EKS-DAR-00512

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00512

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	526.6	2.3E-158	4	287	284

Status

Unreviewed

Ensembl Protein

ENSDARP00000044356

UniProt Accession

B8A6G8;

Protein Name

Protein Synonyms/Alias

Cyclin-dependent kinase-like 1; Novel protein similar to vertebrate cyclin-dependent kinase-like 1 (CDC2-related kinase) (CDKL1, zgc:101002);

Gene Name

cdkl1

Gene Synonyms/Alias

cdkl1; CH211-282C13.4; CH211-282C13.4-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000017329	ENSDARP00000044356	ENSDART00000044357

Organism

Danio rerio

Functional Description

Protein Length

350

Protein Sequence
(FASTA)

MEKYEKISKI GEGSYGVVFK CRNKDTGQIV AIKKFVESED DPIIKKIALR EIRMLKQLKH 60

PNLVNLMEVF RRKRKLHLVF EYCDHTVLNE LDRYPRGVPE HMVKSIIWQT LQAVNFCHKQ 120

NCIHRDVKPE NILITKHQVI KLCDFGFARI LTGPCDYYTD YVATRWYRAP ELLVGDTQYG 180

PPVDVWAVGC VFAELLSGAP LWPGKSDVDQ LYLIRKTLGE LIPRHQQVFS TNQFFSGVCV 240

PEPQEMEPLE LKYPNLSYQA LSLMKGCLRM DPAERLSCEQ LLEQPYFDSL REESESVTRE 300

LDRKKRTRQP RKHLPPGYLP QLASSTVFPA VENRRNYNNL RKFNYHLPNI 350

Nucleotide Sequence
(FASTA)

ATGGAGAAGT ATGAGAAGAT CAGTAAGATT GGCGAAGGCT CGTACGGCGT TGTGTTCAAG 60

TGCAGGAATA AAGACACCGG ACAGATTGTC GCCATCAAGA AGTTTGTGGA GTCTGAGGAT 120

GATCCCATCA TTAAGAAAAT AGCGCTCAGA GAAATCCGCA TGCTGAAGCA ACTAAAACAT 180

CCAAACCTGG TGAATCTGAT GGAGGTGTTC AGAAGAAAGA GAAAACTTCA CCTGGTGTTT 240

GAGTACTGCG ACCACACTGT CCTGAATGAG CTGGACAGAT ACCCACGAGG TGTTCCAGAG 300

CATATGGTTA AAAGCATCAT CTGGCAAACA CTTCAGGCTG TGAACTTCTG CCACAAACAA 360

AATTGTATTC ACCGAGATGT GAAGCCTGAA AACATTCTCA TCACCAAACA TCAGGTCATC 420

AAACTCTGCG ACTTCGGCTT TGCCAGGATT CTTACGGGTC CGTGTGATTA TTACACAGAT 480

TATGTCGCGA CACGGTGGTA TCGAGCTCCA GAACTGTTAG TGGGAGACAC ACAGTACGGC 540

CCGCCGGTAG ACGTCTGGGC TGTAGGATGT GTTTTTGCGG AGCTACTCTC TGGCGCCCCC 600

TTGTGGCCGG GCAAATCTGA TGTAGACCAG CTGTATCTGA TCAGGAAAAC TCTGGGTGAG 660

TTGATTCCTC GACATCAACA GGTGTTCAGC ACCAACCAGT TCTTTAGCGG CGTTTGTGTG 720

CCTGAGCCAC AGGAGATGGA GCCTCTTGAA CTGAAGTATC CCAACTTGTC GTACCAGGCA 780

CTGAGCCTCA TGAAGGGTTG TCTGCGGATG GATCCGGCTG AGAGGTTGTC CTGTGAGCAG 840

TTACTGGAAC AGCCCTACTT TGACAGTCTG CGAGAGGAGA GCGAGAGTGT GACGCGTGAA 900

CTGGACCGCA AGAAACGCAC ACGGCAGCCA CGCAAACACC TGCCACCTGG GTATCTGCCT 960

CAGTTGGCTA GCAGCACCGT CTTTCCTGCA GTGGAGAACA GAAGAAACTA CAACAACCTG 1020

CGCAAATTCA ACTATCATCT TCCCAACATA TGA 1053

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         yek++k+GeGsyGvv+kcrnkdtgqivaikkf+esedd+ +kkialrei++lkqlkh+nl

Q: 4     YEKISKIGEGSYGVVFKCRNKDTGQIVAIKKFVESEDDPIIKKIALREIRMLKQLKHPNL  63

         9***********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnl+evfrrk+kl+lvfey+d+tvl+el+ryp+Gv+e++vk+i++q+l+a++fchk+n+i

Q: 64    VNLMEVFRRKRKLHLVFEYCDHTVLNELDRYPRGVPEHMVKSIIWQTLQAVNFCHKQNCI  123

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrd+kpenili+k++v+klcdfGfar+l++p d+ytdyvatrwyrapellvgdt+yG++v

Q: 124   HRDVKPENILITKHQVIKLCDFGFARILTGPCDYYTDYVATRWYRAPELLVGDTQYGPPV  183

         ************************************************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         dvwa+Gc++aell+G pl+pgksdvdqly+irktlGeliprhq++fs+n++f+Gv +pe+

Q: 184   DVWAVGCVFAELLSGAPLWPGKSDVDQLYLIRKTLGELIPRHQQVFSTNQFFSGVCVPEP  243

         ************************************************************

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         +++e+le kyp+l++ +l+l+k+cl++dpaerlsce+ll+++yf

Q: 244   QEMEPLELKYPNLSYQALSLMKGCLRMDPAERLSCEQLLEQPYF  287

         ******************************************98

Domain Sequence
(FASTA)

YEKISKIGEG SYGVVFKCRN KDTGQIVAIK KFVESEDDPI IKKIALREIR MLKQLKHPNL 60

VNLMEVFRRK RKLHLVFEYC DHTVLNELDR YPRGVPEHMV KSIIWQTLQA VNFCHKQNCI 120

HRDVKPENIL ITKHQVIKLC DFGFARILTG PCDYYTDYVA TRWYRAPELL VGDTQYGPPV 180

DVWAVGCVFA ELLSGAPLWP GKSDVDQLYL IRKTLGELIP RHQQVFSTNQ FFSGVCVPEP 240

QEMEPLELKY PNLSYQALSL MKGCLRMDPA ERLSCEQLLE QPYF 284

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013