EKS-DAR-00044
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00044
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak288.21.4E-858171086270
StatusUnreviewed
Ensembl ProteinENSDARP00000049468
UniProt AccessionB0V237;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene Namejak3
Gene Synonyms/Alias jak3; DKEY-205D4.1-001;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000010252ENSDARP00000049468ENSDART00000049469
OrganismDanio rerio
Functional Description
Protein Length1103
Protein Sequence
(FASTA)
MSEEEEVPLM KSERAGSQRS SCDSALQVHL YYSPSLNSET TFSIPTGHVT AESVCVLAAK 60
ASGILPVYHN LFALASEDLS YWYPPNHLFK SEEPVKVYYR VRFFFSSWFG QESRASYRFS 120
LSKGRIFAVL DYAVIDYVFA QSRSDFVTGC GGISPALSLQ QECLGLAVLD LWRLAKERNQ 180
SLAEICNTTS YKSCLPETHR QDIQRMNRLA RYQIRKTLKR FLKKLGKCSA GERSLKLKYL 240
MKLSELEPDY GSESFPLHHS GWLEQSEQQR VLAVKVSGEG GIQIQKTDRQ EWQTFCDFPQ 300
IIDISIKRLC QEQMPLEGRV VTLTRQDDQC MEAEFQTLTD ALSFVSLVDG YFRLTTDSTH 360
YFCAEVAPPS LLEDIQNYCH GPITSEFAVH KLKKAGGKNG MFLLRHSPKE FDKYFLTVCI 420
QTPLGMDYKD CLIEKNEKFS LAGIHNSFIN LKQLIDFYQL STLYVSDIPV TLGKCCPPRA 480
KELTNMIIIR NSSMTEIPSS PTLQRHKPSH MQFHMIKHED LIWSESLGQG SFTHIFRGSK 540
IDQRDGGTHS TEVLLKVLDA NHKNCWESLF EAASLMSQIS HRHLLLVYGI SVHKSKNIMV 600
QEFVKHGALD LYLKRSMCVS VSWKLDVAKQ LACALNFLEE KNIAHGNICA KNLLLVREGD 660
SPFIKLSDPG VSMSLLGKDV VLDRIPWVAP EVLDTLEIEL ECDKWSFGTT LWEIFNGGEA 720
PLQGLDLMQK LQFYENFSNL PTLEWTELAE LISHCMQYQP ELRPSCRSII RQLNSLITSD 780
YEILHATDTL PESNGFWKKL NIFKKQQEDV FEERYLRFIS VLGKGNFGSV ELCRYDPWGD 840
NTGELVAVKE LQSNKQATMA DFQREIQTIS SLHCDYIVKY KGICYSTGRL STKLVMEYLP 900
YGSLIGYMEK HRHNVGNRKL LLFASQICKG MEYLQSMRYV HRDLAARNIL VASDNLVKIA 960
DFGLTKIIPV DKEYYRVTQP GESPVFWYAP ESISELKFSH KSDVWSFGIV LHELFSYCDI 1020
SQNPKKLCIQ KIGRYVHSPS MAIHLLTLLK NNWRLPAPAQ CPLKVHSIMM QCWEFNSENR 1080
PSFSSLKDLI ENSLLDEREG CKG 1103
Nucleotide Sequence
(FASTA)
ATGAGTGAAG AGGAAGAGGT GCCGTTGATG AAGAGTGAAC GGGCCGGCAG TCAGCGGTCC 60
AGCTGTGACT CAGCCCTGCA GGTGCATCTG TACTACAGTC CCAGTTTAAA CTCAGAGACC 120
ACCTTCAGCA TACCCACCGG ACATGTGACA GCTGAGAGCG TGTGTGTGCT CGCTGCTAAA 180
GCCAGTGGAA TTCTTCCTGT GTATCACAAC CTCTTTGCTT TGGCATCAGA GGATCTTTCA 240
TACTGGTATC CACCAAATCA TCTGTTTAAG AGTGAGGAGC CCGTCAAAGT TTACTATAGA 300
GTGAGGTTTT TCTTCTCAAG CTGGTTTGGT CAAGAGTCGA GAGCATCGTA CCGCTTTAGC 360
CTCAGCAAGG GACGAATCTT TGCTGTGCTG GACTATGCTG TCATTGACTA TGTTTTTGCT 420
CAATCCCGCA GTGATTTTGT GACTGGATGT GGTGGGATTT CTCCTGCATT GAGTTTGCAG 480
CAGGAATGTT TAGGTTTGGC AGTGCTGGAT CTGTGGCGTT TGGCCAAAGA GAGAAACCAG 540
AGCCTTGCAG AGATCTGCAA TACAACAAGC TACAAGTCCT GCCTCCCGGA GACTCACCGA 600
CAGGACATCC AGCGCATGAA CCGCCTGGCG CGATATCAGA TCCGCAAAAC ACTGAAGCGC 660
TTCCTGAAGA AGCTGGGCAA GTGCTCGGCT GGAGAGCGAA GCCTGAAGCT CAAGTACCTG 720
ATGAAGCTGA GTGAGCTGGA GCCGGATTAT GGTTCAGAGA GCTTCCCCCT CCACCACTCC 780
GGGTGGTTGG AACAGAGCGA GCAGCAGAGA GTTCTAGCCG TCAAAGTGTC CGGAGAGGGA 840
GGCATTCAGA TACAGAAAAC AGACAGACAG GAATGGCAGA CATTCTGTGA CTTCCCCCAG 900
ATCATTGACA TTAGCATTAA GCGTCTCTGT CAAGAGCAGA TGCCTCTGGA AGGAAGGGTG 960
GTCACACTCA CGCGCCAGGA TGACCAGTGC ATGGAAGCTG AGTTTCAAAC CCTGACAGAC 1020
GCCCTTTCCT TTGTATCTCT GGTTGATGGA TATTTTAGAC TGACCACAGA TTCAACTCAC 1080
TATTTCTGCG CAGAAGTGGC CCCACCAAGC CTGCTGGAGG ACATACAGAA TTACTGCCAC 1140
GGCCCGATCA CGTCAGAATT TGCGGTGCAC AAGCTTAAGA AAGCTGGAGG CAAGAATGGG 1200
ATGTTTCTTT TACGCCACAG TCCCAAGGAA TTTGACAAGT ACTTCCTCAC AGTTTGTATA 1260
CAGACTCCTT TGGGGATGGA TTACAAGGAC TGCCTGATAG AGAAAAATGA GAAGTTCAGT 1320
CTGGCTGGGA TCCACAACTC ATTCATCAAT CTGAAACAGC TCATCGACTT CTATCAGCTC 1380
AGTACGCTAT ACGTTTCAGA CATCCCTGTC ACCCTGGGCA AGTGCTGCCC ACCCAGAGCA 1440
AAAGAGCTCA CAAACATGAT CATCATCCGT AACAGCAGTA TGACTGAGAT ACCCAGTTCC 1500
CCCACCTTAC AGAGACACAA ACCAAGCCAC ATGCAGTTCC ACATGATTAA ACATGAGGAC 1560
CTCATCTGGA GTGAAAGTTT AGGTCAAGGT TCCTTCACGC ACATCTTTAG AGGTAGTAAA 1620
ATAGACCAGA GGGATGGAGG AACACACTCC ACCGAGGTCC TTCTGAAAGT CCTGGATGCA 1680
AATCATAAAA ACTGCTGGGA GTCTCTTTTC GAGGCGGCCA GTTTGATGAG TCAAATCTCC 1740
CACAGGCACC TTCTTTTGGT GTATGGCATT AGTGTGCACA AATCCAAAAA CATCATGGTG 1800
CAGGAGTTTG TGAAGCACGG CGCACTGGAC CTGTACCTGA AGAGGAGCAT GTGTGTCTCA 1860
GTCAGCTGGA AACTAGATGT GGCCAAACAA CTGGCCTGTG CTCTTAACTT CCTGGAGGAG 1920
AAGAATATTG CACATGGGAA TATTTGTGCA AAGAATCTGC TGTTGGTCCG AGAGGGCGAC 1980
TCACCCTTCA TTAAACTGAG TGACCCTGGC GTCAGCATGT CCTTGCTGGG CAAAGATGTG 2040
GTGTTGGACC GAATCCCATG GGTGGCCCCA GAAGTTCTGG ATACACTTGA GATTGAACTG 2100
GAGTGTGACA AGTGGAGCTT TGGGACAACG CTGTGGGAGA TTTTCAATGG TGGAGAAGCT 2160
CCATTACAGG GCCTGGACCT CATGCAGAAG CTGCAGTTTT ATGAGAACTT CTCGAACCTT 2220
CCAACGCTGG AGTGGACTGA ACTGGCTGAG CTGATCTCTC ACTGTATGCA GTACCAGCCT 2280
GAGCTCAGAC CGTCCTGCAG GAGCATCATC CGACAGCTGA ACAGCCTCAT CACTTCAGAT 2340
TATGAGATTC TTCATGCGAC TGACACACTG CCTGAAAGCA ATGGCTTCTG GAAGAAACTG 2400
AACATATTCA AAAAGCAACA GGAGGATGTT TTTGAGGAGA GATACCTGCG ATTCATCTCT 2460
GTTCTGGGAA AGGGTAACTT TGGCAGTGTT GAGCTTTGCC GTTATGATCC ATGGGGTGAT 2520
AACACTGGAG AACTGGTGGC TGTGAAGGAA CTTCAGTCTA ACAAGCAAGC CACAATGGCA 2580
GATTTCCAGA GAGAAATCCA GACCATCAGC TCCCTGCACT GTGACTACAT TGTCAAATAC 2640
AAGGGCATCT GCTACAGCAC AGGTCGGCTG AGCACAAAAC TGGTGATGGA GTATCTTCCA 2700
TACGGCAGTC TCATTGGTTA TATGGAGAAA CACAGACACA ATGTGGGCAA TCGCAAACTA 2760
TTGCTATTTG CCTCGCAGAT ATGTAAGGGA ATGGAGTACC TGCAAAGCAT GCGTTACGTT 2820
CACCGTGATC TAGCTGCTCG CAATATTCTA GTCGCCAGCG ACAATCTGGT CAAAATTGCA 2880
GATTTCGGAC TGACCAAGAT CATCCCGGTG GATAAAGAGT ACTACCGTGT CACACAGCCA 2940
GGAGAAAGTC CTGTTTTCTG GTATGCACCT GAATCCATCT CAGAACTGAA ATTCTCCCAC 3000
AAGTCAGATG TGTGGAGTTT TGGCATTGTT TTACATGAGC TCTTTTCTTA CTGCGACATC 3060
AGTCAAAACC CCAAAAAGTT GTGCATCCAG AAGATTGGCA GATATGTCCA TAGTCCATCC 3120
ATGGCCATCC ATCTCCTCAC TCTTCTCAAG AATAACTGGA GATTACCAGC TCCAGCTCAG 3180
TGTCCACTAA AGGTGCACAG TATTATGATG CAGTGCTGGG AATTCAACAG TGAGAACAGG 3240
CCGAGCTTCT CCTCTTTAAA GGATCTGATT GAGAATAGCC TGTTAGATGA AAGAGAGGGA 3300
TGTAAAGGGT AA 3312
Domain Profile
S: 2     kqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlsheh  61
         ++i+ Lgkg+f++v+++r+d+ gd+t+e va+k L++  +  ++df+re++++s+l+ + 
Q: 817   RFISVLGKGNFGSVELCRYDPWGDNTGELVAVKELQSNKQATMADFQREIQTISSLHCDY  876
         67899*******************************99**********************
S: 62    ivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLed  119
         ivk+kg+c++ g+   +lVmey+++GsL  y++k+++++   +ll +a+q++k+meYL++
Q: 877   IVKYKGICYSTGRLstKLVMEYLPYGSLIGYMEKHRHNVGNRKLLLFASQICKGMEYLQS  936
         **********998778********************************************
S: 120   kklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwlap  178
         +++vhrd+aarn+Lv++++       vk++d+gl+k ++ d eYy v ++++s+++w+ap
Q: 937   MRYVHRDLAARNILVASDNL------VKIADFGLTKIIPVDkEYYRVTQPGESPVFWYAP  990
         ********************......**********************************
S: 179   eclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklell  225
         e++se k +s +sdvWsFg++l+el++ c+ +++p    +++++          ++l ll
Q: 991   ESISELK-FSHKSDVWSFGIVLHELFSyCDISQNPkklcIQKIGRYvhspsmaiHLLTLL  1049
         *******.***************************9988555555577777779******
S: 226   eekerlpkpk.cpaelaelmtnclsyepsqrpsFrai  261
         +++ rlp+p  cp +++ +m++c++ + ++rpsF+ +
Q: 1050  KNNWRLPAPAqCPLKVHSIMMQCWEFNSENRPSFSSL  1086
         **********************************987
Domain Sequence
(FASTA)
RFISVLGKGN FGSVELCRYD PWGDNTGELV AVKELQSNKQ ATMADFQREI QTISSLHCDY 60
IVKYKGICYS TGRLSTKLVM EYLPYGSLIG YMEKHRHNVG NRKLLLFASQ ICKGMEYLQS 120
MRYVHRDLAA RNILVASDNL VKIADFGLTK IIPVDKEYYR VTQPGESPVF WYAPESISEL 180
KFSHKSDVWS FGIVLHELFS YCDISQNPKK LCIQKIGRYV HSPSMAIHLL TLLKNNWRLP 240
APAQCPLKVH SIMMQCWEFN SENRPSFSSL 270
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-GAM-00014
EKS-GAA-00050
EKS-ICT-00030
EKS-LAC-00034
EKS-ORN-00050
EKS-ORL-00047
EKS-TAR-00050
EKS-TEN-00054
EKS-XIM-00048
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR019749; Band_41_domain.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
Pfam
PF07714; Pkinase_Tyr; 2.
PF00017; SH2; 1.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
Prints
PR01823; JANUSKINASE.
PR00109; TYRKINASE.
Created Date20-Feb-2013