTHMSLV GTFPWMAPEV IQSLPVSETC DTFSYGVVLW 180

EMLTQEIPFK GLEGLQVAWL VVEKHERLTI PSSCPASFAC LMRSCWATEP KERPLFKHIL 240

ST 242

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

dre:559247

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00454

; SAM; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013