EKS-DAR-00549

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00549

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	395.2	2.6E-118	86	369	284

Status

Unreviewed

Ensembl Protein

ENSDARP00000019044

UniProt Accession

B0S6F4;

Protein Name

Protein Synonyms/Alias

MAP kinase-interacting serine/threonine kinase 2;

Gene Name

mknk2b

Gene Synonyms/Alias

mknk2b; mknk2; DKEY-45M5.1-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000015164	ENSDARP00000123408	ENSDART00000133794
ENSDARG00000015164	ENSDARP00000019044	ENSDART00000016422

Organism

Danio rerio

Functional Description

Protein Length

475

Protein Sequence
(FASTA)

MVQNKITEVT GFHRSFKGQN PFETEEFSKT GSHLLESAFN FDCSARPDMP SSQPIDIPDS 60

KKRNKKKKRC RATDSFSGRF EDVYKLQDEV LGEGAYARVQ TCISQITQKE YAVKIIEKRP 120

GHSRSRVFRE VEMLYQCQGH RSILELVEFF EEEDKFYLVF EKLRGGSILA HIHKRRYFGE 180

QEASIVVQDI ASALDFLHNK GMAHRDLKPE NILCEHEHRI SPVKICDFDL GSGIKLNSDS 240

SPISTPELLT PCGSAEYMAP EVVEAFNEEA TIYDKRCDLW SLGVILYIML SGYPPFVGRC 300

GSDCGWENGE PCQACQNMLF ESIQEGKYEF PEKEWAHISS SAKDLISKLL VRDAKKRLSA 360

AQVLQHPWVQ GGAFDCLPSS NLPQRNSSTK DLTFFAGKAV AMNRQLAQQD DLEEQQQQDS 420

PQVITASSTS MRLSPPSNSK LAKRRQRSSL LKGAPVSASE LRQLLAPLVI VGDCA 475

Nucleotide Sequence
(FASTA)

ATGGTGCAGA ACAAAATCAC CGAAGTTACC GGATTCCATC GCTCTTTTAA GGGCCAAAAT 60

CCCTTTGAAA CGGAGGAATT TTCCAAAACA GGATCCCATC TCCTTGAATC TGCCTTTAAT 120

TTTGATTGTT CCGCCCGACC TGACATGCCA TCCAGCCAGC CCATCGACAT CCCCGATTCC 180

AAAAAGAGAA ACAAGAAGAA AAAGAGATGC CGGGCAACTG ACAGTTTCTC AGGGCGATTT 240

GAGGATGTAT ATAAACTGCA AGATGAAGTG CTGGGGGAAG GAGCCTATGC CAGGGTCCAG 300

ACCTGCATCA GTCAAATCAC CCAAAAAGAA TATGCTGTTA AGATAATTGA GAAGAGGCCA 360

GGACACAGCA GAAGTCGTGT TTTTAGAGAG GTGGAAATGC TGTACCAGTG CCAGGGCCAC 420

AGAAGTATTC TGGAGCTAGT GGAGTTCTTT GAGGAGGAGG ACAAGTTTTA CCTTGTGTTT 480

GAGAAGCTCA GAGGAGGCTC CATCTTGGCC CACATTCACA AGAGGAGATA CTTCGGCGAA 540

CAGGAAGCCA GCATTGTGGT GCAGGACATT GCGAGTGCAC TGGACTTCCT TCACAATAAA 600

GGAATGGCCC ACAGAGACTT GAAGCCTGAA AACATCTTGT GTGAACACGA GCACAGGATT 660

TCGCCTGTCA AGATTTGTGA TTTTGATTTG GGCAGTGGAA TTAAACTCAA TAGCGACAGT 720

TCACCCATCT CCACTCCTGA GCTCCTCACT CCATGTGGAT CTGCTGAATA CATGGCGCCG 780

GAAGTTGTGG AAGCCTTCAA CGAGGAGGCC ACCATTTACG ATAAGCGCTG TGACCTGTGG 840

AGCCTGGGCG TCATCCTCTA CATCATGCTA AGCGGTTACC CTCCTTTTGT GGGTCGCTGT 900

GGAAGTGACT GTGGATGGGA GAATGGAGAA CCTTGTCAAG CTTGCCAGAA CATGTTGTTT 960

GAAAGCATCC AGGAGGGAAA GTATGAGTTT CCAGAGAAAG AGTGGGCTCA TATTTCCTCC 1020

AGCGCCAAAG ACCTCATTTC CAAACTGCTT GTACGGGACG CCAAGAAACG TCTCAGCGCT 1080

GCTCAGGTTC TCCAACATCC CTGGGTACAA GGGGGTGCCT TTGATTGTCT CCCCTCATCC 1140

AACTTGCCTC AAAGGAATAG CAGCACTAAG GATCTGACCT TCTTTGCGGG CAAAGCTGTA 1200

GCCATGAACC GGCAACTGGC CCAGCAAGAC GACCTGGAAG AACAACAGCA GCAGGACTCT 1260

CCTCAGGTCA TTACAGCCAG TTCCACATCC ATGCGCCTCT CCCCTCCCTC CAACTCCAAA 1320

CTGGCCAAGC GCAGACAGAG GAGCAGCCTA CTGAAAGGAG CGCCCGTGTC TGCCTCAGAG 1380

CTCAGGCAGC TCCTGGCACC GCTGGTCATT GTGGGGGATT GTGCATGA 1428

Domain Profile

S: 2     lteevlGeGisgkvlecvkkktgekyalkil.....kdrkkvrrevelhvqasghknive  56

         l++evlGeG++++v++c+++ t+++ya+ki+     ++r++v+reve+++q++gh+ i+e

Q: 86    LQDEVLGEGAYARVQTCISQITQKEYAVKIIekrpgHSRSRVFREVEMLYQCQGHRSILE  145

         789*********************************************************

S: 57    lidvfensfedekrlllvlekleGGellsriqerkaftekeasevvkdiasalkflhskn  116

         l+++fe    +e++++lv+ekl+GG++l++i++r++f e+eas vv+diasal+flh+k+

Q: 146   LVEFFE----EEDKFYLVFEKLRGGSILAHIHKRRYFGEQEASIVVQDIASALDFLHNKG  201

         ******....9*************************************************

S: 117   iahrDlkpenlLyeskeknapvklcDfglaket..eee.......eelktpcltaeyvaP  167

         +ahrDlkpen+L+e++++ +pvk+cDf+l++++  + +       +el tpc++aey+aP

Q: 202   MAHRDLKPENILCEHEHRISPVKICDFDLGSGIklN-SdsspistPELLTPCGSAEYMAP  260

         ********************************9543.25899999***************

S: 168   evleaekeeallydksCDlWslGvilyillcGypPfyskkg...........raiskklk  216

         ev+ea++eea++ydk+CDlWslGvilyi+l+GypPf++++g           +a++++l+

Q: 261   EVVEAFNEEATIYDKRCDLWSLGVILYIMLSGYPPFVGRCGsdcgwengepcQACQNMLF  320

         ****************************************99******************

S: 217   eriqegkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265

         e+iqegkyefPe+eW+++s++akdli+klL+rd+k+rl++++vl+hpwv

Q: 321   ESIQEGKYEFPEKEWAHISSSAKDLISKLLVRDAKKRLSAAQVLQHPWV  369

         ************************************************8

Domain Sequence
(FASTA)

LQDEVLGEGA YARVQTCISQ ITQKEYAVKI IEKRPGHSRS RVFREVEMLY QCQGHRSILE 60

LVEFFEEEDK FYLVFEKLRG GSILAHIHKR RYFGEQEASI VVQDIASALD FLHNKGMAHR 120

DLKPENILCE HEHRISPVKI CDFDLGSGIK LNSDSSPIST PELLTPCGSA EYMAPEVVEA 180

FNEEATIYDK RCDLWSLGVI LYIMLSGYPP FVGRCGSDCG WENGEPCQAC QNMLFESIQE 240

GKYEFPEKEW AHISSSAKDL ISKLLVRDAK KRLSAAQVLQ HPWV 284

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Monodelphis domestica"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013