EKS-DAR-00771

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00771

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	358.3	5.9E-107	625	879	255

Status

Unreviewed

Ensembl Protein

ENSDARP00000114050

UniProt Accession

E7FD80;

Protein Name

Protein Synonyms/Alias

Gene Name

si:dkey-108d10.2

Gene Synonyms/Alias

si:dkey-108d10.2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000013310	ENSDARP00000012804	ENSDART00000006615
ENSDARG00000013310	ENSDARP00000114050	ENSDART00000143099

Organism

Danio rerio

Functional Description

Protein Length

1321

Protein Sequence
(FASTA)

MEIMSNLPTG EAGGDHTNAV SMSAGMERAD VTSPSPVSKQ RSLRAVYVLN DGLKAVAANS 60

PESGALQCLQ RACDAESAIL TTVTFGRLDF GETTVLDTFY DADIAVVDMS DVFRQPSLFY 120

HLGVRESFDM ANNVILYHDM DPDTAQSLKD MVAQKNTASS GNYYFIPYLM TPNNEYLCCE 180

NVAQRRASEY MQPNWDNLLG PLCVPLVDRF VSLLKDIHVT SCASYKDALL NDIRKARDKY 240

QGEELAKELS RIKLRIDNTE VLTQDIVMNL LFSYRDIQDY DAMVKLVQTI EMLPTCDLAN 300

QPMIQFHYAF ALNRRNSPGD REQALRVMLQ VLQSCEHPAP DMFCLCGRIY KDIFLDSDCK 360

DTKNRDNAIQ WYRKGFELQP TLYSGINLAV LLIVAGQQFE TSIELRKIGS LEKMNNYWDV 420

GQFFTVSMLA NDIPKAVQAA EKLFKLKPPI WYLRSVVQNL QLIQHFKKQN TEHSPQRERL 480

NFWMDIIVEA TQGTTNGLRF PVLILEPTKV YQPSYVSINS EAEEKNVSIW HVSPAETKGI 540

HEWNFTASSI KGISISKFDE RCCFLYVHDN SDDFQIYFST EDQCGRFCSM VKELITDGSG 600

NAVELEGEGD GDTLEYEYDY NENGDRVVLG RGTYGVVYAG RDLSNQVRIA IKEIPERDSR 660

YSQPLHEEIA LHKYLKHRNI VQYLGSVSED GYIKIFMEQV PGGSLSALLR SKWGPLKEAT 720

IIFYTRQILE GIRYLHENQI VHRDIKGDNV LVNTYSGVLK ISDFGTSKRL AGVNPCTETF 780

TGTLQYMAPE IIDKGPRGYG APADIWSLGC TIIEMATGKP PFHELGEPQA AMFKVGMFKI 840

HPEIPESLSS EAKSFILSSF EPDPNKRAMA GDLLKDPFLR QNIKGKKNKI AFKPSDYIRS 900

VSLPVQLQTE ATGSSSSEPG SVSPDCDSKQ DVFFEKKKRS SSENLIKPPS STFLSVPDES 960

PTAEDRSSPA SSENSDSGLF LLKKDSERRA ILYKVLNEDQ DKVTSNLMEN HIQGQEELKL 1020

SVDHIKQIIC ILRDFIRCPE RRVMATTISK LKLDLDFDST SINQIQLVLF GFQDSVNKVL 1080

RNHHIKPHWM FAMDNIIRRA VQAAVTILIP ELQTHFGPAS ESEGADKDAD EVDEEDDADF 1140

GSVARTTQED QVLTSGVSTL SSVISHDAQR LQHPLGAQLG RLKQETCRLL EELVQKEREY 1200

QQVLRQTLQQ RVHDIELIRI RQQPAAAEMP TTPSVFHVTA QPEPDKKLTD WLKEQGADSE 1260

TIDKFVAEDY SLSDVLCDIT KEDLRCLRLR GGMLCRIWKA IQQHRNKGLR KVKNDEGNSE 1320

G 1321

Nucleotide Sequence
(FASTA)

ATGGAGATCA TGTCCAATCT ACCTACAGGA GAGGCTGGTG GCGACCACAC CAATGCGGTT 60

TCCATGTCTG CGGGCATGGA GAGAGCCGAT GTGACCAGCC CGAGTCCGGT GAGCAAACAG 120

AGGTCCCTGC GGGCTGTGTA TGTGCTGAAT GATGGACTGA AGGCAGTGGC TGCGAATAGC 180

CCGGAGTCCG GGGCTCTCCA GTGTCTCCAG CGCGCCTGCG ACGCGGAGAG TGCCATATTG 240

ACCACAGTCA CCTTCGGACG ATTAGACTTT GGGGAGACCA CTGTGCTTGA TACTTTTTAC 300

GATGCAGATA TTGCAGTTGT GGACATGAGT GATGTGTTCA GACAGCCCTC TTTGTTTTAT 360

CACCTCGGGG TCCGTGAGAG CTTTGACATG GCCAACAATG TTATCCTCTA CCACGACATG 420

GACCCCGACA CAGCACAGTC CCTTAAGGAC ATGGTGGCAC AGAAAAACAC AGCCTCTAGT 480

GGGAACTACT ATTTCATCCC ATACCTGATG ACACCCAACA ACGAGTACTT GTGCTGTGAG 540

AATGTGGCCC AGCGCAGAGC ATCAGAGTAC ATGCAGCCCA ACTGGGACAA CCTTTTAGGA 600

CCTCTGTGTG TCCCTTTGGT GGACCGCTTC GTCAGCCTTC TCAAAGACAT TCATGTCACG 660

TCTTGTGCTT CATACAAAGA TGCACTCCTG AATGACATCC GAAAAGCTCG AGATAAATAC 720

CAGGGTGAGG AGCTGGCCAA AGAGCTTTCC CGTATCAAAC TCCGCATCGA CAACACTGAG 780

GTTTTGACTC AAGATATTGT CATGAACCTG CTTTTCTCCT ACAGAGACAT ACAGGATTAT 840

GATGCTATGG TTAAACTGGT GCAGACCATT GAGATGTTGC CCACCTGTGA CTTGGCCAAC 900

CAGCCCATGA TTCAGTTCCA CTATGCTTTT GCGCTCAATA GACGAAACAG CCCTGGTGAT 960

CGAGAGCAGG CGCTGCGTGT GATGTTGCAG GTTCTTCAAT CGTGTGAACA CCCTGCTCCT 1020

GACATGTTCT GCTTGTGTGG CCGCATATAT AAAGACATCT TTCTAGACTC AGACTGTAAA 1080

GACACCAAAA ACAGAGACAA CGCCATCCAG TGGTATAGAA AAGGTTTCGA GCTTCAGCCC 1140

ACGCTCTATT CAGGGATTAA TCTAGCAGTG CTGCTTATAG TAGCCGGGCA GCAGTTCGAG 1200

ACTTCCATAG AACTCAGGAA GATCGGCAGT CTGGAGAAGA TGAATAACTA CTGGGACGTT 1260

GGACAGTTTT TTACTGTCAG CATGCTGGCC AATGACATCC CCAAAGCTGT GCAGGCCGCT 1320

GAGAAACTCT TCAAGCTCAA ACCACCTATA TGGTACCTGC GGTCAGTGGT CCAAAACCTC 1380

CAGCTGATTC AGCATTTCAA GAAGCAGAAC ACTGAACACT CGCCTCAAAG AGAGAGACTC 1440

AACTTCTGGA TGGACATTAT CGTGGAGGCC ACGCAGGGAA CCACCAACGG CCTTCGTTTT 1500

CCGGTGTTGA TTCTGGAGCC CACTAAAGTT TACCAGCCAT CTTATGTATC GATTAACAGT 1560

GAAGCAGAAG AGAAGAATGT GTCTATATGG CACGTGTCGC CCGCTGAGAC GAAGGGAATA 1620

CACGAGTGGA ACTTCACTGC GTCGTCCATT AAAGGCATCA GTATCTCAAA GTTTGATGAG 1680

CGCTGCTGCT TTCTGTACGT CCATGATAAT TCAGATGACT TCCAGATCTA CTTCTCCACA 1740

GAGGACCAGT GCGGCAGGTT CTGCTCAATG GTGAAAGAGC TCATCACAGA TGGATCTGGA 1800

AATGCTGTTG AGCTGGAGGG CGAAGGAGAC GGAGACACCT TGGAGTATGA GTATGACTAC 1860

AATGAGAACG GTGACCGGGT GGTTCTGGGC AGGGGGACCT ATGGAGTTGT CTACGCAGGG 1920

AGAGACCTGA GCAATCAGGT GCGCATTGCC ATCAAGGAGA TCCCTGAGAG AGACAGCAGG 1980

TATTCCCAAC CACTGCATGA GGAAATCGCC CTTCACAAGT ACCTGAAACA CAGAAACATA 2040

GTTCAGTACC TGGGCTCAGT GTCAGAGGAT GGTTATATCA AGATCTTCAT GGAGCAGGTC 2100

CCTGGAGGAA GTCTGTCAGC GTTGTTGCGT TCAAAGTGGG GTCCTTTGAA AGAAGCCACC 2160

ATAATCTTTT ACACTCGGCA GATCCTGGAA GGCATTCGTT ATTTGCATGA AAACCAAATA 2220

GTTCATCGGG ATATCAAAGG AGACAATGTT TTAGTCAACA CTTACAGTGG CGTGTTGAAA 2280

ATCTCCGACT TCGGCACGTC AAAGAGACTG GCTGGAGTCA ATCCCTGCAC TGAGACCTTC 2340

ACTGGCACCT TGCAGTATAT GGCCCCTGAG ATCATCGATA AGGGACCCAG AGGTTATGGG 2400

GCCCCTGCTG ACATCTGGTC TTTGGGCTGC ACCATCATTG AGATGGCGAC AGGCAAACCT 2460

CCTTTTCATG AGCTGGGAGA GCCACAGGCC GCCATGTTTA AGGTGGGCAT GTTTAAGATC 2520

CATCCGGAGA TCCCGGAGTC TCTTTCGTCG GAGGCAAAAT CCTTCATCCT GTCCAGCTTT 2580

GAGCCTGATC CCAATAAACG AGCAATGGCC GGCGACCTGC TCAAAGACCC CTTCCTGCGG 2640

CAGAACATCA AAGGCAAGAA GAACAAGATC GCTTTCAAAC CCTCAGACTA CATCCGCAGT 2700

GTTTCTCTAC CCGTCCAGCT GCAGACAGAA GCCACAGGCA GCAGCAGCAG CGAGCCGGGC 2760

TCCGTCTCTC CAGACTGCGA CTCCAAACAA GATGTGTTTT TCGAGAAGAA GAAGCGTTCA 2820

AGCTCCGAAA ACCTCATTAA ACCACCCAGC TCAACCTTTC TCAGTGTTCC AGATGAGAGT 2880

CCGACAGCAG AAGACCGTAG CTCTCCAGCC TCCTCTGAGA ACAGCGACTC TGGTCTCTTC 2940

CTGCTCAAGA AAGACAGTGA AAGACGGGCC ATTCTCTACA AGGTCCTCAA TGAAGACCAG 3000

GATAAAGTAA CCTCCAACCT CATGGAGAAC CACATCCAGG GTCAAGAGGA GCTGAAGTTG 3060

TCTGTGGATC ACATTAAACA AATCATCTGC ATCTTGAGAG ACTTCATACG CTGCCCTGAA 3120

CGTCGTGTTA TGGCCACCAC CATCTCAAAA CTCAAACTGG ACCTGGACTT TGATAGCACA 3180

TCGATCAACC AGATTCAACT CGTTCTGTTC GGCTTTCAGG ACTCTGTGAA TAAAGTGTTA 3240

CGGAACCACC ACATTAAACC ACACTGGATG TTTGCCATGG ATAACATCAT CAGACGGGCT 3300

GTGCAGGCAG CTGTTACCAT TTTAATTCCA GAGCTGCAGA CACATTTTGG TCCCGCATCA 3360

GAGAGCGAGG GCGCAGATAA AGACGCAGAT GAAGTAGATG AAGAGGACGA TGCAGACTTT 3420

GGATCAGTAG CACGTACAAC ACAGGAAGAT CAAGTTCTCA CATCTGGAGT CAGCACACTT 3480

AGTTCAGTCA TATCCCATGA TGCGCAGCGG CTACAGCACC CCCTAGGAGC ACAGCTGGGA 3540

CGACTCAAAC AGGAAACTTG CAGGCTTCTG GAGGAGCTGG TGCAGAAGGA GAGAGAATAT 3600

CAGCAGGTTC TGAGACAAAC TCTCCAACAG CGGGTACATG ACATCGAGCT TATCAGGATC 3660

AGACAGCAGC CTGCTGCAGC AGAGATGCCC ACTACACCCT CAGTATTTCA CGTTACTGCA 3720

CAACCCGAGC CTGACAAGAA GCTGACGGAT TGGCTGAAGG AGCAGGGAGC AGACAGCGAG 3780

ACGATAGACA AGTTTGTTGC AGAAGATTAT TCACTCAGCG ACGTTCTCTG CGATATTACT 3840

AAAGAAGATC TTCGATGCCT GAGGCTTAGG GGTGGAATGC TGTGTCGGAT CTGGAAAGCC 3900

ATTCAACAAC ATCGCAACAA AGGACTTCGA AAGGTCAAAA ACGACGAGGG AAATTCAGAA 3960

GGATGA 3966

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+g+G++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k lkH+n

Q: 625   DRVVLGRGTYGVVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKYLKHRN  679

         5789**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkleesvikkytkqileglayLHekk  121

         iv+y+G+ +e++++kif+E+v+gGsls+ll+ k+g+l+e +i +yt+qileg++yLHe++

Q: 680   IVQYLGSVSEDGYIKIFMEQVPGGSLSALLRsKWGPLKEATIIFYTRQILEGIRYLHENQ  739

         *******************************9****************************

S: 122   ivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikkke  180

         ivHRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k+

Q: 740   IVHRDIKGDNVLVNTySGVLKISDFGTSKRLAGVNPC---TETFTGTLQYMAPEIIDKGP  796

         *************************************...8*******************

S: 181   kgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkdfl  240

         +gyg+ aDiWslgc++iem+tgk+Pf+el+e++a+mfkvg+ k++Peipe+ls+e+k+f+

Q: 797   RGYGAPADIWSLGCTIIEMATGKPPFHELGEPQAAMFKVGMFKIHPEIPESLSSEAKSFI  856

         ************************************************************

S: 241   ekcleldpkkrpsaeeLLkhefl  263

          + +e dp+kr+ a +LLk++fl

Q: 857   LSSFEPDPNKRAMAGDLLKDPFL  879

         *********************96

Domain Sequence
(FASTA)

DRVVLGRGTY GVVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKY LKHRNIVQYL 60

GSVSEDGYIK IFMEQVPGGS LSALLRSKWG PLKEATIIFY TRQILEGIRY LHENQIVHRD 120

IKGDNVLVNT YSGVLKISDF GTSKRLAGVN PCTETFTGTL QYMAPEIIDK GPRGYGAPAD 180

IWSLGCTIIE MATGKPPFHE LGEPQAAMFK VGMFKIHPEI PESLSSEAKS FILSSFEPDP 240

NKRAMAGDLL KDPFL 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013