EKS-DAR-00836

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00836

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	487.0	2.8E-146	76	342	267

Status

Unreviewed

Ensembl Protein

ENSDARP00000049436

UniProt Accession

Q5TZ42;

Protein Name

Protein Synonyms/Alias

CDC42 binding protein kinase beta (DMPK-like); Novel protein similar to vertebrate CDC42 binding protein kinase beta (DMPK-like) (CDC42BPB);

Gene Name

cdc42bpb

Gene Synonyms/Alias

cdc42bpb; DKEYP-93H6.2-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000019383	ENSDARP00000049436	ENSDART00000049437

Organism

Danio rerio

Functional Description

Protein Length

1708

Protein Sequence
(FASTA)

MSAKVRLKKL EQLLLDGHQK NDKSLSVETL LDILICLYNE CSNSPLKREK HVTDFLEWVK 60

PFTTTVKEMR LHRDDFEMLK VIGRGAFGEV AVVKMKHTER VYAMKILNKW EMLKRAETAC 120

FREERNVLVN GDCQWITTLH YAFQDDNYLY LVMDYYVGGD LLTLLSKFED RLPEDMAKFY 180

VAEMVLAIHS IHQQRYVHRD IKPDNVLLDM NGHIRLADFG SCLKMMQDGT VQSSVAVGTP 240

DYISPEILQA MEDGMGKYGP ECDWWSLGVC MYEMLYGETP FYAESLVETY GKIMNHEERF 300

QFPSHITDVS EDAKDLIQRL ICSRERRLGQ HGIEEFRKHA FFSGIDWENI RNMEAPYIPD 360

VSSPSDTSNF DVDDDVLKNP DIAPPVSHTG FTGQHLPFVG FTYTTESCFS DGGSMRGVAL 420

SDGGTGEDLQ DGGMQVEAFE KRIRCLEQEK LELNRKLQES TQAVQSLHGS GRGAGTLGRD 480

KEIKKLNEEI DRLKKKLADS DRLEHQLEEA VTLRQDFESS STKLKALDKQ VKALKLEKED 540

IHKQLVESLD RLKSQTKELK DAHQQRKLAM QEFSEVNERM AELRSQKQRL SRQLRDKEEE 600

MEVVMQKIDA MRQDIRKTEK ARKELESQLE DARAEASKER KLREHSEVYS KQLESELETL 660

KVKQGAGRAS GLGAETQQEL TKLKSELDKK GLYYEEELVR REASHTTEMK NLRKELQDSE 720

GQQLSLHKEL LALKEKLEKA KRERQIEMEE AINALKEQYE RERNLMSEDN RKLTAETDRL 780

CSFVDKLTAQ NRQLEDELQE LASKKESVAH WEAQIAEIIQ WVSDEKDARG YLQALASKMT 840

EELESLRSSS LGSRTLDPLW KVRRSQKLDM SARLELQSAL EAEIRAKQLV HDELRKVKAA 900

NISFESKLKD TEAKNRELEE QLENMKKEME ESRSRSDKGL KLPDFQDSIF DYFNTSPLAH 960

ELTFRTSSVG DVDVAPQKTD IPPSSPSAAT EQDEAVKPQA TTPATPSPMY QPTLTAPKPK 1020

AHQLSIKTFS SPTQCTHCTS LMVGQMRQGY ACEVCSFICH VSCKDNAPQL CPIPPEQTKR 1080

PLGIDVQRGI GTAYKGFVRI PKPTGVKKGW QRAYAVVCDC KLFLYEVPEG KSTQPVVMAS 1140

QVLDLRDEEF SVSSVLASDV IHANHKDVPC IFRVTSSALK SSIRPVPLLI LAESEAEKRK 1200

WVGILEGLQS ILAKNRLKNR VVHVLHEAYD SSLPAIKTTL SAAIVDRERI VLGTEDGLFV 1260

VEITRDVIVR AADCKKVCQI ELIPKEKMVA LLSGRNRHVH LYPWAALEGA EGGFDAKLTD 1320

TRGCQAMTIG NLRPGGPACL FAGVKRQVFC YEITRAKPHH RKLWEVQAPG VVQWLGIIRE 1380

RICVGYPSGF ALLAMQGESS PVSLVSPGDP SLAFLAQQPL DALHAMEVGS NELLLCFSQL 1440

GVYVDATGRR SRTQELMWPS TPLACSSNSN CLTVYSDYGV DVFDVHTMEW VQTISLRKIR 1500

PLNVEGSLNL LSIEQPHLIY FSNNSSDGCD LAIPETSDNS KKLMVRTRSK RKFLFKVPEE 1560

ERLQQRREML RDPEMRSKLI SHPTNFNHVA HMGPGDGMQV LMDLPLSVMP SSQDDLSKDK 1620

PRPLSSISRQ QRSKTHITRT ASGGGDFGGA GSSRSISDQD QDYEREPDSD STKHSTPSNS 1680

SNPSSPPSPN SPHRSQLTLD SLDQSLDG 1708

Nucleotide Sequence
(FASTA)

ATGTCTGCGA AGGTGCGCCT GAAGAAGTTG GAGCAGTTGC TGCTGGATGG CCATCAGAAA 60

AACGACAAGT CACTGAGTGT GGAGACACTG CTGGATATTC TCATATGTTT ATACAACGAG 120

TGCAGCAACT CGCCCTTAAA ACGGGAAAAA CACGTGACGG ACTTTTTGGA ATGGGTGAAG 180

CCGTTTACAA CCACTGTGAA AGAGATGCGC CTTCACAGAG ACGACTTCGA GATGCTGAAA 240

GTGATCGGCA GGGGAGCCTT TGGAGAGGTT GCTGTGGTAA AGATGAAGCA CACAGAGCGG 300

GTTTACGCCA TGAAGATCCT CAACAAGTGG GAGATGCTGA AAAGGGCTGA GACGGCATGC 360

TTTCGGGAAG AGAGGAACGT CCTGGTGAAT GGAGACTGCC AGTGGATCAC TACCCTTCAT 420

TATGCTTTTC AGGATGACAA CTATCTGTAC TTGGTGATGG ATTATTACGT TGGCGGTGAC 480

CTGCTGACGC TGCTTAGTAA ATTTGAAGAC CGGCTGCCGG AGGACATGGC CAAGTTCTAC 540

GTGGCGGAGA TGGTTCTCGC CATCCACTCC ATCCATCAGC AGCGCTACGT ACACAGGGAT 600

ATAAAACCCG ACAACGTGCT GCTGGACATG AACGGCCACA TCCGACTCGC TGACTTCGGC 660

TCCTGTCTGA AGATGATGCA AGACGGCACG GTCCAATCTT CAGTGGCTGT GGGCACACCA 720

GACTACATCT CTCCAGAGAT CCTGCAGGCC ATGGAGGACG GCATGGGGAA ATACGGGCCG 780

GAGTGTGACT GGTGGTCGCT GGGCGTTTGC ATGTATGAGA TGCTGTACGG CGAGACACCC 840

TTTTACGCCG AATCCCTGGT GGAGACCTAT GGAAAGATCA TGAACCATGA GGAGCGTTTC 900

CAGTTCCCTT CCCACATCAC GGATGTATCC GAGGATGCTA AAGACCTGAT CCAGAGGCTG 960

ATTTGCAGCC GAGAGCGCCG TTTGGGTCAA CATGGCATCG AGGAGTTCAG GAAGCACGCC 1020

TTTTTCTCCG GCATCGACTG GGAGAACATC CGGAACATGG AGGCGCCATA CATCCCTGAC 1080

GTCAGCTCTC CATCAGACAC CTCCAACTTT GATGTAGATG ATGACGTACT GAAGAATCCA 1140

GACATTGCTC CTCCAGTTTC TCACACGGGT TTCACCGGGC AGCACTTGCC CTTTGTGGGC 1200

TTCACCTACA CTACAGAGAG CTGTTTCTCA GACGGCGGCA GCATGAGGGG TGTGGCGCTG 1260

TCTGACGGGG GCACCGGGGA GGATCTCCAG GATGGAGGCA TGCAGGTGGA GGCCTTTGAG 1320

AAGAGGATTC GCTGCCTGGA GCAAGAGAAA TTGGAGCTTA ACCGTAAGCT GCAAGAATCC 1380

ACTCAGGCTG TTCAATCTCT TCATGGCTCT GGTCGAGGAG CCGGCACTCT CGGACGAGAT 1440

AAAGAGATTA AAAAACTTAA TGAGGAAATC GATCGGCTTA AAAAGAAACT GGCAGACTCT 1500

GATAGGCTGG AGCACCAGTT GGAGGAAGCA GTGACTCTTC GACAGGACTT TGAAAGTTCC 1560

TCCACCAAAC TAAAAGCCCT GGACAAGCAA GTCAAAGCTC TCAAGCTGGA GAAAGAGGAT 1620

ATTCATAAGC AACTGGTGGA GTCTTTGGAC CGCCTGAAGT CTCAGACCAA GGAGCTGAAG 1680

GACGCGCACC AGCAGAGGAA GCTGGCCATG CAGGAGTTCT CGGAGGTGAA CGAGCGTATG 1740

GCCGAACTGC GCTCCCAGAA GCAGCGTCTG TCGCGCCAGC TGCGGGACAA GGAGGAGGAG 1800

ATGGAGGTGG TGATGCAGAA AATCGACGCC ATGCGCCAGG ACATCCGCAA AACCGAGAAG 1860

GCCCGCAAGG AGCTGGAGTC TCAGCTGGAG GATGCGCGTG CCGAAGCTTC TAAGGAGCGT 1920

AAACTTCGAG AGCACAGTGA GGTTTACTCC AAACAACTGG AGAGTGAACT GGAGACACTC 1980

AAGGTGAAGC AGGGCGCAGG TCGTGCGTCA GGCCTCGGTG CAGAGACTCA GCAGGAGCTC 2040

ACCAAACTCA AGTCTGAGCT AGATAAGAAA GGACTGTATT ATGAGGAAGA GCTGGTGAGA 2100

CGTGAAGCCA GTCACACTAC AGAGATGAAA AACCTGAGGA AGGAGCTCCA GGACTCTGAG 2160

GGTCAGCAGC TCTCCCTGCA CAAAGAGCTG CTTGCGCTTA AAGAAAAACT GGAAAAGGCC 2220

AAGAGAGAAC GGCAAATTGA GATGGAAGAG GCCATTAATG CCCTGAAAGA GCAGTATGAA 2280

CGTGAACGCA ACCTTATGAG TGAAGACAAC CGCAAACTCA CTGCAGAAAC AGACCGGCTC 2340

TGCAGTTTTG TGGACAAGCT GACCGCTCAG AACAGGCAAC TGGAGGACGA GCTCCAGGAA 2400

CTGGCATCAA AGAAGGAGAG CGTAGCACAC TGGGAAGCAC AGATCGCAGA GATTATCCAG 2460

TGGGTGAGCG ATGAGAAAGA CGCACGCGGC TACCTTCAGG CTCTGGCCTC CAAGATGACA 2520

GAAGAGTTGG AGTCTCTGCG CAGCTCCAGT TTGGGATCCA GAACACTGGA TCCGTTGTGG 2580

AAGGTGCGTC GCAGTCAAAA GCTGGATATG TCTGCCCGTC TAGAGCTGCA GTCGGCCTTG 2640

GAAGCTGAAA TCCGTGCCAA GCAACTGGTT CACGATGAAC TGCGCAAGGT CAAAGCTGCC 2700

AACATCTCTT TCGAGAGCAA ACTGAAGGAC ACCGAGGCCA AGAACAGAGA GTTGGAGGAA 2760

CAGCTGGAGA ACATGAAGAA GGAGATGGAG GAGAGCCGCT CACGATCAGA CAAAGGCCTG 2820

AAACTGCCAG ACTTCCAGGA CTCCATCTTT GACTACTTCA ATACCTCTCC TCTTGCCCAT 2880

GAGCTGACAT TCAGAACCAG CTCTGTCGGA GATGTGGACG TCGCACCTCA GAAGACTGAC 2940

ATTCCCCCTT CCTCCCCATC AGCAGCTACA GAACAGGATG AAGCAGTCAA GCCTCAAGCG 3000

ACCACTCCTG CTACTCCTTC TCCAATGTAT CAGCCCACTC TCACTGCACC AAAGCCCAAA 3060

GCCCATCAGC TGAGCATCAA GACCTTCTCC AGCCCGACTC AGTGCACTCA CTGTACTTCA 3120

CTGATGGTGG GCCAGATGCG TCAAGGATAC GCCTGCGAGG TATGCTCTTT CATCTGCCAC 3180

GTGTCCTGTA AAGACAACGC ACCCCAGCTC TGCCCCATTC CTCCCGAGCA GACCAAGAGG 3240

CCTCTGGGTA TTGATGTGCA GAGGGGCATT GGCACTGCGT ACAAAGGTTT TGTCAGGATC 3300

CCGAAGCCCA CCGGAGTGAA GAAGGGCTGG CAGAGAGCAT ATGCTGTAGT GTGTGACTGT 3360

AAACTCTTTC TCTACGAGGT GCCAGAAGGG AAGTCCACTC AACCTGTCGT GATGGCCAGT 3420

CAGGTCCTTG ACTTGAGGGA TGAGGAGTTC TCTGTTAGCT CTGTGTTGGC ATCTGATGTG 3480

ATCCATGCCA ACCATAAAGA CGTTCCCTGT ATATTCAGGG TAACCTCGTC GGCTCTGAAA 3540

TCCTCGATCC GGCCAGTTCC TTTGCTGATT TTAGCTGAGA GCGAGGCGGA GAAGAGGAAG 3600

TGGGTGGGCA TCCTAGAGGG CCTGCAGAGC ATCCTAGCCA AAAACCGGCT GAAGAACCGC 3660

GTGGTGCATG TGCTGCACGA GGCCTACGAC AGCAGCCTAC CTGCCATCAA AACTACACTT 3720

TCTGCTGCCA TCGTAGATCG AGAACGAATT GTCTTGGGGA CAGAAGATGG CCTTTTTGTA 3780

GTCGAGATCA CCAGAGATGT CATTGTTCGT GCCGCTGACT GTAAAAAAGT CTGCCAGATC 3840

GAGCTCATCC CCAAAGAGAA GATGGTGGCC CTGCTTTCTG GCCGTAATCG CCATGTCCAT 3900

TTATACCCCT GGGCGGCACT AGAGGGCGCT GAAGGGGGTT TCGATGCCAA GCTGACAGAT 3960

ACGAGAGGCT GCCAGGCCAT GACCATCGGT AACCTCCGCC CTGGCGGTCC AGCGTGTCTC 4020

TTTGCAGGCG TGAAGCGGCA GGTTTTCTGT TATGAAATCA CACGAGCGAA ACCCCATCAT 4080

CGCAAACTCT GGGAAGTGCA GGCGCCAGGG GTCGTCCAAT GGCTGGGGAT AATTCGAGAA 4140

CGGATCTGCG TAGGTTACCC ATCAGGCTTT GCTCTGCTGG CCATGCAGGG AGAATCGTCG 4200

CCGGTCAGTC TGGTGAGCCC AGGTGACCCC TCGCTGGCAT TTTTGGCCCA GCAGCCTCTG 4260

GATGCACTTC ATGCTATGGA AGTGGGGTCC AATGAGCTGC TGCTGTGCTT CAGTCAGCTG 4320

GGAGTGTACG TGGACGCGAC TGGAAGACGA TCACGAACTC AGGAGCTCAT GTGGCCCTCC 4380

ACACCGCTCG CCTGCAGCTC AAACTCGAAC TGCCTGACGG TGTACAGCGA TTATGGGGTC 4440

GACGTGTTTG ATGTTCACAC TATGGAATGG GTTCAGACCA TCTCATTAAG AAAAATTCGA 4500

CCTCTGAATG TGGAAGGCAG TCTAAACCTT TTGAGCATTG AGCAACCCCA TCTCATCTAT 4560

TTCAGCAACA ACTCCTCGGA TGGCTGTGAC CTGGCCATCC CCGAGACCTC AGACAACAGC 4620

AAGAAGCTGA TGGTGAGGAC GCGCAGCAAG AGGAAGTTCC TTTTTAAAGT ACCAGAGGAG 4680

GAGCGGCTGC AGCAGAGAAG GGAGATGCTG AGGGATCCTG AAATGAGATC CAAGCTAATC 4740

TCTCACCCCA CCAACTTCAA TCACGTTGCT CACATGGGCC CAGGCGACGG CATGCAGGTC 4800

CTCATGGATC TGCCTCTGAG TGTGATGCCC TCTTCTCAGG ATGACCTGTC TAAAGACAAA 4860

CCTCGACCTC TGTCTAGCAT CTCACGCCAA CAGAGGAGCA AGACCCACAT CACCCGTACC 4920

GCCTCAGGAG GGGGAGACTT CGGAGGAGCA GGGTCGTCCC GCAGTATTTC TGATCAGGAT 4980

CAAGACTACG AGCGAGAGCC CGACTCAGAC TCGACCAAGC ATTCCACCCC CTCGAACAGC 5040

TCCAACCCCA GCAGCCCACC GAGCCCCAAC TCTCCCCACC GCAGTCAGCT GACTCTGGAC 5100

AGCCTGGATC AGTCCCTGGA TGGTTGA 5127

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         fe+lkviGrGafgevavv++k+te+vyamkil+k+e+lkrae+a+freer+vlv++d++w

Q: 76    FEMLKVIGRGAFGEVAVVKMKHTERVYAMKILNKWEMLKRAETACFREERNVLVNGDCQW  135

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqd++ylylvm+y+vGGdlltllsk+ed+lpe++a+fy+ae+vla++s+h+ +

Q: 136   ITTLHYAFQDDNYLYLVMDYYVGGDLLTLLSKFEDRLPEDMAKFYVAEMVLAIHSIHQQR  195

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         yvhrdikpdn+lld++Ghi+ladfGsclk+++dgtv+ssvavGtpdyispe+l+a+e+g+

Q: 196   YVHRDIKPDNVLLDMNGHIRLADFGSCLKMMQDGTVQSSVAVGTPDYISPEILQAMEDGM  255

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakd  239

         g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nh+e+++fp++  +vse+akd

Q: 256   GKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHItDVSEDAKD  315

         *************************************************988********

S: 240   likklltsreerlgregiedlkkhpff  266

         li++l++sre+rlg++gie+++kh+ff

Q: 316   LIQRLICSRERRLGQHGIEEFRKHAFF  342

         **************************9

Domain Sequence
(FASTA)

FEMLKVIGRG AFGEVAVVKM KHTERVYAMK ILNKWEMLKR AETACFREER NVLVNGDCQW 60

ITTLHYAFQD DNYLYLVMDY YVGGDLLTLL SKFEDRLPED MAKFYVAEMV LAIHSIHQQR 120

YVHRDIKPDN VLLDMNGHIR LADFGSCLKM MQDGTVQSSV AVGTPDYISP EILQAMEDGM 180

GKYGPECDWW SLGVCMYEML YGETPFYAES LVETYGKIMN HEERFQFPSH ITDVSEDAKD 240

LIQRLICSRE RRLGQHGIEE FRKHAFF 267

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0035556	; P:intracellular signal transduction

KEGG

dre:567039

;

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013