EKS-DAR-00021

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00021

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	523.3	2.2E-157	994	1261	268

Status

Unreviewed

Ensembl Protein

ENSDARP00000023951

UniProt Accession

F1QNX5;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

insra

Gene Synonyms/Alias

insra;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000011948	ENSDARP00000023951	ENSDART00000008302

Organism

Danio rerio

Functional Description

Protein Length

1353

Protein Sequence
(FASTA)

MRLRTLIVLV ASVYTVCNCQ QTNGEICSSK DIRNNVTNLR VLENCTVIEG HLKILLMFTT 60

KPEDFRGLSY PKLTVVTDYL LLFRVYGLES LSDLFPNLTV VRGNNLFFNY ALVLFEMLQL 120

KEIGLHSLMN ITRGAVRVEK NPDLCYLSTL DWSMILDSVE DNYIVANKND RECGDICPGT 180

VLGKTTCPLT TINGDFSERC WNQKYCQRMC PSSCKHRACT KDSQCCHDQC LGGCLEPHSS 240

NKCVACRNFM HNNMCVEKCP HGFYTFKGWR CVSFSFCQEL HNKCKQGKGD CHEYVIHNGA 300

CIPECPSGYT TVNSTTLNCT PCAGLCPKVC MGLKTVDSVT AAQALRGCTV INGSLVINIR 360

GGNNIAAELE ANLGQLEEIT GYLTVRHSYA LVSLSFLRKL RIIHGETQEV GNYSFYALDN 420

QNLRQLWDWS KHNLTIQQGR MFFHHNSKLC MSEIRRMEEV TGTKNRQTKN DIVSKTNGDQ 480

ASCESKVLKF TRISTLSDKI IIKWEAFWPP DFRDLLGFMV LYKEAPYKNV TEFDGQDACG 540

SNSWVIADVD PPPRATEGKE HEPGYLIFPL KPWTQYAIMV KTQLSASDEH QVHGAKSEII 600

YVRTNATKPS VPLDPISSSN SSSQIILKWK PPNDPNGNIT HYLVFCQQQP EASELYKFDY 660

CQKGMKLPTR APTQVDNEEE QKWNQTEEQG PDSRCCACPK TEKQLKKEAE ETEYRKTFEN 720

YLHNEVFELR PSRQRRSLVG IANRTSSRLF TTPSSLPNGS ATRSPEEEAE ANKISLIVQA 780

KESTVISNLR HFTSYQIEIH ACNHGSDPTR CSMAAYVSAR TMPEEKADDI VGKITCEVFE 840

YSVHIRWIEP KAPNGMIILY EVHYKRLGDT EELHHCVSRK NYIADGGCKL RVVHPGNYTV 900

RIRATSLAGN GSWTEPTHFY VQDLRVDPSN VLKIVIGPVI CFFLLLLLCV GFYIVKKKQT 960

EGPTGRLYTS PNPEYFSPDE VYEPDEWEVP REKITLLREL GQGSFGMVYE GNGKDIVKGE 1020

SQTRVAVKTV NESASLRERI EFLNEASVMK AFSCHHVVRL LGVVSKGQPT LVVMELMTHG 1080

DLKSFLRSLR PDSENNPGRP PPTLKEMIQM AAEIADGMAY LNAKKFVHRD LAARNCMVAE 1140

DLTVKIGDFG MTRDIYETDY YRKGGKGLLP VRWMAPESLK DGVFTAHSDC WSFGVVLWEV 1200

STLAEQPYQG LSNEQVLKFV MEGGYLDRPD NCADRLHNLM QMCWHYNPKM RPTFQEIIEM 1260

LREDLHPSFQ EVSFFYSEEN KPPETEEFDM DLENMESIPL DPSSYSQREC CLDGDEGSSV 1320

GLRGSYEEHV PYTHMNGGKK NGRILSLPRS TPS 1353

Nucleotide Sequence
(FASTA)

ATGCGGCTGC GGACTTTGAT TGTTTTGGTT GCGTCTGTCT ACACTGTTTG CAACTGTCAA 60

CAAACAAATG GAGAAATTTG CTCAAGTAAA GACATCCGAA ATAACGTGAC CAACCTGCGG 120

GTGCTGGAGA ACTGCACTGT TATCGAAGGC CACTTAAAGA TCCTGCTCAT GTTCACCACC 180

AAACCAGAGG ATTTCCGTGG CCTGAGTTAC CCCAAGCTGA CAGTAGTGAC GGACTACCTG 240

CTCCTGTTTC GTGTTTACGG CCTGGAGAGC CTCAGTGACC TGTTCCCCAA CCTAACAGTG 300

GTGCGTGGCA ATAATCTGTT CTTCAACTAT GCGCTGGTGC TCTTTGAGAT GCTGCAGCTG 360

AAGGAGATCG GCCTTCACAG CCTGATGAAC ATCACTCGCG GAGCCGTGCG TGTGGAAAAG 420

AACCCGGACC TCTGCTACCT CTCCACCCTC GACTGGTCCA TGATCCTGGA CTCTGTGGAG 480

GACAACTACA TTGTGGCCAA TAAGAATGAT CGGGAGTGTG GAGACATCTG TCCAGGCACG 540

GTTCTGGGCA AAACAACATG CCCCCTCACC ACTATCAACG GCGACTTCAG CGAGCGCTGC 600

TGGAACCAGA AGTACTGCCA GAGAATGTGT CCATCCTCAT GCAAGCACCG CGCCTGCACT 660

AAAGACAGCC AGTGCTGCCA CGACCAGTGT CTGGGCGGCT GTTTGGAGCC CCACTCGTCT 720

AACAAATGCG TGGCCTGCCG CAACTTCATG CACAACAACA TGTGTGTCGA AAAGTGCCCA 780

CATGGTTTCT ACACCTTCAA GGGCTGGCGC TGCGTCAGCT TCAGCTTTTG CCAGGAGCTC 840

CACAACAAGT GCAAGCAAGG CAAAGGTGAC TGCCACGAAT ACGTCATTCA CAACGGCGCC 900

TGCATCCCTG AGTGCCCTTC AGGATACACC ACTGTCAACT CCACTACGTT GAACTGCACC 960

CCTTGTGCTG GCCTCTGTCC CAAAGTGTGC ATGGGGTTGA AGACAGTGGA CTCGGTCACC 1020

GCGGCGCAGG CTCTGAGAGG ATGCACTGTG ATCAATGGCA GTTTGGTCAT CAACATCCGC 1080

GGAGGGAATA ACATAGCCGC TGAGCTAGAA GCTAACCTGG GACAGCTGGA GGAGATCACT 1140

GGTTACCTGA CAGTGAGACA CTCTTACGCC CTTGTCTCTC TGTCTTTTCT TCGCAAGCTC 1200

AGAATCATCC ATGGAGAGAC ACAAGAAGTC GGGAATTATT CATTTTACGC CCTTGATAAC 1260

CAGAACCTGC GTCAGCTGTG GGACTGGAGC AAACACAACC TGACCATCCA ACAGGGTCGC 1320

ATGTTTTTCC ATCACAACTC CAAACTCTGC ATGTCAGAAA TCCGGAGGAT GGAGGAGGTG 1380

ACGGGTACCA AAAACAGGCA AACAAAGAAT GACATCGTCT CAAAAACAAA TGGAGATCAG 1440

GCTTCATGTG AGAGCAAAGT TTTAAAATTC ACCCGAATCA GTACACTTTC TGACAAGATC 1500

ATAATAAAAT GGGAAGCTTT CTGGCCACCA GATTTTCGAG ACCTCCTAGG ATTCATGGTT 1560

TTGTATAAAG AAGCACCATA TAAGAACGTG ACTGAGTTTG ATGGTCAGGA CGCGTGTGGC 1620

TCTAACAGCT GGGTAATAGC AGATGTGGAC CCTCCACCTC GCGCCACAGA GGGAAAGGAG 1680

CACGAGCCTG GGTACCTCAT CTTCCCTCTG AAGCCCTGGA CGCAGTACGC CATCATGGTC 1740

AAAACACAGC TCTCTGCTTC TGATGAGCAC CAAGTCCACG GAGCAAAGAG TGAAATCATT 1800

TATGTCCGCA CCAATGCTAC CAAGCCATCA GTGCCTCTGG ACCCCATATC CTCGTCAAAC 1860

TCCTCATCCC AGATCATTCT AAAATGGAAG CCACCAAACG ATCCTAATGG AAACATCACT 1920

CATTACCTGG TCTTTTGCCA GCAACAGCCA GAGGCCAGCG AGCTCTACAA ATTTGATTAC 1980

TGCCAGAAAG GTATGAAGCT GCCCACCAGA GCCCCCACAC AAGTGGACAA CGAAGAGGAG 2040

CAGAAGTGGA ACCAAACTGA GGAGCAGGGC CCTGATAGCC GCTGCTGCGC TTGTCCTAAA 2100

ACAGAGAAAC AACTGAAGAA AGAGGCGGAA GAGACGGAGT ATCGAAAAAC CTTTGAGAAC 2160

TACCTCCATA ATGAAGTGTT TGAGCTCAGG CCATCAAGAC AGCGCAGATC TCTGGTGGGC 2220

ATTGCTAATA GGACGTCCTC TCGTCTTTTC ACCACACCCT CCTCACTCCC CAATGGCTCT 2280

GCTACTCGTA GCCCAGAAGA GGAAGCAGAG GCCAACAAGA TTTCACTGAT TGTTCAGGCC 2340

AAGGAGTCAA CAGTCATCTC CAATCTACGG CATTTCACCA GCTACCAGAT AGAAATCCAT 2400

GCATGCAACC ATGGCAGTGA CCCGACTCGA TGCAGTATGG CAGCCTACGT CAGTGCCCGC 2460

ACCATGCCTG AAGAAAAAGC TGATGACATT GTGGGAAAGA TCACCTGTGA GGTGTTCGAG 2520

TACTCTGTGC ACATCAGATG GATTGAGCCC AAGGCCCCTA ATGGCATGAT TATTCTCTAT 2580

GAAGTCCATT ACAAGAGACT GGGAGATACA GAGGAGCTGC ACCACTGCGT ATCCAGGAAG 2640

AATTATATTG CAGACGGAGG GTGCAAGCTG AGAGTGGTGC ATCCTGGGAA CTATACAGTG 2700

CGGATCAGAG CGACCTCTCT GGCAGGCAAT GGATCATGGA CAGAGCCAAC ACACTTCTAT 2760

GTGCAGGACC TACGTGTGGA TCCATCCAAC GTGCTGAAGA TTGTGATTGG TCCAGTTATA 2820

TGTTTTTTTC TGCTCCTATT GTTATGTGTG GGCTTTTACA TAGTCAAGAA AAAGCAAACA 2880

GAAGGTCCGA CCGGCCGACT TTACACATCT CCAAATCCAG AGTATTTCAG TCCAGATGAG 2940

GTGTATGAGC CGGACGAATG GGAAGTGCCC CGTGAAAAGA TCACTCTATT GAGAGAGTTG 3000

GGCCAGGGAT CTTTCGGTAT GGTTTATGAG GGCAATGGAA AGGACATAGT GAAAGGAGAG 3060

TCGCAGACGC GTGTGGCGGT GAAGACGGTT AATGAGTCTG CCAGTCTCAG AGAGAGAATT 3120

GAGTTCCTCA ATGAAGCTTC TGTCATGAAG GCCTTCAGCT GCCACCATGT GGTGAGGCTT 3180

CTGGGAGTGG TGTCTAAAGG CCAGCCAACT CTGGTGGTGA TGGAGCTCAT GACACACGGT 3240

GATCTGAAGA GTTTCCTGCG CTCTCTCAGA CCTGACTCAG AGAATAACCC AGGCCGGCCT 3300

CCTCCGACTC TGAAGGAGAT GATTCAGATG GCCGCAGAGA TAGCAGATGG CATGGCTTAT 3360

CTTAATGCCA AAAAGTTTGT GCACAGAGAT CTTGCTGCCA GGAACTGCAT GGTGGCCGAA 3420

GACCTGACTG TAAAAATTGG AGATTTTGGC ATGACCAGAG ATATTTATGA GACGGATTAC 3480

TACAGAAAGG GTGGGAAGGG TCTTCTTCCA GTGAGATGGA TGGCACCAGA GTCGCTGAAG 3540

GATGGTGTTT TCACAGCTCA CTCAGACTGC TGGTCGTTTG GTGTGGTGTT ATGGGAAGTC 3600

AGCACTCTGG CTGAACAGCC GTATCAAGGC CTGTCCAATG AACAGGTCCT TAAATTTGTG 3660

ATGGAAGGAG GATATCTGGA CAGACCAGAC AACTGCGCAG ACAGATTACA TAACCTGATG 3720

CAGATGTGCT GGCATTATAA TCCCAAAATG CGGCCCACCT TCCAGGAGAT CATCGAGATG 3780

CTCCGCGAAG ATCTGCATCC CTCGTTTCAG GAGGTCTCCT TCTTCTACAG CGAGGAAAAC 3840

AAGCCACCGG AAACAGAGGA GTTTGACATG GACCTGGAGA ACATGGAGAG CATCCCGCTG 3900

GACCCGTCCT CGTACTCACA GAGGGAGTGC TGTCTGGACG GGGACGAGGG CTCCTCCGTG 3960

GGCCTTCGGG GCAGTTATGA GGAGCATGTG CCGTACACGC ATATGAACGG CGGCAAGAAA 4020

AACGGACGCA TCTTATCTCT ACCCCGATCC ACCCCTTCTT AA 4062

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+llrelGqGsfGmvyeG++kd+vkge++trva+ktvne+as reriefl+easvmk+f+

Q: 994   ITLLRELGQGSFGMVYEGNGKDIVKGESQTRVAVKTVNESASLRERIEFLNEASVMKAFS  1053

         789*********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvskgqp+lvvmelm++Gdlks+lrslrp++en+++++pp+l+++iqmaae

Q: 1054  CHHVVRLLGVVSKGQPTLVVMELMTHGDLKSFLRSLRPDSENNPGRPPPTLKEMIQMAAE  1113

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+akkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw

Q: 1114  IADGMAYLNAKKFVHRDLAARNCMVAEDLTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1173

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         m+peslkdGvft++sd wsfGvvlwe+ tlaeqpyqGlsneqvlkfv++gg+l++p+nc

Q: 1174  MAPESLKDGVFTAHSDCWSFGVVLWEVSTLAEQPYQGLSNEQVLKFVMEGGYLDRPDNCA  1233

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

         ++l++lm++cw+ynpk+rp+f ei+e+l

Q: 1234  DRLHNLMQMCWHYNPKMRPTFQEIIEML  1261

         *************************975

Domain Sequence
(FASTA)

ITLLRELGQG SFGMVYEGNG KDIVKGESQT RVAVKTVNES ASLRERIEFL NEASVMKAFS 60

CHHVVRLLGV VSKGQPTLVV MELMTHGDLK SFLRSLRPDS ENNPGRPPPT LKEMIQMAAE 120

IADGMAYLNA KKFVHRDLAA RNCMVAEDLT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180

MAPESLKDGV FTAHSDCWSF GVVLWEVSTL AEQPYQGLSN EQVLKFVMEG GYLDRPDNCA 240

DRLHNLMQMC WHYNPKMRPT FQEIIEML 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0048589	; P:developmental growth
GO:0009790	; P:embryo development
GO:0046777	; P:protein autophosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 1.
PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 2.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013