EKS-DAR-00434

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00434

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	538.8	4.2E-162	397	673	277

Status

Unreviewed

Ensembl Protein

ENSDARP00000067688

UniProt Accession

G1K2P2;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

fgfr1b

Gene Synonyms/Alias

fgfr1b;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000011190	ENSDARP00000069743	ENSDART00000075259
ENSDARG00000011190	ENSDARP00000067688	ENSDART00000067689
ENSDARG00000011190	ENSDARP00000069753	ENSDART00000075269

Organism

Danio rerio

Functional Description

Protein Length

740

Protein Sequence
(FASTA)

MIFLSAAVSL RMLKSWRLLV LLLILTQLCT VQSRPAVTEQ GHIVASSEDE DDDESSSEEN 60

KPSSSQELLP MAPRWAQPEK MEKKLHAVPA SKTVKFRCQA EGNPIPKLRW LKNGKEFKRD 120

QRIGGYKLRE HMWTIIMESV VPSDKGNYTC LVENEYGSIN HTYQLDVVER SPHRPILYAG 180

LPANRTAVVG SDVEFVCKVF SDPQPHIQWL KHIRVNGSQL GPDGLPYVRV LKTAGLNTTD 240

KEMEVLQLRN VSFEDAGEYT CLAGNSIGIS HHSAWLTVVK APTAPSAVPS QSYLEVLIYC 300

IGFFLIFLMV GIATIVKIRS SSKKSDFNSQ LAVHKLAKSI PLRRQITVSV ESSSSLNSGV 360

MLVRPSRLSS SGTPMLSGVS EYELPQDPCW EVSRERLVLG KPLGEGCFGQ VVMGEAIGLD 420

KDKPNRITKV AVKMLKSDAT EKDLSDLISE MEMMKMIGKH KNIINLLGAC TQDGPLYVIV 480

EFASKGNLRE YLRARRPHGM EYCYNPDPLP IESMSIKDLV SCAYQVARGM EYLASKKCIH 540

RDLAARNVLV TEDNVMKIAD FGLARDVHHI DYYKKTTNGR LPVKWMAPEA LFDRIYTHQS 600

DVWSFGVLLW EIFTLGGSPY PGVPVEELFK LLREGHRMDK PSACTQELYL MMKDCWHAVP 660

TQRPTFKQLV EDLDRTLSLI SNQEYLELSV PLEPMYSQVI LNERSSTCSS EQDSVFLQEP 720

GPEDPCIPPS QQPMRSFKKR 740

Nucleotide Sequence
(FASTA)

ATGATCTTTC TGTCAGCCGC CGTTTCTCTC AGGATGCTGA AATCTTGGCG TCTGCTTGTC 60

CTGTTGCTGA TCCTAACCCA GCTCTGCACC GTCCAGTCAC GGCCTGCCGT CACCGAACAA 120

GGTCATATAG TAGCATCTTC AGAGGATGAG GACGATGACG AGTCTTCCTC AGAAGAGAAC 180

AAGCCATCGA GTAGCCAAGA GCTCTTACCG ATGGCGCCTC GCTGGGCTCA GCCTGAAAAG 240

ATGGAGAAAA AGCTTCATGC CGTGCCGGCC AGCAAAACGG TGAAATTCCG ATGTCAGGCC 300

GAAGGAAACC CAATTCCCAA ACTACGCTGG CTAAAGAATG GAAAAGAGTT CAAAAGAGAC 360

CAGCGCATCG GCGGCTACAA GCTGCGGGAA CACATGTGGA CCATAATCAT GGAGTCGGTG 420

GTGCCTTCAG ACAAGGGCAA CTACACGTGC CTTGTGGAGA ACGAATACGG GAGCATCAAC 480

CACACCTATC AGCTGGACGT AGTGGAGCGA TCACCTCACA GACCCATCCT GTACGCTGGA 540

CTCCCTGCTA ACCGAACCGC TGTGGTCGGC AGTGATGTAG AGTTTGTGTG CAAAGTGTTC 600

AGCGATCCTC AACCCCACAT CCAATGGCTC AAACACATCA GGGTGAACGG AAGCCAACTA 660

GGACCTGACG GACTTCCTTA CGTGCGCGTA CTAAAGACTG CTGGCCTTAA TACCACAGAC 720

AAGGAGATGG AAGTGCTCCA GTTGAGGAAC GTGTCCTTTG AGGATGCTGG GGAGTATACT 780

TGCTTGGCAG GCAATTCTAT CGGGATCTCC CATCATTCAG CATGGCTGAC CGTTGTTAAA 840

GCCCCCACTG CTCCCTCCGC AGTGCCCAGT CAGTCCTACC TGGAGGTGCT GATCTACTGC 900

ATTGGCTTCT TCCTCATCTT CCTCATGGTA GGAATCGCCA CCATCGTCAA AATCCGCAGC 960

TCCTCCAAGA AGAGCGACTT CAACAGCCAG CTGGCCGTCC ATAAGCTGGC CAAGAGCATC 1020

CCTCTGCGCA GACAGATTAC TGTGTCAGTG GAGTCCAGCT CGTCTCTGAA CTCAGGTGTG 1080

ATGCTAGTCC GGCCTTCACG TCTCTCCTCC AGCGGGACCC CGATGCTATC TGGGGTCTCC 1140

GAATACGAGC TACCTCAGGA CCCCTGCTGG GAAGTGTCCA GAGAGAGGCT AGTGCTCGGG 1200

AAGCCACTGG GCGAAGGCTG CTTTGGGCAG GTGGTGATGG GAGAAGCCAT CGGACTGGAC 1260

AAAGACAAGC CGAACCGCAT CACAAAAGTC GCTGTGAAGA TGCTGAAATC CGACGCCACC 1320

GAAAAGGACC TGTCTGACCT GATCTCAGAG ATGGAGATGA TGAAGATGAT TGGAAAACAC 1380

AAAAACATCA TAAACCTGCT TGGAGCTTGT ACACAAGATG GCCCGCTGTA TGTGATTGTG 1440

GAGTTCGCCT CCAAAGGAAA CCTGCGGGAA TACCTGCGCG CTCGCCGACC ACATGGCATG 1500

GAGTACTGTT ACAATCCTGA CCCACTGCCC ATCGAGAGCA TGTCCATCAA AGACCTGGTC 1560

TCCTGCGCAT ACCAGGTGGC GCGGGGCATG GAATACCTGG CATCCAAAAA GTGTATCCAC 1620

AGAGACTTGG CAGCACGCAA TGTACTAGTA ACAGAGGATA ATGTAATGAA GATAGCAGAC 1680

TTCGGCCTGG CGCGAGACGT CCATCACATA GACTACTACA AGAAGACCAC TAATGGTCGT 1740

CTTCCTGTTA AATGGATGGC GCCCGAGGCT TTATTCGACA GGATTTACAC ACATCAGAGT 1800

GACGTGTGGT CTTTCGGGGT TCTTTTGTGG GAGATCTTCA CTCTCGGAGG ATCTCCTTAT 1860

CCTGGAGTGC CTGTAGAGGA GCTCTTCAAG CTGCTGAGAG AAGGACACCG CATGGACAAA 1920

CCCTCCGCCT GCACACAGGA GCTATATCTG ATGATGAAGG ACTGCTGGCA TGCGGTTCCA 1980

ACACAGAGAC CAACATTTAA ACAGCTGGTA GAAGACCTGG ATCGCACCCT GTCCCTGATC 2040

TCAAATCAGG AGTATCTGGA GCTGTCGGTG CCGCTGGAGC CCATGTACTC TCAGGTCATC 2100

CTGAATGAAC GCAGCTCCAC ATGTTCGTCC GAGCAAGACT CCGTTTTCTT GCAAGAACCC 2160

GGACCTGAAG ATCCCTGCAT CCCTCCTTCA CAACAACCCA TGCGCTCCTT CAAAAAACGC 2220

TGA 2223

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv+ eaigldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+

Q: 397   LVLGKPLGEGCFGQVVMGEAIGLDKDKPNRITKVAVKMLKSDATEKDLSDLISEMEMMKM  456

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyvive+a+kGnlre+lrarrp+g+e+++++   + e+++

Q: 457   IGKHKNIINLLGACTQDGPLYVIVEFASKGNLREYLRARRPHGMEYCYNPDPLPIESMSI  516

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlardvh+idyykkt

Q: 517   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDVHHIDYYKKT  576

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkll+eGh

Q: 577   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLREGH  636

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp+ ct+ely +m++cwha++++rptfkqlvedl

Q: 637   RMDKPSACTQELYLMMKDCWHAVPTQRPTFKQLVEDL  673

         ***********************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVMGEA IGLDKDKPNR ITKVAVKMLK SDATEKDLSD LISEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEFASKG NLREYLRARR PHGMEYCYNP DPLPIESMSI 120

KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD VHHIDYYKKT 180

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLREGH 240

RMDKPSACTQ ELYLMMKDCW HAVPTQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation
GO:0036342	; P:post-anal tail morphogenesis

KEGG

dre:567905

;

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 2.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013