EKS-DAR-00913

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00913

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	362.5	2.0E-108	19	273	255

Status

Unreviewed

Ensembl Protein

ENSDARP00000043308

UniProt Accession

B0UXU4;

Protein Name

Protein Synonyms/Alias

Novel protein (Zgc:158710);

Gene Name

tbck

Gene Synonyms/Alias

tbck; DKEY-42O17.1; DKEY-42O17.1-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000013667	ENSDARP00000109057	ENSDART00000125099
ENSDARG00000013667	ENSDARP00000053027	ENSDART00000053028
ENSDARG00000013667	ENSDARP00000043308	ENSDART00000043309

Organism

Danio rerio

Functional Description

Protein Length

893

Protein Sequence
(FASTA)

MQPLRDAELG ASTFFASPLP HDVCGSNGLP LTPNSIKILG RFQILKTITH PRLCQYVDIS 60

RGKHERLVIV AEHYEKSLKD LLKQRKPVSP EKVLQVAYEV LEGLEFMNKH GMVHRALSPN 120

NVLLDRADKV KLAKFGLYHM TDHGADVDFP IGYPSYLPPE VIAQGCFYSS EPSINEAPQP 180

SGPKTDVWSL GVLLFELCVG RQILQNIDIS ERMKFIITLG CMDDIITVLA EEHGCIDTIK 240

DLPENVQALL RKCLTFLPSK RPTPSDLLGD AVFESISSEY TPYQSPVHLF SASPRCAYLQ 300

LPDDISELCR ENGENYLSER AIDEVYHLWC LAGGDLEKEL TNQEIIQSKP PICTLPKFIL 360

EDGESFGQGR DRSFLLDDTT VTLSLFQLRN RLKDVAGETY FPLLEDEQCS LPQSSSSNEL 420

SATVTLPLII RERDTEYQLT RIVLFHRLLK AYPYKKNQIW KEARVDIPPL LRGLAWAALL 480

GVEGDIQSKY DSIDKDTPIP TDRQIEVDIP RCHQYDELLS SPQGHVKFRR VLKAWVVSHP 540

DLVYWQGLDS LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLTVFSQM 600

IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG NSSFPFCIGV 660

AILQQLRDRL LANGFNECIL LFSDLPEIDI ERCVRESINL FCWTPKSATY RQHAQPNKPP 720

SESNSFGKTP SYYASEFQEL TKTDLSREPL KLSELKAEVS PRISVEDLID LCELSGPAFF 780

KTPVKRARTG KPKILAVDIR SLEDFSRGHI YGSINIPYTS TFGPEGELLQ CPASSSLAGY 840

RLRVIVILSS VMKNAITFAT HLVKVNFPRV CVLDGGMNKM KSTGLLTVPS PQI 893

Nucleotide Sequence
(FASTA)

ATGCAGCCCC TCAGAGATGC CGAGTTGGGG GCTTCCACCT TCTTCGCTTC TCCTCTTCCT 60

CACGATGTGT GCGGCAGCAA TGGGCTTCCT CTCACCCCAA ACTCCATCAA GATCCTGGGA 120

CGCTTCCAGA TCCTCAAAAC CATCACCCAT CCCAGACTGT GCCAATATGT GGACATCAGC 180

AGAGGAAAGC ACGAGCGCCT GGTTATTGTA GCTGAGCACT ATGAAAAAAG CTTGAAGGAC 240

CTTTTGAAGC AGCGGAAACC TGTCAGTCCA GAGAAGGTGC TACAGGTTGC CTATGAAGTG 300

CTGGAAGGAT TGGAGTTCAT GAATAAGCAC GGGATGGTGC ATCGCGCTTT ATCTCCTAAC 360

AATGTCCTCC TAGATCGTGC GGATAAAGTG AAGCTGGCCA AATTTGGCCT GTATCATATG 420

ACCGACCATG GAGCAGATGT CGACTTCCCA ATTGGGTATC CATCTTACCT GCCTCCGGAG 480

GTTATTGCTC AGGGCTGTTT CTATTCCAGC GAGCCCTCCA TCAATGAGGC CCCGCAGCCT 540

TCAGGGCCCA AAACTGACGT CTGGTCTCTC GGGGTGCTTC TGTTTGAACT CTGTGTGGGA 600

AGGCAGATTC TGCAGAACAT AGACATCAGC GAGAGAATGA AGTTCATCAT CACCTTAGGG 660

TGCATGGATG ACATCATTAC AGTATTAGCC GAGGAACACG GGTGCATAGA CACAATTAAG 720

GATCTGCCTG AAAACGTGCA GGCTTTATTG AGGAAATGCC TGACGTTTCT CCCTTCAAAA 780

CGACCCACTC CTTCTGATCT TCTGGGAGAC GCAGTGTTTG AGAGCATATC TTCTGAGTAT 840

ACTCCCTATC AGAGTCCTGT GCATCTGTTC TCCGCCTCAC CACGATGTGC TTATCTACAG 900

CTTCCTGATG ACATCAGTGA ACTCTGTAGA GAGAATGGAG AGAACTACCT GTCGGAGAGA 960

GCCATAGATG AGGTTTATCA CCTGTGGTGT CTGGCAGGGG GAGACCTGGA GAAAGAGCTC 1020

ACCAATCAGG AGATCATCCA GTCCAAACCA CCCATCTGCA CGCTTCCCAA GTTTATTTTG 1080

GAGGATGGCG AGTCGTTTGG ACAGGGCCGG GACAGAAGCT TCCTCCTGGA TGACACAACT 1140

GTGACACTTT CTCTCTTTCA GCTCAGAAAC AGGCTGAAGG ATGTGGCGGG AGAGACATAC 1200

TTTCCATTAT TGGAGGATGA GCAGTGCAGC CTGCCTCAGT CCAGCAGCAG TAATGAACTG 1260

TCTGCCACCG TCACACTGCC CCTCATTATC CGAGAGAGAG ACACCGAGTA CCAGCTCACA 1320

CGCATCGTCC TCTTCCACAG ACTGCTCAAG GCATACCCTT ACAAGAAGAA CCAGATCTGG 1380

AAGGAGGCGA GGGTTGACAT TCCTCCTCTT CTGAGGGGTC TGGCCTGGGC GGCTTTACTC 1440

GGAGTTGAGG GCGACATCCA ATCAAAATAC GACTCCATCG ATAAGGACAC GCCCATCCCC 1500

ACTGACAGAC AGATTGAAGT GGATATTCCT CGCTGTCACC AATATGATGA GCTGCTGTCG 1560

TCGCCGCAGG GCCATGTCAA GTTTCGGCGG GTGCTGAAGG CTTGGGTTGT GTCTCATCCC 1620

GATCTGGTTT ACTGGCAAGG CTTGGATTCA CTTTGTGCAC CTTTCCTTTA TTTAAATTTC 1680

AACAATGAAG CTCTTGCGTA CGCATGCATG TCGGCCTTCA TCCCCAAATA TCTGTACAAT 1740

TTCTTCCTGA AGGACAACTC GCATGTAATA CAAGAATATC TGACCGTCTT CTCTCAGATG 1800

ATTGCGTTTC ACGACCCCGA GCTCAGCAAC CACCTCAACG AGATTGGATT CATACCTGAT 1860

CTCTACGCAA TCCCATGGTT TCTTACAATG TTCACACACG TGTTTCCCCT GCACAAGATC 1920

TTCCACCTGT GGGACACTCT GCTCTTGGGA AACTCCTCGT TCCCCTTCTG CATTGGTGTA 1980

GCCATCTTAC AGCAGCTGAG AGACCGTCTG CTGGCCAACG GCTTCAACGA GTGCATACTG 2040

CTCTTCTCTG ACCTCCCTGA GATCGACATT GAACGCTGTG TTCGAGAATC CATCAACCTT 2100

TTTTGCTGGA CTCCTAAAAG TGCCACTTAC CGCCAGCATG CCCAGCCAAA CAAACCTCCC 2160

AGCGAGAGCA ACAGCTTCGG CAAAACACCT TCATATTACG CATCAGAGTT TCAAGAACTG 2220

ACCAAAACTG ACCTGAGCCG TGAGCCACTC AAGCTGAGCG AGCTGAAAGC AGAAGTGTCT 2280

CCGCGTATTT CTGTGGAAGA CCTCATTGAC CTGTGTGAGC TGAGTGGACC AGCTTTCTTT 2340

AAAACTCCCG TCAAGAGGGC CAGGACTGGC AAACCCAAAA TTCTTGCGGT GGACATCAGG 2400

AGCCTTGAAG ACTTCAGTCG AGGCCACATC TACGGCAGCA TTAATATTCC ATACACCTCC 2460

ACGTTTGGAC CAGAGGGAGA GCTGCTCCAG TGTCCCGCTA GCAGCAGCCT AGCCGGATAC 2520

AGACTCCGCG TCATCGTCAT CCTCAGCAGC GTCATGAAGA ACGCTATCAC TTTTGCGACT 2580

CATCTGGTGA AGGTGAATTT CCCTCGTGTT TGCGTTCTGG ACGGTGGAAT GAACAAGATG 2640

AAGTCCACCG GCCTGCTGAC AGTCCCGTCC CCTCAGATAT AA 2682

Domain Profile

S: 2     laqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlelsL  61

         l++d++GsnGlpl++n++kilGrfqiLk+++h+rLcqY+disrgkher+++vaeh+e+sL

Q: 19    LPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVIVAEHYEKSL  78

         69**********************************************************

S: 62    eDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyGL  121

          Dllk+rkpvs  +vl++ayevl+gl+++nkh++vhral+p+++lldr ++ vkLak+GL

Q: 79    KDLLKQRKPVSPEKVLQVAYEVLEGLEFMNKHGMVHRALSPNNVLLDRADK-VKLAKFGL  137

         ************************************************998.********

S: 122   yhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglillel  172

         yh+t++G+dvdfpigy+syl Pe+i+q+         ++ + ++++k DvWsLg++l+el

Q: 138   YHMTDHGADVDFPIGYPSYLPPEVIAQGcfyssepsiNEAPQPSGPKTDVWSLGVLLFEL  197

         ************************************99**********************

S: 173   ilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtll  232

         ++g+++ +++d+ser+k++ +l++ d+ + +laee++c d ik+l+e+++all+kCLt+l

Q: 198   CVGRQILQNIDISERMKFIITLGCMDDIITVLAEEHGCIDTIKDLPENVQALLRKCLTFL  257

         ************************************************************

S: 233   pskRpspdellkekvf  248

         pskRp+p++ll + vf

Q: 258   PSKRPTPSDLLGDAVF  273

         ***********99987

Domain Sequence
(FASTA)

LPHDVCGSNG LPLTPNSIKI LGRFQILKTI THPRLCQYVD ISRGKHERLV IVAEHYEKSL 60

KDLLKQRKPV SPEKVLQVAY EVLEGLEFMN KHGMVHRALS PNNVLLDRAD KVKLAKFGLY 120

HMTDHGADVD FPIGYPSYLP PEVIAQGCFY SSEPSINEAP QPSGPKTDVW SLGVLLFELC 180

VGRQILQNID ISERMKFIIT LGCMDDIITV LAEEHGCIDT IKDLPENVQA LLRKCLTFLP 240

SKRPTPSDLL GDAVF 255

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

dre:791155

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013