EKS-DAR-00594

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00594

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Abl	547.4	9.3E-165	246	497	252

Status

Unreviewed

Ensembl Protein

ENSDARP00000117887

UniProt Accession

B0UXN7;

Protein Name

Protein Synonyms/Alias

Novel protein similar to vertebrate Abelson murine leukemia viral oncogene homolog 2 (Arg, Abelson-related gene) (ABL2);

Gene Name

abl2

Gene Synonyms/Alias

abl2; CH211-80A15.2-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000013841	ENSDARP00000041696	ENSDART00000041697
ENSDARG00000013841	ENSDARP00000117887	ENSDART00000138548

Organism

Danio rerio

Functional Description

Protein Length

587

Protein Sequence
(FASTA)

MTLRTLPSSS SFEEEWVRLT KLPSTQDDHY CLAEALHRPF GLDSTALTEA VRWSSKENLL 60

GAAESDPNLF VALYDFVASG DNTLSITKGE KLRVLGYNQN GEWSEVRSKN GQGWVPSNYI 120

TPVNSLEKHS WYHGPVSRSA AEYLLSSLIN GSFLVRESES SPGQLSISLR YEGRVYHYRI 180

NTASDGKVYV TAESRFSTLA ELVHHHSTVA DGLVTTLHYP APKCNKPTVY GVSPIHDKWE 240

MERTDITMKH KLGGGQYGEV YVGVWKKYNL TVAVKTLKED TMEVEEFLKE ASVMKEVKHP 300

NLVQLLGVCT LEPPFYIVTE YMPHGNLLDY LRECERDQVN AVVLLYMATQ ISSAMEYLEK 360

KNFIHRDLAA RNCLVGENHV VKVADFGLSR LMTGDTYTAH AGAKFPIKWT APESLAYNTF 420

SIKSDVWAFG VLLWEIATYG MSPYPGIDLS QVYDLLEKGY RMEQPEGCPP KVYELMRACW 480

QWSPLDRPSF AEIHQAFETM FHDSSISEEV AEELCKTASG GQSGVAHTFG PDMPLLPSKS 540

RGQKKHSENK ENMEEAGPHG PAGIQAQLRL SRLRKKLKRM GVVFLID 587

Nucleotide Sequence
(FASTA)

ATGACATTGA GGACCCTTCC GTCCAGCAGC AGTTTTGAGG AAGAGTGGGT CAGGCTGACC 60

AAACTACCCA GCACACAGGA TGACCACTAT TGCCTCGCAG AAGCCCTGCA CAGGCCGTTT 120

GGACTGGACT CGACGGCGCT GACGGAGGCG GTGCGCTGGA GCTCCAAGGA GAATCTGCTG 180

GGTGCTGCTG AAAGTGACCC CAACCTTTTT GTGGCACTTT ACGACTTTGT TGCCAGTGGT 240

GACAACACAC TAAGCATCAC GAAAGGAGAG AAGCTGCGAG TGTTGGGTTA TAACCAGAAT 300

GGAGAATGGA GTGAAGTCCG CTCAAAGAAC GGCCAGGGCT GGGTACCCAG TAACTACATC 360

ACCCCCGTAA ACAGTCTGGA GAAGCACAGC TGGTACCATG GGCCCGTGTC CCGCAGCGCT 420

GCCGAGTACC TGCTCAGTAG CTTGATCAAC GGCAGCTTCC TGGTGCGGGA AAGCGAGAGC 480

AGCCCCGGCC AGCTCTCCAT CTCTCTTCGC TATGAGGGAC GGGTCTATCA TTACCGCATC 540

AACACGGCCT CTGATGGAAA GGTCTATGTG ACAGCAGAGA GTCGTTTCAG CACGTTAGCT 600

GAGCTGGTTC ATCATCATTC CACAGTTGCG GATGGACTGG TAACCACTCT GCATTATCCT 660

GCTCCCAAAT GCAACAAGCC CACCGTCTAC GGCGTCTCTC CCATCCACGA CAAGTGGGAG 720

ATGGAGCGCA CCGACATCAC CATGAAGCAC AAATTGGGTG GAGGACAGTA CGGAGAGGTG 780

TACGTTGGAG TTTGGAAAAA GTACAACCTC ACTGTAGCTG TAAAAACACT AAAGGAGGAC 840

ACCATGGAGG TTGAGGAGTT TCTTAAGGAG GCCTCAGTCA TGAAGGAGGT CAAACATCCC 900

AATCTAGTAC AGTTACTGGG TGTGTGTACT TTGGAGCCTC CCTTCTACAT TGTGACCGAG 960

TACATGCCCC ATGGGAACCT GCTGGATTAC CTGCGTGAGT GTGAAAGGGA CCAGGTGAAT 1020

GCTGTGGTGC TGCTCTACAT GGCCACTCAG ATCTCCTCCG CCATGGAGTA TCTGGAGAAG 1080

AAGAACTTCA TCCATAGGGA CCTGGCAGCT CGTAATTGTC TAGTAGGAGA GAATCACGTG 1140

GTGAAGGTGG CTGATTTCGG ACTGAGCCGT CTGATGACGG GTGACACCTA CACAGCTCAT 1200

GCGGGAGCCA AATTCCCCAT CAAATGGACC GCACCAGAGA GTCTGGCCTA CAACACCTTC 1260

TCCATCAAAT CAGATGTGTG GGCATTTGGA GTTTTGCTTT GGGAGATTGC GACGTACGGC 1320

ATGTCTCCAT ATCCAGGAAT TGACCTGTCT CAGGTATATG ATCTGCTGGA GAAGGGCTAC 1380

CGCATGGAGC AGCCCGAAGG CTGTCCTCCT AAAGTCTACG AGCTCATGAG AGCCTGCTGG 1440

CAGTGGAGTC CACTGGATAG ACCCTCATTT GCTGAGATTC ATCAGGCCTT TGAAACCATG 1500

TTTCATGACT CAAGCATTTC AGAAGAGGTA GCTGAAGAGC TGTGTAAAAC TGCGTCTGGT 1560

GGGCAGAGTG GAGTTGCCCA CACCTTCGGC CCTGATATGC CACTCTTGCC CTCAAAGTCT 1620

CGTGGGCAGA AGAAACACTC AGAGAACAAA GAGAATATGG AGGAGGCAGG ACCCCACGGC 1680

CCTGCAGGTA TACAGGCTCA ACTCCGGCTC AGTCGGCTCA GAAAGAAGCT CAAGAGAATG 1740

GGAGTGGTGT TCCTTATTGA TTAA 1764

Domain Profile

S: 1     iimkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkelkhpnlvql  60

         i+mkhklgggqygevy+gvwkky+ltvavktlkedtmeveeflkea+vmke+khpnlvql

Q: 246   ITMKHKLGGGQYGEVYVGVWKKYNLTVAVKTLKEDTMEVEEFLKEASVMKEVKHPNLVQL  305

         89**********************************************************

S: 61    lgvctreppfyiitefmsygnlldylreadreeveavvllymatqissameylekknfih  120

         lgvct eppfyi+te+m++gnlldylre++r++v+avvllymatqissameylekknfih

Q: 306   LGVCTLEPPFYIVTEYMPHGNLLDYLRECERDQVNAVVLLYMATQISSAMEYLEKKNFIH  365

         ************************************************************

S: 121   rdlaarnclvgenklvkvadfglsrlmkedtytahagakfpikwtapeslaynkfsiksd  180

         rdlaarnclvgen++vkvadfglsrlm++dtytahagakfpikwtapeslayn+fsiksd

Q: 366   RDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSD  425

         ************************************************************

S: 181   vwafgvllweiatygmspypgidlsqvyellekgyrmerpegcppkvyelmracwkwsps  240

         vwafgvllweiatygmspypgidlsqvy+llekgyrme+pegcppkvyelmracw+wsp

Q: 426   VWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWQWSPL  485

         ************************************************************

S: 241   drpsfaeihqal  252

         drpsfaeihqa+

Q: 486   DRPSFAEIHQAF  497

         *********986

Domain Sequence
(FASTA)

ITMKHKLGGG QYGEVYVGVW KKYNLTVAVK TLKEDTMEVE EFLKEASVMK EVKHPNLVQL 60

LGVCTLEPPF YIVTEYMPHG NLLDYLRECE RDQVNAVVLL YMATQISSAM EYLEKKNFIH 120

RDLAARNCLV GENHVVKVAD FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNTFSIKSD 180

VWAFGVLLWE IATYGMSPYP GIDLSQVYDL LEKGYRMEQP EGCPPKVYEL MRACWQWSPL 240

DRPSFAEIHQ AF 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity

KEGG

dre:570636

;

InterPros

IPR015015	; F-actin_binding.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF08919	; F_actin_bind; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00808	; FABD; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013