EKS-DAR-00818
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00818
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/WEE323.32.1E-96183455273
StatusReviewed
Ensembl ProteinENSDARP00000126447
UniProt AccessionQ1LX51; A4IFZ5; Q1LX50; Q32PP5;
Protein NameWee1-like protein kinase 2
Protein Synonyms/Alias Wee1-like protein kinase 1B; Wee1B kinase;
Gene Namewee2
Gene Synonyms/Alias wee2; wee1b; si:ch211-238n5.5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000012718ENSDARP00000040073ENSDART00000040074
ENSDARG00000012718ENSDARP00000126447ENSDART00000151974
ENSDARG00000012718ENSDARP00000121512ENSDART00000136710
ENSDARG00000012718ENSDARP00000126564ENSDART00000151990
ENSDARG00000012718ENSDARP00000109848ENSDART00000121699
OrganismDanio rerio
Functional DescriptionOocyte-specific protein tyrosine kinase thatphosphorylates and inhibits cdk1 and acts as a key regulator of meiosis. Required to maintain meiotic arrest in oocytes by phosphorylating cdk1 at 'Tyr-15', leading to inhibit cdk1 activity and prevent meiotic reentry (By similarity).
Protein Length485
Protein Sequence
(FASTA)
MASVNATQQH LNFSSSWEED SSDNSFDEWT HKSVPLRSPC RTPRIQRHRN RSITVSPSVP 60
TSPIPYAAWK KLRLCDSPST PKSLLSKSTM PCSSSKTCRS QRFLRLSTAF ERVPSVNINP 120
FTPDTVRRNS EHYKRKSQRS DDDEDYGPRS KEIQNSSEDE SFFLPSKRPA VSARMLSRYE 180
SEFLELACIG VGEFGSVYRC VKRLDGCMYA IKRSRRPIAG SANEQLALKE VYAHAVLGHH 240
PHVVRYYSAW AEDDHMIIQN EYCDGGSLHD AITEKREQGE FFSVPELRDL LLQVSMGLKY 300
IHNSGLVHLD IKPSNIFICR RSTLSAGGEG DSEEEDESHS SGVVYKIGDL GHVTSISSPQ 360
VEEGDSRFLA YEVLREDYTH LPKADIFALG LTVLLAAGAS PLPQNGDDWH RLRQGELPNL 420
PHELPALFKD LLKSLLDPDP TARPSATALC RHDVLCKERA GKLATQLRKE LNVEKFRTAM 480
LERQN 485
Nucleotide Sequence
(FASTA)
ATGGCCTCTG TGAATGCAAC GCAGCAGCAT CTGAACTTCT CCAGCAGCTG GGAGGAGGAC 60
AGCAGTGACA ATAGTTTTGA TGAATGGACA CACAAGAGTG TCCCCCTTAG AAGCCCCTGC 120
CGGACACCCC GGATACAACG ACACCGTAAC AGAAGCATCA CAGTTTCTCC TTCAGTCCCT 180
ACCTCTCCCA TACCATATGC TGCCTGGAAA AAGCTTCGAC TTTGTGACTC GCCCAGCACA 240
CCAAAAAGTT TGCTGTCTAA ATCAACGATG CCTTGCTCTA GCAGCAAAAC GTGTCGCAGT 300
CAGCGATTCC TACGCCTGTC TACTGCATTT GAACGAGTTC CTTCAGTGAA CATTAATCCT 360
TTTACACCAG ACACCGTGCG CAGAAACAGT GAACACTACA AGAGAAAGAG TCAAAGGAGT 420
GATGATGATG AGGACTATGG ACCAAGATCT AAAGAAATTC AGAATTCATC CGAGGATGAA 480
AGTTTCTTCC TCCCCTCGAA GAGGCCAGCA GTGTCAGCCC GCATGCTGTC GCGTTACGAG 540
AGTGAGTTTC TAGAGCTGGC CTGCATTGGC GTGGGCGAGT TTGGTTCCGT GTATCGATGT 600
GTGAAGAGGT TGGATGGTTG CATGTACGCC ATCAAGCGCT CTCGCAGGCC AATCGCAGGC 660
TCCGCTAATG AGCAGCTTGC CTTGAAGGAA GTGTACGCCC ATGCTGTGTT GGGCCATCAC 720
CCTCATGTTG TCCGATACTA CTCTGCATGG GCTGAAGATG ACCATATGAT TATACAGAAT 780
GAGTACTGTG ATGGTGGCAG CCTTCATGAT GCTATAACTG AAAAGAGAGA GCAAGGGGAG 840
TTCTTCAGCG TTCCCGAGCT CAGGGATCTG CTCCTACAGG TCTCCATGGG GCTCAAGTAC 900
ATCCACAACT CAGGCCTGGT GCATCTTGAC ATCAAACCGA GTAATATTTT CATCTGTCGT 960
CGATCCACCT TGAGTGCTGG TGGAGAGGGA GATAGTGAAG AAGAGGATGA AAGCCACTCT 1020
TCTGGAGTTG TATATAAAAT TGGTGACCTG GGTCATGTAA CGTCCATCTC AAGCCCTCAG 1080
GTAGAGGAAG GGGACAGTCG CTTTCTGGCT TATGAGGTCC TGCGAGAGGA CTACACGCAT 1140
CTTCCTAAAG CAGATATTTT TGCGCTGGGT CTGACAGTGT TGTTGGCTGC AGGTGCTTCA 1200
CCACTTCCCC AGAATGGGGA TGATTGGCAC AGATTGAGGC AAGGAGAACT ACCCAACCTG 1260
CCACATGAGT TACCAGCACT CTTTAAAGAC CTTCTAAAGT CACTATTAGA TCCTGATCCT 1320
ACTGCAAGGC CATCTGCAAC AGCTTTGTGT CGGCATGATG TTCTATGTAA GGAGAGAGCT 1380
GGAAAACTTG CTACACAGCT TCGCAAAGAG CTAAATGTGG AGAAATTCAG AACAGCTATG 1440
CTGGAAAGGC AAAACTGA 1458
Domain Profile
S: 1     FeevekiGkGefgevfkvvkredgklyAikkskkplkglskekkalrEvtahavlgqhen  60
         F e++ iG+Gefg+v+++vkr+dg++yAik+s++p++g+ +e+ al+Ev+ahavlg+h++
Q: 183   FLELACIGVGEFGSVYRCVKRLDGCMYAIKRSRRPIAGSANEQLALKEVYAHAVLGHHPH  242
         778999******************************************************
S: 61    vvryisaWeeddslyiqtElCeggsLeaalqeceakkkaleeaelkkilldlllglrylH  120
         vvry+saW+edd+++iq+E+C+ggsL++a++e  ++ + ++  el+++ll+++ gl+y+H
Q: 243   VVRYYSAWAEDDHMIIQNEYCDGGSLHDAITEKREQGEFFSVPELRDLLLQVSMGLKYIH  302
         ************************************************************
S: 121   ssslvHlDikpenifi.....................tkevtlklgDlGlvtelnsedks  159
         +s lvHlDikp+nifi                     ++ v++k+gDlG+vt++   +++
Q: 303   NSGLVHLDIKPSNIFIcrrstlsaggegdseeedeshSSGVVYKIGDLGHVTSI---SSP  359
         ***********************************999999*************...9**
S: 160   kveEGDsrylakEilqeeyskl.kaDiFslgltilevaanvelPsnGeaWhklRkgklpd  218
         +veEGDsr+la E+l+e+y++l kaDiF+lglt+l +a++ +lP+nG+ Wh+lR+g+lp 
Q: 360   QVEEGDSRFLAYEVLREDYTHLpKADIFALGLTVLLAAGASPLPQNGDDWHRLRQGELP-  418
         ***********************************************************.
S: 219   eilkelsedlrellklmlepdperRptaeellkhevl  255
         ++ +el   +++llk++l+pdp+ Rp+a++l +h+vl
Q: 419   NLPHELPALFKDLLKSLLDPDPTARPSATALCRHDVL  455
         9********************************9886
Domain Sequence
(FASTA)
FLELACIGVG EFGSVYRCVK RLDGCMYAIK RSRRPIAGSA NEQLALKEVY AHAVLGHHPH 60
VVRYYSAWAE DDHMIIQNEY CDGGSLHDAI TEKREQGEFF SVPELRDLLL QVSMGLKYIH 120
NSGLVHLDIK PSNIFICRRS TLSAGGEGDS EEEDESHSSG VVYKIGDLGH VTSISSPQVE 180
EGDSRFLAYE VLREDYTHLP KADIFALGLT VLLAAGASPL PQNGDDWHRL RQGELPNLPH 240
ELPALFKDLL KSLLDPDPTA RPSATALCRH DVL 273
KeywordAlternative splicing; ATP-binding; Coiled coil; Complete proteome; Kinase; Magnesium; Meiosis; Metal-binding; Nucleotide-binding; Nucleus; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Meleagris gallopavo"; ?>Mustela putorius furo"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pteropus vampyrus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00397
EKS-CAJ-00429
EKS-EQC-00418
EKS-GAM-00247
EKS-GAG-00359
EKS-GAA-00519
EKS-LAC-00439
EKS-MEG-00354
EKS-MUP-00421
EKS-OCP-00090
EKS-ORN-00542
EKS-ORC-00398
EKS-ORL-00500
EKS-OTG-00430
EKS-PTV-00122
EKS-SUS-00380
EKS-TAR-00539
EKS-TEN-00536
EKS-XIM-00533
Gene Ontology
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0007126; P:meiosis
GO:0007067; P:mitosis
KEGG
dre:327471;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR017164; Wee1-like_protein_kinase.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013