EKS-DAR-00618

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00618

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	442.9	1.0E-132	205	492	288

Status

Unreviewed

Ensembl Protein

ENSDARP00000003221

UniProt Accession

O73736;

Protein Name

Protein Synonyms/Alias

ACVR1 activin A receptor, type I; Activin receptor-like kinase 8;

Gene Name

acvr1l

Gene Synonyms/Alias

acvr1l; acvr1, alk8;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000014986	ENSDARP00000003221	ENSDART00000017977
ENSDARG00000014986	ENSDARP00000108954	ENSDART00000122860
ENSDARG00000014986	ENSDARP00000111550	ENSDART00000127520

Organism

Danio rerio

Functional Description

Protein Length

506

Protein Sequence
(FASTA)

MGHCSTQIII LFLLQFLQTS AKDVSIDCMC VGSDCNEQQC TGDQCYTSVI ISNDVTTFKR 60

GCLIGPASKR MTCSATASAS HVVECCSQHM CNANVSKETL LRLLLTSPEE KKTVHYRVEM 120

LVLFVLGPFV VLGLLSFLAL LVCRRLHHGR LERLHEFDTE QGAIDGLIAS NVGDSTLADL 180

MDHSCTSGSG SGLPFLVQRT VARQISLVEC VGKGRYGEVW RGQWQGENVA VKIFSSRDEK 240

SWFRETEIYN TVLLRHENIL GFMASDMTSR NSSTQLWLIT HYHENGSLYD YLQRVAVEMA 300

DGLHMAASIA SGLVHLHTEI FGTEGKPAIA HRDLKSKNIL VKKDLQCCIA DLGLAVTHTQ 360

SDNQLDVGNN PKVGTKRYMA PEVLDETIQT DCFDAYKRVD IWAFGLVLWE IARRTISNGI 420

VEEYKPPFYD LVPNDPSFDD MRKVVCVEQQ RPFIPNRWFS DPTLSALVKL MKECWYQNPS 480

ARLTALRIKK TLDKIHSSLE KGKTDC 506

Nucleotide Sequence
(FASTA)

ATGGGGCATT GCAGCACCCA AATCATCATC CTGTTCCTGC TTCAGTTCTT ACAGACATCA 60

GCTAAAGATG TCTCCATTGA CTGCATGTGT GTCGGCAGTG ACTGTAATGA GCAGCAGTGT 120

ACTGGTGACC AGTGTTACAC CTCCGTTATC ATTAGCAATG ATGTGACGAC GTTCAAGCGG 180

GGCTGCTTGA TCGGGCCGGC GAGCAAGCGC ATGACCTGCT CCGCAACAGC TTCTGCTAGT 240

CATGTGGTAG AATGCTGTTC TCAACACATG TGCAACGCCA ACGTCTCCAA AGAGACCCTA 300

CTTCGACTGC TGCTCACAAG TCCAGAAGAA AAGAAGACTG TTCATTACCG CGTGGAAATG 360

TTGGTTCTGT TTGTGTTGGG GCCGTTTGTG GTTCTGGGTC TGCTGTCTTT TCTGGCTTTG 420

CTGGTGTGCC GTCGACTCCA TCATGGGCGT CTGGAGAGAC TGCACGAGTT TGACACTGAA 480

CAGGGGGCCA TCGATGGGCT TATCGCGTCT AATGTCGGAG ACAGCACACT TGCGGATCTG 540

ATGGATCACT CCTGCACTTC AGGCAGTGGT TCAGGACTGC CCTTCCTGGT TCAGAGAACG 600

GTTGCGCGGC AGATCAGCCT GGTGGAGTGT GTTGGTAAAG GACGGTACGG TGAAGTGTGG 660

AGAGGTCAAT GGCAAGGAGA AAATGTAGCC GTGAAGATCT TTTCCTCTAG AGATGAGAAG 720

TCATGGTTTC GAGAAACAGA AATTTACAAC ACTGTTCTGC TACGACATGA AAATATATTA 780

GGCTTCATGG CTTCTGACAT GACCTCCCGA AACTCTAGCA CTCAGCTGTG GCTGATCACA 840

CACTATCACG AGAATGGCTC TCTGTATGAC TACCTGCAGC GTGTGGCTGT GGAGATGGCA 900

GATGGACTGC ACATGGCGGC TTCGATTGCC AGCGGGCTGG TGCACCTGCA CACGGAGATC 960

TTTGGCACGG AGGGCAAACC GGCCATCGCT CACAGAGACC TGAAGAGCAA GAACATCCTT 1020

GTGAAGAAAG ATTTGCAGTG CTGCATCGCT GACCTGGGTC TGGCAGTAAC ACACACGCAG 1080

TCTGATAATC AGCTTGATGT GGGAAATAAT CCTAAAGTGG GAACCAAACG CTACATGGCA 1140

CCGGAGGTTC TAGATGAGAC CATTCAGACG GACTGTTTTG ACGCCTATAA GAGGGTGGAT 1200

ATCTGGGCCT TTGGGTTGGT GCTGTGGGAG ATCGCACGCA GAACCATCAG CAATGGAATT 1260

GTAGAGGAAT ACAAGCCGCC TTTCTATGAC CTGGTTCCTA ATGATCCCAG CTTTGACGAC 1320

ATGAGGAAAG TGGTTTGTGT GGAGCAGCAA AGGCCATTCA TTCCCAACCG CTGGTTTTCA 1380

GATCCTACCC TGTCTGCTCT GGTGAAGCTG ATGAAAGAGT GCTGGTACCA GAACCCCTCG 1440

GCTCGTCTCA CTGCCCTGCG CATCAAAAAG ACTCTGGATA AAATCCACAG TTCACTGGAG 1500

AAGGGCAAAA CCGACTGCTG A 1521

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++l+e++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+eiy+tvllrhenil+f+a

Q: 205   ISLVECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFMA  264

         6799********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t+yhe+gsL+dyL+r  +++ + l++a s+asGl hLH+ei+gt+

Q: 265   SDMTSRNSSTQLWLITHYHENGSLYDYLQRVAVEMADGLHMAASIASGLVHLHTEIFGTE  324

         ***********************************************************9

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkkdl+cciaDlGLa++++++ ++ld+ +n +vGtkRYmaPE

Q: 325   G--KPAIAHRDLKSKNILVKKDLQCCIADLGLAVTHTQSDNQLDVGNNPKVGTKRYMAPE  382

         9..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++++++f+a+kr+D++++gLvlWE+a+R+ + +++veeyk+pf++ v++dPs+++m

Q: 383   VLDETIQTDCFDAYKRVDIWAFGLVLWEIARRTIS-NGIVEEYKPPFYDLVPNDPSFDDM  441

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++++rP ip++w ++++l++l kl++ecW+++p+aRltalr+kk+l

Q: 442   RKVVCVEQQRPFIPNRWFSDPTLSALVKLMKECWYQNPSARLTALRIKKTL  492

         *************************************************97

Domain Sequence
(FASTA)

ISLVECVGKG RYGEVWRGQW QGENVAVKIF SSRDEKSWFR ETEIYNTVLL RHENILGFMA 60

SDMTSRNSST QLWLITHYHE NGSLYDYLQR VAVEMADGLH MAASIASGLV HLHTEIFGTE 120

GKPAIAHRDL KSKNILVKKD LQCCIADLGL AVTHTQSDNQ LDVGNNPKVG TKRYMAPEVL 180

DETIQTDCFD AYKRVDIWAF GLVLWEIARR TISNGIVEEY KPPFYDLVPN DPSFDDMRKV 240

VCVEQQRPFI PNRWFSDPTL SALVKLMKEC WYQNPSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

dre:30615

;

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013