EKS-DAR-00620

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00620

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	433.8	6.1E-130	229	516	288

Status

Unreviewed

Ensembl Protein

ENSDARP00000015287

UniProt Accession

Q1RLX1;

Protein Name

Protein Synonyms/Alias

Bone morphogenetic protein receptor, type 1a; Zgc:136731 protein;

Gene Name

bmpr1aa

Gene Synonyms/Alias

bmpr1aa; bmpr1a, zgc:136731; CH211-134M17.5-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000019728	ENSDARP00000015287	ENSDART00000026768

Organism

Danio rerio

Functional Description

Protein Length

527

Protein Sequence
(FASTA)

MRQLLFITVV LTGVCLLLTL CSGAGQNPDH VLQGTGVKLD SRRPGDDSTI APEDAARFLS 60

CHCSGHCPDD AKNNTCETNG QCFAIIEEDE NGDVILSSGC MKYEGSHFQC KDSQFAQTRR 120

TIECCQFDFC NQDLKPELPP RDSEPPDPHW LAFLISVTVC FCALICVTVI CYYRYKWQTE 180

RQRYHRDLEQ DEAFIPAGES LKDLINQSQT SGSGSGLPLL VQRTIAKQIQ TVRMIGKGRY 240

GEVWLGRWRG EKVAVKVFFT REEASWFRET EIYQTVLMRH ENILGFIAAD INGTGASTQL 300

YLITDYHENG SLYDYLKFTT LDTQALLRLA FSAACGLCHL HTEIYGTQGK PAIAHRDLKS 360

KNILIKKNGT CCIADLGLAV KFNSDTNEVD LPLSTRMGTR RYMAPEVLDE TLNKNHFQAY 420

IMADIYSYGL VIWEMARRCV TGGIVEEYQL PYYEMVPSDP SYEDMLEVVC VKGLRPTVSN 480

RWNSDECLRA MLKLMSECWA HNPASRLTIL RVKKTLAKMV ESQDIKI 527

Nucleotide Sequence
(FASTA)

ATGCGTCAGC TTTTGTTCAT CACTGTGGTT TTGACTGGAG TCTGTCTTCT TCTCACACTC 60

TGCTCTGGAG CAGGTCAGAA TCCTGATCAT GTGCTGCAGG GCACTGGAGT GAAACTGGAC 120

TCCAGGAGAC CTGGGGATGA CTCTACTATT GCACCAGAAG ATGCTGCTCG CTTCCTCAGC 180

TGCCACTGCT CAGGACATTG CCCCGATGAT GCCAAGAACA ATACCTGCGA GACAAATGGG 240

CAGTGCTTCG CAATTATTGA GGAAGATGAA AATGGAGACG TGATCTTAAG CTCAGGCTGT 300

ATGAAATATG AGGGCTCACA CTTTCAGTGC AAGGATTCAC AGTTTGCACA GACTCGTCGA 360

ACCATTGAAT GCTGCCAGTT TGATTTTTGT AATCAAGACC TGAAGCCTGA GCTGCCGCCT 420

CGAGACTCGG AACCACCAGA CCCTCACTGG CTGGCCTTTC TCATCTCAGT GACTGTGTGC 480

TTCTGTGCTC TCATCTGTGT CACTGTCATC TGTTATTACA GGTATAAGTG GCAGACAGAG 540

AGGCAGCGCT ACCACAGAGA CCTGGAGCAA GACGAGGCCT TTATCCCAGC AGGAGAATCC 600

CTGAAAGACC TCATCAACCA GTCTCAGACC TCAGGCAGTG GCTCTGGACT CCCTCTGCTG 660

GTGCAGCGCA CTATAGCAAA GCAGATCCAG ACAGTGCGAA TGATCGGAAA AGGACGATAT 720

GGAGAAGTGT GGCTTGGTCG GTGGAGAGGA GAGAAGGTAG CAGTGAAGGT GTTCTTTACC 780

CGAGAGGAGG CCAGCTGGTT CAGAGAGACA GAGATCTATC AAACCGTGCT CATGAGACAT 840

GAGAACATAC TCGGCTTTAT CGCTGCTGAT ATAAATGGCA CAGGAGCCTC TACGCAGCTG 900

TACCTGATCA CAGACTACCA TGAGAATGGC TCTCTGTATG ACTATCTGAA GTTCACGACT 960

TTGGACACAC AGGCTCTACT CAGACTGGCC TTCTCTGCAG CCTGTGGCCT GTGTCACCTG 1020

CATACGGAGA TCTACGGCAC GCAGGGAAAA CCAGCGATCG CTCACAGAGA CCTGAAGAGC 1080

AAGAACATTC TCATCAAGAA AAACGGCACC TGCTGCATCG CTGACCTCGG CCTTGCTGTG 1140

AAATTCAACA GTGACACAAA TGAAGTGGAC CTCCCATTAA GCACACGTAT GGGAACCAGG 1200

CGCTACATGG CTCCAGAAGT GTTGGACGAG ACTCTGAATA AGAATCATTT CCAGGCCTAC 1260

ATCATGGCAG ACATCTACAG CTATGGGCTG GTTATTTGGG AAATGGCCAG ACGCTGTGTC 1320

ACTGGAGGGA TTGTTGAGGA GTATCAGCTG CCATATTATG AGATGGTGCC TTCAGACCCA 1380

TCTTATGAAG ACATGTTGGA GGTTGTTTGT GTCAAAGGAC TGCGGCCCAC CGTATCCAAC 1440

AGATGGAACA GTGATGAGTG CTTAAGGGCC ATGCTAAAGC TGATGTCTGA ATGCTGGGCC 1500

CACAATCCTG CATCACGCTT AACCATCCTA CGAGTCAAGA AGACTTTAGC CAAAATGGTG 1560

GAATCTCAAG ACATTAAAAT CTGA 1584

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++ +++igkGrygeVw +++rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 229   IQTVRMIGKGRYGEVWLGRWRGEKVAVKVFFTREEASWFRETEIYQTVLMRHENILGFIA  288

         68899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad++ ++ +t+l+l+t+yhe+gsL+dyLk +tld++ llrla s+a+Gl+hLH+ei gt+

Q: 289   ADINGTGASTQLYLITDYHENGSLYDYLKFTTLDTQALLRLAFSAACGLCHLHTEIYGTQ  348

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNil+kk++tcciaDlGLa+k++++++e+dl  ++++Gt+RYmaPE

Q: 349   G--KPAIAHRDLKSKNILIKKNGTCCIADLGLAVKFNSDTNEVDLPLSTRMGTRRYMAPE  406

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+a+ +aD+Ys gLv+WE+a+Rc + +++veey+lp++e+v+sdPs+e+m

Q: 407   VLDETLNKNHFQAYIMADIYSYGLVIWEMARRCVT-GGIVEEYQLPYYEMVPSDPSYEDM  465

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

          evv++k lrP+++++w+++e+l+++ kl++ecW+++p++Rlt lrvkk+l

Q: 466   LEVVCVKGLRPTVSNRWNSDECLRAMLKLMSECWAHNPASRLTILRVKKTL  516

         *************************************************97

Domain Sequence
(FASTA)

IQTVRMIGKG RYGEVWLGRW RGEKVAVKVF FTREEASWFR ETEIYQTVLM RHENILGFIA 60

ADINGTGAST QLYLITDYHE NGSLYDYLKF TTLDTQALLR LAFSAACGLC HLHTEIYGTQ 120

GKPAIAHRDL KSKNILIKKN GTCCIADLGL AVKFNSDTNE VDLPLSTRMG TRRYMAPEVL 180

DETLNKNHFQ AYIMADIYSY GLVIWEMARR CVTGGIVEEY QLPYYEMVPS DPSYEDMLEV 240

VCVKGLRPTV SNRWNSDECL RAMLKLMSEC WAHNPASRLT ILRVKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0070724	; C:BMP receptor complex
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030509	; P:BMP signaling pathway
GO:0061371	; P:determination of heart left/right asymmetry
GO:0009953	; P:dorsal/ventral pattern formation
GO:0060972	; P:left/right pattern formation
GO:0051260	; P:protein homooligomerization

KEGG

dre:58145

;

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013