EKS-DAR-00591

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00591

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PDK1	399.3	1.8E-119	60	320	261

Status

Unreviewed

Ensembl Protein

ENSDARP00000019085

UniProt Accession

Q6NZV1;

Protein Name

Protein Synonyms/Alias

Zgc:77318;

Gene Name

pdpk1b

Gene Synonyms/Alias

pdpk1b;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000018285	ENSDARP00000019085	ENSDART00000003789

Organism

Danio rerio

Functional Description

Protein Length

537

Protein Sequence
(FASTA)

MARATSQIYD VASLHSSVLI SCPSMVRGQQ DTPRLHGNSM EGPAPNAQPA QPRKKRPEDF 60

RFGKILGEGS FSTVVLAKEH TTGKEYAIKI LEKRHIMKEN KAQYVKRERD IMSHLDHPFF 120

VKLYFTFQDE EKLYFGLSYA KNGELLKYIR KIGSFDETCT RFYSAEIVCA LEYLHQKGII 180

HRDLKPENIL LSEEMHIQIT DFGTAKQLSS DSKQARANSF VGTAQYVSPE LLTEKSACKS 240

SDLWALGCII YQLVAGLPPF RAGNEYLIFQ KIIKLEYEFP EKFFPKAKDL VEQLLSLDSC 300

KRIGCDEMGG YGPLKSHPFF ESVGWDDLHL QTPPKLTAYL PAMSEDDEDC YGNYDDLLSQ 360

FSCMQVAQPG PAPLVPVTGE TSQPTYNPSP SVDQFIHIHE LDSNSMELDL QYSNEEKRIL 420

LDKQSAANPW HQFVENNLIL KMGPVDKRKG LFARRRQLLL TEGPHLYYVD PVNKVLKGEI 480

PWSPELRPEA KNFKTFFVHT PNRTYYLMDP SGNADKWCKK IQEVWRKIYH KHQSPSL 537

Nucleotide Sequence
(FASTA)

ATGGCAAGAG CCACGAGTCA GATTTATGAT GTTGCATCCC TCCACTCCTC TGTTCTCATC 60

TCCTGTCCAT CCATGGTAAG AGGCCAGCAG GACACGCCTC GTCTCCACGG CAACAGCATG 120

GAGGGACCGG CACCAAACGC CCAGCCCGCC CAGCCTCGCA AGAAGAGACC CGAGGACTTC 180

CGATTCGGCA AAATCCTGGG AGAAGGCTCT TTCTCTACTG TTGTCTTGGC AAAGGAACAC 240

ACGACGGGGA AGGAATATGC AATTAAGATC CTGGAGAAGC GCCACATAAT GAAGGAGAAT 300

AAAGCGCAGT ATGTCAAGAG AGAACGAGAC ATAATGTCAC ACCTGGATCA TCCGTTCTTC 360

GTCAAACTCT ACTTCACCTT TCAGGACGAG GAGAAGCTGT ATTTTGGATT AAGCTACGCT 420

AAAAATGGCG AATTGCTGAA ATACATTCGA AAAATCGGCT CATTTGATGA GACCTGCACA 480

CGCTTTTACT CTGCTGAGAT CGTTTGTGCT CTGGAGTACT TGCATCAGAA GGGCATCATC 540

CACAGAGACC TGAAGCCGGA GAATATTCTG CTCAGTGAGG AGATGCACAT TCAAATAACT 600

GATTTTGGCA CGGCTAAACA ACTGTCCTCC GACAGCAAAC AGGCAAGAGC AAACTCATTT 660

GTTGGTACGG CTCAGTACGT CTCTCCTGAA TTACTGACTG AGAAATCTGC CTGCAAGAGT 720

TCGGATCTCT GGGCATTAGG CTGCATCATC TACCAGCTTG TTGCTGGTTT GCCGCCATTC 780

AGAGCTGGGA ATGAGTATCT AATATTCCAG AAGATTATAA AACTCGAGTA TGAGTTTCCT 840

GAGAAATTCT TCCCCAAAGC TAAAGACCTC GTGGAGCAAC TTCTGTCACT GGATTCGTGC 900

AAGCGGATTG GCTGTGATGA AATGGGCGGC TACGGTCCGT TGAAGTCCCA CCCTTTCTTT 960

GAAAGCGTCG GCTGGGACGA TTTACATTTG CAGACTCCAC CCAAACTAAC GGCGTACCTT 1020

CCAGCAATGT CTGAGGATGA TGAGGACTGC TATGGAAATT ATGATGATCT CCTGAGCCAG 1080

TTCAGCTGTA TGCAGGTGGC CCAGCCTGGC CCCGCCCCTT TAGTTCCTGT TACTGGAGAG 1140

ACGAGTCAAC CTACATATAA CCCCTCCCCC AGTGTTGATC AGTTTATACA TATTCATGAG 1200

CTGGACAGTA ATAGCATGGA GCTCGACCTA CAGTACAGCA ACGAGGAGAA ACGCATCCTA 1260

CTGGACAAGC AGAGCGCTGC AAACCCATGG CACCAGTTTG TGGAGAATAA CCTCATCTTA 1320

AAAATGGGCC CTGTGGACAA ACGCAAAGGT CTGTTTGCAC GGAGGAGGCA GTTGCTGCTG 1380

ACTGAGGGTC CTCACTTGTA CTATGTGGAT CCGGTCAATA AAGTTCTGAA AGGGGAGATT 1440

CCTTGGTCAC CAGAACTACG GCCTGAAGCC AAGAACTTTA AAACCTTCTT TGTTCACACG 1500

CCAAACCGGA CGTACTATTT AATGGACCCA AGCGGAAACG CTGACAAATG GTGCAAGAAA 1560

ATCCAAGAAG TCTGGCGAAA GATCTACCAC AAACACCAGA GCCCCAGCCT ATAG 1614

Domain Profile

S: 1     fkfekelgeGsystvvlarekeskkeyaikvlekryiikekkvkyvtrekevlaklnehp  60

         f f+k+lgeGs+stvvla+e ++ keyaik+lekr+i+ke+k +yv+re++++++l +hp

Q: 60    FRFGKILGEGSFSTVVLAKEHTTGKEYAIKILEKRHIMKENKAQYVKRERDIMSHL-DHP  118

         789*****************************************************.9**

S: 61    givkLyatfqDeeslyfvleyakkGdllellkkvgsfdeactryyaaellsaleflhkkg  120

         ++vkLy+tfqDee+lyf l+yak+G+ll++++k+gsfde+ctr+y+ae++ ale+lh+kg

Q: 119   FFVKLYFTFQDEEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYSAEIVCALEYLHQKG  178

         ************************************************************

S: 121   iihrDlkpeniLldkdgkilitDfGsakvlepklkedskkeeeesarsksfvGtaeyvsP  180

         iihrDlkpeniLl ++++i+itDfG+ak l++++k+         ar++sfvGta+yvsP

Q: 179   IIHRDLKPENILLSEEMHIQITDFGTAKQLSSDSKQ---------ARANSFVGTAQYVSP  229

         ******************************777766.........9**************

S: 181   elLtdsevskssDlWalgcilyqllaGkpPfraeneylifkkilkleyafpegfpekakd  240

         elLt+++++kssDlWalgci+yql+aG+pPfra neylif+ki+kley+fpe+f++kakd

Q: 230   ELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYEFPEKFFPKAKD  289

         ************************************************************

S: 241   lveklLvkdakerltlee......ikahkff  265

         lve+lL  d  +r++++e      +k h+ff

Q: 290   LVEQLLSLDSCKRIGCDEmggygpLKSHPFF  320

         ******************************9

Domain Sequence
(FASTA)

FRFGKILGEG SFSTVVLAKE HTTGKEYAIK ILEKRHIMKE NKAQYVKRER DIMSHLDHPF 60

FVKLYFTFQD EEKLYFGLSY AKNGELLKYI RKIGSFDETC TRFYSAEIVC ALEYLHQKGI 120

IHRDLKPENI LLSEEMHIQI TDFGTAKQLS SDSKQARANS FVGTAQYVSP ELLTEKSACK 180

SSDLWALGCI IYQLVAGLPP FRAGNEYLIF QKIIKLEYEF PEKFFPKAKD LVEQLLSLDS 240

CKRIGCDEMG GYGPLKSHPF F 261

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

dre:403000

;

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013