EKS-DAR-00751

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00751

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	428.7	1.4E-128	222	469	248

Status

Unreviewed

Ensembl Protein

ENSDARP00000008826

UniProt Accession

Q5TYU7;

Protein Name

Protein Synonyms/Alias

Novel protein tyrosine kinase;

Gene Name

blk

Gene Synonyms/Alias

blk; bltk, si:dkey-33i22.2; DKEY-33I22.2-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000007783	ENSDARP00000008826	ENSDART00000020099
ENSDARG00000007783	ENSDARP00000120039	ENSDART00000138028

Organism

Danio rerio

Functional Description

Protein Length

485

Protein Sequence
(FASTA)

MGCACSDQNH PKGHEHYNST NSKTSHASRD HKKQNNNQDE DVVIAQYDFQ PASENDLQFK 60

KGDRLRIIKE NGEWWLAKSL VTGYEGFIPS TYVARAQTLQ VERWFFKDMN RRDTERLLLA 120

PGNKPGSFLV RESETTKGAF SLSIRDSTPE QGDVVKHYKI RALDNGGYYI SPSTSFSSLQ 180

ELVKYYSRTA DGLCQRLGNP CKSTAPQRPW AQDEWEIPRE TLKLVKKLGA GQFGEVWMGF 240

YKNNQKVAIK TLKEGTMEPE AFLQEANLMK QLQHERLVKL HAVVTREPIY IVTEYMANGS 300

LLDFLKTDDG HKLKLSKLID MTAQIAEGMA YIERKNYIHR DLRAANILVS ETLHCKIADF 360

GLARIIETEY TAQEGAKFPI KWTAPEAINY GTFTIKSDVW SFGILLTEIV TYGRVPYPGM 420

TNPEVIRNLD RNYRMPCPDA CPGELYDIMT KCWMEKPEDR PTFEYLQDTL NDFFIATEGQ 480

YEMQP 485

Nucleotide Sequence
(FASTA)

ATGGGTTGTG CTTGTAGTGA CCAGAACCAT CCAAAAGGTC ATGAGCATTA TAATTCAACA 60

AACTCTAAGA CATCTCACGC GTCAAGAGAT CACAAGAAGC AAAACAACAA CCAAGATGAA 120

GATGTTGTTA TTGCACAATA TGACTTCCAG CCTGCTAGTG AAAATGATCT TCAATTCAAA 180

AAAGGGGACA GACTCAGGAT TATTAAGGAA AATGGAGAAT GGTGGTTGGC GAAGTCCTTG 240

GTCACAGGTT ATGAGGGATT TATTCCATCT ACGTATGTGG CAAGAGCGCA AACGCTACAG 300

GTGGAGCGAT GGTTTTTTAA GGACATGAAT CGTAGAGATA CAGAGCGTCT TCTGCTAGCA 360

CCAGGAAATA AACCTGGTTC CTTTCTTGTG AGAGAAAGTG AAACAACCAA AGGTGCGTTC 420

TCTCTGTCCA TCAGAGACTC CACTCCAGAG CAGGGTGATG TGGTCAAGCA CTATAAGATT 480

CGAGCCCTGG ATAATGGCGG ATATTACATC TCCCCGTCCA CAAGCTTTTC TTCTCTTCAA 540

GAGCTGGTGA AGTATTACTC TAGGACAGCG GATGGTTTGT GCCAGAGGTT AGGAAATCCC 600

TGTAAAAGCA CCGCCCCTCA GAGACCCTGG GCTCAGGATG AGTGGGAGAT TCCCAGAGAA 660

ACTCTGAAGC TGGTGAAGAA ATTGGGTGCT GGTCAGTTTG GAGAAGTGTG GATGGGGTTC 720

TACAAAAACA ACCAAAAAGT TGCCATCAAG ACTTTAAAGG AAGGCACGAT GGAGCCTGAA 780

GCCTTCCTGC AGGAGGCCAA TCTGATGAAG CAGCTCCAGC ATGAGAGACT GGTCAAACTG 840

CACGCTGTCG TCACCAGAGA GCCCATTTAT ATTGTCACTG AGTACATGGC TAATGGAAGC 900

CTGTTAGACT TTCTGAAGAC AGACGATGGC CATAAATTAA AACTTTCCAA GCTGATTGAT 960

ATGACTGCTC AAATAGCGGA GGGCATGGCT TACATCGAGA GAAAAAACTA CATTCACAGA 1020

GACCTGCGTG CCGCTAATAT TCTCGTCTCA GAGACCCTGC ACTGTAAAAT AGCTGACTTT 1080

GGTCTTGCCA GGATCATAGA AACAGAATAC ACTGCACAAG AGGGTGCAAA GTTCCCTATT 1140

AAGTGGACGG CTCCTGAAGC CATCAACTAC GGTACTTTCA CCATCAAGTC AGACGTGTGG 1200

TCCTTCGGAA TTCTTTTAAC AGAGATTGTC ACATATGGCC GAGTACCGTA TCCAGGCATG 1260

ACGAATCCGG AGGTGATCCG TAACCTTGAC AGGAACTATA GGATGCCGTG TCCAGACGCA 1320

TGTCCAGGAG AGCTCTATGA CATCATGACA AAGTGTTGGA TGGAAAAGCC AGAGGACAGG 1380

CCTACTTTTG AATATCTGCA GGACACACTC AATGACTTCT TCATTGCTAC TGAAGGCCAG 1440

TATGAGATGC AGCCATAA 1458

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lklvkklG+GqfGevw+g +k++ kva+ktlkegt++peafl+ea+++k+l+he+lvkl+

Q: 222   LKLVKKLGAGQFGEVWMGFYKNNQKVAIKTLKEGTMEPEAFLQEANLMKQLQHERLVKLH  281

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ ePiyivte+ma+Gslldflk+++g+klkl+kl+d++aq+aeGmay+e+kn+ihr

Q: 282   AVVTR-EPIYIVTEYMANGSLLDFLKTDDGHKLKLSKLIDMTAQIAEGMAYIERKNYIHR  340

         *****.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+e+l +k+adfGlar+i + eyta+egak+PikWtaPeai++g+ftiksdv

Q: 341   DLRAANILVSETLHCKIADFGLARII-ETEYTAQEGAKFPIKWTAPEAINYGTFTIKSDV  399

         **************************.689******************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillteivt+G+vPypGmtn ev+++++r+yr+p+p++cp ely+++++cw ++pe+

Q: 400   WSFGILLTEIVTYGRVPYPGMTNPEVIRNLDRNYRMPCPDACPGELYDIMTKCWMEKPED  459

         ************************************************************

S: 241   rPtfetlqev  250

         rPtfe+lq +

Q: 460   RPTFEYLQDT  469

         *******986

Domain Sequence
(FASTA)

LKLVKKLGAG QFGEVWMGFY KNNQKVAIKT LKEGTMEPEA FLQEANLMKQ LQHERLVKLH 60

AVVTREPIYI VTEYMANGSL LDFLKTDDGH KLKLSKLIDM TAQIAEGMAY IERKNYIHRD 120

LRAANILVSE TLHCKIADFG LARIIETEYT AQEGAKFPIK WTAPEAINYG TFTIKSDVWS 180

FGILLTEIVT YGRVPYPGMT NPEVIRNLDR NYRMPCPDAC PGELYDIMTK CWMEKPEDRP 240

TFEYLQDT 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

dre:567764

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013