EKS-DAR-00513

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00513

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	439.4	9.0E-132	13	297	285

Status

Unreviewed

Ensembl Protein

ENSDARP00000012498

UniProt Accession

B9X2H6;

Protein Name

Protein Synonyms/Alias

Cyclin dependent kinase like 5 long;

Gene Name

cdkl5

Gene Synonyms/Alias

cdkl5; Cdkl5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000015240	ENSDARP00000012498	ENSDART00000010026
ENSDARG00000015240	ENSDARP00000111280	ENSDART00000127502

Organism

Danio rerio

Functional Description

Protein Length

1039

Protein Sequence
(FASTA)

MKIPDIGNVM NKFEVLGIVG EGAYGVVLKC RHKETKELVA IKKFKDSEEN EEVKETTLRE 60

LKMLRTLKQD NIVELKEAFR RRGKLYLVFE YVEKNMLELL EELPNGALPD KVRSYIFQLI 120

KAIHWCHKNE IVHRDIKPEN LLISANDILK LCDFGFARNL SEGSDANYTE YVATRWYRSP 180

ELLLGAPYGK AVDMWSVGCI LGELSDGQPL FPGESEIDQL FTIQKVLGPL PPEQMKLFYS 240

NPRFAGLRFP SVSHPQTLDR RYLGIINGLM LDLMKNLLCL NPTERFLTEQ CLNHPVFQGL 300

RGPEQPAVPS PTPPRSSKRK PYHGDNTIPS RSHGSKSSSH RRANSKDCSS LPRHEDLHRS 360

TDSFLNGTNM PTSSTLSPTL HPKSYQAQTL SRSASSNKDL ANNNLPHLLS PKDAKGKTEF 420

DFNLGPKVGV ASVGMDTSTG KYLKSSKQGR HSSFLEGKTS TLQSGDKHSR HNYMESSHGS 480

MPSTSSSKSS SSFLSLSKSH GALNDAKSVS NLAETRLHLD DPMAGSGSGS RYFPSSCLDL 540

NAAPGSPRGE RHAGTERQGH SPSGRGSNRL EGGTLDSRRS SGRKKTPDEP KPTDTLDPSR 600

AAGGHAHNLP SPHESYPYGL GYTSPFSSQQ RPHRHSMYVR RERHRPHGQE NNLVVGQGVP 660

TRASSLQLLS PQLQHRTLPR HNTSSSREEL TPELSRNDQS PKEKPHSRPL IKDSTRDNTA 720

TFHTQRPKNE AGMYHDAHME DGTSSKENRI IYSDSMPRRV GSFYRVPSPR PDNTFLETTG 780

QSRVQAVAAE NPTMTNHSKR QTNFDPWNNS EAMVMNPPEV PKQKEKQGFF RAIKKKKKKS 840

QPVPSETQQD QLVLQRPVKS SSHHSSRHRN RDRERERDME RDRERERDRN RDRDRERDRD 900

NTWPPEKQPE VQPQNQPLKS LRKLLHLSSP ATSNQPPPPD RSAELRFQPL PNPPSKANLN 960

EVRGHPAGSV TPNTKSRKPH NYPLPGQIES SWHVSALNRA EGAPYPDQLA NKGGQNGIGF 1020

TRAARTRMPN LNDLKETAL 1039

Nucleotide Sequence
(FASTA)

ATGAAGATTC CTGACATCGG TAATGTGATG AATAAATTTG AGGTCCTTGG GATTGTAGGA 60

GAGGGAGCCT ATGGGGTGGT CCTGAAATGC AGACACAAGG AGACAAAAGA GCTTGTGGCC 120

ATTAAGAAGT TCAAGGACAG TGAAGAGAAT GAGGAAGTTA AAGAGACGAC GTTACGGGAG 180

CTGAAGATGC TCCGTACGCT CAAACAAGAC AACATCGTAG AGCTGAAAGA GGCTTTCCGT 240

CGACGGGGAA AACTCTACCT GGTGTTTGAA TATGTGGAGA AGAATATGCT GGAGTTATTA 300

GAGGAACTGC CCAATGGTGC ACTGCCTGAT AAAGTACGAA GCTACATCTT TCAGCTAATC 360

AAAGCTATTC ACTGGTGCCA TAAGAATGAG ATCGTCCACA GAGATATCAA GCCTGAGAAT 420

CTCCTCATCA GCGCCAATGA TATCCTGAAG CTGTGTGATT TCGGCTTTGC CCGAAATCTG 480

TCTGAAGGTA GCGATGCCAA CTATACCGAG TACGTGGCTA CTAGGTGGTA CCGCTCACCT 540

GAACTGCTCC TCGGGGCTCC ATATGGGAAG GCGGTGGACA TGTGGTCGGT GGGGTGTATT 600

TTGGGAGAGC TCAGTGATGG GCAGCCCCTG TTTCCGGGCG AGAGTGAAAT CGACCAGCTC 660

TTCACTATTC AGAAGGTGTT GGGCCCTCTA CCACCAGAGC AGATGAAGCT GTTCTACAGC 720

AACCCTCGTT TCGCCGGACT GAGATTTCCT TCTGTAAGTC ACCCTCAGAC GCTTGATCGA 780

AGGTACCTGG GCATCATCAA TGGACTCATG TTGGATTTAA TGAAGAACCT GCTGTGCCTG 840

AACCCTACCG AACGCTTTCT GACAGAGCAG TGTCTGAACC ACCCAGTGTT TCAAGGTCTG 900

AGAGGGCCTG AGCAGCCAGC TGTCCCGTCA CCCACCCCGC CGCGCTCCTC CAAGAGAAAA 960

CCCTATCACG GAGACAACAC CATACCCAGC CGAAGTCACG GCAGTAAGAG TTCAAGTCAC 1020

CGGCGTGCGA ACAGCAAAGA CTGCTCCTCT CTACCACGCC ATGAGGACCT CCACCGGAGC 1080

ACCGACAGCT TCCTAAATGG CACCAACATG CCAACGTCAT CCACCCTGAG TCCTACACTA 1140

CACCCCAAAA GCTACCAGGC CCAGACTCTC AGCCGCTCGG CCTCTTCCAA CAAAGACCTG 1200

GCCAACAACA ACCTTCCGCA TCTCCTCAGC CCTAAAGATG CGAAAGGAAA GACAGAGTTT 1260

GATTTCAATC TGGGGCCTAA AGTTGGAGTT GCCTCCGTGG GTATGGACAC ATCTACCGGC 1320

AAGTACCTCA AATCATCCAA ACAAGGCCGT CACTCATCCT TCCTGGAAGG AAAGACCAGC 1380

ACGCTGCAGT CCGGGGACAA GCACAGTCGG CACAACTACA TGGAGTCCTC ACACGGATCC 1440

ATGCCTTCCA CGTCCTCCTC CAAAAGCTCC TCATCCTTCC TCAGCTTGTC CAAAAGCCAC 1500

GGCGCACTTA ATGACGCCAA GTCTGTGAGC AATCTAGCAG AGACACGACT CCACCTGGAT 1560

GATCCTATGG CAGGATCCGG TTCAGGCTCT CGATATTTCC CGTCCAGCTG CCTGGATCTA 1620

AACGCAGCTC CTGGTAGCCC CAGAGGTGAA CGGCATGCTG GGACGGAGCG GCAGGGTCAC 1680

AGTCCCAGTG GCCGGGGGAG CAATCGCCTT GAAGGGGGCA CTCTGGACTC GCGGCGCTCC 1740

TCGGGACGGA AAAAGACACC AGATGAACCG AAGCCTACTG ATACTCTGGA TCCAAGCAGA 1800

GCTGCGGGAG GCCATGCTCA CAATCTCCCG TCGCCACATG AATCCTATCC TTACGGTCTT 1860

GGATACACCA GCCCGTTCTC CTCGCAGCAG CGACCTCATC GGCACTCTAT GTATGTGCGG 1920

AGAGAGCGAC ACCGGCCGCA CGGCCAGGAG AACAATTTGG TGGTTGGACA GGGAGTGCCA 1980

ACGCGTGCCA GCAGCCTACA GCTCCTTTCG CCGCAGCTTC AGCACCGCAC ACTCCCACGC 2040

CACAACACCA GTTCCTCCAG AGAAGAGCTC ACGCCAGAGC TCAGCAGGAA TGACCAGTCT 2100

CCCAAAGAGA AGCCTCATTC TCGCCCCCTG ATTAAAGATT CGACGAGGGA CAACACAGCT 2160

ACCTTCCACA CACAACGCCC AAAAAACGAG GCTGGGATGT ACCACGACGC TCATATGGAG 2220

GACGGGACCT CATCCAAGGA GAACAGAATC ATCTACAGTG ACTCGATGCC TCGCAGAGTG 2280

GGAAGCTTTT ACAGAGTCCC ATCTCCTCGA CCTGACAACA CGTTTCTTGA GACCACTGGA 2340

CAGAGCAGAG TGCAAGCGGT GGCGGCAGAA AACCCAACCA TGACAAACCA CTCCAAACGT 2400

CAGACCAATT TTGACCCCTG GAATAATTCA GAGGCGATGG TTATGAACCC ACCAGAGGTC 2460

CCGAAACAAA AAGAAAAACA AGGTTTCTTT CGAGCCATAA AGAAGAAAAA GAAAAAATCG 2520

CAGCCGGTAC CTAGTGAAAC CCAGCAGGAC CAGCTCGTTT TACAGAGACC GGTCAAATCC 2580

TCGTCTCATC ACAGCAGTCG ACACCGCAAC CGAGACCGCG AGCGCGAACG GGACATGGAG 2640

AGGGACAGAG AGCGTGAGCG GGACCGAAAC CGCGACAGAG ATCGTGAGCG GGACAGGGAC 2700

AACACTTGGC CTCCAGAGAA GCAGCCGGAA GTGCAGCCTC AGAACCAGCC TCTGAAGTCC 2760

CTGCGGAAGC TCCTCCACCT CTCCTCTCCT GCTACATCCA ATCAGCCTCC ACCTCCTGAT 2820

CGCTCGGCCG AACTGCGCTT CCAGCCCCTT CCAAATCCCC CCTCTAAAGC CAACCTGAAC 2880

GAGGTCAGAG GACACCCGGC GGGCAGCGTC ACCCCCAACA CCAAAAGCCG CAAACCCCAC 2940

AACTACCCTC TGCCAGGCCA GATTGAATCC AGCTGGCACG TCTCTGCTCT GAATCGGGCA 3000

GAGGGTGCGC CATACCCCGA CCAATTGGCA AACAAAGGTG GGCAGAACGG TATCGGCTTC 3060

ACTAGAGCCG CTCGCACCAG GATGCCGAAC CTCAATGATC TGAAAGAAAC GGCCCTTTAG 3120

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         +e lg vGeG+yGvvlkcr+k+t+++vaikkf++se+++evk+++lre+k+l++lk++n+

Q: 13    FEVLGIVGEGAYGVVLKCRHKETKELVAIKKFKDSEENEEVKETTLRELKMLRTLKQDNI  72

         799*********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         v+l+e+frr+ klylvfeyv+k++l+ le+ pnG   ++v+++++q++kai++chkn+i+

Q: 73    VELKEAFRRRGKLYLVFEYVEKNMLELLEELPNGALPDKVRSYIFQLIKAIHWCHKNEIV  132

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarlla.apgdvytdyvatrwyrapellvgdtkyGks  179

         hrdikpen+lis ++++klcdfGfar+l+ +++++yt+yvatrwyr+pell+g + yGk+

Q: 133   HRDIKPENLLISANDILKLCDFGFARNLSeGSDANYTEYVATRWYRSPELLLG-APYGKA  191

         ****************************9788899******************.9*****

S: 180   vdvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpe  239

         vd+w++Gc+l el++G+plfpg+s++dql++i+k+lG+l p+++k+f++n++faG+++p+

Q: 192   VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPPEQMKLFYSNPRFAGLRFPS  251

         ************************************************************

S: 240   vedleslekkyp.klnevlldllkkclkldpaerlsceellkheyf  284

         v+++++l+++y   +n ++ldl+k++l l+p+er+++e++l+h++f

Q: 252   VSHPQTLDRRYLgIINGLMLDLMKNLLCLNPTERFLTEQCLNHPVF  297

         ***********9899****************************998

Domain Sequence
(FASTA)

FEVLGIVGEG AYGVVLKCRH KETKELVAIK KFKDSEENEE VKETTLRELK MLRTLKQDNI 60

VELKEAFRRR GKLYLVFEYV EKNMLELLEE LPNGALPDKV RSYIFQLIKA IHWCHKNEIV 120

HRDIKPENLL ISANDILKLC DFGFARNLSE GSDANYTEYV ATRWYRSPEL LLGAPYGKAV 180

DMWSVGCILG ELSDGQPLFP GESEIDQLFT IQKVLGPLPP EQMKLFYSNP RFAGLRFPSV 240

SHPQTLDRRY LGIINGLMLD LMKNLLCLNP TERFLTEQCL NHPVF 285

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

dre:559341

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR024767	; PRP38_C.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF12871	; PRP38_assoc; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013