EKS-DAR-00652
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00652
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR122.73.6E-35697948252
StatusUnreviewed
Ensembl ProteinENSDARP00000012063
UniProt AccessionF1QMP1;
Protein Name
Protein Synonyms/Alias
Gene Nameegfra
Gene Synonyms/Alias egfra;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000013847ENSDARP00000121251ENSDART00000136906
ENSDARG00000013847ENSDARP00000113854ENSDART00000147261
ENSDARG00000013847ENSDARP00000099170ENSDART00000108964
ENSDARG00000013847ENSDARP00000125265ENSDART00000150499
ENSDARG00000013847ENSDARP00000083024ENSDART00000088591
ENSDARG00000013847ENSDARP00000012063ENSDART00000027219
ENSDARG00000013847ENSDARP00000104998ENSDART00000128514
OrganismDanio rerio
Functional Description
Protein Length1172
Protein Sequence
(FASTA)
LNGSFCVCLC VSVCQGANNK LTLLGTVEDH YQVLLRMYRN CTVVLENLEI THITEKYDLS 60
FLKSIQEVGG YVLIAVNTVS KIPLENLRII RGHSLYEDKF ALAVLVNYNN SIEQGVKELP 120
LTSLTEILKG GVRFNMNNHL CNVGTIEWAD ILNMKSLPTI VSHNISYGKN CGKCDPSCFN 180
GSCWGTGPDK CQRMTKVICA EQCSGRCKGP RPIDCCNEHC AAGCTGPRPT DCLACKDFQD 240
EGTCKDACPR LMLYDPNTHQ LAPNPYGKYS FGATCIKTCP HNYVVTDHGA CVRTCSPGTY 300
EVDEGGVRKC KRCEGLCPKV CNGLGMGPLA NVLSINATNI DSFENCTKIS GNVAILSTTF 360
RGDPHTNTSG LDPAKLSVLS TVKEITGYLM IQLWPESMQS LSAFENLEVI RGRTKTQGTY 420
SFAVTKTAIT HLGMRSLREI SDGDVSIVKN KNLCYSSPEH WKRLFKSKQQ SVKMIENMDA 480
ATCANQNSTC NEMCTADGCW GPGPTMCFGC EHYSRGKHCV ASCNLLNGEP REYEVNKTCM 540
ECDPECLLMN ETQTCNGPGP DKCTVCANYK DGPHCVHRCP QGVPGEKDTL IWKYADVTHV 600
CQPCHENCTQ GCTGPDLKDC KDFKSSGLPM IAAGVVGGLL AFVILALGVA VLLRRRHIRR 660
KRTLRRLLQE RELVEPLTPS GEAPNQALLR ILKETEFKKI KVLGSGAFGT VHKGLWVPEG 720
ENVKIPVAIK VLREATSPKA NKEIMDSVYI FFSIYRTNHC YTITCLITLT CLVHLINLVR 780
PLNVTLRYIE VSRRISSQIL FTVIMTKINQ LLEMSVLKNL HYVILLIHTF QPVLASRKAF 840
LTFLLHISKI TLFSPHALPV DGIIHESVLK LTFDRSSSSK NIPQTFWSIL TCKYADLLSS 900
VVTGGRLSSV NSLSFPVYSA NLMYMHKTES WMIDAESRPR FRELIAEFTK MARDPSRYLV 960
IQGDDRMHLP SPSDSKFYRS LMSGELDEAV DADEYLVPNH SFFSSPSTSR TQLLHSVSLN 1020
SSFGNCNSRN GNGYPVRENS MVLRYIPDPT ERFQEGDFQP APGYNEYMNQ NESSMINPVY 1080
QQPHGPPRTL LHSSPALDET EEEYLNCFKS PAPASVVEYL NTSHTQLLST KPFFSMDNPD 1140
YQQDFCPLEL KTHTNGHLPA AQNQEYMGLE VH 1172
Nucleotide Sequence
(FASTA)
TTGAATGGTT CTTTCTGTGT GTGTTTGTGT GTTTCAGTGT GTCAGGGAGC AAACAACAAA 60
CTGACTCTTC TGGGAACAGT GGAAGACCAT TATCAGGTTC TGCTCAGAAT GTACAGAAAC 120
TGCACTGTGG TTCTGGAGAA CCTGGAAATT ACACATATAA CAGAGAAATA TGACCTGTCC 180
TTCCTCAAGA GCATCCAGGA AGTTGGTGGC TATGTTCTTA TCGCGGTCAA TACGGTTTCC 240
AAAATCCCTC TGGAGAACCT GCGCATCATT CGCGGACACT CACTTTATGA AGACAAATTT 300
GCCTTGGCCG TCCTGGTGAA CTATAACAAC AGCATCGAAC AAGGCGTAAA AGAGTTGCCG 360
CTGACTAGTT TAACTGAAAT ACTGAAGGGT GGAGTCAGAT TTAACATGAA CAACCATTTA 420
TGTAACGTGG GGACCATCGA GTGGGCCGAC ATCCTGAACA TGAAGAGCCT GCCTACAATC 480
GTGAGCCATA ATATAAGCTA TGGAAAAAAC TGTGGAAAGT GCGATCCAAG CTGTTTCAAT 540
GGCTCCTGCT GGGGCACCGG ACCCGACAAA TGCCAGAGAA TGACGAAAGT GATCTGTGCG 600
GAGCAATGTT CAGGGAGGTG TAAAGGACCC AGACCCATTG ACTGCTGTAA TGAACACTGT 660
GCTGCTGGAT GCACTGGACC CAGACCTACA GACTGTCTGG CCTGTAAGGA CTTCCAGGAT 720
GAAGGGACAT GTAAGGACGC ATGTCCGCGG CTCATGCTCT ACGACCCAAA CACACACCAG 780
CTCGCGCCAA ACCCATATGG GAAGTACAGC TTTGGGGCGA CGTGCATCAA GACATGCCCA 840
CACAACTATG TGGTGACGGA TCACGGGGCC TGTGTGAGAA CATGCAGCCC TGGCACCTAT 900
GAAGTGGATG AGGGTGGAGT TCGCAAATGT AAGAGGTGTG AAGGCCTGTG TCCAAAAGTG 960
TGTAATGGGT TGGGAATGGG GCCTTTAGCC AATGTCCTGT CAATCAATGC CACCAACATC 1020
GACTCCTTTG AGAACTGCAC TAAAATCAGC GGCAATGTTG CCATCCTCAG CACCACATTC 1080
AGAGGTGACC CACATACTAA CACTTCAGGA CTGGATCCAG CAAAGCTCAG TGTATTGAGT 1140
ACTGTCAAAG AAATCACTGG TTACCTGATG ATTCAGCTGT GGCCGGAGAG CATGCAGTCC 1200
CTTAGTGCCT TCGAAAACCT TGAGGTCATC CGAGGACGGA CAAAAACACA AGGAACGTAC 1260
AGCTTTGCTG TCACCAAGAC GGCCATCACT CATTTAGGCA TGCGTTCTCT GAGGGAGATC 1320
AGTGACGGGG ACGTGTCCAT CGTTAAGAAT AAGAATCTCT GCTACAGCAG CCCTGAACAC 1380
TGGAAACGCC TCTTCAAGTC CAAACAACAG TCGGTCAAAA TGATTGAAAA TATGGATGCT 1440
GCCACCTGCG CCAATCAGAA CAGCACATGT AATGAGATGT GCACGGCTGA CGGCTGCTGG 1500
GGTCCCGGCC CCACCATGTG CTTCGGCTGT GAGCATTACA GCCGCGGAAA ACACTGCGTG 1560
GCTTCTTGCA ACCTGCTGAA TGGTGAGCCG CGTGAATATG AGGTCAATAA AACATGCATG 1620
GAATGCGATC CTGAATGTCT GCTCATGAAT GAAACCCAGA CCTGCAACGG CCCTGGACCC 1680
GACAAATGTA CAGTGTGTGC AAACTATAAA GACGGACCGC ACTGTGTGCA TCGCTGCCCG 1740
CAAGGTGTAC CAGGAGAGAA AGACACACTC ATCTGGAAAT ACGCTGACGT GACACACGTT 1800
TGCCAGCCCT GTCATGAAAA CTGCACCCAG GGATGTACGG GGCCTGATCT AAAGGACTGC 1860
AAAGATTTCA AAAGCTCTGG TTTGCCGATG ATAGCTGCTG GCGTTGTCGG AGGTCTACTG 1920
GCGTTTGTTA TTCTGGCTCT TGGAGTGGCC GTTCTCCTGC GCAGACGCCA CATCCGGAGG 1980
AAGAGGACTC TGAGACGACT CCTGCAAGAG AGAGAGCTTG TGGAGCCTCT GACCCCCAGC 2040
GGCGAAGCCC CCAATCAGGC CTTACTGCGC ATCCTCAAAG AGACGGAGTT CAAGAAGATC 2100
AAAGTGCTGG GCTCCGGGGC TTTCGGCACT GTGCACAAGG GCCTTTGGGT TCCAGAAGGA 2160
GAGAATGTGA AGATCCCTGT CGCCATCAAG GTCTTAAGAG AAGCCACGTC TCCCAAAGCT 2220
AACAAGGAGA TAATGGATTC AGTCTATATA TTTTTTTCAA TCTACAGAAC AAACCATTGT 2280
TATACAATAA CTTGCCTAAT TACCCTAACC TGTCTAGTTC ACCTAATTAA CCTAGTTAGG 2340
CCTTTAAATG TCACTTTAAG GTATATAGAA GTGTCTAGAA GAATATCTAG TCAAATATTA 2400
TTTACTGTCA TCATGACAAA GATAAATCAG TTATTAGAGA TGAGTGTGTT GAAAAATCTT 2460
CATTATGTTA TCCTTCTCAT TCATACATTT CAACCTGTTT TAGCTAGTAG AAAAGCATTC 2520
CTCACATTTC TCTTACACAT TAGCAAAATC ACACTCTTTT CTCCTCATGC TCTCCCTGTA 2580
GATGGAATTA TTCATGAATC TGTCCTGAAA CTGACTTTTG ATCGCTCCAG TTCAAGCAAA 2640
AATATTCCTC AGACATTTTG GTCCATATTG ACATGTAAGT ATGCAGATTT ATTGAGTTCT 2700
GTTGTTACTG GAGGCCGTTT AAGTTCAGTG AACTCATTGT CATTTCCAGT TTATTCTGCT 2760
AATCTGATGT ATATGCACAA AACAGAAAGT TGGATGATTG ATGCTGAGAG CAGACCCCGC 2820
TTCAGGGAGC TCATCGCAGA GTTCACTAAA ATGGCTCGTG ACCCGTCCCG CTATCTGGTC 2880
ATTCAGGGGG ACGACCGCAT GCATTTACCC AGTCCTTCTG ACTCCAAGTT CTACCGCAGC 2940
CTGATGAGCG GAGAGCTGGA CGAGGCCGTG GACGCAGACG AGTATTTAGT GCCCAATCAC 3000
AGCTTCTTCA GCAGCCCGAG CACGTCCCGC ACACAACTGC TGCACTCTGT GAGCCTGAAC 3060
AGCAGCTTTG GAAACTGTAA TAGTAGAAAC GGGAATGGTT ATCCAGTGAG GGAGAACAGC 3120
ATGGTCCTGC GCTACATCCC AGACCCCACA GAGCGCTTTC AGGAGGGAGA CTTTCAGCCT 3180
GCGCCGGGTT ATAACGAATA TATGAACCAG AATGAGTCCA GCATGATCAA CCCAGTGTAC 3240
CAGCAGCCCC ACGGACCCCC GCGGACCCTC CTGCACTCCT CCCCAGCGCT GGACGAGACG 3300
GAAGAGGAGT ATCTGAACTG CTTCAAGAGC CCGGCTCCGG CTTCAGTGGT GGAGTATCTG 3360
AACACGTCCC ACACACAGCT GCTCTCCACA AAGCCCTTCT TCAGCATGGA CAACCCCGAC 3420
TACCAGCAGG ACTTCTGCCC GCTGGAGCTC AAAACACACA CCAACGGGCA CCTGCCGGCC 3480
GCGCAGAACC AGGAGTACAT GGGCCTGGAG GTGCACTAG 3519
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         +kk+kvlGsGafGtv+kG+w+pegenvkipvaikvl+e+t++kanke++d +++++s+ +
Q: 697   FKKIKVLGSGAFGTVHKGLWVPEGENVKIPVAIKVLREATSPKANKEIMDSVYIFFSIYR  756
         59*******************************************************988
S: 61    anlvrllg..lclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyle  118
         +n +  ++  + l+  ++l+  ++pl   l y++  + ++ sq    ++v ++k  + le
Q: 757   TNHCYTITclITLTCLVHLINLVRPLNVTLRYIEVSR-RISSQI--LFTVIMTKINQLLE  813
         77776665123455569****************9877.688775..57888888888888
S: 119   ekrlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkr  178
             v ++l    +l+++++ v  +   +  +l + +k    +   +p+  +  es+lk 
Q: 814   MS--VLKNLHYVILLIHTFQPVLASRKAFLTFLLHISKITLFSPHALPVDGIIHESVLKL  871
         65..66899999**********999999888888888889999999**************
S: 179   kythqsdvwsyGvtvwelltfGakpydgipakei.pdllekGerlaqppictidvymvlv  237
         ++ + s       t w +lt     y+++ ++ +    l + + l+ p   +  +ym   
Q: 872   TFDRSSSSKNIPQTFWSILTC---KYADLLSSVVtGGRLSSVNSLSFPVYSANLMYMHKT  928
         *******************96...355555554416789*********************
S: 238   kcwmidaesrpkfkelaeef  257
         + wmidaesrp+f+el++ef
Q: 929   ESWMIDAESRPRFRELIAEF  948
         ******************99
Domain Sequence
(FASTA)
FKKIKVLGSG AFGTVHKGLW VPEGENVKIP VAIKVLREAT SPKANKEIMD SVYIFFSIYR 60
TNHCYTITCL ITLTCLVHLI NLVRPLNVTL RYIEVSRRIS SQILFTVIMT KINQLLEMSV 120
LKNLHYVILL IHTFQPVLAS RKAFLTFLLH ISKITLFSPH ALPVDGIIHE SVLKLTFDRS 180
SSSKNIPQTF WSILTCKYAD LLSSVVTGGR LSSVNSLSFP VYSANLMYMH KTESWMIDAE 240
SRPRFRELIA EF 252
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Caenorhabditis elegans"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-CAE-00255
EKS-DRM-00152
EKS-EQC-00289
EKS-GAA-00368
EKS-MEG-00239
EKS-MOD-00292
EKS-MUP-00295
EKS-ORN-00386
EKS-ORA-00262
EKS-ORL-00358
EKS-PES-00265
EKS-TAG-00314
EKS-TAR-00390
EKS-TEN-00385
EKS-XIM-00378
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 3.
Prosites
Prints
Created Date20-Feb-2013