EKS-DAR-00892

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00892

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMK2	585.2	2.9E-176	13	271	259

Status

Reviewed

Ensembl Protein

ENSDARP00000040048

UniProt Accession

Q6DGS3; A8WGM2;

Protein Name

Calcium/calmodulin-dependent protein kinase type II delta 2 chain

Protein Synonyms/Alias

Calcium/calmodulin-dependent protein kinase type II delta-A chain; CaM kinase II subunit delta-A; CaM-kinase II delta-A chain; CaMK-II subunit delta-A;

Gene Name

camk2d2

Gene Synonyms/Alias

camk2d2; camk2d, camk2da; zgc:92792;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000014273	ENSDARP00000040048	ENSDART00000040049
ENSDARG00000014273	ENSDARP00000044895	ENSDART00000044896

Organism

Danio rerio

Functional Description

CaM-kinase II (CAMK2) is a prominent kinase in thecentral nervous system (By similarity).

Protein Length

493

Protein Sequence
(FASTA)

MALTICTRFT DEYQLFEELG KGAFSVVRRC VKISSGQEYA AKIINTKKLS ARDHQKLERE 60

ARICRLLKHP NIVRLHDSIS EEGFHYLVFD LVTGGELFED IVAREYYSEA DASHCIQQIL 120

ESVHHCHVNG IVHRDLKPEN LLLASKMKGA AVKLADFGLA IEVQGDQQAW FGFAGTPGYL 180

SPEVLRKDPY GKPVDMWACG VILYILLVGY PPFWDEDQHR LYQQIKAGAY DFPSPEWDTV 240

TPEAKDLINK MLTINPSKRI TAAEALKHPW ICQRSTVASM MHRQETVECL KKFNARRKLK 300

GAILTTLLVT RNFSAAKSLL NKKPDGVKEP QTTVIHNPVD RNKESTESAN TTIEDEDLKA 360

RKQEIIKVTE QLIESINNGD FEAYAKICDP GLTSFEPEAL GNLVEGHDFH RFYFENALSK 420

GNKPVHTILL NPHVHLIGED AACIAYIRLT QYMDGSGMPR TMQSEETRVW HRRDGKWLNI 480

HFHRSGAPSV PIN 493

Nucleotide Sequence
(FASTA)

ATGGCTCTGA CCATCTGCAC CAGATTCACG GACGAATATC AGCTTTTTGA GGAGCTCGGA 60

AAGGGCGCGT TCTCTGTCGT GAGGCGATGC GTGAAGATAT CATCCGGCCA AGAGTATGCG 120

GCCAAAATCA TCAACACAAA GAAGCTGTCC GCCAGGGATC ACCAGAAGCT GGAGAGAGAG 180

GCCAGGATTT GTCGTCTCTT GAAACATCCG AATATTGTTC GACTGCATGA CAGCATATCG 240

GAGGAGGGCT TCCATTACCT CGTTTTTGAT CTGGTGACTG GAGGTGAACT GTTCGAGGAC 300

ATCGTAGCGA GAGAGTATTA CAGCGAGGCT GATGCCAGTC ACTGCATTCA GCAGATTTTG 360

GAGAGTGTTC ATCACTGCCA TGTTAATGGG ATCGTCCACA GGGACCTGAA GCCTGAGAAT 420

CTGCTGTTGG CCAGTAAGAT GAAGGGGGCG GCTGTTAAGC TTGCTGACTT TGGTTTGGCC 480

ATTGAGGTCC AGGGTGATCA GCAGGCTTGG TTTGGATTTG CTGGTACTCC AGGGTATCTG 540

TCTCCAGAGG TGCTGAGGAA AGATCCTTAT GGCAAACCGG TGGACATGTG GGCTTGCGGT 600

GTGATCCTCT ACATTCTGCT GGTTGGATAT CCGCCATTTT GGGATGAAGA CCAGCATCGC 660

CTCTATCAGC AGATCAAGGC TGGTGCCTAT GATTTTCCTT CTCCCGAGTG GGACACCGTG 720

ACCCCTGAAG CTAAAGATCT GATTAATAAG ATGTTGACTA TCAATCCCTC TAAACGTATC 780

ACAGCTGCTG AAGCCCTCAA ACACCCCTGG ATCTGCCAAC GCTCCACTGT TGCCTCAATG 840

ATGCACAGAC AGGAAACCGT GGAGTGCTTG AAGAAATTCA ACGCCAGAAG GAAACTCAAG 900

GGTGCAATTC TGACCACTCT CCTGGTCACA AGAAACTTCT CAGCAGCCAA AAGCTTGTTG 960

AACAAGAAGC CAGATGGTGT GAAGGAGCCA CAAACTACCG TGATCCACAA CCCAGTGGAC 1020

AGAAACAAGG AGTCTACAGA GAGTGCCAAC ACAACTATTG AGGATGAAGA CCTTAAAGCT 1080

CGAAAGCAGG AGATCATAAA GGTGACAGAG CAGCTGATTG AATCCATCAA CAACGGCGAC 1140

TTTGAGGCTT ATGCAAAGAT TTGCGATCCT GGTCTTACTT CCTTTGAGCC TGAAGCTTTG 1200

GGAAACCTGG TGGAGGGGCA TGATTTCCAC AGGTTCTACT TTGAAAACGC GCTCTCCAAA 1260

GGTAACAAAC CTGTACACAC TATCCTTCTG AACCCTCATG TGCACCTGAT TGGGGAGGAT 1320

GCGGCCTGTA TCGCGTACAT CCGCTTGACC CAGTACATGG ATGGCAGCGG GATGCCACGC 1380

ACCATGCAGT CGGAGGAGAC CCGTGTCTGG CACCGTCGAG ATGGCAAGTG GCTGAACATC 1440

CACTTTCATC GCTCTGGAGC CCCCAGTGTG CCCATCAATT AA 1482

Domain Profile

S: 1     yqlfeelgkgafsvvrrcvkvttgqeyaakiintkklsardhqklerearicrllkhpni  60

         yqlfeelgkgafsvvrrcvk+++gqeyaakiintkklsardhqklerearicrllkhpni

Q: 13    YQLFEELGKGAFSVVRRCVKISSGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI  72

         9***********************************************************

S: 61    vrlhdsiseegfhylvfdlvtggelfedivareyyseadashciqqilesvlhihqngvv  120

         vrlhdsiseegfhylvfdlvtggelfedivareyyseadashciqqilesv+h+h ng+v

Q: 73    VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVHHCHVNGIV  132

         ************************************************************

S: 121   hrdlkpenlllaskakgaavkladfglaievqgdqqawfgfagtpgylspevlrkdpygk  180

         hrdlkpenlllask+kgaavkladfglaievqgdqqawfgfagtpgylspevlrkdpygk

Q: 133   HRDLKPENLLLASKMKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGK  192

         ************************************************************

S: 181   pvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeakdlinkml  240

         pvd+wacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeakdlinkml

Q: 193   PVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKML  252

         ************************************************************

S: 241   tinpakritadealkhpwi  259

         tinp+krita+ealkhpwi

Q: 253   TINPSKRITAAEALKHPWI  271

         ******************8

Domain Sequence
(FASTA)

YQLFEELGKG AFSVVRRCVK ISSGQEYAAK IINTKKLSAR DHQKLEREAR ICRLLKHPNI 60

VRLHDSISEE GFHYLVFDLV TGGELFEDIV AREYYSEADA SHCIQQILES VHHCHVNGIV 120

HRDLKPENLL LASKMKGAAV KLADFGLAIE VQGDQQAWFG FAGTPGYLSP EVLRKDPYGK 180

PVDMWACGVI LYILLVGYPP FWDEDQHRLY QQIKAGAYDF PSPEWDTVTP EAKDLINKML 240

TINPSKRITA AEALKHPWI 259

Keyword

Alternative splicing; ATP-binding; Calmodulin-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004683	; F:calmodulin-dependent protein kinase activity

KEGG

dre:436815

;

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR013543	; Ca/CaM-dep_prot_kinase-assoc.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF08332	; CaMKII_AD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013