EKS-DAR-00423

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00423

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/Akt	498.9	6.4E-150	150	407	258

Status

Unreviewed

Ensembl Protein

ENSDARP00000111701

UniProt Accession

E7EYV0;

Protein Name

Protein Synonyms/Alias

Gene Name

akt2

Gene Synonyms/Alias

akt2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000011219	ENSDARP00000111701	ENSDART00000130397
ENSDARG00000011219	ENSDARP00000023119	ENSDART00000026767

Organism

Danio rerio

Functional Description

Protein Length

479

Protein Sequence
(FASTA)

MNEISVVREG WLHKRGEYIK TWRPRYFILK SDGSFIGYKE KPETSDANQP PLNNFSVAEC 60

QLMKTERPRP NTFVIRCLQW TTVIERTFHV DSNSEREEWI RAIQAVANGL KSREEDEPMD 120

INFGSPGDNS LEGMEAAITK SRTKVTMSDF DYLKLLGKGT FGKVILVREK ATGMYYAMKI 180

LRKEVIIAKD EVAHTITESR VLQNTRHPFL TTLKYAFQTR DRLCFVMEYA NGGELFFHLS 240

RERVFTEDRA RFYGAEIVSA LEYLHSKDVV YRDLKLENLM LDKDGHIKIT DFGLCKEGIT 300

NEATMKTFCG TPEYLAPEVL EDNDYGRAVD WWGLGVVMYE MMCGRLPFYN QDHERLFELI 360

LMEEIRFPRN LSPEAKALLA GLLKKDPKQR LGGGPEDAKE VMTHKFFNNM NWQDVLQKKL 420

VPPFKPQVTS ETDTRYFDDE FTAQTITVTP PDQYDSLDAE DPDTRTHFSQ FMLSTQATR 479

Nucleotide Sequence
(FASTA)

ATGAACGAGA TCAGCGTCGT CAGAGAGGGC TGGCTCCACA AAAGAGGTGA ATACATTAAG 60

ACTTGGAGGC CTCGATATTT CATCCTAAAG AGTGATGGCT CTTTTATCGG CTACAAGGAG 120

AAGCCGGAGA CGTCAGACGC CAATCAGCCA CCTCTCAATA ACTTCTCTGT CGCAGAGTGT 180

CAGCTGATGA AGACTGAACG ACCTCGGCCA AACACTTTTG TCATTCGTTG CTTGCAGTGG 240

ACCACTGTTA TCGAGCGCAC CTTTCATGTG GACAGCAATT CTGAAAGAGA GGAGTGGATA 300

CGTGCCATCC AGGCTGTGGC CAACGGGCTC AAGTCCCGGG AAGAGGATGA GCCAATGGAT 360

ATCAACTTTG GCTCCCCTGG AGACAACAGT CTAGAGGGGA TGGAGGCTGC CATCACAAAG 420

TCCCGCACCA AAGTGACCAT GAGTGACTTT GACTACTTAA AGCTGCTGGG TAAAGGCACT 480

TTTGGTAAGG TTATTCTAGT GAGGGAGAAG GCTACTGGCA TGTACTACGC CATGAAGATC 540

CTACGCAAAG AGGTCATCAT CGCTAAGGAC GAAGTTGCAC ACACAATCAC AGAAAGCAGA 600

GTGTTGCAGA ACACACGGCA TCCTTTCCTT ACAACACTAA AATACGCCTT CCAGACGCGA 660

GATCGACTGT GTTTCGTCAT GGAGTACGCA AATGGAGGCG AGCTGTTCTT CCACTTGTCT 720

CGAGAGCGTG TGTTTACGGA GGACAGAGCT CGCTTCTATG GGGCAGAAAT CGTTTCAGCG 780

TTGGAGTATC TGCACTCTAA AGATGTCGTC TACAGGGACC TAAAGCTGGA GAATCTAATG 840

CTGGATAAAG ATGGTCACAT TAAAATCACA GACTTTGGCC TGTGTAAAGA GGGCATTACT 900

AATGAGGCCA CCATGAAGAC ATTCTGTGGG ACCCCAGAGT ACCTTGCTCC TGAGGTATTA 960

GAAGACAACG ATTATGGCCG TGCAGTGGAC TGGTGGGGTC TTGGAGTGGT AATGTATGAA 1020

ATGATGTGCG GTCGGCTGCC GTTCTACAAC CAGGACCACG AGCGTCTGTT TGAGCTCATT 1080

TTAATGGAGG AGATCCGCTT CCCTAGAAAC CTCTCACCCG AGGCCAAAGC ACTGCTGGCC 1140

GGCCTTCTCA AAAAAGACCC CAAACAGAGG CTTGGCGGAG GTCCTGAAGA TGCCAAAGAA 1200

GTGATGACAC ACAAGTTCTT CAACAACATG AACTGGCAAG ATGTGCTTCA AAAGAAGCTC 1260

GTTCCACCCT TCAAGCCGCA AGTGACCTCA GAGACAGACA CACGCTACTT TGATGATGAG 1320

TTCACTGCAC AGACCATTAC TGTCACTCCA CCTGACCAAT ATGACAGTCT TGACGCGGAG 1380

GACCCAGATA CACGCACACA CTTCTCCCAG TTCATGCTGT CTACACAGGC AACTCGCTAG 1440

Domain Profile

S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60

         fd+lkllGkGtfGkvilvrekat+ +ya+kil+kevi+akdevaht+te+rvl++t+hpf

Q: 150   FDYLKLLGKGTFGKVILVREKATGMYYAMKILRKEVIIAKDEVAHTITESRVLQNTRHPF  209

         9***********************************************************

S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskdv  120

         l++lky+fqt+++lc+v+ey+nGGelffhls+ervf+edrarfygaeivsal+ylhskdv

Q: 210   LTTLKYAFQTRDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSALEYLHSKDV  269

         ************************************************************

S: 121   vyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygkav  180

         vyrdlklenl+ldkdGhikitdfGlcke+i++++++ktfcGtpeylapevled+dyg+av

Q: 270   VYRDLKLENLMLDKDGHIKITDFGLCKEGITNEATMKTFCGTPEYLAPEVLEDNDYGRAV  329

         ************************************************************

S: 181   dwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpkk  240

         dwwglGvv+yem+cGrlpfyn+dhe+lfelil+ee++fpr+ls+eak ll+Gllkkdpk+

Q: 330   DWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRNLSPEAKALLAGLLKKDPKQ  389

         ************************************************************

S: 241   rlGggkddakeireheff  258

         rlGgg++dake+++h+ff

Q: 390   RLGGGPEDAKEVMTHKFF  407

         *****************9

Domain Sequence
(FASTA)

FDYLKLLGKG TFGKVILVRE KATGMYYAMK ILRKEVIIAK DEVAHTITES RVLQNTRHPF 60

LTTLKYAFQT RDRLCFVMEY ANGGELFFHL SRERVFTEDR ARFYGAEIVS ALEYLHSKDV 120

VYRDLKLENL MLDKDGHIKI TDFGLCKEGI TNEATMKTFC GTPEYLAPEV LEDNDYGRAV 180

DWWGLGVVMY EMMCGRLPFY NQDHERLFEL ILMEEIRFPR NLSPEAKALL AGLLKKDPKQ 240

RLGGGPEDAK EVMTHKFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013