EKS-DAR-00743
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00743
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src452.95.6E-136270519250
StatusReviewed
Ensembl ProteinENSDARP00000003208
UniProt AccessionQ6EWH2; F8W4M2; Q58HR4; Q6DI27; Q9I8J8;
Protein NameTyrosine-protein kinase fyna
Protein Synonyms/Alias Proto-oncogene c-Fyna;
Gene Namefyna
Gene Synonyms/Alias fyna; fyn;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000011370ENSDARP00000003208ENSDART00000023320
ENSDARG00000011370ENSDARP00000123888ENSDART00000150232
ENSDARG00000011370ENSDARP00000046413ENSDART00000046414
OrganismDanio rerio
Functional DescriptionTyrosine-protein kinase implicated in the control ofcell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in cntn1-mediated signaling (By similarity). Required for convergent extension cell movements during gastrulation, acting with yes via rhoa. May be required for epiboly to occur, possibly through its effects in calcium signaling.
Protein Length536
Protein Sequence
(FASTA)
MGCVQCKDKE ATKLTDERET SVSQHAGYRY GSDPTPQHYP SFGVTAIPNY NNFHAPVSQG 60
VTVFGGVNSS SHSGTLRSRG GTGVTLFVAL YDYEARSEDD LSFRKGEKFQ ILNSTEGDWW 120
EARSLLQVEQ DTYPNYVAPV DSIQAEDWYF GKLGRKDAER QLLSNGNPRG TFLIRESETT 180
KGAYSLSIQD WDETKGDHVK HYKIRKLDNG GYYITTRAQF ETLQQLVHHY SARAAGLCCR 240
LIVPCHKGMP RLADLSVKTK DVWEIPRESL QLIKRLGNGQ FGEVWMGTWN GNTKVAVKTL 300
KPGTMSPESF LEEAQIMKKL RHDKLVQLYA VVSEEPIYIV TEYMSKGSLL DFLKDGEGRG 360
LKLPNLVDMA AQVAAGMAYI ERMNYIHRDL RSANILVGDS LVCKIADFGL ARLIEDNEYT 420
ARQGAKFPIK WTAPEAALYG RFTIKSDVWS FGILLTELVT KGRVPYPGMN NREVLEQVER 480
GYRMPCPQDC PSSLHELMLQ CWKRDPEERP TFEYLQAFLE DYFTATEPQY QPGDNL 536
Nucleotide Sequence
(FASTA)
ATGGGCTGTG TGCAATGTAA GGACAAAGAG GCAACCAAAC TCACAGACGA AAGAGAAACT 60
AGCGTCTCGC AGCATGCGGG ATATCGATAT GGGTCTGATC CGACTCCTCA GCACTACCCC 120
AGCTTTGGAG TCACCGCCAT TCCCAACTAC AACAACTTCC ATGCGCCTGT CAGTCAGGGA 180
GTGACCGTGT TTGGTGGAGT GAACTCATCG TCGCACTCGG GAACGCTACG ATCCCGGGGA 240
GGAACAGGAG TCACACTCTT TGTAGCACTT TATGATTATG AGGCAAGGTC AGAGGATGAC 300
CTGAGCTTCA GGAAAGGGGA AAAGTTCCAG ATTTTAAATA GCACGGAAGG AGACTGGTGG 360
GAGGCACGCT CTCTCCTACA GGTGGAACAG GATACATACC CAAATTATGT GGCTCCAGTC 420
GACTCCATAC AGGCAGAAGA TTGGTACTTT GGAAAACTAG GCCGTAAAGA TGCAGAACGA 480
CAACTGCTGT CAAATGGAAA TCCCAGAGGC ACTTTCCTTA TAAGGGAGAG TGAGACCACG 540
AAAGGAGCAT ATTCATTGTC CATACAGGAC TGGGATGAAA CTAAAGGCGA CCATGTGAAG 600
CACTACAAAA TACGAAAGTT GGACAATGGA GGATATTACA TCACCACTAG AGCTCAGTTT 660
GAAACTCTTC AGCAGCTTGT GCACCATTAT TCAGCCCGGG CTGCAGGACT TTGTTGCCGT 720
TTAATAGTCC CATGCCATAA AGGCATGCCC CGCCTCGCAG ACCTGTCCGT CAAAACCAAA 780
GATGTATGGG AAATCCCACG GGAGTCACTT CAGCTCATCA AACGATTGGG GAATGGACAG 840
TTCGGAGAGG TCTGGATGGG CACTTGGAAC GGCAACACTA AAGTGGCAGT GAAGACCTTG 900
AAACCAGGCA CAATGTCCCC AGAGTCATTC CTGGAGGAGG CTCAGATAAT GAAGAAACTG 960
AGGCATGACA AGCTGGTGCA GCTGTATGCG GTCGTCTCTG AAGAACCCAT CTACATTGTG 1020
ACAGAATATA TGAGCAAAGG AAGTCTGTTG GACTTCCTGA AGGATGGTGA AGGACGTGGG 1080
CTTAAATTGC CAAATTTAGT CGACATGGCT GCTCAGGTTG CTGCTGGCAT GGCTTACATC 1140
GAAAGGATGA ACTACATCCA CAGAGATCTG CGGTCTGCCA ATATACTTGT TGGGGACAGC 1200
TTAGTGTGCA AGATTGCAGA TTTCGGACTG GCCAGACTAA TAGAAGACAA TGAATACACA 1260
GCACGACAAG GTGCCAAGTT CCCAATAAAG TGGACGGCTC CAGAAGCAGC GCTCTACGGA 1320
CGGTTTACTA TCAAGTCAGA CGTGTGGTCA TTTGGAATAC TACTCACTGA GCTGGTCACC 1380
AAAGGACGTG TGCCCTATCC AGGCATGAAC AACCGGGAAG TCTTGGAGCA AGTGGAGCGT 1440
GGTTACAGGA TGCCTTGCCC TCAGGACTGT CCCAGCTCCC TGCATGAGCT CATGCTCCAG 1500
TGCTGGAAGA GGGACCCCGA AGAGCGGCCC ACCTTTGAGT ATCTGCAAGC CTTCCTGGAG 1560
GATTACTTCA CTGCCACTGA ACCACAGTAC CAACCCGGGG ACAACCTCTA A 1611
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         l+l+k+lG+GqfGevw+g+w+g++kvavktlk+gt+spe+fleeaqi+kklrh+klv+ly
Q: 270   LQLIKRLGNGQFGEVWMGTWNGNTKVAVKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLY  329
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvse ePiyivte+m+kGslldflk+ eg+ lklp+lvd+aaqva+Gmay+e++n+ihr
Q: 330   AVVSE-EPIYIVTEYMSKGSLLDFLKDGEGRGLKLPNLVDMAAQVAAGMAYIERMNYIHR  388
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+++n+lvg+slv+k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv
Q: 389   DLRSANILVGDSLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  448
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillte+vtkG+vPypGm+n+evleqvergyr+p+p++cp++l+el+l+cwk+dpee
Q: 449   WSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPSSLHELMLQCWKRDPEE  508
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe+lq++l
Q: 509   RPTFEYLQAFL  519
         *******9876
Domain Sequence
(FASTA)
LQLIKRLGNG QFGEVWMGTW NGNTKVAVKT LKPGTMSPES FLEEAQIMKK LRHDKLVQLY 60
AVVSEEPIYI VTEYMSKGSL LDFLKDGEGR GLKLPNLVDM AAQVAAGMAY IERMNYIHRD 120
LRSANILVGD SLVCKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180
SFGILLTELV TKGRVPYPGM NNREVLEQVE RGYRMPCPQD CPSSLHELML QCWKRDPEER 240
PTFEYLQAFL 250
KeywordAlternative splicing; ATP-binding; Complete proteome; Cytoplasm; Developmental protein; Kinase; Lipoprotein; Manganese; Metal-binding; Myristate; Nucleotide-binding; Nucleus; Palmitate; Phosphoprotein; Proto-oncogene; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gallus gallus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-GAG-00309
EKS-LOA-00374
EKS-MEG-00300
EKS-NOL-00335
EKS-ORN-00470
EKS-ORL-00432
EKS-OTG-00370
EKS-TAG-00440
EKS-TAR-00466
EKS-TEN-00462
EKS-XIM-00460
Gene Ontology
GO:0005829; C:cytosol
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0004672; F:protein kinase activity
GO:0060027; P:convergent extension involved in gastrulation
GO:0051480; P:cytosolic calcium ion homeostasis
GO:0001702; P:gastrulation with mouth forming second
GO:0046777; P:protein autophosphorylation
GO:0045859; P:regulation of protein kinase activity
KEGG
dre:373872;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013