EPS-DAR-00045

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-DAR-00045

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	276.1	6.9E-82	24	288	265

Status

Unreviewed

Ensembl Protein

ENSDARP00000011459

UniProt Accession

Q5U386;

Protein Name

Protein Synonyms/Alias

Protein phosphatase 1A, magnesium dependent, alpha isoform;

Gene Name

ppm1bb

Gene Synonyms/Alias

ppm1bb; ppm1a;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000011496	ENSDARP00000011459	ENSDART00000011662

Organism

Danio rerio

Functional Description

Protein Length

382

Protein Sequence
(FASTA)

MGAFLDKPKT EKHNAHGAGN GLNFGLSSMQ GWRVEMEDAH TAVVGLPHGL DDWSFFAVYD 60

GHAGSRVANY CSKHLLEHII TSSEDFRSGP DSVEGVKIGI RSGFLKIDEY MRNFSDLRNG 120

MDRSGSTAVG VLVSPEHLYF INCGDSRAVL SRAGQVRFST QDHKPCNPRE KERIQNAGGS 180

VMIQRVNGSL AVSRALGDYD YKCVDGKGPT EQLVSPEPEV FEVPRVSDED EFVVLACDGI 240

WDVMSNEELC DFVRSRLEVW DDLEKVCNSV VDTCLHKGSR DNMSVVLVCF PNAPKVSEEA 300

VKKEAELDKF LEARVEELME KSGEEGIPDL SHIMHNLHPE TIPNLPPGGG LPSKRSVIEA 360

VYNRLNPHRE EDGSGGDLDD PW 382

Nucleotide Sequence
(FASTA)

ATGGGGGCCT TCTTGGACAA ACCGAAAACG GAGAAACATA ATGCACACGG GGCAGGCAAT 60

GGTCTCAACT TCGGCCTAAG TAGCATGCAG GGATGGCGGG TCGAAATGGA GGACGCACAT 120

ACAGCTGTGG TTGGTCTGCC GCATGGCCTG GATGACTGGT CTTTCTTCGC GGTGTACGAC 180

GGTCACGCAG GTTCTCGTGT GGCCAACTAT TGTTCCAAAC ACTTACTGGA GCACATTATT 240

ACCAGCAGTG AGGACTTCCG CTCAGGCCCT GACTCGGTGG AAGGCGTTAA AATCGGCATT 300

CGCTCAGGCT TTTTGAAGAT CGATGAGTAC ATGCGCAACT TCTCAGACCT ACGTAACGGT 360

ATGGACCGTA GTGGTTCCAC AGCAGTCGGT GTGCTGGTGT CTCCCGAGCA CCTCTATTTC 420

ATCAACTGCG GTGACTCCCG TGCTGTGCTG AGCCGCGCAG GACAAGTGCG GTTCTCCACA 480

CAAGACCACA AACCGTGCAA CCCACGTGAA AAAGAGCGCA TTCAGAACGC AGGCGGTTCT 540

GTGATGATCC AAAGGGTGAA TGGTTCTCTG GCTGTGTCGC GCGCTTTAGG GGATTATGAC 600

TACAAGTGTG TGGACGGAAA GGGCCCAACT GAGCAGCTGG TATCTCCGGA ACCGGAGGTG 660

TTCGAAGTCC CACGCGTTTC AGACGAGGAT GAGTTTGTGG TGCTCGCCTG CGATGGCATC 720

TGGGACGTGA TGAGCAACGA GGAGCTGTGT GATTTTGTGC GCTCTCGCCT GGAGGTGTGG 780

GATGACTTGG AGAAAGTCTG CAACTCTGTG GTTGACACCT GTTTACATAA GGGAAGCCGT 840

GACAACATGA GTGTTGTTCT AGTATGTTTC CCCAATGCAC CAAAGGTATC AGAGGAGGCT 900

GTTAAGAAAG AGGCAGAGTT GGATAAGTTC CTGGAGGCCC GTGTTGAAGA ACTAATGGAG 960

AAGTCAGGGG AGGAAGGCAT CCCAGATCTA AGCCACATCA TGCACAACCT TCATCCTGAA 1020

ACCATCCCCA ACCTGCCACC AGGAGGTGGT CTACCTAGCA AACGTAGTGT AATTGAGGCC 1080

GTTTACAACA GGCTAAACCC ACACAGAGAA GAAGATGGGA GCGGAGGAGA CCTTGACGAC 1140

CCCTGGTAG 1149

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheila  62

         +g++s++g+r emeda+t++      p   d ++ff+vyDGh+gs+va++cs++l e++

Q: 24    FGLSSMQGWRVEMEDAHTAVV---GLPHGLDDWSFFAVYDGHAGSRVANYCSKHLLEHII  80

         799**************9844...44555556**************************99

S: 63    eele...sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyv  119

         +  e   s+ ++ + vk  ++++Fl++de ++++++ ++ +d+sGstav +l+++++ly+

Q: 81    TSSEdfrSGPDSVEGVKIGIRSGFLKIDEYMRNFSDLRNGMDRSGSTAVGVLVSPEHLYF  140

         998888788888899999******************************************

S: 120   anvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRalG  179

         +n+GdSravL+r g++   ++dHkp +++E+eRi++aggsv+ +   Rv+G+LavsRalG

Q: 141   INCGDSRAVLSRAGQVRFSTQDHKPCNPREKERIQNAGGSVMIQ---RVNGSLAVSRALG  197

         ********************************************...*************

S: 180   dlylk.........pyvtpePevtshrl.tsedefliLasDGlwdvvsneeavslvrdvl  229

         d+++k         ++v+pePev+++++ + edef++La+DG+wdv+snee++++vr++l

Q: 198   DYDYKcvdgkgpteQLVSPEPEVFEVPRvSDEDEFVVLACDGIWDVMSNEELCDFVRSRL  257

         **************************99566777**************************

S: 230   ekkeaeqeaakkLvklalargskdnvsaivv  260

         e  ++++++++++v+++l++gs+dn+s+++v

Q: 258   EVWDDLEKVCNSVVDTCLHKGSRDNMSVVLV  288

         **************************99875

Domain Sequence
(FASTA)

FGLSSMQGWR VEMEDAHTAV VGLPHGLDDW SFFAVYDGHA GSRVANYCSK HLLEHIITSS 60

EDFRSGPDSV EGVKIGIRSG FLKIDEYMRN FSDLRNGMDR SGSTAVGVLV SPEHLYFINC 120

GDSRAVLSRA GQVRFSTQDH KPCNPREKER IQNAGGSVMI QRVNGSLAVS RALGDYDYKC 180

VDGKGPTEQL VSPEPEVFEV PRVSDEDEFV VLACDGIWDV MSNEELCDFV RSRLEVWDDL 240

EKVCNSVVDT CLHKGSRDNM SVVLV 265

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0030512	; P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0006470	; P:protein dephosphorylation

KEGG

dre:100003481

;

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013