EKS-DAR-00357
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00357
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec410.25.8E-123365609245
StatusUnreviewed
Ensembl ProteinENSDARP00000022015
UniProt AccessionF1R3M1;
Protein Name
Protein Synonyms/Alias
Gene Nameitk
Gene Synonyms/Alias itk;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000017565ENSDARP00000022015ENSDART00000003993
OrganismDanio rerio
Functional Description
Protein Length616
Protein Sequence
(FASTA)
MYPRVILKET LYKKSQQKRR TSPCNYKERT FILNTQDLAY FEQRPGKKPT QKGCIELSHI 60
KCVEIVRSDV PIPCDYKYPF QIIHDSYYLY VFAPDNDCRL KWVKALKEAI QNNSLFLKYH 120
PDFWGEGKWR CCQQTEKLAT GCSEYYPNGA KPLPPTPDPS RRSSEPEERI VVALRNFTPK 180
EHTDLPLQKD EEYFIVDCSE PNWWTVKDKD GNVGSVPCIY VTEKLSNNIE KFEWYNKDIN 240
RTEAEDLLMQ ENKDGGFMVR NSKHAGVYTV SIFTRVSGSN GEKCPQVKHY QIKVQSEGEK 300
VLYYLAEKYL FPTIPELIRY HQHNPAGLIT RLRHCVSRNV PNSARIKELS SDKWEIHPDE 360
VKLSVELGSG QFGLVWKGSW QDMEVAVKTV REGFMSEEEF KEEAQVMMKL SHNRLVQLYG 420
VVTQRSPIYL VFEFMENGCL TEFLRAKKGK LSQKALLEMC LDVSEGMAYL ESSNFIHRDL 480
AARNCLVSEN SVVKIADFGM TRFVLDDQYT SSHGSKFPVR WSSPEVIKFG KYSSKSDVWS 540
FGVFMWEVYS EGRTPYDNRS NSEVVETLNA GHRLLKPRLC PQSVYELMQW SWKEKPEDRP 600
SFALLLHELA CLDQEP 616
Nucleotide Sequence
(FASTA)
ATGTACCCAA GGGTCATCCT AAAGGAGACG CTGTACAAGA AGTCACAGCA GAAGAGAAGA 60
ACATCACCGT GCAATTACAA AGAGAGGACA TTCATATTAA ACACACAGGA CCTGGCTTAC 120
TTTGAACAGC GTCCCGGGAA AAAGCCAACT CAAAAAGGCT GCATCGAGCT TTCTCATATA 180
AAGTGTGTGG AGATTGTGCG TAGTGATGTT CCCATTCCCT GTGATTACAA GTATCCTTTC 240
CAGATCATCC ATGACAGCTA CTATCTGTAT GTGTTTGCTC CAGACAACGA CTGCAGGTTA 300
AAATGGGTCA AAGCTTTAAA AGAAGCCATA CAAAATAACA GCTTATTCCT GAAATACCAT 360
CCTGACTTCT GGGGAGAAGG AAAATGGAGA TGTTGTCAGC AGACGGAGAA GCTGGCGACG 420
GGATGCAGTG AATACTATCC CAATGGAGCC AAACCTCTTC CGCCAACGCC GGATCCATCG 480
CGCCGATCCT CAGAGCCAGA GGAGAGGATT GTTGTGGCTT TGAGGAATTT CACCCCTAAA 540
GAACACACAG ATCTGCCCCT GCAAAAAGAT GAAGAGTATT TTATTGTTGA TTGTTCCGAA 600
CCCAACTGGT GGACCGTGAA AGACAAAGAC GGAAATGTTG GTTCAGTGCC ATGCATATAC 660
GTTACAGAAA AACTCTCAAA CAACATTGAG AAATTTGAAT GGTACAATAA GGACATAAAT 720
CGAACGGAGG CAGAGGACTT ACTAATGCAA GAGAACAAGG ACGGGGGTTT CATGGTCCGT 780
AATTCTAAGC ATGCAGGTGT TTACACCGTG TCCATATTCA CCAGAGTTTC AGGGTCTAAT 840
GGCGAGAAAT GTCCCCAAGT TAAGCACTAC CAGATCAAAG TACAGAGTGA AGGTGAAAAA 900
GTCTTGTATT ACTTAGCTGA GAAATATTTG TTCCCAACCA TTCCAGAGCT CATCCGCTAC 960
CACCAACACA ATCCGGCAGG TTTGATCACC AGACTGAGGC ACTGTGTGTC TAGAAATGTC 1020
CCAAACTCTG CAAGGATCAA GGAGTTATCA TCAGATAAGT GGGAGATTCA CCCTGATGAA 1080
GTGAAATTAA GTGTGGAACT GGGCAGTGGG CAGTTTGGCT TGGTGTGGAA GGGAAGTTGG 1140
CAAGACATGG AGGTGGCAGT TAAGACGGTT CGTGAGGGAT TTATGTCAGA GGAGGAATTC 1200
AAAGAAGAAG CACAAGTTAT GATGAAACTA TCCCACAATA GGCTGGTGCA GTTGTATGGT 1260
GTGGTCACTC AGCGTTCACC CATATACCTG GTATTCGAAT TCATGGAAAA CGGTTGCCTT 1320
ACGGAGTTCT TGCGGGCTAA AAAAGGCAAA CTTTCCCAAA AGGCTCTGCT GGAGATGTGT 1380
TTGGACGTAA GTGAAGGAAT GGCCTACCTT GAAAGCTCTA ACTTCATCCA CAGGGACTTG 1440
GCTGCGAGAA ACTGTTTGGT TTCTGAAAAT AGTGTGGTGA AGATAGCAGA TTTTGGAATG 1500
ACAAGGTTTG TCCTGGATGA CCAGTATACA AGTTCTCATG GATCCAAATT TCCAGTCAGG 1560
TGGTCTTCTC CAGAGGTGAT CAAATTTGGG AAGTACAGCA GCAAATCAGA TGTGTGGTCC 1620
TTTGGTGTGT TCATGTGGGA GGTGTACAGT GAGGGACGCA CACCCTATGA CAACCGTAGC 1680
AATTCAGAAG TAGTGGAGAC CCTAAATGCA GGGCATAGAC TCCTGAAACC ACGGCTCTGT 1740
CCTCAGAGTG TGTACGAGTT AATGCAGTGG AGCTGGAAAG AGAAACCTGA GGATCGACCC 1800
TCATTTGCGC TTCTCCTGCA TGAACTGGCC TGCCTTGATC AAGAACCTTG A 1851
Domain Profile
S: 5     kelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqlygvcl  64
          elgsgqfg+v +g w+  ++va+k+++eg msee+f eea+vmmklsh++lvqlygv +
Q: 365   VELGSGQFGLVWKGSWQD-MEVAVKTVREGFMSEEEFKEEAQVMMKLSHNRLVQLYGVVT  423
         69**************85.89***************************************
S: 65    kqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrdlaar  124
         ++ piy+v+e++engcl ++lr kk+kl+++ llemc dv+egm+yle+++fihrdlaar
Q: 424   QRSPIYLVFEFMENGCLTEFLRAKKGKLSQKALLEMCLDVSEGMAYLESSNFIHRDLAAR  483
         ************************************************************
S: 125   nclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvwafgv  184
         nclv+e++vvk++dfg++r+vlddqy+ss g+kfpv+ws+pev+++ kyssksdvw+fgv
Q: 484   NCLVSENSVVKIADFGMTRFVLDDQYTSSHGSKFPVRWSSPEVIKFGKYSSKSDVWSFGV  543
         ************************************************************
S: 185   lmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeerptfk  244
         +mwev+seg+ py+++snsevve+++ g+rl +p+l++++vye+m+  wkekpe+rp+f+
Q: 544   FMWEVYSEGRTPYDNRSNSEVVETLNAGHRLLKPRLCPQSVYELMQWSWKEKPEDRPSFA  603
         ************************************************************
S: 245   ellsal  250
          ll++l
Q: 604   LLLHEL  609
         **9987
Domain Sequence
(FASTA)
VELGSGQFGL VWKGSWQDME VAVKTVREGF MSEEEFKEEA QVMMKLSHNR LVQLYGVVTQ 60
RSPIYLVFEF MENGCLTEFL RAKKGKLSQK ALLEMCLDVS EGMAYLESSN FIHRDLAARN 120
CLVSENSVVK IADFGMTRFV LDDQYTSSHG SKFPVRWSSP EVIKFGKYSS KSDVWSFGVF 180
MWEVYSEGRT PYDNRSNSEV VETLNAGHRL LKPRLCPQSV YELMQWSWKE KPEDRPSFAL 240
LLHEL 245
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00101
EKS-ANC-00099
EKS-BOT-00110
EKS-CAJ-00111
EKS-CAF-00112
EKS-CAP-00105
EKS-EQC-00108
EKS-FEC-00105
EKS-GAG-00090
EKS-GAA-00128
EKS-GOG-00111
EKS-HOS-00113
EKS-ICT-00105
EKS-LAC-00114
EKS-LOA-00106
EKS-MAM-00105
EKS-MEG-00085
EKS-MOD-00106
EKS-MUM-00112
EKS-MUP-00113
EKS-MYL-00124
EKS-NOL-00103
EKS-OCP-00072
EKS-ORN-00134
EKS-ORA-00089
EKS-ORC-00102
EKS-ORL-00125
EKS-OTG-00112
EKS-PAT-00100
EKS-PES-00093
EKS-POA-00103
EKS-RAN-00108
EKS-SAH-00102
EKS-TAG-00138
EKS-TAR-00137
EKS-TEN-00127
EKS-XET-00091
EKS-XIM-00131
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00402; TECBTKDOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013