EKS-DAR-00087

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00087

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	337.5	1.2E-100	26	335	310

Status

Unreviewed

Ensembl Protein

ENSDARP00000022588

UniProt Accession

A8E4S2;

Protein Name

Protein Synonyms/Alias

Cdk8 protein; Cyclin-dependent kinase 8;

Gene Name

cdk8

Gene Synonyms/Alias

cdk8;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000016496	ENSDARP00000022588	ENSDART00000007066

Organism

Danio rerio

Functional Description

Protein Length

465

Protein Sequence
(FASTA)

MDYDFKVKLT GERERVEDLF EYEGCKVGRG TYGHVYKAKR KDGKDDKDYA LKQIEGTGIS 60

MSACREIALL RELKHPNVIS LQKVFLSHAD RKVWLLFDYA EHDLWHIIKF HRASKANKKP 120

LQLPRGMVKS LLYQILDGIH YLHANWVLHR DLKPANILVM GEGPERGRVK IADMGFARLF 180

NSPLKPLADL DPVVVTFWYR APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED 240

IKTSNPYHHD QLDRIFNVMG FPADKDWEDI KKMPEHSTLM KDFRRNTYTN CSLIKYMEKH 300

KVKPDSKAFH LLQKLLTMDP IRRITSEQAM QDPYFLEEPL PTSDVFAGCQ IPYPKREFLT 360

EEEPEDKADK KNQQQQQQGN NHTNGAGHTG NPDNSHAQGP PLKKVRVVPP TTTSSGLIMT 420

SDYQRSNPHA AYQNPGPSTS LPQSSMGYSS TSQQPPQYSH QTHRY 465

Nucleotide Sequence
(FASTA)

ATGGACTATG ACTTCAAAGT GAAGCTCACC GGGGAGAGAG AACGAGTCGA GGACCTCTTT 60

GAGTACGAAG GATGTAAAGT TGGACGGGGG ACTTATGGCC ATGTGTACAA AGCGAAGAGG 120

AAAGATGGGA AGGATGATAA AGATTATGCT CTGAAGCAGA TTGAAGGCAC AGGGATCTCC 180

ATGTCCGCCT GCAGAGAGAT AGCACTGCTG CGTGAACTAA AGCACCCCAA TGTGATCTCA 240

CTGCAGAAGG TTTTCCTGTC ACATGCAGAC CGCAAAGTTT GGCTTCTCTT TGACTACGCT 300

GAACATGACC TCTGGCACAT CATCAAGTTC CACAGAGCCT CTAAGGCCAA TAAGAAGCCT 360

CTTCAGCTGC CGCGTGGGAT GGTAAAGTCT TTGCTCTACC AGATCCTGGA CGGCATCCAC 420

TATTTGCACG CCAACTGGGT CCTGCACAGA GACCTGAAAC CTGCCAACAT ATTGGTAATG 480

GGAGAAGGTC CTGAAAGAGG ACGTGTGAAG ATAGCTGATA TGGGTTTTGC ACGGCTCTTC 540

AACTCACCAC TGAAGCCTTT AGCGGATCTG GATCCAGTAG TTGTTACGTT CTGGTACAGA 600

GCACCAGAGT TGCTGCTGGG AGCCAGGCAT TACACCAAAG CCATCGATAT CTGGGCAATT 660

GGCTGTATCT TTGCTGAGCT TTTGACCTCA GAGCCCATCT TCCATTGTCG ACAGGAGGAC 720

ATTAAGACCA GTAATCCCTA CCATCACGAT CAGCTCGACC GCATCTTTAA TGTCATGGGC 780

TTTCCTGCAG ACAAAGACTG GGAGGACATT AAGAAGATGC CGGAACACTC GACACTGATG 840

AAAGACTTTA GGAGGAATAC GTACACTAAC TGCAGCCTTA TAAAGTATAT GGAGAAGCAT 900

AAAGTCAAGC CTGACAGCAA AGCATTCCAC TTGCTGCAAA AGCTGCTTAC CATGGACCCA 960

ATCCGCAGAA TCACATCTGA GCAGGCCATG CAGGACCCGT ACTTCCTGGA GGAGCCTTTA 1020

CCCACATCTG ATGTCTTTGC TGGCTGCCAG ATTCCTTATC CTAAAAGAGA ATTCCTGACG 1080

GAAGAGGAGC CAGAAGACAA GGCAGATAAA AAAAACCAGC AGCAGCAGCA GCAGGGGAAC 1140

AACCACACCA ATGGGGCAGG GCACACAGGT AACCCTGACA ACAGCCACGC ACAAGGCCCG 1200

CCTCTGAAGA AGGTGAGAGT GGTTCCGCCC ACCACTACCT CAAGTGGCCT GATCATGACC 1260

TCAGATTACC AGCGCTCCAA TCCACATGCT GCCTACCAGA ACCCAGGACC AAGCACATCA 1320

TTGCCCCAAA GCAGCATGGG ATACTCCTCT ACCTCCCAGC AGCCTCCACA GTACTCGCAC 1380

CAGACCCATC GTTACTGA 1398

Domain Profile

S: 6     kigeGtygkvykakdke..tgevvAlKkirlekekegvpitalrEisllkelkhknivkL  63

         k+g+Gtyg+vykak+k+  +++ +AlK+i    e +g++++a+rEi+ll+elkh+n+++L

Q: 26    KVGRGTYGHVYKAKRKDgkDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL  81

         79************986447778******....999************************

S: 64    levva.kdkkklyLvfefleqdLkkllkkkkkk.......klsleevkslllqlleglay  115

         ++v+  ++++k++L+f+++e+dL++++k ++++       +l++ +vksll+q+l+g++y

Q: 82    QKVFLsHADRKVWLLFDYAEHDLWHIIKFHRASkankkplQLPRGMVKSLLYQILDGIHY  141

         ****94555*********************9999999*9*********************

S: 116   lHsnkilHRDlKpqNlLiske....gklklaDfGlarafssplk...tytkevvTlwYra  168

         lH+n++lHRDlKp+N+L++ e    g++k+aD+G+ar f+splk   +++++vvT+wYra

Q: 142   LHANWVLHRDLKPANILVMGEgperGRVKIADMGFARLFNSPLKplaDLDPVVVTFWYRA  201

         *******************9988889*************99999665699**********

S: 169   PelLlgakeYstavDiWsvgcilaelltrkplfqgkse.........idqlerifkllgt  219

         PelLlga++Y++a+DiW++gci+aellt++p+f++++e         +dql+rif+++g

Q: 202   PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEdiktsnpyhHDQLDRIFNVMGF  261

         ************************************************************

S: 220   psekvwpevsklpeyk...ksfpkkkkk..klkekvkklk....ekaldllekllaldpk  270

         p +k+w++++k+pe++   k+f++++++  +l ++++k k    +ka++ll+kll++dp

Q: 262   PADKDWEDIKKMPEHStlmKDFRRNTYTncSLIKYMEKHKvkpdSKAFHLLQKLLTMDPI  321

         ***************96644777777764455666644333354679*************

S: 271   kRisakealqhkyf  284

         +Ri++++a+q++yf

Q: 322   RRITSEQAMQDPYF  335

         *************9

Domain Sequence
(FASTA)

KVGRGTYGHV YKAKRKDGKD DKDYALKQIE GTGISMSACR EIALLRELKH PNVISLQKVF 60

LSHADRKVWL LFDYAEHDLW HIIKFHRASK ANKKPLQLPR GMVKSLLYQI LDGIHYLHAN 120

WVLHRDLKPA NILVMGEGPE RGRVKIADMG FARLFNSPLK PLADLDPVVV TFWYRAPELL 180

LGARHYTKAI DIWAIGCIFA ELLTSEPIFH CRQEDIKTSN PYHHDQLDRI FNVMGFPADK 240

DWEDIKKMPE HSTLMKDFRR NTYTNCSLIK YMEKHKVKPD SKAFHLLQKL LTMDPIRRIT 300

SEQAMQDPYF 310

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013