EPS-DAR-00056

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-DAR-00056

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	217.9	4.0E-64	95	344	250

Status

Unreviewed

Ensembl Protein

ENSDARP00000008977

UniProt Accession

F1R0V7;

Protein Name

Protein Synonyms/Alias

Gene Name

ppm1k

Gene Synonyms/Alias

ppm1k;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000010655	ENSDARP00000124125	ENSDART00000148285
ENSDARG00000010655	ENSDARP00000113331	ENSDART00000145550
ENSDARG00000010655	ENSDARP00000048813	ENSDART00000048814
ENSDARG00000010655	ENSDARP00000008977	ENSDART00000015591

Organism

Danio rerio

Functional Description

Protein Length

372

Protein Sequence
(FASTA)

MSVALLVRYA TLSGSRVCSR AAFNLTNAHQ EDPRRALHTP SSPRFSNSRF DPDSSGRPTT 60

WDSFGIWDNR IDEPILLPSS IRYGKLIPKV NLSRVGSASQ IGQRKENEDR YQMSQMTDNI 120

MYFAVFDGHG GAEAADFCHK NMEKHIKDIA AEETNLEFVL TKAFLEVDKA LARHLHFSAD 180

ASVLSAGTTA TVALLRDGIE LVVGSVGDSR AMMCRKGKAV KLTVDHTPER KDEKERIRRS 240

GGFITWNSLG QPHVNGRLAM TRSIGDFDLK ATGVIAEPET KRISLHHVHD SFLALTTDGI 300

NFIMNSQEIC DVINQCHDPK EAAQRISEQA LQYGSEDNST IIVVPFGAWG KHKSSEVSFS 360

FSRSFVSSGR FA 372

Nucleotide Sequence
(FASTA)

ATGTCAGTGG CTCTCCTGGT GCGATATGCC ACGCTCAGCG GGTCCCGTGT CTGCAGCAGA 60

GCTGCTTTCA ACCTGACCAA TGCCCATCAG GAAGACCCAA GACGGGCTCT ACACACTCCA 120

TCCTCTCCTC GGTTCAGCAA TTCTCGATTT GATCCAGACA GCAGTGGTCG TCCGACTACC 180

TGGGACTCCT TCGGGATCTG GGACAACCGC ATCGATGAAC CAATCTTGCT TCCATCGAGC 240

ATCCGCTATG GTAAACTTAT TCCCAAAGTT AACCTGTCCA GGGTGGGCAG CGCCTCGCAG 300

ATCGGCCAGC GGAAAGAAAA TGAAGACCGC TATCAGATGT CACAAATGAC TGACAACATC 360

ATGTACTTTG CTGTTTTCGA TGGACACGGG GGTGCAGAGG CTGCTGATTT CTGCCATAAG 420

AACATGGAGA AGCATATCAA AGACATCGCA GCGGAGGAAA CTAACTTGGA GTTCGTTTTA 480

ACCAAAGCTT TTCTTGAGGT GGACAAAGCA TTAGCGAGGC ATCTTCACTT CAGTGCAGAT 540

GCCTCTGTGT TGAGTGCAGG AACCACAGCC ACGGTGGCTC TGCTAAGGGA TGGGATCGAG 600

CTGGTGGTGG GCAGCGTCGG GGACAGCCGT GCCATGATGT GCCGCAAAGG CAAGGCCGTC 660

AAACTCACCG TGGATCACAC GCCTGAAAGG AAGGATGAAA AAGAGAGGAT ACGCAGGAGC 720

GGAGGTTTCA TTACATGGAA TAGTTTGGGT CAACCACACG TCAATGGCAG ACTGGCCATG 780

ACCCGCAGCA TTGGGGATTT CGACCTCAAA GCGACAGGCG TCATCGCAGA ACCAGAGACT 840

AAGAGAATTT CTTTGCATCA CGTCCATGAT TCCTTCCTGG CTCTCACTAC TGATGGCATC 900

AACTTCATCA TGAACAGTCA GGAGATCTGT GATGTCATCA ATCAATGTCA TGACCCCAAA 960

GAGGCCGCAC AACGCATATC TGAGCAGGCT CTTCAGTATG GTTCTGAAGA CAACAGCACT 1020

ATCATCGTGG TGCCGTTCGG TGCCTGGGGC AAACACAAAA GCTCCGAAGT CAGCTTCTCC 1080

TTCAGCCGCA GCTTCGTCTC CAGTGGCCGC TTCGCCTGA 1119

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheila  62

         vg +s+ g+r+e ed+ ++s+        +d++ +f+v+DGhgg e+a+fc+++++++++

Q: 95    VGSASQIGQRKENEDRYQMSQ-------MTDNIMYFAVFDGHGGAEAADFCHKNMEKHIK  147

         678888899999999886522.......233478**************************

S: 63    eelesseseerkvkkalakaFlstdeelkvleeksldidk....sGstavvalikds.kl  117

                 ee++++ +l+kaFl++d++l    + + + d+     G+ta+val++d  +l

Q: 148   DIAA----EETNLEFVLTKAFLEVDKAL--ARHLHFSADAsvlsAGTTATVALLRDGiEL  201

         **77....9*******************..444444444456889************9**

S: 118   yvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkd.ga.RvlGvLavs  175

         +v  vGdSra++cr+gkav+l++dH+p+r+dE+eRi++ gg ++ ++ g+ +v+G La++

Q: 202   VVGSVGDSRAMMCRKGKAVKLTVDHTPERKDEKERIRRSGGFITWNSlGQpHVNGRLAMT  261

         ****************************************99997779999*********

S: 176   RalGdlylkpy.vtpePevtshrltsede.fliLasDGlwdvvsneeavslvrdvlekke  233

         R++Gd++lk   v++ePe+  + l++ ++ fl L +DG+  +++++e++++++++++

Q: 262   RSIGDFDLKATgVIAEPETKRISLHHVHDsFLALTTDGINFIMNSQEICDVINQCHD---  318

         *********555************998888***************************...

S: 234   aeqeaakkLvklalargskdnvsaivv  260

          ++eaa+++ ++al++gs+dn ++ivv

Q: 319   -PKEAAQRISEQALQYGSEDNSTIIVV  344

         .*********************99997

Domain Sequence
(FASTA)

VGSASQIGQR KENEDRYQMS QMTDNIMYFA VFDGHGGAEA ADFCHKNMEK HIKDIAAEET 60

NLEFVLTKAF LEVDKALARH LHFSADASVL SAGTTATVAL LRDGIELVVG SVGDSRAMMC 120

RKGKAVKLTV DHTPERKDEK ERIRRSGGFI TWNSLGQPHV NGRLAMTRSI GDFDLKATGV 180

IAEPETKRIS LHHVHDSFLA LTTDGINFIM NSQEICDVIN QCHDPKEAAQ RISEQALQYG 240

SEDNSTIIVV 250

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0007420	; P:brain development
GO:0048565	; P:digestive tract development
GO:0007507	; P:heart development
GO:0001889	; P:liver development
GO:0043066	; P:negative regulation of apoptotic process
GO:0031016	; P:pancreas development
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013