EKS-DAR-00682

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00682

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	325.2	6.3E-97	34	292	259

Status

Unreviewed

Ensembl Protein

ENSDARP00000114830

UniProt Accession

E7F1B6;

Protein Name

Protein Synonyms/Alias

Gene Name

slkb

Gene Synonyms/Alias

slkb; OTTDARG00000030021;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000012574	ENSDARP00000015688	ENSDART00000017965
ENSDARG00000012574	ENSDARP00000114830	ENSDART00000134399

Organism

Danio rerio

Functional Description

Protein Length

969

Protein Sequence
(FASTA)

MSFFNFRKIF KLGIEKKKKQ YDHVHRDTNP EEIWEIVGEL GDGAFGKVFK AQNKQTGIFA 60

AAKVIDTKTE DELEDYMVEI DILASCDHHN IVKLLDAFYF ESKLWILIEF CAGGAVDAVM 120

LELERPLTEP QIRVVCKQTL DALLYLHDNK VIHRDLKAGN ILLTLDGDVK LADFGVSAKN 180

TKTVQRRDSF IGTPYWMAPE VVMCETSKDR PYDYKADIWS LGITLIELAQ IEPPNHEMNP 240

MRVLLKIAKA EPPTLLQPSK WSPEFRDFLK HALEKNVDNR WSTAQLLQHP FVSTVTDSRP 300

LRELIAEAKA EVTEEMEEEE DDEEHEGNLL GHKRAPSDAS VGSSEDEKLP QSPSTLESVP 360

ERIEEVSAPK LADDIVTAEI KKEEDPLKTE ENHILDKAAS ESNKQELKTE GEPDVVPSET 420

PAEGIIQPAK PDGEKLREEE VLGNGELVQK EPASDVCSPT DKEKAVIEES SKAVAPSSPV 480

PEKEKKEKLE DEQKQSPVKP HYVKKEDSDS GISSTTDTSS NSSSIDLNLS ISSFISKSKE 540

MGTNSQQDNK RQKKTLKKTR KFMVDGVEVS VTTSKIITDN DTKNEEMRFL RRQELRELRL 600

LQKEEQRAQQ QLSNKLQQQR DQICRRFEHE TTSKKRQYDT EVENMERQQK QTIERLEQEH 660

TERLRDEAKR IKAEQDKELS KFQNTHKNRK KEEQEFVQKQ QQDLDSALKK IIQQHKLELA 720

TTERDCLNHK QQLLRAREAA MWELEERHLQ EKHQLYKQQL KDQYFMQRHQ LLKRHEKEME 780

QMHRYNQRLM EDMKNRQMQE KTRLPKIQRS DAKTRMAMFK KSLRITTTGV TAELERERVK 840

QFAAQEEKRQ KNERLHQQQK HENQMRDLQT QCDANSRELQ QLQNEKCHLL IEHETQKLKE 900

LDEEHGAELK DWREKLRPRK KALEEEFARK LQEQEVFFKM SGESACLNPS TQSRISKFYP 960

VPSVQSTGF 969

Nucleotide Sequence
(FASTA)

ATGTCCTTCT TTAATTTCCG AAAGATCTTT AAACTGGGGA TAGAGAAGAA GAAGAAACAA 60

TATGATCACG TGCACAGGGA CACAAACCCA GAGGAAATAT GGGAGATTGT TGGAGAACTG 120

GGGGATGGAG CCTTTGGGAA GGTGTTCAAG GCACAGAACA AGCAGACTGG TATTTTTGCG 180

GCTGCAAAGG TGATCGACAC TAAAACTGAA GATGAGCTGG AGGACTACAT GGTGGAGATC 240

GACATCTTGG CATCATGTGA TCATCACAAC ATCGTCAAGC TGCTCGACGC TTTTTACTTT 300

GAGAGCAAAC TGTGGATCCT GATCGAGTTC TGTGCCGGCG GGGCCGTCGA TGCCGTCATG 360

CTTGAACTGG AAAGGCCTCT GACGGAGCCG CAGATCAGGG TGGTTTGTAA GCAGACTCTG 420

GATGCTCTGC TGTATCTGCA TGACAACAAG GTCATTCACA GAGACCTGAA GGCTGGAAAC 480

ATCCTGCTCA CGCTGGATGG AGACGTCAAA TTGGCGGATT TTGGAGTGTC TGCCAAGAAC 540

ACGAAGACTG TTCAGCGAAG AGACTCTTTC ATTGGAACCC CTTACTGGAT GGCTCCAGAG 600

GTGGTGATGT GCGAGACGTC GAAGGACAGG CCGTATGACT ATAAGGCTGA TATCTGGTCT 660

CTGGGAATCA CTCTGATTGA ACTGGCTCAG ATCGAACCTC CAAACCACGA GATGAACCCG 720

ATGAGAGTCC TGCTGAAGAT CGCCAAAGCT GAGCCTCCTA CTCTACTACA GCCCTCCAAA 780

TGGTCTCCTG AGTTCAGGGA CTTCCTCAAA CACGCGCTGG AAAAAAACGT GGACAACAGG 840

TGGAGCACAG CGCAACTCCT CCAGCACCCG TTTGTGAGCA CTGTAACTGA CAGCCGGCCG 900

CTGCGGGAGC TGATCGCAGA GGCAAAGGCG GAGGTTACGG AGGAGATGGA GGAGGAGGAG 960

GATGATGAAG AGCATGAAGG AAACCTGCTT GGACACAAAC GCGCCCCGTC TGATGCAAGT 1020

GTCGGCAGTT CTGAAGACGA GAAGCTTCCT CAGTCTCCAT CCACATTAGA GTCAGTTCCT 1080

GAGAGGATCG AGGAGGTCTC CGCTCCCAAA CTAGCAGATG ATATTGTTAC AGCTGAAATA 1140

AAGAAAGAAG AAGATCCTCT GAAGACAGAA GAGAACCACA TACTAGATAA AGCAGCATCT 1200

GAATCCAACA AACAAGAGCT TAAAACTGAA GGAGAACCAG ACGTGGTTCC CTCAGAAACT 1260

CCAGCTGAGG GAATAATCCA ACCGGCCAAA CCTGATGGAG AGAAACTGAG GGAGGAGGAG 1320

GTGTTGGGAA ATGGTGAGCT CGTCCAGAAA GAGCCTGCGT CAGATGTGTG TTCACCAACT 1380

GACAAAGAGA AAGCAGTGAT CGAGGAGTCC AGTAAAGCAG TGGCTCCATC ATCTCCAGTG 1440

CCAGAGAAAG AGAAGAAGGA GAAGCTTGAG GACGAGCAGA AGCAGAGCCC AGTGAAACCC 1500

CATTATGTGA AGAAAGAGGA CTCCGATTCG GGCATCAGCT CTACAACTGA CACCAGCAGC 1560

AACAGCAGCA GTATAGACCT CAACCTGTCC ATCTCCAGCT TCATCAGCAA ATCCAAGGAG 1620

ATGGGAACCA ACTCACAGCA GGATAACAAG AGGCAGAAAA AAACCCTGAA GAAGACGCGT 1680

AAGTTCATGG TGGACGGAGT GGAGGTCAGC GTTACAACAT CCAAGATCAT CACAGACAAT 1740

GACACCAAAA ACGAGGAGAT GCGATTCCTG AGGCGTCAGG AGCTGCGAGA GCTGAGACTC 1800

CTGCAGAAGG AAGAGCAGAG AGCACAACAA CAGCTCAGCA ACAAACTCCA GCAGCAGAGA 1860

GATCAGATCT GCCGACGCTT CGAACACGAG ACCACGAGTA AGAAGCGTCA GTACGACACA 1920

GAGGTGGAGA ACATGGAGAG GCAGCAGAAA CAGACCATCG AGCGTCTGGA GCAGGAGCAC 1980

ACAGAGCGTC TGCGGGACGA GGCCAAACGC ATCAAAGCAG AGCAGGACAA AGAGCTCTCT 2040

AAATTCCAGA ACACGCACAA GAACCGCAAG AAGGAGGAGC AGGAGTTTGT TCAGAAGCAG 2100

CAGCAGGATC TGGACAGCGC TCTGAAGAAG ATCATTCAGC AGCACAAGCT TGAGCTGGCC 2160

ACCACAGAGA GAGACTGTCT CAACCACAAA CAGCAGCTGC TCAGAGCTCG AGAAGCAGCC 2220

ATGTGGGAGC TGGAGGAGCG CCACCTGCAG GAGAAACACC AGCTCTACAA ACAGCAGCTG 2280

AAGGACCAGT ACTTCATGCA GAGGCACCAG CTGCTCAAGA GACATGAGAA GGAGATGGAG 2340

CAGATGCACA GGTACAACCA GCGTCTGATG GAGGATATGA AGAACAGGCA GATGCAGGAG 2400

AAAACCAGAC TGCCCAAGAT CCAGCGCAGC GACGCAAAGA CCCGCATGGC CATGTTCAAG 2460

AAGAGTCTGA GGATCACCAC CACTGGAGTG ACTGCAGAGC TGGAGAGAGA GAGAGTCAAA 2520

CAGTTTGCAG CACAGGAGGA AAAGCGTCAG AAGAACGAGC GTCTTCATCA GCAGCAGAAG 2580

CATGAGAATC AGATGCGGGA TCTGCAGACT CAGTGTGACG CAAACAGCAG AGAACTGCAG 2640

CAGCTGCAGA ATGAGAAGTG CCATCTGCTG ATCGAGCATG AGACACAGAA GCTGAAGGAG 2700

CTTGATGAAG AGCATGGCGC TGAGCTCAAG GACTGGAGAG AGAAACTCAG ACCCCGCAAG 2760

AAGGCTCTGG AGGAGGAGTT TGCCCGTAAA CTGCAGGAAC AGGAAGTGTT CTTCAAGATG 2820

AGCGGAGAGT CTGCGTGTCT GAACCCCTCC ACACAGAGTC GCATCTCCAA GTTCTACCCC 2880

GTCCCGAGTG TGCAGTCCAC CGGCTTTTAA 2910

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +e++ e+g+Ga+gkv++a++k+tg ++a k+i+++++++le+++ ei +l +++h+niv+

Q: 34    WEIVGELGDGAFGKVFKAQNKQTGIFAAAKVIDTKTEDELEDYMVEIDILASCDHHNIVK  93

         78999*******************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +l++f+ e++lw+++e++agG+++ ++  el+++l+E qi+++++++l+aL ylH++kvi

Q: 94    LLDAFYFESKLWILIEFCAGGAVDAVML-ELERPLTEPQIRVVCKQTLDALLYLHDNKVI  152

         **************************99.9******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe...ekgY  177

         Hrd+ka+niLlt +g+VkL+dfgv+a+ +kt+++r++++gtpywmAPEv+ +e   ++ Y

Q: 153   HRDLKAGNILLTLDGDVKLADFGVSAKNTKTVQRRDSFIGTPYWMAPEVVMCEtskDRPY  212

         ****************************************************9998999*

S: 178   dekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekc  237

         d+kaDiwslGIt+iela+ epP ++++p+++llki+k epp+l +++k+s+ef++f++++

Q: 213   DYKADIWSLGITLIELAQIEPPNHEMNPMRVLLKIAKAEPPTLLQPSKWSPEFRDFLKHA  272

         ************************************************************

S: 238   lqknpekRpsasellkhkFl  257

         l+kn+++R+s+++ll+h+F+

Q: 273   LEKNVDNRWSTAQLLQHPFV  292

         *******************7

Domain Sequence
(FASTA)

WEIVGELGDG AFGKVFKAQN KQTGIFAAAK VIDTKTEDEL EDYMVEIDIL ASCDHHNIVK 60

LLDAFYFESK LWILIEFCAG GAVDAVMLEL ERPLTEPQIR VVCKQTLDAL LYLHDNKVIH 120

RDLKAGNILL TLDGDVKLAD FGVSAKNTKT VQRRDSFIGT PYWMAPEVVM CETSKDRPYD 180

YKADIWSLGI TLIELAQIEP PNHEMNPMRV LLKIAKAEPP TLLQPSKWSP EFRDFLKHAL 240

EKNVDNRWST AQLLQHPFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR022165	; PKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF12474	; PKK; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013