EKS-DAR-00838

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00838

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	450.0	5.6E-135	60	322	263

Status

Unreviewed

Ensembl Protein

ENSDARP00000076409

UniProt Accession

Q90Y37;

Protein Name

Protein Synonyms/Alias

Rho coiled-coil associated kinase alpha; Rho-associated, coiled-coil containing protein kinase 2;

Gene Name

rock2a

Gene Synonyms/Alias

rock2a; rock2; DKEY-18J18.1-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000017500	ENSDARP00000076409	ENSDART00000081971
ENSDARG00000017500	ENSDARP00000122621	ENSDART00000133882

Organism

Danio rerio

Functional Description

Protein Length

1357

Protein Sequence
(FASTA)

MIKDPRSAIN LESLLDSMNA LVLDLDFPAL RKNKNIENFL NRYEKVMNHI RELQMRPEDF 60

DRVKVIGRGA FGEVQLVRHK ASQKVYAMKV LSKFEMIKRS DSAFFWEERD IMAFADSPWV 120

VQLCCAFQDD RSLYMVMEYM PGGDLVNLTS TYDVPEKWAK FYTAEVVLAL DAIHSMGFIH 180

RDVKPDNMLL DRYGHLKLAD FGTCMKMDGT GMVHCDTAVG TPDYISPEVL KSQGGDGYYG 240

RECDWWSVGV FIYEMLVGDT PFYADSLVGT YSKIMDHKNS LNFPDDVEIS QEGKNIICAF 300

LTDREVRLGR SGVEEIKRHP FFRNDQWTFS TIRETAAPVV PELSSDIDTS NFDEIEEDKG 360

EVETFPTPKA FVGNQLPFVG FTYFKENQLL NAVNSSAMKN DHPVSNREDN LALQKKLHCL 420

EEQLNNEMQA KDELEQKYRS NSNRLEKITK ELDEEMNSRK GLESTLRQLE REKALLQHKS 480

VESHRRAESE ADRKRCLENE VNSLRDQLDE MKKKNQNSHI SNEKNIHLQK QLDEANALLR 540

AESEVATRMR KTQTESSKQL QQLEAHVREL QDKCCMLENS KLTLERENIS LQAALDTEKR 600

EQTQGSETIS DLQARITGME DEVRQMRQAL SKAETEKRQL QEKLTDMEKE KSNNQIDMTY 660

KLKMLQQGLE QEEAAHKATK ARLADKNMIS ESIEGAKSEA VKELEQKLQE ERSSKQRVEN 720

RVLELEKKNS MLDCDYKQSL QKLEELRRHK ERLTEEVKNL NLKIEQEVQK RTLTQNDLKV 780

QNQQLSTLRT SEKQLKQEIN HILEIKRSLE KQNMELRKER QDSDGQMKEL QDQLEAEQYF 840

STLYKTQVRE LKEECEEKNK LYKDVQQNLQ ELQEERDSLA AQLEITLTKA DSEQLARSIA 900

EEQYSDLEKE KIMKELEIKE MMARHRQELA EKDTTISSLE EANRTLTSDV ANLANEKEEF 960

NNKLKEAEDY LQNLKNEEQS ITQVKLALEK QLQSERTLKT QAVNKLAEIM NRKEVRGGGS 1020

RRGNDTDVRR KEKENRKLQL ELRSEREKLN STIIKYQREI NDIQAQLLDE SQVRIELQMA 1080

LDSKDSDIEQ LRSLLNSLNV QSLDSASMSS GPDMDTDESL LEIRLEGWLS LPVRNNTKRF 1140

GWERKYVVVS SKKILFYNSE QDKEHSNPYM VLDIDKLFHV RSVTQTDVYR ADAKEIPRIF 1200

QILYANEGES KKEQELEPLP GDKSSYICHK GHEFIPTLYH FPTNCEACTK PLWNMFKPPP 1260

ALECRRCHIK CHKDHMDKKE EVIAPCRVDM STAKNLLLLA SSQEDQQKWV SRLMKKIPKK 1320

PPAPDAPHRS SPRVPVKVQS SQSMRRPSRQ IPAGKPS 1357

Nucleotide Sequence
(FASTA)

ATGATCAAAG ACCCGCGGTC TGCGATCAAC TTGGAAAGTT TGCTGGACTC CATGAATGCC 60

CTGGTTTTAG ATCTGGACTT TCCGGCCTTA CGTAAAAATA AAAACATCGA GAATTTCTTG 120

AACAGATATG AGAAAGTCAT GAACCATATA AGGGAGCTCC AGATGAGGCC AGAGGATTTT 180

GACAGAGTGA AGGTGATTGG TAGAGGAGCA TTCGGGGAAG TCCAGCTGGT TAGGCATAAG 240

GCCTCTCAGA AAGTGTACGC CATGAAGGTG CTCAGCAAGT TCGAAATGAT CAAACGCTCA 300

GATTCTGCCT TCTTCTGGGA GGAACGGGAC ATCATGGCGT TTGCAGACAG CCCATGGGTC 360

GTACAGCTGT GCTGTGCGTT CCAGGATGAC CGCTCTCTCT ACATGGTAAT GGAGTACATG 420

CCAGGTGGAG ATCTAGTCAA TCTCACCAGC ACATATGATG TCCCAGAGAA GTGGGCAAAG 480

TTTTACACAG CAGAGGTGGT GTTGGCTTTA GACGCTATTC ACTCCATGGG CTTCATTCAT 540

CGAGACGTCA AACCAGACAA CATGCTGCTG GACCGCTACG GACACCTCAA ACTGGCAGAC 600

TTCGGGACCT GCATGAAAAT GGATGGGACA GGGATGGTTC ATTGTGACAC CGCTGTAGGA 660

ACCCCAGACT ACATTTCGCC GGAGGTTTTG AAGTCTCAGG GAGGAGACGG ATACTATGGT 720

CGCGAGTGTG ACTGGTGGTC AGTGGGAGTG TTTATCTACG AGATGCTGGT TGGTGATACA 780

CCGTTCTACG CTGATTCTCT TGTGGGGACA TACAGCAAGA TTATGGACCA TAAGAACTCT 840

CTCAACTTCC CTGATGATGT TGAGATCTCT CAAGAAGGCA AAAACATTAT CTGTGCCTTC 900

CTTACTGACA GGGAGGTTCG CCTGGGTCGA AGTGGTGTAG AAGAAATTAA AAGACATCCT 960

TTCTTTAGAA ATGACCAGTG GACCTTCAGC ACTATTAGAG AGACTGCAGC TCCTGTGGTT 1020

CCAGAGCTGA GCAGTGACAT AGACACCAGT AATTTTGATG AAATTGAGGA GGATAAAGGA 1080

GAAGTGGAGA CCTTTCCCAC ACCTAAAGCC TTTGTTGGGA ATCAGCTGCC CTTTGTGGGA 1140

TTCACCTACT TCAAAGAGAA CCAGTTGTTG AATGCTGTGA ACAGTTCAGC AATGAAAAAT 1200

GACCACCCAG TATCTAACAG AGAGGACAAT TTAGCCCTCC AGAAGAAGCT TCACTGTCTA 1260

GAAGAGCAGC TCAACAATGA AATGCAGGCC AAAGATGAGT TGGAGCAGAA ATACAGAAGC 1320

AACAGTAACC GCCTGGAAAA GATCACCAAA GAGCTCGATG AAGAGATGAA TAGCAGGAAA 1380

GGTCTGGAGT CGACCCTGAG ACAGCTGGAG AGAGAGAAGG CTCTGCTGCA GCACAAGAGT 1440

GTGGAGAGTC ACCGCAGGGC CGAGAGCGAG GCCGACCGCA AACGCTGCCT GGAGAATGAA 1500

GTCAATAGTC TGAGGGATCA GCTGGATGAA ATGAAGAAGA AGAACCAGAA CTCGCACATC 1560

TCCAACGAGA AGAACATCCA CCTGCAGAAA CAGCTGGATG AGGCTAATGC TTTACTGCGG 1620

GCAGAATCTG AGGTGGCCAC ACGGATGCGT AAAACTCAGA CGGAGAGCTC CAAACAGCTG 1680

CAGCAGCTGG AGGCGCATGT AAGAGAACTG CAGGACAAAT GCTGCATGCT GGAGAACAGT 1740

AAGCTCACGC TGGAGAGGGA GAACATCAGC CTGCAGGCCG CACTGGACAC AGAGAAACGA 1800

GAGCAGACAC AGGGATCCGA GACCATCTCT GATCTACAGG CACGAATCAC TGGTATGGAG 1860

GATGAGGTGA GGCAAATGAG GCAGGCCCTA TCTAAGGCTG AGACGGAAAA AAGGCAACTT 1920

CAGGAGAAGC TCACAGATAT GGAGAAGGAG AAGAGCAATA ACCAAATTGA CATGACCTAT 1980

AAGCTGAAGA TGTTGCAGCA GGGTTTGGAG CAGGAGGAGG CAGCACACAA GGCCACTAAA 2040

GCTCGACTCG CTGACAAAAA CATGATCAGC GAGTCCATCG AAGGAGCCAA ATCTGAAGCT 2100

GTAAAGGAGC TGGAGCAAAA GCTGCAGGAG GAACGTTCCT CTAAACAGCG TGTGGAGAAC 2160

AGGGTGTTAG AACTGGAGAA GAAGAACTCC ATGCTCGACT GTGACTATAA ACAATCGCTC 2220

CAAAAACTAG AGGAACTGCG GCGACACAAG GAGAGACTCA CAGAAGAGGT GAAGAATCTG 2280

AACCTGAAGA TTGAACAAGA GGTTCAGAAA CGCACTTTGA CTCAGAATGA CCTGAAGGTT 2340

CAGAACCAGC AGCTCAGCAC CCTGAGAACA TCAGAGAAAC AGCTCAAACA GGAGATCAAC 2400

CACATTCTAG AAATTAAACG CAGCCTGGAA AAACAAAACA TGGAACTGCG CAAGGAACGT 2460

CAGGATTCTG ATGGGCAGAT GAAGGAACTG CAGGATCAGT TGGAAGCAGA GCAGTATTTC 2520

TCTACGCTGT ATAAGACACA AGTGCGAGAG CTGAAGGAGG AGTGTGAGGA GAAAAATAAA 2580

CTTTATAAAG ACGTGCAGCA GAATCTACAG GAGCTGCAGG AGGAAAGGGA TTCACTTGCG 2640

GCCCAGTTGG AGATCACACT AACCAAAGCA GACTCTGAGC AGCTGGCACG CTCTATTGCG 2700

GAGGAGCAGT ATTCAGACCT AGAGAAAGAG AAGATCATGA AGGAGCTGGA GATCAAGGAG 2760

ATGATGGCCA GACACCGACA GGAGCTCGCT GAGAAAGACA CCACCATCAG CTCCTTAGAG 2820

GAAGCCAATC GCACATTGAC CAGTGATGTG GCAAACCTGG CCAATGAGAA GGAAGAATTC 2880

AACAACAAGC TGAAGGAGGC AGAGGACTAC CTGCAGAATC TGAAGAATGA AGAGCAATCC 2940

ATCACTCAGG TCAAGCTAGC GCTGGAGAAA CAACTGCAGT CAGAGAGAAC CCTCAAAACA 3000

CAGGCGGTGA ACAAGCTGGC AGAGATCATG AACAGAAAGG AGGTCAGAGG TGGTGGCAGC 3060

CGCCGTGGAA ATGATACAGA CGTGAGGAGG AAGGAGAAAG AAAACAGGAA GCTGCAGCTG 3120

GAGCTTCGTT CAGAAAGAGA GAAGCTCAAC AGCACAATCA TCAAATACCA GAGAGAGATC 3180

AACGACATAC AAGCGCAACT GTTGGATGAG TCTCAGGTGC GCATTGAGCT TCAGATGGCT 3240

CTGGACAGTA AAGACAGTGA TATTGAGCAG CTGCGGAGTC TGCTGAACTC ACTCAACGTT 3300

CAGTCGCTGG ACTCGGCCAG TATGAGCAGC GGTCCAGACA TGGACACAGA TGAGTCTTTG 3360

CTTGAGATCA GATTGGAGGG TTGGCTGTCT TTACCTGTCA GAAACAACAC CAAACGCTTT 3420

GGATGGGAAA GAAAGTATGT TGTGGTGAGC AGCAAGAAGA TCCTCTTTTA CAACAGCGAA 3480

CAGGACAAAG AGCACTCCAA CCCGTACATG GTGTTGGACA TAGATAAACT TTTCCATGTG 3540

CGCTCTGTAA CCCAGACGGA TGTTTATCGC GCTGACGCCA AAGAAATCCC CAGAATATTC 3600

CAGATTTTGT ATGCTAACGA GGGCGAGAGC AAGAAAGAGC AGGAACTGGA GCCTCTTCCA 3660

GGTGACAAGT CAAGCTACAT TTGCCATAAG GGTCACGAGT TCATCCCCAC CCTCTATCAC 3720

TTCCCCACCA ACTGTGAAGC CTGTACCAAA CCCCTGTGGA ACATGTTTAA GCCACCGCCT 3780

GCCCTCGAAT GCAGACGATG CCACATCAAG TGCCACAAAG ACCACATGGA TAAGAAGGAG 3840

GAAGTCATCG CGCCCTGCAG AGTCGACATG TCTACAGCTA AGAATCTGCT GCTGTTAGCT 3900

TCGTCTCAGG AGGACCAGCA GAAGTGGGTT AGCCGTCTAA TGAAGAAAAT CCCCAAAAAA 3960

CCTCCAGCCC CAGACGCCCC TCACCGCTCC TCTCCTAGAG TCCCTGTCAA AGTACAAAGC 4020

AGTCAATCCA TGAGGAGACC CAGTCGGCAG ATACCCGCCG GCAAACCCAG TTAA 4074

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         f+ +kviGrGafgev++vr+ka++kvyamk+l+k+e++kr++saff+eerd++++ads+w

Q: 60    FDRVKVIGRGAFGEVQLVRHKASQKVYAMKVLSKFEMIKRSDSAFFWEERDIMAFADSPW  119

         6789********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         +vql +afqd++ ly+vmey++GGdl++l s y+  +pe++a+fy+ae+vlald++h++g

Q: 120   VVQLCCAFQDDRSLYMVMEYMPGGDLVNLTSTYD--VPEKWAKFYTAEVVLALDAIHSMG  177

         **********************************..9***********************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         ++hrd+kpdn+lld+ Gh+kladfG+c+k++ +g+v++++avGtpdyispevlk+++ g+

Q: 178   FIHRDVKPDNMLLDRYGHLKLADFGTCMKMDGTGMVHCDTAVGTPDYISPEVLKSQG-GD  236

         ********************************************************9.**

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240

         g+yg+ecdwws+Gv++ye+lvg+tpfya+slv tyski++hk+sl+fp+d+++s+e k++

Q: 237   GYYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDHKNSLNFPDDVEISQEGKNI  296

         ************************************************************

S: 241   ikklltsreerlgregiedlkkhpff  266

         i+++lt+re rlgr+g+e++k+hpff

Q: 297   ICAFLTDREVRLGRSGVEEIKRHPFF  322

         *************************9

Domain Sequence
(FASTA)

FDRVKVIGRG AFGEVQLVRH KASQKVYAMK VLSKFEMIKR SDSAFFWEER DIMAFADSPW 60

VVQLCCAFQD DRSLYMVMEY MPGGDLVNLT STYDVPEKWA KFYTAEVVLA LDAIHSMGFI 120

HRDVKPDNML LDRYGHLKLA DFGTCMKMDG TGMVHCDTAV GTPDYISPEV LKSQGGDGYY 180

GRECDWWSVG VFIYEMLVGD TPFYADSLVG TYSKIMDHKN SLNFPDDVEI SQEGKNIICA 240

FLTDREVRLG RSGVEEIKRH PFF 263

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005886	; C:plasma membrane
GO:0005773	; C:vacuole
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000910	; P:cytokinesis
GO:0035556	; P:intracellular signal transduction
GO:0048333	; P:mesodermal cell differentiation
GO:0060775	; P:planar cell polarity pathway involved in gastrula mediolateral intercalation
GO:0007039	; P:vacuolar protein catabolic process

KEGG

dre:317747

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020684	; Rho-assoc_coiled-coil_kin.
IPR015008	; Rho-bd.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02185	; HR1; 1.
PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF08912	; Rho_Binding; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013