EKS-DAR-00042

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00042

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	320.7	1.7E-95	821	1091	271

Status

Unreviewed

Ensembl Protein

ENSDARP00000028132

UniProt Accession

F1QPM9;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

jak2b

Gene Synonyms/Alias

jak2b;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000018882	ENSDARP00000028132	ENSDART00000016019
ENSDARG00000018882	ENSDARP00000105218	ENSDART00000122405

Organism

Danio rerio

Functional Description

Protein Length

1112

Protein Sequence
(FASTA)

MVTSTTRILV QSSPPFSRST CTIAAGAADS SPICYPPGEY ITEQLIIHAA KESGVSPVYC 60

SLFGLYKEDE AIWLSPNHVL HLDETANESL LFRIRYYFPG WYSCGTSRAY RYGVTKGSES 120

PVLDDYVMSY LFAQWRSDFV NGWVKLSGSH ENQEECLGMA VLDMMRTAKE KDCSPLDIYN 180

DISYKSFLPK DMRERIQDYH FVTRKRIRYR FRKVVQQLSQ CRATARDLKL KYLISLESLD 240

NGFFTERFQV KEPSTEQVTI VVSADRGIQW CHERHKDTQS EDLLQTYCDF AEVVDISIRQ 300

ASKDGTNMNR IVSINRQDGT PLELVFSTSM QALSFVSLID GYYRLTTDAH HYLCKDVAPP 360

YLLEAIESYC HGPISMDFAI SKLRKSGNQK GLFVLRCSPK DYNKYFLTLA FGGYGNVEYK 420

HCLITRSESG NYNLSGTKKS FRSLQDLLKC YQKETVKSDG IVFQFSKCCS PRPKEKSSLL 480

VCRSHRGLEV PLSSSLQRHN ISQMVFHKIK KEDLELGESQ GQGTFTKIFK GIRKEQGDYG 540

ETHKTEVIVK VLDKAHRNYS ESFFEAASMM SQLTHKHLVL TYGICVCGDE NIMVQEYVKF 600

GSLDTYLKKN KSSVSVNILW KLEVAKQLAW AMLYLEEKSL AHGNVCAKNI LLIREEDRAL 660

GNTPFIKLSD PGISITVLPR EILVERIPWV PPECILDPKN LSLATDKWSF GTTLWEICSG 720

GEQPLANMDN SKKHLFYENH HQLPAPKWTE LANLINSCMD YEPTFRPSFK AIIRDLNSLF 780

CPDYEIVKES DIMPSRAAAS IFNTGTFKNN EPVQFEERHL IFLQQLGKGN FGSVEMCRYD 840

PLQDNTGEVV AVKKLQHSTT EHIRDFEREI EILKSLQHEN IVKYKGVCYG AGRRNLRLVM 900

EYLPYGSLRD YLNKNRDRID HQKLVHYASQ ICKGMEYLAT KRYIHRDLAT RNILVESECR 960

VKIGDFGLTK VLPQDKEYYK VKEPGESPIF WYAPESLTES KFSVASDVWS FGVVLYELFT 1020

YSDKLCSPPT VFLSMVGGDK QGQTIVYHLI ELLKRGNRLP QPMGCPTEMF EIMQECWDND 1080

PSLRPNFKEL ALRVDLIRDS SDADRYTQVP EF 1112

Nucleotide Sequence
(FASTA)

ATGGTGACGT CCACCACGAG GATCCTTGTC CAAAGCAGCC CACCGTTCTC AAGATCCACC 60

TGTACCATAG CAGCCGGAGC GGCCGACTCC AGCCCGATCT GTTACCCGCC TGGAGAGTAC 120

ATCACAGAGC AGCTCATCAT CCACGCTGCC AAGGAGAGCG GAGTGTCACC AGTATACTGC 180

AGCCTCTTTG GGCTCTACAA AGAAGATGAA GCCATCTGGT TATCACCCAA TCACGTCCTC 240

CATTTAGATG AAACCGCCAA TGAGAGTTTG CTATTTAGAA TAAGGTACTA TTTTCCTGGC 300

TGGTACAGTT GCGGGACGTC CCGGGCGTAC CGCTATGGAG TGACTAAGGG ATCCGAGAGC 360

CCGGTCCTAG ACGACTATGT AATGTCTTAC CTCTTTGCTC AGTGGAGGAG TGACTTTGTC 420

AATGGCTGGG TGAAGTTGTC GGGAAGCCAC GAGAATCAGG AGGAGTGCCT TGGCATGGCT 480

GTGTTGGACA TGATGAGGAC TGCCAAAGAG AAAGATTGCT CGCCGCTGGA CATCTATAAT 540

GACATTAGTT ATAAATCATT CCTCCCGAAA GACATGAGGG AGCGAATCCA GGACTATCAT 600

TTTGTCACAA GAAAGCGCAT CCGCTATCGC TTCCGAAAAG TGGTGCAGCA GCTGAGCCAG 660

TGCCGGGCCA CTGCGCGAGA CCTAAAGCTC AAATACCTGA TCAGCCTGGA GTCTCTGGAC 720

AATGGTTTCT TCACCGAACG CTTCCAGGTC AAAGAGCCTT CGACCGAGCA GGTCACTATC 780

GTCGTCTCTG CAGATCGAGG CATTCAGTGG TGCCACGAGC GACATAAAGA CACACAGTCT 840

GAGGACCTGC TGCAGACGTA TTGTGATTTC GCGGAAGTTG TCGATATCAG TATCAGGCAA 900

GCCAGCAAAG ACGGTACCAA CATGAACCGC ATTGTCTCCA TCAACAGACA GGATGGAACA 960

CCTCTAGAGT TGGTGTTTTC CACCTCAATG CAGGCCTTGT CTTTTGTATC TCTAATTGAT 1020

GGTTACTACA GACTGACCAC AGATGCCCAT CACTACCTCT GTAAGGATGT CGCCCCGCCG 1080

TATCTGCTGG AAGCCATCGA GAGCTACTGC CACGGCCCGA TATCAATGGA TTTTGCGATC 1140

AGTAAACTAC GCAAGTCAGG GAACCAGAAA GGCCTCTTTG TGCTCCGATG CAGCCCTAAA 1200

GACTACAACA AATACTTTCT GACTCTTGCA TTCGGGGGGT ATGGAAATGT AGAGTACAAG 1260

CACTGTCTCA TTACCAGATC TGAAAGCGGC AACTACAATC TTAGTGGAAC CAAAAAAAGT 1320

TTTAGAAGCT TACAGGATCT GCTGAAGTGT TACCAGAAGG AAACAGTGAA ATCTGACGGT 1380

ATCGTCTTTC AGTTCAGCAA GTGCTGTTCA CCAAGGCCCA AAGAGAAGTC GAGTTTGCTG 1440

GTGTGCAGAA GTCATCGGGG TTTGGAGGTT CCTCTGTCCT CCTCACTGCA GAGACACAAC 1500

ATCAGCCAGA TGGTCTTTCA CAAAATCAAG AAAGAAGACC TCGAGCTTGG TGAAAGTCAA 1560

GGTCAGGGAA CTTTTACAAA GATCTTCAAA GGGATTCGGA AAGAGCAGGG AGACTATGGA 1620

GAAACCCATA AAACTGAAGT CATTGTCAAA GTCTTGGACA AAGCACACAG AAATTATTCT 1680

GAGTCTTTCT TCGAGGCGGC CAGCATGATG AGTCAGCTCA CTCACAAGCA TCTGGTGTTG 1740

ACCTACGGCA TCTGTGTGTG CGGAGACGAG AACATCATGG TGCAGGAATA TGTCAAGTTT 1800

GGCTCCTTGG ACACATATCT GAAGAAAAAC AAGAGCTCGG TATCAGTCAA TATCCTGTGG 1860

AAGCTGGAAG TGGCCAAGCA GCTCGCCTGG GCTATGCTCT ATTTGGAGGA GAAGAGTCTG 1920

GCTCATGGGA ACGTGTGCGC AAAAAACATC CTTTTGATCA GGGAGGAGGA CAGGGCGCTG 1980

GGAAACACGC CGTTCATTAA ACTGAGTGAC CCTGGCATCA GCATCACTGT GCTGCCCAGA 2040

GAGATTCTCG TAGAGCGAAT CCCCTGGGTG CCCCCTGAAT GCATATTAGA CCCCAAAAAC 2100

CTGAGTCTAG CCACTGACAA ATGGAGCTTT GGGACAACTT TATGGGAGAT TTGCAGCGGA 2160

GGAGAACAGC CACTTGCCAA CATGGACAAT TCCAAGAAAC ACTTATTTTA TGAAAACCAT 2220

CACCAACTAC CCGCCCCGAA GTGGACAGAG CTGGCTAACC TGATCAACAG CTGCATGGAC 2280

TACGAGCCGA CGTTCAGGCC ATCGTTCAAA GCCATCATTC GAGACCTAAA CAGTCTCTTC 2340

TGCCCTGATT ATGAGATCGT GAAGGAGAGC GACATCATGC CCAGCAGAGC AGCAGCGTCT 2400

ATATTCAACA CTGGAACATT TAAGAATAAT GAACCCGTGC AGTTTGAGGA GAGACATCTG 2460

ATTTTCCTGC AGCAGCTGGG CAAGGGTAAT TTTGGCAGTG TGGAAATGTG CAGGTACGAC 2520

CCTCTGCAGG ACAACACCGG CGAGGTGGTG GCGGTGAAAA AGCTTCAGCA CAGCACCACT 2580

GAGCACATTC GGGACTTTGA GCGGGAAATC GAGATCCTTA AATCCCTCCA GCATGAGAAC 2640

ATTGTGAAAT ATAAAGGCGT GTGCTACGGT GCAGGGAGGA GAAACCTACG GCTGGTTATG 2700

GAGTACCTGC CTTACGGAAG TCTACGGGAC TATCTCAACA AAAACAGAGA TCGGATTGAC 2760

CACCAGAAAC TTGTCCATTA TGCATCTCAG ATATGCAAGG GCATGGAATA CCTTGCGACG 2820

AAACGGTACA TTCACCGAGA CCTGGCCACA CGAAACATCC TGGTGGAGAG CGAGTGCAGG 2880

GTGAAGATTG GAGACTTTGG CTTGACCAAG GTTTTACCTC AGGACAAAGA GTACTACAAG 2940

GTTAAGGAGC CTGGAGAGAG TCCCATTTTC TGGTATGCTC CTGAGTCTCT GACTGAGAGC 3000

AAGTTCTCGG TAGCGTCCGA CGTCTGGAGT TTCGGAGTGG TTCTGTATGA ACTCTTTACA 3060

TACAGCGACA AGCTCTGTAG CCCACCGACG GTGTTTTTGA GTATGGTCGG AGGCGACAAG 3120

CAGGGACAAA CGATAGTCTA TCATCTCATC GAGCTGTTGA AAAGAGGAAA CCGTTTACCA 3180

CAACCCATGG GCTGTCCTAC AGAGATGTTC GAGATCATGC AGGAATGCTG GGACAACGAT 3240

CCTAGTCTTC GGCCAAATTT CAAAGAGCTT GCTCTCCGCG TAGACCTGAT CCGGGACAGC 3300

AGCGATGCAG ACCGATATAC CCAAGTGCCT GAGTTTTAA 3339

Domain Profile

S: 2     kqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlsheh  61

          ++++Lgkg+f++v+++r+d+ +d+t+e va+k L++s+ +++rdf+re+eil++l+he+

Q: 821   IFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTTEHIRDFEREIEILKSLQHEN  880

         6789********************************************************

S: 62    ivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLed  119

         ivk+kgvc+  g++  rlVmey+++GsL++yL+k+++++++++l+++a+q++k+meYL +

Q: 881   IVKYKGVCYGAGRRnlRLVMEYLPYGSLRDYLNKNRDRIDHQKLVHYASQICKGMEYLAT  940

         *********999888*********************************************

S: 120   kklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwlap  178

         k+++hrd+a+rn+Lve+e +      vk++d+gl+k+++qd eYy v+e+++s+i+w+ap

Q: 941   KRYIHRDLATRNILVESECR------VKIGDFGLTKVLPQDkEYYKVKEPGESPIFWYAP  994

         ********************......**********************************

S: 179   eclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklell  225

         e+l+e+k +s+asdvWsFgv+lyel+t  +k +sp    l++ + +        +++ell

Q: 995   ESLTESK-FSVASDVWSFGVVLYELFTySDKLCSPptvfLSMVGGDkqgqtivyHLIELL  1053

         *******.*******************99999999**9977777777788999*******

S: 226   eekerlpkpk.cpaelaelmtnclsyepsqrpsFrail  262

         ++++rlp+p  cp+e++e+m++c++++ps rp F++++

Q: 1054  KRGNRLPQPMgCPTEMFEIMQECWDNDPSLRPNFKELA  1091

         **********************************9985

Domain Sequence
(FASTA)

IFLQQLGKGN FGSVEMCRYD PLQDNTGEVV AVKKLQHSTT EHIRDFEREI EILKSLQHEN 60

IVKYKGVCYG AGRRNLRLVM EYLPYGSLRD YLNKNRDRID HQKLVHYASQ ICKGMEYLAT 120

KRYIHRDLAT RNILVESECR VKIGDFGLTK VLPQDKEYYK VKEPGESPIF WYAPESLTES 180

KFSVASDVWS FGVVLYELFT YSDKLCSPPT VFLSMVGGDK QGQTIVYHLI ELLKRGNRLP 240

QPMGCPTEMF EIMQECWDND PSLRPNFKEL A 271

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.

Pfam

PF07714	; Pkinase_Tyr; 2.
PF00017	; SH2; 1.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013