EKS-DAR-00041
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00041
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak326.43.2E-978131084272
StatusUnreviewed
Ensembl ProteinENSDARP00000026708
UniProt AccessionF1QWX8;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene Namejak2a
Gene Synonyms/Alias jak2a;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000007915ENSDARP00000107572ENSDART00000127639
ENSDARG00000007915ENSDARP00000026708ENSDART00000004255
OrganismDanio rerio
Functional Description
Protein Length1095
Protein Sequence
(FASTA)
MMLANTENEQ KQASGAALQV RLYCCRDGAG VISYPAGEYT AEELSVTAAK QCGVSPVHCA 60
LFGLMRERDR VWLPPNHIFK IEPSANETLL FRVRFYFPGW YGSGCSSARR YGLSRSSEAP 120
VCDDITTAYL CAQWRSDFLS GAVSVPVSLE FQEECLGLAV LDIMRLAKEK GKSPVDIYNH 180
SSYKSFLPKN MREHIQNQHL VTRKRIRFRF RRFLQQFGSC KAAPRELKLK YVVSLETLQP 240
AFYSEHFRVS EASAGSVTIV VSGDRGIQWC RAAAPEPEDL QVYCDFSDVI DISIKQGTKD 300
GSVENRIVTI NRQDSQTLEL EFQSLSEALS FVSLIDGYYR LTTDAHHYLC KEVAPPRLLE 360
AIQINCHGPL STEFAVSRLR RCEGQPGVYI LRCSPKDYDR YFLSFMVEAE GQLELKHCLV 420
LRSLSGEFVL SGARCSFSSL SELLARYQKE ALRSDTHVFQ LRRCCPPRSK DKSNLLVCRT 480
HQGSEVCAPS SEHRLVNQMI FHKIHREDLQ TTEGLGQGTF TQVFRGIRRE VGDYGEVHKM 540
EVVMKILDKS HRNYTESFFE SASMMSQLSH KHLLLNYGIC VCADEHIMVQ EYVRFGSLDT 600
YLKRNRNTIN ITWKLEVAKQ LAWALHHLEE KSLTHGNVCA RNVLVTREED RKTGTPPFIK 660
LSDPGISITV QPREILLERI PWVPPECVKD SRNLSLAADK WSFGTTLWEI YCGGEQPLAA 720
YDTAKKLLFY EDKHQLPAPK WTELASVINS CMDYEPLHRP SFRALIRDLN SLYTPDYELL 780
VESDTVPSRH RGPGLAGAFE SQEPTQFQAR HLIFLQLLGK GNFGSVEKCR YDPLQDNTGE 840
VVAVKKLQHS TAEHLRDFER EIEILRSLQH ENIVRYKGVC YSAGRNNLRL VMEFLPFGSL 900
RDYLSKNRER FDHSKLLLYA SQICKGMDYL AEKRYVHRDL ATRNILVESE FRVKIGDFGL 960
TKVLPQDKEY YTVREPGESP IFWYAPESLT ESKFSVASDV WSFGVVLYEL FTYSEKSCSP 1020
PAVFMEQMGE DKQGQMIVYH LIDLLKRNYR LPAPDGCPAE IHALMKQCWA PEPADRPLFR 1080
DLARTVEDIQ DSQSG 1095
Nucleotide Sequence
(FASTA)
ATGATGCTGG CCAACACAGA GAACGAGCAG AAGCAGGCGA GTGGCGCCGC CCTGCAGGTC 60
CGTCTGTACT GCTGCAGAGA CGGGGCCGGA GTCATCAGCT ATCCTGCAGG AGAATACACA 120
GCGGAGGAGC TGAGCGTCAC TGCAGCCAAA CAATGCGGGG TCAGCCCTGT GCACTGTGCT 180
CTGTTCGGGC TGATGCGGGA GCGGGACCGT GTCTGGCTGC CACCCAATCA CATCTTCAAG 240
ATCGAGCCCT CGGCCAATGA GACGCTGCTG TTCAGAGTCA GGTTCTATTT CCCCGGCTGG 300
TACGGCAGCG GCTGCAGCTC CGCCCGCAGG TACGGCCTCA GCAGGAGCTC CGAGGCGCCG 360
GTGTGTGATG ACATCACCAC AGCGTACCTG TGCGCACAGT GGCGGTCAGA CTTCCTGAGC 420
GGAGCGGTCA GTGTCCCCGT CAGTCTGGAG TTTCAGGAGG AGTGTTTGGG TTTGGCGGTT 480
CTGGACATCA TGCGATTGGC TAAAGAGAAG GGCAAATCAC CTGTCGACAT CTACAACCAC 540
AGCAGTTATA AGTCGTTTCT GCCGAAGAAC ATGCGGGAGC ACATCCAGAA CCAGCACTTG 600
GTGACCCGCA AGAGGATCCG CTTCCGCTTC CGCCGCTTCC TCCAGCAGTT CGGCTCCTGT 660
AAAGCCGCGC CGCGAGAGCT GAAGCTCAAA TACGTGGTGA GCCTGGAGAC GCTGCAGCCG 720
GCCTTCTACA GCGAGCACTT CCGGGTCAGC GAGGCGTCCG CAGGAAGTGT CACCATCGTG 780
GTGAGCGGAG ACCGCGGCAT CCAGTGGTGT CGGGCGGCGG CGCCGGAGCC AGAGGATCTG 840
CAGGTGTACT GCGACTTCTC AGACGTCATC GACATCAGCA TCAAGCAGGG GACCAAAGAC 900
GGGTCGGTGG AGAACAGGAT CGTCACTATA AACCGACAGG ACAGCCAGAC ACTGGAGCTG 960
GAGTTCCAGT CTCTGAGTGA GGCTCTGTCG TTTGTGTCTC TGATCGACGG CTACTACAGA 1020
CTGACCACAG ACGCCCATCA TTACCTGTGT AAGGAGGTGG CGCCCCCTAG ACTACTGGAG 1080
GCCATTCAGA TCAACTGCCA TGGGCCTTTG TCGACGGAGT TCGCCGTCAG CCGTCTGCGG 1140
CGCTGTGAGG GTCAGCCGGG TGTCTACATC CTGCGCTGCA GCCCTAAAGA CTACGACAGG 1200
TACTTCCTGT CCTTCATGGT GGAGGCGGAG GGCCAGCTGG AGCTGAAGCA CTGTCTGGTG 1260
TTGCGCTCTC TCTCCGGGGA GTTTGTGCTG AGCGGCGCAC GCTGCAGCTT CAGCAGTCTG 1320
AGTGAGCTAC TGGCACGCTA CCAGAAGGAG GCGCTGCGCT CCGACACACA CGTCTTCCAG 1380
CTGCGCCGCT GCTGCCCGCC GCGCAGCAAA GATAAGTCGA ATCTGCTGGT GTGCCGCACT 1440
CATCAAGGCT CTGAGGTGTG TGCGCCGTCC TCTGAGCACC GGCTGGTCAA CCAGATGATC 1500
TTCCACAAGA TCCACAGAGA AGACCTGCAG ACGACGGAGG GTCTGGGTCA GGGCACCTTC 1560
ACACAGGTCT TCCGTGGCAT CCGGCGAGAG GTTGGAGATT ATGGAGAAGT GCACAAGATG 1620
GAGGTGGTGA TGAAGATTCT GGACAAGAGT CACCGCAACT ACACTGAGTC GTTCTTCGAG 1680
TCGGCCAGTA TGATGAGCCA GCTCTCCCAT AAACACCTGC TGCTGAACTA CGGCATCTGT 1740
GTGTGCGCGG ATGAACACAT CATGGTGCAG GAGTACGTGC GCTTCGGCTC TCTGGACACG 1800
TACCTGAAGA GAAACCGCAA CACCATCAAC ATCACCTGGA AGCTGGAGGT GGCTAAGCAG 1860
CTAGCATGGG CGCTACATCA CCTGGAGGAG AAAAGTCTGA CCCATGGGAA CGTCTGCGCC 1920
AGGAATGTTC TGGTGACCCG TGAGGAGGAC CGTAAAACAG GGACACCACC CTTCATCAAG 1980
CTCAGCGACC CGGGCATCAG CATCACCGTC CAGCCCAGAG AGATTCTGCT GGAGCGTATC 2040
CCCTGGGTTC CTCCAGAGTG TGTGAAGGAC AGCAGGAATC TCAGTCTGGC TGCAGATAAG 2100
TGGAGCTTCG GCACCACACT GTGGGAGATC TACTGCGGAG GAGAACAGCC GCTCGCTGCG 2160
TACGACACGG CCAAGAAGCT GCTGTTCTAT GAGGATAAGC ACCAGCTGCC GGCCCCTAAG 2220
TGGACCGAGT TGGCCAGTGT GATCAACAGC TGTATGGACT ATGAGCCGCT GCACCGGCCG 2280
TCCTTCAGGG CGCTGATCCG AGACCTCAAC AGCCTCTACA CTCCAGACTA TGAGCTGCTG 2340
GTAGAGAGCG ACACAGTTCC CAGCAGGCAT CGGGGCCCAG GCCTCGCCGG AGCCTTCGAG 2400
AGTCAGGAGC CCACACAGTT CCAGGCGCGA CACCTGATAT TCCTGCAGCT GCTGGGGAAG 2460
GGTAATTTCG GCAGTGTGGA GAAGTGCCGC TATGACCCGC TGCAGGATAA CACCGGTGAG 2520
GTCGTGGCGG TGAAGAAGCT TCAGCACAGC ACGGCGGAGC ACCTGCGCGA CTTCGAGCGC 2580
GAGATCGAGA TCCTGCGGTC GCTGCAGCAC GAGAACATCG TGCGCTATAA GGGCGTGTGT 2640
TACAGCGCAG GACGCAACAA CCTGCGGCTG GTGATGGAGT TCCTCCCGTT CGGCAGCCTG 2700
CGAGACTACC TGAGCAAGAA CAGGGAACGC TTCGACCACA GCAAACTGCT GCTGTACGCC 2760
TCGCAGATCT GCAAGGGCAT GGACTATCTG GCAGAGAAGC GTTACGTTCA TCGGGATCTG 2820
GCCACGCGCA ACATCCTGGT GGAGAGCGAG TTTCGGGTGA AGATCGGAGA CTTCGGCCTG 2880
ACTAAAGTTC TCCCTCAGGA TAAGGAGTAT TACACAGTGC GAGAGCCCGG AGAAAGCCCC 2940
ATATTCTGGT ATGCGCCGGA GTCTCTGACC GAGAGTAAGT TCAGCGTGGC GTCAGACGTC 3000
TGGAGTTTCG GAGTCGTCCT CTATGAACTG TTCACCTACA GTGAGAAGAG CTGCAGTCCT 3060
CCAGCGGTGT TCATGGAGCA GATGGGTGAG GATAAACAGG GTCAGATGAT CGTCTATCAC 3120
CTGATCGACC TGCTGAAGCG GAACTACCGG CTGCCCGCTC CAGATGGGTG TCCAGCAGAG 3180
ATCCATGCGC TGATGAAGCA GTGCTGGGCC CCGGAGCCGG CCGATCGCCC CCTGTTCAGA 3240
GACCTCGCTC GCACAGTCGA GGACATCCAG GACAGCCAGA GCGGCTGA 3288
Domain Profile
S: 2     kqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlsheh  61
          +++ Lgkg+f++v+++r+d+ +d+t+e va+k L++s+ ++ rdf+re+eil++l+he+
Q: 813   IFLQLLGKGNFGSVEKCRYDPLQDNTGEVVAVKKLQHSTAEHLRDFEREIEILRSLQHEN  872
         56789*******************************************************
S: 62    ivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLed  119
         iv +kgvc++ g+n  rlVme+++ GsL++yL+k++e+ ++s+ll +a+q++k+m+YL +
Q: 873   IVRYKGVCYSAGRNnlRLVMEFLPFGSLRDYLSKNRERFDHSKLLLYASQICKGMDYLAE  932
         *************99*********************************************
S: 120   kklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwlap  178
         k++vhrd+a+rn+Lve+e +      vk++d+gl+k+++qd eYy+vre+++s+i+w+ap
Q: 933   KRYVHRDLATRNILVESEFR------VKIGDFGLTKVLPQDkEYYTVREPGESPIFWYAP  986
         ********************......**********************************
S: 179   eclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklell  225
         e+l+e+k +s+asdvWsFgv+lyel+t  +k++sp    +++++ +        +++ ll
Q: 987   ESLTESK-FSVASDVWSFGVVLYELFTySEKSCSPpavfMEQMGEDkqgqmivyHLIDLL  1045
         *******.*******************99999*****8888887779999**********
S: 226   eekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263
         +++ rlp+p+ cpae++ lm++c++ ep +rp Fr++++
Q: 1046  KRNYRLPAPDgCPAEIHALMKQCWAPEPADRPLFRDLAR  1084
         ************************************987
Domain Sequence
(FASTA)
IFLQLLGKGN FGSVEKCRYD PLQDNTGEVV AVKKLQHSTA EHLRDFEREI EILRSLQHEN 60
IVRYKGVCYS AGRNNLRLVM EFLPFGSLRD YLSKNRERFD HSKLLLYASQ ICKGMDYLAE 120
KRYVHRDLAT RNILVESEFR VKIGDFGLTK VLPQDKEYYT VREPGESPIF WYAPESLTES 180
KFSVASDVWS FGVVLYELFT YSEKSCSPPA VFMEQMGEDK QGQMIVYHLI DLLKRNYRLP 240
APDGCPAEIH ALMKQCWAPE PADRPLFRDL AR 272
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Drosophila melanogaster"; ?>Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-DRM-00011
EKS-GAA-00047
EKS-ORN-00047
EKS-ORL-00044
EKS-TEN-00052
EKS-XIM-00045
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR019749; Band_41_domain.
IPR019748; FERM_central.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
Pfam
PF07714; Pkinase_Tyr; 2.
PF00017; SH2; 1.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
Prints
PR01823; JANUSKINASE.
PR00109; TYRKINASE.
Created Date20-Feb-2013