EKS-DAR-00444

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00444

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	612.6	1.6E-184	388	666	279

Status

Reviewed

Ensembl Protein

ENSDARP00000003372

UniProt Accession

Q1ECX4; A8WGJ6; Q90ZY7;

Protein Name

Serine/threonine-protein kinase tousled-like 2

Protein Synonyms/Alias

PKU-alpha; Tousled-like kinase 2;

Gene Name

tlk2

Gene Synonyms/Alias

tlk2; zgc:136697;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000010779	ENSDARP00000114778	ENSDART00000141937
ENSDARG00000010779	ENSDARP00000003372	ENSDART00000006490

Organism

Danio rerio

Functional Description

Negative regulator of amino acid starvation-inducedautophagy (By similarity).

Protein Length

697

Protein Sequence
(FASTA)

MMEELHSLDP RRQELLEARF TGVGVAKGSG HNESSNQSLC SVGSLSDKEL ETPEKKSNDQ 60

RTRKRKGDPF DSQGKGGGRG HKISDYFEFA GGSGTGTSPA RGIPPVARSS PQHSLSNPPA 120

AVQQGSPSSI SSVNTDHSHT STSHKPASIH TQHRASQSEL TMEKLAALES SKSSDLEKKE 180

GRIDDLLRVN CDLRRQIDEQ QKMLEWCKER LNKCVTMSKK LLIEKSKQEK IACREKSMQD 240

RLRLGHFTTV RHGASFTEQW TDGYAFQNLV KQQERVNGQR EEIERQRKLL IKKKPPSASQ 300

TPPPNLEPNK RKSKSNGAEN EMLSLAEYHE QEEIFKLRLG HLKKEEAEIQ VELERLERVR 360

NLHIRELKRI HNEDNSQFKD HPTLNDRYLL LHLLGRGGFS EVYKAFDLTE QRYVAVKIHQ 420

LNKNWRDEKK ENYHKHACRE YRIHKELDHP RIVKLYDYFS LDTDSFCTVL EYCEGNDLDF 480

YLKQHKLMSE KEARSIIMQV VNALKYLNEI RPPIIHYDLK PGNILLVNGT ACGEIKITDF 540

GLSKIMDDDN YGVDGMELTS QGAGTYWYLP PECFVVGKEP PKISNKVDVW SVGVIFYQCL 600

YGKKPFGHNQ SQQDILQENT ILKATEVQFP PKPGVSPEAK AFIRRCLVYR KEDRIDVHQL 660

ASDPYLLPHI RKSVAATGNS SMAVASTSNS SNSSASN 697

Nucleotide Sequence
(FASTA)

ATGATGGAGG AATTGCACAG CTTGGATCCT CGAAGGCAAG AGCTGCTGGA GGCCCGTTTC 60

ACAGGAGTCG GAGTTGCCAA GGGATCTGGA CACAACGAGT CCTCCAACCA GAGCTTGTGT 120

AGTGTGGGCT CTCTCAGTGA CAAAGAATTG GAGACCCCAG AGAAGAAATC TAATGACCAG 180

AGGACACGTA AAAGGAAAGG AGACCCCTTT GACAGCCAGG GCAAAGGAGG AGGAAGAGGA 240

CACAAAATTA GTGATTATTT TGAGTTTGCA GGCGGTAGTG GTACAGGTAC CAGTCCAGCT 300

CGTGGCATTC CTCCAGTGGC GCGCTCCTCT CCTCAGCACT CTCTATCTAA TCCTCCTGCT 360

GCCGTGCAGC AAGGAAGCCC CTCCTCCATC AGTTCAGTAA ACACAGACCA CTCCCACACC 420

TCCACCTCCC ACAAGCCAGC CTCAATACAC ACTCAGCACC GAGCTTCACA GTCTGAGCTG 480

ACTATGGAGA AATTAGCAGC GCTGGAGAGC AGTAAGAGTT CAGATCTGGA GAAGAAAGAA 540

GGACGTATCG ATGACCTGCT CAGGGTGAAC TGTGACCTGC GCAGACAGAT CGATGAGCAG 600

CAGAAGATGC TGGAGTGGTG TAAAGAACGC CTCAATAAAT GTGTGACCAT GAGTAAGAAA 660

CTGCTTATCG AAAAGTCCAA ACAGGAGAAA ATTGCTTGCA GAGAAAAGAG CATGCAGGAC 720

CGACTACGAC TTGGTCATTT CACCACTGTA CGACACGGAG CCTCATTTAC AGAGCAGTGG 780

ACGGATGGAT ATGCGTTTCA GAATCTAGTC AAACAACAGG AGAGAGTCAA CGGGCAGAGG 840

GAGGAAATAG AGAGACAGAG AAAACTGCTA ATAAAAAAGA AACCACCCAG CGCCAGTCAG 900

ACTCCTCCTC CTAATCTAGA ACCCAACAAA CGCAAAAGCA AGAGCAACGG CGCCGAGAAT 960

GAAATGTTGT CTCTAGCAGA GTACCACGAG CAAGAAGAAA TTTTCAAACT GAGACTTGGC 1020

CACCTAAAGA AGGAGGAAGC CGAGATCCAG GTGGAACTGG AGCGGTTGGA GCGTGTGCGT 1080

AATCTTCACA TCCGCGAGCT CAAGAGAATC CACAATGAAG ATAACTCCCA GTTTAAAGAT 1140

CATCCTACGC TAAATGACCG TTACCTGCTC TTGCATCTGC TCGGACGAGG AGGCTTCAGT 1200

GAGGTCTACA AGGCCTTCGA CTTAACTGAG CAGAGGTACG TGGCTGTGAA GATTCACCAG 1260

CTTAATAAGA ACTGGAGAGA CGAGAAGAAA GAAAACTACC ACAAGCATGC CTGTCGAGAA 1320

TATAGAATCC ATAAAGAGCT GGACCATCCC AGAATAGTCA AACTGTATGA CTACTTTTCC 1380

CTGGATACTG ACTCATTCTG CACTGTTCTG GAGTACTGCG AGGGAAACGA TCTGGATTTC 1440

TACCTGAAGC AGCACAAGTT AATGTCAGAA AAAGAGGCCC GGTCCATCAT AATGCAGGTC 1500

GTCAATGCCC TCAAGTACCT AAATGAAATC CGCCCGCCGA TCATCCATTA CGACCTCAAA 1560

CCAGGTAACA TCCTGCTGGT GAATGGCACA GCATGTGGAG AGATAAAGAT CACAGACTTT 1620

GGGCTGTCCA AGATCATGGA TGATGACAAC TATGGCGTGG ATGGCATGGA GTTGACGTCA 1680

CAAGGGGCAG GGACATACTG GTATCTTCCT CCAGAGTGCT TTGTGGTTGG AAAAGAGCCA 1740

CCTAAGATCT CCAACAAAGT GGATGTTTGG TCAGTTGGAG TTATCTTTTA CCAGTGCCTC 1800

TATGGAAAGA AGCCGTTCGG TCATAATCAG TCCCAGCAGG ACATCCTTCA GGAGAACACT 1860

ATTCTCAAAG CCACAGAGGT GCAGTTTCCT CCCAAACCAG GAGTCTCGCC TGAGGCTAAG 1920

GCCTTCATCC GCAGATGTCT GGTGTACCGT AAGGAGGACC GTATTGATGT TCACCAGCTG 1980

GCCAGTGACC CCTACCTCCT CCCGCACATA CGCAAGTCCG TGGCGGCCAC GGGTAACTCC 2040

AGCATGGCCG TGGCCTCCAC CTCCAACTCC TCCAACAGCA GCGCCTCAAA CTGA 2094

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqryvavkihqlnk+w+dekkeny+kha+reyrihkel

Q: 388   YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL  447

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtdsfctvley+egndldfylkqhkl+sekearsiimq+v+alkyl

Q: 448   DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQVVNALKYL  507

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         nei+ppiihydlkpgnillv+gtacgeikitdfglskimddd+y++d g+eltsqgagty

Q: 508   NEIRPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDNYGVD-GMELTSQGAGTY  566

         *********************************************99.************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdil+entilkate

Q: 567   WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGKKPFGHNQSQQDILQENTILKATE  626

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kp vs+eakafirrcl yrkedridv+qla+d+yl

Q: 627   VQFPPKPGVSPEAKAFIRRCLVYRKEDRIDVHQLASDPYL  666

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LTEQRYVAVK IHQLNKNWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDSFC TVLEYCEGND LDFYLKQHKL MSEKEARSII MQVVNALKYL 120

NEIRPPIIHY DLKPGNILLV NGTACGEIKI TDFGLSKIMD DDNYGVDGME LTSQGAGTYW 180

YLPPECFVVG KEPPKISNKV DVWSVGVIFY QCLYGKKPFG HNQSQQDILQ ENTILKATEV 240

QFPPKPGVSP EAKAFIRRCL VYRKEDRIDV HQLASDPYL 279

Keyword

Alternative splicing; ATP-binding; Coiled coil; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

dre:407732

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013