EKS-DAR-00757

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00757

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	340.6	1.1E-101	138	395	258

Status

Unreviewed

Ensembl Protein

ENSDARP00000114579

UniProt Accession

F1QKS7;

Protein Name

Protein Synonyms/Alias

Gene Name

map3k9

Gene Synonyms/Alias

map3k9;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000013491	ENSDARP00000114579	ENSDART00000146522
ENSDARG00000013491	ENSDARP00000057184	ENSDART00000057185

Organism

Danio rerio

Functional Description

Protein Length

554

Protein Sequence
(FASTA)

MDAFSFPFNS SGPDSADGDG AAAEPQPGAR LLGFGPAAAA TPSGAGYWTA VFDYEATAED 60

ELSLRKGDRV EVLSKDSLVS GDEGWWTGMI EDRVGIFPSN YVSSNGISEK IRDTPEDYCD 120

YSVPPLHLLQ IDFSELALEE MIGVGGFGKV YRAIWNGQEV AVKAARRDPD EDVSQTLESV 180

RQEAKLFAML THPNIMALLG VCLQEPNLCL VMEYARGGPL NRALAGKRIP PHTLVDWAVQ 240

IARAMLYLHC QAIVPVIHRD LKSSNILILE RVENDDLSNK TLKVTDFGLA REWHRTTKMS 300

AAGTYAWMAP EVIRSSTFSK GSDVWSYGVL LWELLTGEVP FRGIDGLAVA YGVAMNKLSL 360

PIPSTCPEPF ARLMEDCWNV DPHSRPPFTS ILDQLTAIEE SGFFEMPAES FQSLQDDWKL 420

EVQEMFDQLR AKEKELRSWE EELSRAALQQ KYQEEALRRR EQELAEREIH ILERELNVII 480

HQLYQEKPRV QHRHGKFRRS RLKLRDGNRI SLPSDFQHKI TVQASPSLDR RRSLLGSNST 540

PPNSPPVLPR LRAI 554

Nucleotide Sequence
(FASTA)

ATGGATGCTT TCAGTTTCCC CTTTAACAGC AGTGGCCCGG ACAGCGCAGA CGGAGATGGA 60

GCCGCCGCAG AGCCTCAGCC GGGGGCTCGT CTCCTCGGGT TTGGCCCTGC GGCGGCGGCG 120

ACCCCATCCG GTGCCGGTTA CTGGACCGCC GTGTTCGACT ACGAGGCGAC CGCCGAGGAC 180

GAGCTCAGCC TGCGGAAGGG GGATCGGGTA GAGGTGCTGT CCAAGGACTC GCTGGTGTCC 240

GGGGATGAGG GCTGGTGGAC AGGTATGATC GAGGACCGGG TCGGTATTTT CCCTAGTAAC 300

TACGTGAGCA GTAACGGAAT CTCGGAGAAG ATCCGGGACA CGCCGGAGGA CTATTGCGAC 360

TATTCGGTGC CACCGTTACA CTTGCTGCAG ATAGATTTCA GTGAGCTGGC TCTGGAGGAG 420

ATGATCGGGG TTGGTGGTTT TGGGAAAGTG TACCGTGCCA TTTGGAATGG GCAGGAGGTG 480

GCGGTAAAGG CGGCCCGCCG GGACCCGGAT GAGGACGTGT CTCAGACGTT GGAGAGTGTT 540

CGTCAGGAGG CCAAGCTCTT TGCCATGCTC ACACACCCCA ACATCATGGC TCTTCTGGGT 600

GTGTGTCTGC AGGAGCCCAA CCTGTGTCTG GTTATGGAGT ACGCCCGCGG CGGGCCGCTC 660

AACCGGGCCC TCGCAGGGAA ACGCATCCCT CCACACACGC TGGTGGACTG GGCTGTGCAG 720

ATCGCACGCG CCATGCTGTA CCTGCACTGC CAGGCCATCG TACCTGTTAT CCACAGAGAC 780

CTCAAGTCCA GCAACATTCT GATCCTGGAG CGTGTGGAGA ACGATGATTT GAGCAACAAG 840

ACTCTGAAGG TGACAGATTT TGGTTTGGCT CGAGAGTGGC ATCGGACCAC GAAGATGAGT 900

GCGGCGGGCA CGTACGCCTG GATGGCACCT GAGGTCATCC GATCATCCAC CTTCTCCAAA 960

GGCAGTGATG TGTGGAGTTA CGGGGTTTTG TTGTGGGAGC TGCTGACAGG AGAGGTGCCG 1020

TTTCGTGGTA TTGACGGTCT GGCAGTGGCT TATGGTGTGG CCATGAATAA ACTGTCCCTG 1080

CCCATTCCCT CCACCTGTCC TGAGCCGTTC GCCCGGCTGA TGGAAGACTG CTGGAATGTG 1140

GACCCTCACT CACGACCCCC CTTCACTAGT ATCCTTGACC AGCTTACAGC CATCGAGGAG 1200

TCCGGCTTCT TTGAAATGCC TGCAGAATCA TTCCAGTCGC TGCAGGATGA CTGGAAGCTG 1260

GAGGTTCAGG AGATGTTCGA CCAGCTCAGA GCCAAAGAGA AGGAGTTGAG ATCCTGGGAG 1320

GAGGAACTGA GTCGTGCAGC TCTACAGCAG AAGTACCAGG AGGAGGCTTT ACGGCGACGA 1380

GAGCAAGAGC TGGCAGAGAG AGAAATTCAC ATCCTGGAGC GAGAGCTCAA CGTCATCATT 1440

CACCAGCTGT ACCAGGAGAA ACCACGAGTG CAGCACCGAC ACGGAAAGTT CCGGCGCAGT 1500

CGACTTAAAC TGCGGGATGG GAACCGCATC AGCCTGCCTT CTGATTTCCA GCATAAAATC 1560

ACAGTCCAAG CATCTCCTTC TTTGGACAGG AGGCGGAGCC TATTAGGAAG CAACTCCACC 1620

CCTCCAAACA GCCCCCCTGT TTTACCACGT CTTCGAGCGA TCCA 1664

Domain Profile

S: 3     leeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpniie  60

         lee+ig g fgkvy+a w+++evavK++r++  e  +++le++++eakl+++l hpni++

Q: 138   LEEMIGVGGFGKVYRAIWNGQEVAVKAARRDPDEdvSQTLESVRQEAKLFAMLTHPNIMA  197

         689***************************999988999*********************

S: 61    llGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapk  120

         llGvcl+epnl+lvmey++gg L+++l++   ++i+++ lv+wa+qiAr+m YLh +a +

Q: 198   LLGVCLQEPNLCLVMEYARGGPLNRALAG---KRIPPHTLVDWAVQIARAMLYLHCQAIV  254

         *****************************...99**************************

S: 121   kiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvlk  173

         ++ihrdLks+n+L+       + ++ktlk++dFG are++++tkmsaagt+awmaPEv++

Q: 255   PVIHRDLKSSNILIlervendDLSNKTLKVTDFGLAREWHRTTKMSAAGTYAWMAPEVIR  314

         *******************99999************************************

S: 174   eekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLm  233

         ++++s+ sDvwSygv+LWellt+evP+++++ la+ay+va+++l+lpips+cpe++++Lm

Q: 315   SSTFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLSLPIPSTCPEPFARLM  374

         ************************************************************

S: 234   kecwnedpekRpsfseivksl  254

         ++cwn dp++Rp f++i+++l

Q: 375   EDCWNVDPHSRPPFTSILDQL  395

         *****************9876

Domain Sequence
(FASTA)

LEEMIGVGGF GKVYRAIWNG QEVAVKAARR DPDEDVSQTL ESVRQEAKLF AMLTHPNIMA 60

LLGVCLQEPN LCLVMEYARG GPLNRALAGK RIPPHTLVDW AVQIARAMLY LHCQAIVPVI 120

HRDLKSSNIL ILERVENDDL SNKTLKVTDF GLAREWHRTT KMSAAGTYAW MAPEVIRSST 180

FSKGSDVWSY GVLLWELLTG EVPFRGIDGL AVAYGVAMNK LSLPIPSTCP EPFARLMEDC 240

WNVDPHSRPP FTSILDQL 258

Keyword

Complete proteome; Reference proteome; SH3 domain.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR015785	; MAPKKK9/10/11-like.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452	; SH3_domain.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00326

; SH3; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50002	; SH3; 1.

Prints

PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013