EKS-DAR-00683

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00683

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	324.5	1.0E-96	397	645	249

Status

Unreviewed

Ensembl Protein

ENSDARP00000020114

UniProt Accession

F1QZR2;

Protein Name

Protein Synonyms/Alias

Gene Name

pak4

Gene Synonyms/Alias

pak4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000018110	ENSDARP00000020114	ENSDART00000009545

Organism

Danio rerio

Functional Description

Protein Length

664

Protein Sequence
(FASTA)

MFSKKKKQRI QISAPSNFEH RVHTDFDEQE QKFVGLPRQW QSLIEDTAKR PKPFIDATVI 60

TTVEPRKTIV RGRKIGDDGS LTWLLDEFET MSVIRSNSLR RGSPPLQPRS DSGSSGGHEN 120

GEHPQYRHTD RYGDSKEREK PRQEHPGTDP RQSQRPGRSS REDGRPQQQP RGQEPSRHKE 180

PDWITPGQHR EREWDREREP RDYSDHVVRR EGANDKRPKS SYTGRDSSPQ SPREKRPLSG 240

PNIRTPNLPV TEGVIKAAQQ TGRPFNTYPR SESDSGRTPS GQDLKPAKSH ESTHHNGPSA 300

GPVRGGSSSS SSGGGQTSSQ GPHRSEPQHH ASHPALGPEP PHGQPMPPPP KPSGPAAPSQ 360

PTRSPQREPQ RVSHEQFRAA LQMVVDPGDP RTYLDHYIKI GEGSTGIVCI ATVKTTGKLV 420

AVKKMDLRKQ QRRELLFNEV VIMRDYHHEN VVEMYNSYLV GDELWVVMEF LEGGALTDIV 480

THTRMNEEQI STVCLSVLKA LSVLHSQGVI HRDIKSDSIL LTHDGRVKLS DFGFCAQVSK 540

EVQRRKSLVG TPYWMAPELI SRLPYGPEVD IWSFGIMVIE MVDGEPPYFN EPPLKAMKMI 600

RDNLPPKLKN LHKVSPLLKG FLDRMLVRDP AQRATAQELL KHPFLTKAGP PSCIVPLMRQ 660

NRMR 664

Nucleotide Sequence
(FASTA)

ATGTTCAGCA AGAAGAAAAA GCAACGCATC CAGATCTCAG CACCTTCGAA CTTTGAGCAT 60

CGTGTCCACA CTGATTTTGA TGAACAGGAG CAGAAGTTTG TTGGCCTTCC ACGCCAATGG 120

CAGAGCCTCA TTGAAGACAC GGCCAAGAGG CCCAAACCCT TCATCGATGC CACAGTCATC 180

ACTACTGTTG AGCCACGCAA GACAATTGTC CGAGGTCGTA AGATCGGTGA CGATGGCTCC 240

CTCACCTGGC TCCTGGATGA GTTTGAAACC ATGTCGGTGA TCCGCTCCAA CTCCCTGCGG 300

AGAGGCAGTC CACCTTTACA ACCACGCAGT GACTCTGGAT CATCAGGAGG CCATGAGAAC 360

GGCGAACACC CCCAATATAG ACACACTGAT CGCTATGGGG ACAGCAAAGA GAGGGAGAAA 420

CCACGTCAGG AGCACCCAGG CACTGATCCT AGACAGTCTC AACGTCCGGG CCGTTCGTCC 480

AGAGAGGATG GCCGGCCTCA GCAGCAGCCT CGTGGTCAGG AGCCCAGCAG ACACAAAGAA 540

CCTGACTGGA TTACACCGGG CCAACACCGA GAACGAGAAT GGGACAGAGA ACGAGAACCA 600

CGTGATTATT CTGACCACGT AGTAAGGAGA GAGGGGGCCA ACGATAAGAG GCCCAAATCC 660

AGCTATACTG GGAGGGATAG CAGCCCACAG TCGCCTCGTG AGAAGAGACC ACTGTCAGGG 720

CCAAACATCC GCACTCCTAA CCTACCTGTT ACAGAGGGAG TGATAAAGGC AGCACAGCAG 780

ACTGGCCGAC CTTTCAACAC ATACCCACGC TCTGAAAGTG ACTCTGGGAG AACCCCCAGC 840

GGTCAGGATT TAAAGCCAGC TAAATCTCAC GAGTCTACCC ACCACAATGG CCCCTCTGCT 900

GGCCCAGTCC GGGGTGGCAG TAGCAGCAGC AGCAGCGGTG GTGGTCAAAC TTCTTCTCAG 960

GGGCCTCACA GATCAGAGCC TCAGCATCAC GCCTCTCATC CAGCCTTGGG GCCTGAGCCT 1020

CCTCACGGCC AGCCCATGCC TCCTCCACCA AAACCATCTG GCCCGGCTGC ACCATCCCAG 1080

CCGACACGCT CACCTCAGCG AGAGCCACAG CGGGTCTCAC ACGAGCAGTT CAGAGCTGCC 1140

CTGCAGATGG TAGTTGATCC TGGCGACCCG CGTACTTATC TGGATCACTA CATTAAGATC 1200

GGAGAAGGCT CCACGGGCAT TGTGTGCATA GCTACTGTGA AGACCACAGG CAAACTGGTG 1260

GCGGTGAAGA AGATGGACCT GCGAAAACAG CAGCGACGAG AACTGCTGTT CAATGAGGTG 1320

GTGATCATGC GGGACTATCA CCATGAGAAC GTGGTGGAGA TGTACAACAG TTACTTGGTG 1380

GGGGATGAAC TCTGGGTTGT CATGGAGTTT CTGGAGGGCG GCGCTTTGAC TGATATAGTC 1440

ACACATACAA GGATGAACGA GGAGCAGATC TCCACCGTGT GTCTGTCAGT GCTAAAAGCT 1500

CTCTCAGTCC TTCACTCTCA GGGAGTCATT CATAGAGACA TCAAGAGTGA CTCCATTCTT 1560

CTCACCCATG ATGGCCGTGT GAAGCTGTCA GACTTTGGTT TTTGCGCCCA GGTCTCTAAA 1620

GAGGTGCAGC GCAGAAAGTC TCTGGTAGGA ACGCCCTACT GGATGGCCCC TGAGCTCATC 1680

TCAAGACTCC CATATGGACC AGAGGTGGAC ATTTGGTCAT TTGGCATTAT GGTCATCGAA 1740

ATGGTGGATG GAGAGCCGCC GTACTTCAAC GAGCCACCGC TCAAGGCTAT GAAGATGATC 1800

CGAGACAATT TGCCACCCAA GCTCAAAAAT CTCCACAAGG TATCGCCTCT TCTCAAGGGA 1860

TTCTTGGACA GGATGCTGGT GCGAGATCCT GCCCAGAGAG CCACAGCTCA AGAGCTGCTA 1920

AAACATCCCT TCCTGACTAA AGCAGGCCCT CCCTCCTGCA TTGTTCCTCT CATGAGACAA 1980

AACCGCATGA GATGA 1995

Domain Profile

S: 4     leeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyle  63

         + +ig+G++g v++a+ k+tg+lva+kk++l+kq++ e+l++e+ ++++++h+n+ve+++

Q: 397   YIKIGEGSTGIVCIATVKTTGKLVAVKKMDLRKQQRRELLFNEVVIMRDYHHENVVEMYN  456

         568*********************************************************

S: 64    sflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrd  123

         s+l+ +elw+vme+l+gG+l+d+v+   +++++Eeqi++++ +vlkaL+ lHs++viHrd

Q: 457   SYLVGDELWVVMEFLEGGALTDIVT---HTRMNEEQISTVCLSVLKALSVLHSQGVIHRD  513

         *************************...9*******************************

S: 124   ikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDi  183

         ik+++iLlt++g+VkLsdfg++aq++k++++rk++vgtpywmAPE+i+  +  Y  ++Di

Q: 514   IKSDSILLTHDGRVKLSDFGFCAQVSKEVQRRKSLVGTPYWMAPELIS--RLPYGPEVDI  571

         ************************************************..9*********

S: 184   wslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpe  243

         ws+GI++ie+++gepP+++++plka+ +i +n ppklk+ +k+s+ +k f++++l ++p+

Q: 572   WSFGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPKLKNLHKVSPLLKGFLDRMLVRDPA  631

         ************************************************************

S: 244   kRpsasellkhkFl  257

         +R++a+ellkh+Fl

Q: 632   QRATAQELLKHPFL  645

         *************7

Domain Sequence
(FASTA)

YIKIGEGSTG IVCIATVKTT GKLVAVKKMD LRKQQRRELL FNEVVIMRDY HHENVVEMYN 60

SYLVGDELWV VMEFLEGGAL TDIVTHTRMN EEQISTVCLS VLKALSVLHS QGVIHRDIKS 120

DSILLTHDGR VKLSDFGFCA QVSKEVQRRK SLVGTPYWMA PELISRLPYG PEVDIWSFGI 180

MVIEMVDGEP PYFNEPPLKA MKMIRDNLPP KLKNLHKVSP LLKGFLDRML VRDPAQRATA 240

QELLKHPFL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013