EKS-DAR-00329

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00329

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/GSK	449.4	1.0E-134	56	340	285

Status

Unreviewed

Ensembl Protein

ENSDARP00000027785

UniProt Accession

Q9YH60;

Protein Name

Protein Synonyms/Alias

Glycogen synthase kinase 3; Glycogen synthase kinase 3 beta;

Gene Name

gsk3b

Gene Synonyms/Alias

gsk3b; GSK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000017803	ENSDARP00000027785	ENSDART00000018228

Organism

Danio rerio

Functional Description

Protein Length

421

Protein Sequence
(FASTA)

MSGRPRTTSF AESCKPVPQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK 60

VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG 120

DKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPMVYVKL YMYQLFRSLA YIHSFGICHR 180

DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV 240

WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP 300

WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELREPNVKL PNGREKPSLF 360

NFTTQELSSN PTLASILIPA HARNQAGAST PTNPSATSDA NSGDRSQTTT AASASASNTS 420

T 421

Nucleotide Sequence
(FASTA)

ATGTCCGGTC GGCCCAGAAC CACCTCCTTC GCAGAAAGCT GCAAGCCAGT GCCGCAGCCG 60

TCGGCATTCG GCAGCATGAA AGTCAGCAGA GATAAAGATG GCAGTAAAGT GACCACAGTG 120

GTGGCGACTC CTGGACAGGG ACCTGACCGG CCGCAGGAGG TCAGCTACAC TGACACCAAG 180

GTCATCGGTA ACGGCTCTTT TGGCGTGGTC TATCAGGCCA AACTCTGTGA CTCAGGAGAA 240

CTGGTGGCCA TTAAGAAGGT TCTTCAGGAC AAGCGATTTA AGAACCGTGA GCTTCAGATC 300

ATGAGGAAAT TAGACCACTG CAACATTGTT CGTCTGCGTT ACTTCTTCTA CTCCAGTGGA 360

GATAAGAAAG ATGAGGTGTA TCTGAATTTG GTTCTGGATT ATGTTCCTGA AACCGTGTAC 420

AGAGTGGCAA GACACTACAG CCGCGCTAAA CAGACTCTTC CCATGGTTTA TGTGAAGTTG 480

TACATGTACC AGCTCTTCAG GAGTCTGGCC TACATCCATT CCTTTGGGAT CTGCCATCGG 540

GACATAAAAC CGCAAAATCT CTTGCTGGAC CCAGACACAG CCGTGCTCAA ACTCTGTGAC 600

TTTGGCAGCG CTAAGCAGTT AGTACGTGGA GAGCCCAATG TGTCCTACAT CTGCTCACGG 660

TACTACAGAG CTCCCGAACT CATCTTTGGA GCCACCGACT ACACCTCCAG CATAGATGTG 720

TGGTCTGCTG GCTGTGTGCT GGCTGAACTG CTGCTCGGAC AGCCCATTTT CCCAGGTGAC 780

AGCGGCGTGG ATCAGCTGGT GGAGATCATC AAGGTGTTGG GAACTCCCAC ACGAGAGCAG 840

ATTCGGGAAA TGAACCCAAA CTACACCGAG TTCAAATTCC CGCAGATTAA GGCCCATCCA 900

TGGACTAAGG TGTTTCGGCC ACGCACTCCC CCTGAAGCCA TTGCCTTGTG CTCCCGGCTG 960

CTGGAATACA CACCGACCGC TCGACTGACT CCTCTCGAGG CCTGCGCTCA TTCCTTCTTC 1020

GATGAACTGC GGGAACCAAA TGTCAAACTT CCAAATGGAC GCGAGAAGCC TTCCTTATTC 1080

AACTTCACAA CTCAAGAGCT GTCCAGTAAC CCTACCCTGG CCTCCATCTT AATCCCCGCT 1140

CATGCACGTA ACCAGGCAGG AGCTTCAACT CCCACCAACC CCTCTGCCAC TTCAGATGCC 1200

AACAGTGGAG ATCGCAGCCA GACGACAACT GCAGCCTCCG CCTCCGCCTC TAACACCTCA 1260

ACCTGA 1266

Domain Profile

S: 1     leelkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHknivrLly  60

         ++++k+ig+GsFg+Vyqa+l+++ e  vaiKkvlqdk++kn+El+i+rkl+H+nivrL+y

Q: 56    YTDTKVIGNGSFGVVYQAKLCDSGEL-VAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRY  114

         5789**********************.*********************************

S: 61    ffsksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylhs  120

         ff++s +kkd+vylnlvl+y+Pet+++v+r+++++k++l++++vkly+yQlfr+lay+hs

Q: 115   FFYSSGDKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPMVYVKLYMYQLFRSLAYIHS  174

         ************************************************************

S: 121   leivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgakey  180

         ++i+HrDiKPqNll+d++t+vlKlcDfGsak+l+++epnvsYi+sRyYRaPEL++ga++y

Q: 175   FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY  234

         ************************************************************

S: 181   ttkiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkfk  240

         t++iDvWsagcvlaEll+g+++f+g+s++dql++i+kvlGtpt+e+i+emn++y+e+kf+

Q: 235   TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFP  294

         ************************************************************

S: 241   kikkvslakvlkkkedkeavdllkkilkyepkkRlsalellahpff  286

         +ik+++++kv++ ++++ea++l++++l+y+p++Rl++le++ah+ff

Q: 295   QIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF  340

         *********************************************9

Domain Sequence
(FASTA)

YTDTKVIGNG SFGVVYQAKL CDSGELVAIK KVLQDKRFKN RELQIMRKLD HCNIVRLRYF 60

FYSSGDKKDE VYLNLVLDYV PETVYRVARH YSRAKQTLPM VYVKLYMYQL FRSLAYIHSF 120

GICHRDIKPQ NLLLDPDTAV LKLCDFGSAK QLVRGEPNVS YICSRYYRAP ELIFGATDYT 180

SSIDVWSAGC VLAELLLGQP IFPGDSGVDQ LVEIIKVLGT PTREQIREMN PNYTEFKFPQ 240

IKAHPWTKVF RPRTPPEAIA LCSRLLEYTP TARLTPLEAC AHSFF 285

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0003146	; P:heart jogging
GO:0001947	; P:heart looping

KEGG

dre:30654

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013