EKS-DAR-00622

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00622

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	411.1	4.9E-123	174	460	287

Status

Unreviewed

Ensembl Protein

ENSDARP00000111494

UniProt Accession

F1QG01;

Protein Name

Protein Synonyms/Alias

Gene Name

acvr2a

Gene Synonyms/Alias

acvr2a;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000011188	ENSDARP00000024124	ENSDART00000002428
ENSDARG00000011188	ENSDARP00000111494	ENSDART00000129522
ENSDARG00000011188	ENSDARP00000096265	ENSDART00000105492

Organism

Danio rerio

Functional Description

Protein Length

495

Protein Sequence
(FASTA)

AILGRSETQE CVFYNYNPSL ENRGNRSGIE PCVGDKDKRL HCFATWRNVS GTVEIVKQGC 60

WLDDVNCYDS TECVEKKEDP DVFFCCCEGN MCNEKFFYNP NTAPVQTTSN PLTQKPPLFS 120

TLLYSIVPIM GIAAIVLLSF WMYRHHKLAY PPVLVPTQDP GPMPPSPTLV QKPLQLLEIK 180

ARGRFGCVWK AQLLNDYVAV KIFPIQDKLS WQNEYDIYNI PGMRHENILQ FIGAEKRGSN 240

LDIELWLITA YHEKSSLTDY LKANVVTWNE LCHIAQTMAR GLAYLHSDFP GHRDGHKPAI 300

AHRDFKSKNV LLKTNLTACI ADFGLALKFE AGKSAGDTHG QVGTRRYMAP EVLEGAINFQ 360

RDAFLRIDMY AVGLVLWELA ARCTASDGPV DEYMLPFEEE VGQHPTLEDM QEVVVHKKLR 420

PTLRECWQKH PGLAMLCETI EECWDHEAEA RLSAGCVEER VVQMQRQTSV SAPEEIVTVV 480

TMVTNVDYPP KESSL 495

Nucleotide Sequence
(FASTA)

GCCATTCTCG GCCGCTCAGA AACACAAGAG TGCGTGTTCT ACAACTACAA CCCCAGCTTG 60

GAGAACCGAG GAAACCGCAG CGGCATTGAG CCTTGCGTGG GAGACAAGGA CAAGAGGCTT 120

CATTGCTTCG CAACTTGGCG AAATGTGTCA GGAACGGTTG AAATAGTAAA GCAAGGCTGC 180

TGGCTTGATG ATGTCAACTG CTATGACAGC ACTGAGTGTG TGGAGAAGAA GGAGGACCCA 240

GATGTGTTCT TCTGCTGCTG TGAGGGCAAT ATGTGCAACG AGAAGTTCTT CTACAATCCC 300

AACACGGCGC CAGTTCAGAC GACATCAAAC CCCTTGACCC AGAAGCCGCC ACTGTTCAGT 360

ACCCTTCTGT ACTCCATCGT GCCCATCATG GGCATTGCAG CCATTGTCCT GCTCTCCTTC 420

TGGATGTATC GGCATCACAA GTTGGCATAC CCTCCTGTTC TGGTGCCTAC CCAGGACCCT 480

GGACCAATGC CACCATCTCC CACCCTGGTC CAAAAGCCAT TGCAATTGTT GGAAATCAAA 540

GCTAGGGGGC GCTTTGGCTG TGTGTGGAAG GCTCAGCTGC TCAATGACTA TGTGGCAGTG 600

AAGATTTTCC CCATTCAGGA CAAACTGTCT TGGCAGAACG AGTATGACAT TTACAACATC 660

CCCGGCATGA GGCATGAAAA TATCCTGCAG TTCATCGGGG CTGAGAAGAG AGGAAGCAAC 720

CTAGACATTG AGCTGTGGCT CATCACGGCT TACCATGAGA AGAGTTCTCT GACGGACTAC 780

TTGAAGGCCA ACGTAGTGAC GTGGAACGAG CTGTGCCACA TCGCTCAGAC CATGGCTCGA 840

GGACTGGCTT ACTTGCACTC CGACTTCCCA GGACACAGAG ATGGTCACAA ACCAGCCATC 900

GCACACAGAG ATTTCAAGAG CAAGAATGTA TTGCTGAAGA CAAACCTGAC AGCCTGTATA 960

GCTGATTTTG GATTGGCTTT AAAGTTTGAG GCTGGGAAGT CAGCTGGGGA CACACATGGG 1020

CAGGTGGGAA CCAGGCGTTA TATGGCCCCA GAGGTGTTGG AGGGGGCGAT CAACTTCCAG 1080

CGGGACGCTT TTCTCAGGAT AGACATGTAT GCAGTGGGGC TGGTGTTGTG GGAGCTGGCG 1140

GCCCGCTGCA CTGCTTCTGA CGGTCCAGTT GACGAGTACA TGCTTCCGTT TGAGGAGGAG 1200

GTGGGCCAAC ATCCCACTCT AGAGGACATG CAGGAGGTGG TGGTCCATAA AAAGCTACGG 1260

CCCACTCTCA GGGAGTGCTG GCAGAAACAT CCGGGTCTGG CCATGCTGTG CGAGACTATA 1320

GAAGAGTGTT GGGACCATGA AGCCGAGGCG CGTCTCTCTG CGGGCTGCGT GGAGGAGCGT 1380

GTGGTCCAGA TGCAGAGGCA GACCAGCGTC TCTGCCCCAG AGGAAATAGT CACCGTTGTA 1440

ACAATGGTGA CCAACGTGGA CTATCCCCCA AAGGAGTCTA GTCTATGA 1488

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l +++vAvKif+ +d+ sw++E +iy+ + +rhenilqfi+

Q: 174   LQLLEIKARGRFGCVWKAQLLNDYVAVKIFPIQDKLSWQNEYDIYNIPGMRHENILQFIG  233

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++  el+l+t+yhek sL+dyLk+++++++el+++a+++a+Gla+LH++ +g++

Q: 234   AEKRGSNLDIELWLITAYHEKSSLTDYLKANVVTWNELCHIAQTMARGLAYLHSDFPGHR  293

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         + +KpaiaHRD+kskN+l+k++lt+ciaD+GLalk+e+ k++ d  ++ qvGt+RYmaPE

Q: 294   DGHKPAIAHRDFKSKNVLLKTNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPE  351

         *****************************************888..79************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vle+a+n+++ +af r+D+Y++gLvlWE+a Rc+++d+ v+ey+lpfee+vg++P+le+m

Q: 352   VLEGAINFQR-DAFLRIDMYAVGLVLWELAARCTASDGPVDEYMLPFEEEVGQHPTLEDM  410

         *********9.9************************************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         +evvv+kklrP+++e w+k++ l++l++++eecWd+++eaRl+a +v++r

Q: 411   QEVVVHKKLRPTLRECWQKHPGLAMLCETIEECWDHEAEARLSAGCVEER  460

         ***********************************************998

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL LNDYVAVKIF PIQDKLSWQN EYDIYNIPGM RHENILQFIG 60

AEKRGSNLDI ELWLITAYHE KSSLTDYLKA NVVTWNELCH IAQTMARGLA YLHSDFPGHR 120

DGHKPAIAHR DFKSKNVLLK TNLTACIADF GLALKFEAGK SAGDTHGQVG TRRYMAPEVL 180

EGAINFQRDA FLRIDMYAVG LVLWELAARC TASDGPVDEY MLPFEEEVGQ HPTLEDMQEV 240

VVHKKLRPTL RECWQKHPGL AMLCETIEEC WDHEAEARLS AGCVEER 287

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0051216	; P:cartilage development
GO:0030902	; P:hindbrain development
GO:0001755	; P:neural crest cell migration
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013