EKS-DAR-00616

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00616

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	451.7	2.0E-135	207	494	288

Status

Unreviewed

Ensembl Protein

ENSDARP00000004431

UniProt Accession

B3DJ37;

Protein Name

Protein Synonyms/Alias

Activin A receptor, type IB;

Gene Name

acvr1b

Gene Synonyms/Alias

acvr1b;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000018968	ENSDARP00000004431	ENSDART00000023094

Organism

Danio rerio

Functional Description

Protein Length

505

Protein Sequence
(FASTA)

MLRDGNVAVM PPRRTAVALL ALCGLLAVGD ALKCNCTACE STGYVCETDG ACMASTSYIN 60

GQEEQQVRIC IPRVSLVPPG QPIYCLSAKG LLNTHCCYTD FCNSINLQIP NGIADGKGGS 120

WGPVELVAVI AGPVFLFCLL LIVGVLLFQH HQRNYNHRQR LDVEDPSCDH LYLAKDKTLQ 180

DLIFDLSTSG SGSGLPLFVQ RTVARTIVLQ EIIGKGRFGE VWRGRWRGGD VAVKIFSSRE 240

ERSWFREAEI YQTIMLRHEN ILGFIAADNK DNGTWTQLWL VSDYHEHGSL FDYLNHYSVT 300

IEGMIKLSLS AASGLAHLHM EILGTQGKPG IAHRDLKSKN ILVKKNGTCA IADLGLAVRH 360

ESITDTIDIA PNQRVGTKRY MAPEVLDETI NMKHFDSFKC ADIYALGLVY WEIARRCNAG 420

GIHEDYQLPY YDLVPSDPSI EEMRKVVCDQ RLRPNVPNWW QSYEALRVMG KIMRECWYAN 480

GAARLTALRI KKTLSQLSVQ EDIKI 505

Nucleotide Sequence
(FASTA)

ATGCTAAGAG ATGGGAATGT TGCAGTCATG CCTCCTCGAC GAACTGCTGT AGCCTTGCTC 60

GCCCTGTGTG GATTACTAGC GGTCGGCGAT GCTCTCAAGT GTAACTGCAC TGCTTGTGAG 120

AGCACAGGTT ATGTGTGCGA GACAGATGGG GCCTGCATGG CCTCCACATC CTACATCAAT 180

GGGCAGGAAG AGCAGCAAGT ACGGATCTGC ATCCCTCGGG TCAGCCTGGT TCCTCCTGGA 240

CAGCCCATCT ACTGCTTGAG CGCTAAAGGC CTGCTCAACA CGCACTGCTG TTACACAGAC 300

TTCTGCAACA GCATCAACCT CCAGATTCCC AATGGGATTG CTGATGGTAA AGGAGGTAGT 360

TGGGGTCCGG TAGAGCTGGT GGCAGTGATA GCAGGCCCGG TCTTCCTCTT TTGCCTGCTG 420

CTTATCGTGG GAGTGCTCCT TTTCCAGCAC CACCAACGAA ACTATAACCA CCGGCAGCGA 480

CTGGATGTTG AGGATCCATC CTGTGATCAC CTGTACTTGG CCAAAGACAA GACCTTACAG 540

GATCTCATCT TCGATCTGTC CACCTCTGGT TCAGGGTCTG GGCTGCCCTT GTTCGTTCAG 600

AGGACTGTGG CCAGGACAAT TGTACTGCAG GAGATCATAG GAAAAGGTCG CTTTGGGGAA 660

GTGTGGAGGG GGAGATGGAG AGGAGGTGAT GTGGCTGTGA AGATCTTTTC ATCCAGGGAG 720

GAACGTTCCT GGTTCCGTGA AGCTGAGATT TACCAAACCA TCATGCTCCG CCATGAAAAC 780

ATCTTGGGCT TCATTGCTGC TGATAATAAA GACAATGGCA CATGGACACA GCTGTGGCTA 840

GTGTCAGACT ACCATGAGCA TGGCTCATTA TTTGACTATC TCAACCACTA CTCCGTCACA 900

ATCGAGGGGA TGATCAAGTT ATCGCTTTCA GCCGCCAGCG GTCTGGCACA TCTGCACATG 960

GAGATCCTGG GCACACAGGG GAAACCAGGC ATCGCACATC GTGACCTCAA ATCCAAAAAC 1020

ATCTTGGTGA AAAAGAATGG TACTTGCGCC ATAGCAGATC TAGGGCTCGC TGTACGGCAC 1080

GAGTCTATCA CTGATACTAT AGACATTGCA CCCAATCAGA GGGTGGGCAC TAAAAGATAT 1140

ATGGCCCCAG AGGTACTAGA TGAAACGATC AACATGAAGC ATTTTGATTC TTTCAAGTGT 1200

GCTGATATCT ATGCTTTGGG ACTGGTATAT TGGGAGATTG CACGACGGTG TAATGCTGGA 1260

GGTATCCATG AAGATTATCA GCTACCCTAC TATGACCTGG TGCCGTCCGA CCCCTCCATA 1320

GAAGAGATGA GGAAGGTGGT GTGTGACCAG AGGCTTCGGC CTAATGTGCC CAACTGGTGG 1380

CAGAGCTATG AGGCGCTGAG AGTGATGGGA AAGATCATGC GGGAGTGTTG GTATGCCAAC 1440

GGAGCGGCGC GGCTTACAGC TCTGCGGATT AAGAAGACTC TTTCGCAACT CAGCGTCCAA 1500

GAAGACATTA AGATCTGA 1518

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++++rg +vAvKifs+++e+sw+rE+eiyqt++lrhenil+fia

Q: 207   IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTIMLRHENILGFIA  266

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+++ +++e +++l ls+asGlahLH+ei gt+

Q: 267   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNHYSVTIEGMIKLSLSAASGLAHLHMEILGTQ  326

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaHRDlkskNilvkk++tc+iaDlGLa+++e+ ++++d+a n++vGtkRYmaPE

Q: 327   G--KPGIAHRDLKSKNILVKKNGTCAIADLGLAVRHESITDTIDIAPNQRVGTKRYMAPE  384

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++e+y+lp+++ v+sdPs+eem

Q: 385   VLDETINMKHFDSFKCADIYALGLVYWEIARRCNA-GGIHEDYQLPYYDLVPSDPSIEEM  443

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv++++lrP++p+ w++ eal+++ k+++ecW+a+++aRltalr+kk+l

Q: 444   RKVVCDQRLRPNVPNWWQSYEALRVMGKIMRECWYANGAARLTALRIKKTL  494

         *************************************************97

Domain Sequence
(FASTA)

IVLQEIIGKG RFGEVWRGRW RGGDVAVKIF SSREERSWFR EAEIYQTIML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNH YSVTIEGMIK LSLSAASGLA HLHMEILGTQ 120

GKPGIAHRDL KSKNILVKKN GTCAIADLGL AVRHESITDT IDIAPNQRVG TKRYMAPEVL 180

DETINMKHFD SFKCADIYAL GLVYWEIARR CNAGGIHEDY QLPYYDLVPS DPSIEEMRKV 240

VCDQRLRPNV PNWWQSYEAL RVMGKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013