EKS-DAR-00433
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00433
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR545.34.2E-164351627277
StatusReviewed
Ensembl ProteinENSDARP00000115638
UniProt AccessionQ90Z00; A2BEU6; A2BEU7; A4JYD6; B3DGB8; Q1LY25; Q800Y8; Q800Y9; Q800Z0; Q800Z1;
Protein NameFibroblast growth factor receptor 1-A
Protein Synonyms/Alias FGFR-1-A; bFGF-R-1-A; Basic fibroblast growth factor receptor 1-A;
Gene Namefgfr1a
Gene Synonyms/Alias fgfr1a; fgfr1; si:ch211-198o12.1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000011027ENSDARP00000013742ENSDART00000024882
ENSDARG00000011027ENSDARP00000116533ENSDART00000147742
ENSDARG00000011027ENSDARP00000110910ENSDART00000127119
ENSDARG00000011027ENSDARP00000115638ENSDART00000135166
ENSDARG00000011027ENSDARP00000069260ENSDART00000074774
OrganismDanio rerio
Functional DescriptionTyrosine-protein kinase that acts as cell-surfacereceptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol- 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by ubiquitination, internalization and degradation (By similarity).
Protein Length696
Protein Sequence
(FASTA)
MKMMMIMKTT LLLISVLLTQ ALQSQGRPAI QDEAPAEPTS YTLDSGEKLE LSCKAKEDTQ 60
KVTWTKDLVP LVDGEHTRLR NDQMEIEKVE PTDSGLYACF AQGLNSNHTE YFNISVTDEE 120
DEVDSSSEEA KLSNDQNLPM APVWAQPDKM EKKLHAVPAS KTVKFRCQAN GNPTPTLKWL 180
KNGKEFKRDQ RIGGFKVREH MWTIIMESVV PSDRGNYTCL VENRHGSINH TYQLDVVERS 240
PHRPILQAGL PANRTAVVGS DVEFECKVFS DPQPHIQWLK HIEVNGSRYG PDGLPYVRAL 300
KVSVDSSSSM HSGGMLVRPS RLSSSGSPML SGVSEYELPQ DPRWEVQRDR LVLGKPLGEG 360
CFGQVMMAEA MGMDKEKPNR ITKVAVKMLK SDATEKDLSD LISEMEMMKI IGKHKNIINL 420
LGACTQDGPL YVIVEFAAKG NLREYLRVRR PPGMEYCYNP DQVPVENMSI KDLVSCAYQV 480
ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT TNGRLPVKWM 540
APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH RMDRPSTCTH 600
ELYMMMRDCW HAVPSQRPTF KQLVEDLDRT LSMTSNQEYL DLSVSLDQFS PNFPDTRSST 660
CSSGEDSVFS HDAGADEPCL PKFPPHPNRG VAFKKR 696
Nucleotide Sequence
(FASTA)
ATGAAGATGA TGATGATAAT GAAGACCACG CTGCTGCTGA TCTCAGTACT GTTAACTCAA 60
GCTCTTCAGT CGCAGGGCAG ACCAGCCATC CAAGATGAGG CCCCGGCTGA GCCCACATCG 120
TACACTCTGG ATTCAGGAGA GAAACTGGAG CTGTCCTGTA AAGCTAAAGA GGACACACAG 180
AAAGTGACCT GGACCAAGGA CCTCGTTCCA CTGGTTGACG GAGAACACAC ACGCCTGCGC 240
AACGATCAGA TGGAGATCGA GAAAGTAGAG CCGACCGACT CTGGTCTGTA TGCTTGCTTT 300
GCTCAGGGAC TCAACAGCAA CCATACAGAA TACTTCAATA TCAGTGTTAC AGATGAAGAA 360
GACGAGGTGG ATTCTTCCTC AGAGGAGGCC AAGCTATCAA ATGACCAAAA TCTTCCGATG 420
GCCCCCGTCT GGGCTCAACC TGATAAGATG GAGAAGAAGC TACATGCGGT TCCTGCCAGT 480
AAAACCGTGA AGTTTCGTTG CCAGGCCAAT GGAAATCCTA CACCGACGCT CAAGTGGCTT 540
AAAAACGGCA AAGAGTTTAA GAGAGACCAG CGAATAGGAG GCTTCAAGGT ACGAGAGCAC 600
ATGTGGACCA TCATAATGGA GTCAGTGGTG CCGTCAGACA GAGGAAACTA CACCTGCCTG 660
GTGGAAAACA GACACGGCAG CATCAATCAC ACATACCAGC TGGACGTAGT CGAGCGTTCA 720
CCGCACCGGC CGATCCTCCA GGCCGGGCTG CCTGCAAACC GTACCGCAGT GGTGGGCAGT 780
GATGTGGAGT TCGAGTGTAA AGTGTTCAGC GATCCTCAGC CTCACATTCA GTGGCTGAAA 840
CACATCGAGG TGAACGGCAG CAGATACGGA CCTGATGGAC TGCCATATGT CCGAGCCTTA 900
AAGGTGTCTG TGGACTCCAG CTCATCTATG CATTCGGGTG GGATGTTGGT CCGTCCATCC 960
CGTCTGTCCT CCAGTGGCTC CCCAATGCTC TCAGGGGTCT CCGAATACGA GCTTCCCCAG 1020
GACCCACGCT GGGAGGTGCA ACGAGACAGG CTGGTTCTCG GGAAACCTCT TGGCGAAGGC 1080
TGCTTTGGAC AGGTGATGAT GGCCGAGGCG ATGGGGATGG ATAAAGAAAA ACCCAATAGA 1140
ATCACCAAAG TGGCCGTCAA GATGCTCAAA TCGGATGCCA CGGAGAAAGA CCTGTCAGAC 1200
CTGATCTCTG AGATGGAGAT GATGAAGATT ATTGGCAAAC ACAAGAACAT CATCAACCTG 1260
CTGGGAGCCT GCACACAAGA CGGTCCGCTG TACGTCATCG TGGAGTTTGC TGCTAAAGGG 1320
AACCTGCGGG AGTATCTGCG CGTACGGCGT CCACCAGGGA TGGAGTACTG TTATAACCCT 1380
GACCAGGTGC CAGTGGAGAA CATGTCCATT AAAGACCTGG TGTCCTGCGC ATATCAGGTG 1440
GCCCGAGGAA TGGAGTATCT CGCATCCAAG AAGTGTATTC ATCGAGACCT GGCTGCTCGG 1500
AATGTGCTGG TGACGGAAGA TAACGTTATG AAGATCGCAG ACTTTGGCCT GGCCAGAGAC 1560
ATCCATCATA TTGATTACTA CAAGAAGACC ACCAATGGTC GTTTGCCGGT GAAATGGATG 1620
GCTCCCGAAG CTCTGTTTGA CCGCATATAC ACCCATCAAA GTGACGTCTG GTCTTTTGGG 1680
GTGCTGCTGT GGGAGATCTT CACTCTGGGG GGCTCTCCGT ACCCCGGCGT CCCCGTCGAG 1740
GAGCTCTTTA AGCTGCTGAA GGAAGGACAC CGCATGGACC GACCCTCCAC ATGCACACAT 1800
GAGCTGTATA TGATGATGAG GGATTGTTGG CACGCCGTCC CGTCTCAGAG ACCCACTTTT 1860
AAACAGCTGG TGGAGGATCT GGACCGCACC CTCTCCATGA CGTCCAATCA GGAGTATCTG 1920
GACCTGTCCG TATCTCTGGA CCAGTTTTCT CCAAACTTCC CGGACACTCG CAGCTCCACC 1980
TGCTCCTCAG GTGAAGACTC AGTGTTTTCT CATGACGCCG GAGCCGATGA GCCCTGTTTG 2040
CCCAAATTCC CACCCCATCC CAACCGAGGA GTGGCCTTTA AAAAGCGCTG A 2091
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         lvlgk+lGeG+fGqv++aea+g+dk+k+++ ++vavkmlk+dat+kdl+dl+seme++k+
Q: 351   LVLGKPLGEGCFGQVMMAEAMGMDKEKPNRITKVAVKMLKSDATEKDLSDLISEMEMMKI  410
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyvive+aakGnlre+lr rrp+g+e+++++ +++ e+++ 
Q: 411   IGKHKNIINLLGACTQDGPLYVIVEFAAKGNLREYLRVRRPPGMEYCYNPDQVPVENMSI  470
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt
Q: 471   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  530
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh
Q: 531   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  590
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm++p++ct+ely++mr+cwha++s+rptfkqlvedl
Q: 591   RMDRPSTCTHELYMMMRDCWHAVPSQRPTFKQLVEDL  627
         ***********************************97
Domain Sequence
(FASTA)
LVLGKPLGEG CFGQVMMAEA MGMDKEKPNR ITKVAVKMLK SDATEKDLSD LISEMEMMKI 60
IGKHKNIINL LGACTQDGPL YVIVEFAAKG NLREYLRVRR PPGMEYCYNP DQVPVENMSI 120
KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180
TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240
RMDRPSTCTH ELYMMMRDCW HAVPSQRPTF KQLVEDL 277
KeywordAlternative splicing; ATP-binding; Cell membrane; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Disulfide bond; Glycoprotein; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Nucleus; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase; Ubl conjugation.
Sequence SourceEnsembl
Orthology
Ortholog group
Homo sapiens"; ?>Macaca mulatta"; ?>
EKS-HOS-00153
EKS-MAM-00144
Gene Ontology
GO:0016023; C:cytoplasmic membrane-bounded vesicle
GO:0005829; C:cytosol
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0017134; F:fibroblast growth factor binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008201; F:heparin binding
GO:0060249; P:anatomical structure homeostasis
GO:0048738; P:cardiac muscle tissue development
GO:0009953; P:dorsal/ventral pattern formation
GO:0031101; P:fin regeneration
GO:0001889; P:liver development
GO:0042664; P:negative regulation of endodermal cell fate specification
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0008284; P:positive regulation of cell proliferation
GO:0043406; P:positive regulation of MAP kinase activity
GO:0010863; P:positive regulation of phospholipase C activity
GO:0036342; P:post-anal tail morphogenesis
GO:0048916; P:posterior lateral line development
GO:0043589; P:skin morphogenesis
KEGG
dre:30705;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 3.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013