EKS-DAR-00795

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00795

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/IRAK	252.3	1.2E-74	207	471	265

Status

Unreviewed

Ensembl Protein

ENSDARP00000109755

UniProt Accession

F1QDA3;

Protein Name

Protein Synonyms/Alias

Gene Name

irak4

Gene Synonyms/Alias

irak4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000010657	ENSDARP00000107009	ENSDART00000126404
ENSDARG00000010657	ENSDARP00000109755	ENSDART00000124530

Organism

Danio rerio

Functional Description

Protein Length

481

Protein Sequence
(FASTA)

MSDVTPNTPV RKLRYSALRA LADLLDPQDT WRSIMADISR PCGEPRYTQM HMRRFEACVL 60

QGKSPTMELL FDWGTSDCTV GDLVEILIRH QLFAAVTVLL PDHSVCHTHT GSVWCEEAAP 120

ASAVCLQACE ITQTVEDNSN KPQKISKPVE DDSNKPVQEQ ELFVEPDSSS GAQESSWDSS 180

QGFHTFSLHE LTAMTQHWDE RPLSDGGCRL GSGGFGVVFR GRMGDKHVAV KKLNPLDGSS 240

YEDLRKQFNQ EIQTLRSLSH ENVLRVLGCS CSGPPLCVVF ELMVNGSLLE RLACAEHTPA 300

LTWRNRCWIT VGAARGLSYL HTHAHIHRDV KSANILLDEG FVAKISDFGL TRSAAAGSLM 360

TLQTERIVGT TAYMAPEALR GEITAKSDVF SFGVVLLEVL SGLPPVDESR DPALLLEMKD 420

DLDDEDLSLL DFTDRRMQEW RTEELQIMWE RLSQCKRANR HPADSQVLSV LEDLHQKVIS 480

R 481

Nucleotide Sequence
(FASTA)

ATGAGTGACG TCACGCCGAA CACACCGGTT CGAAAGCTCC GGTACTCCGC GCTAAGAGCT 60

TTAGCAGACC TGCTGGACCC GCAGGACACC TGGAGGAGCA TCATGGCGGA CATCAGCAGA 120

CCCTGCGGGG AACCCAGATA CACACAGATG CACATGAGGC GGTTTGAAGC ATGCGTCCTG 180

CAGGGAAAGA GTCCCACCAT GGAGCTGCTG TTCGACTGGG GAACCTCAGA CTGCACTGTT 240

GGAGATCTGG TGGAGATCCT GATCCGCCAT CAGCTGTTCG CCGCCGTCAC AGTCCTGCTG 300

CCCGATCACA GCGTCTGCCA CACTCACACA GGCTCAGTGT GGTGTGAGGA AGCGGCTCCC 360

GCGTCTGCAG TGTGTCTGCA GGCATGCGAA ATCACCCAAA CTGTAGAGGA CAACAGTAAT 420

AAACCCCAAA AAATCTCTAA ACCTGTGGAG GATGACAGTA ATAAACCCGT CCAGGAGCAG 480

GAGCTGTTTG TGGAGCCGGA CAGCAGCTCT GGAGCACAGG AGAGCAGCTG GGACTCCAGC 540

CAAGGCTTCC ACACCTTCAG TCTCCATGAG CTGACGGCGA TGACGCAGCA CTGGGACGAG 600

AGGCCACTTT CGGATGGGGG CTGCCGGCTG GGCTCTGGAG GGTTCGGAGT GGTGTTCAGA 660

GGACGCATGG GGGATAAACA TGTGGCGGTC AAGAAACTCA ATCCTTTGGA CGGCAGTTCA 720

TATGAAGACC TCAGAAAGCA GTTTAACCAG GAGATTCAGA CACTCAGAAG TCTGAGTCAT 780

GAGAATGTGT TGCGTGTGTT GGGCTGCTCG TGCTCCGGCC CGCCGCTGTG TGTGGTGTTT 840

GAGCTGATGG TGAACGGCTC TCTGCTGGAG CGACTGGCCT GCGCTGAACA CACACCTGCG 900

CTCACCTGGA GGAACAGATG CTGGATCACT GTTGGAGCTG CCCGGGGCCT GAGCTACCTG 960

CACACACACG CACACATCCA CAGAGACGTC AAGAGCGCCA ACATCTTACT GGACGAGGGT 1020

TTTGTGGCGA AGATTTCAGA CTTCGGCTTG ACTCGCTCTG CGGCTGCAGG TTCGCTCATG 1080

ACTCTGCAGA CAGAGAGGAT TGTGGGAACG ACGGCCTACA TGGCTCCAGA GGCCCTGAGG 1140

GGGGAAATCA CCGCCAAATC AGACGTCTTC AGCTTCGGCG TGGTGCTGCT GGAGGTTTTG 1200

TCTGGGCTTC CTCCAGTGGA CGAGAGTCGG GATCCTGCAC TGTTGCTGGA GATGAAGGAT 1260

GATCTGGATG ATGAGGATCT CTCTCTGCTG GACTTCACTG ACCGCCGCAT GCAGGAGTGG 1320

AGAACAGAAG AGCTGCAGAT CATGTGGGAG AGGTTAAGTC AATGCAAACG CGCGAATAGA 1380

CATCCTGCGG ATTCACAGGT TCTGTCTGTG CTGGAGGATC TGCATCAGAA AGTGATCTCC 1440

AGATGA 1446

Domain Profile

S: 4     dnrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdnilel  63

         + r+g Ggfg+v+rg++ ++ vavkkl+    +s + l+++f++E+++l ++ H+n+l +

Q: 207   GCRLGSGGFGVVFRGRMGDKHVAVKKLNPLDGSSYEDLRKQFNQEIQTLRSLSHENVLRV  266

         579*********************************************************

S: 64    lgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefLHeasps  123

         lg s  +  lc+v+++m nGsL +rL c + ++ L+W+ R+ i++G+ar++++LH++  +

Q: 267   LGCSCSGPPLCVVFELMVNGSLLERLACAEHTPALTWRNRCWITVGAARGLSYLHTH--A  324

         *********************************************************..*

S: 124   lihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtlaYlpeefirv  183

         +ih+d+ksaNiLLDe + +K++Dfgl+r   ++++ s + l+t++++gt+aY+++e++r

Q: 325   HIHRDVKSANILLDEGFVAKISDFGLTR---SAAAGSLMTLQTERIVGTTAYMAPEALR-  380

         ****************************...66677778888*****************.

S: 184   gqltvkvDvySfGiVllEvltGlravdedrktkyLkdllkeeieeekveilekfldkkag  243

         g++t k+Dv+SfG+VllEvl+Gl+ vde+r++  L+++ k+++++e++ +l +f+d++++

Q: 381   GEITAKSDVFSFGVVLLEVLSGLPPVDESRDPALLLEM-KDDLDDEDL-SLLDFTDRRMQ  438

         *************************************9.9****9995.6779*******

S: 244   kleeellealielalaclaekakkrPtmsqvlell  278

         +  +e l+ + e  ++c    a++ P  sqvl+ l

Q: 439   EWRTEELQIMWERLSQCKR--ANRHPADSQVLSVL  471

         **99999999988899965..99999999998765

Domain Sequence
(FASTA)

GCRLGSGGFG VVFRGRMGDK HVAVKKLNPL DGSSYEDLRK QFNQEIQTLR SLSHENVLRV 60

LGCSCSGPPL CVVFELMVNG SLLERLACAE HTPALTWRNR CWITVGAARG LSYLHTHAHI 120

HRDVKSANIL LDEGFVAKIS DFGLTRSAAA GSLMTLQTER IVGTTAYMAP EALRGEITAK 180

SDVFSFGVVL LEVLSGLPPV DESRDPALLL EMKDDLDDED LSLLDFTDRR MQEWRTEELQ 240

IMWERLSQCK RANRHPADSQ VLSVL 265

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR011029	; DEATH-like.
IPR017428	; Interleukin-1_rcpt-assoc_kin4.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013