EKS-DAR-00625

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00625

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	381.7	4.5E-114	211	509	299

Status

Unreviewed

Ensembl Protein

ENSDARP00000106831

UniProt Accession

B0V0H4;

Protein Name

Protein Synonyms/Alias

Bone morphogenetic protein receptor, type II b (Serine/threonine kinase);

Gene Name

bmpr2b

Gene Synonyms/Alias

bmpr2b; DKEY-56K23.1-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000020057	ENSDARP00000008469	ENSDART00000002334
ENSDARG00000020057	ENSDARP00000106831	ENSDART00000125961

Organism

Danio rerio

Functional Description

Protein Length

1071

Protein Sequence
(FASTA)

MRVRILNRTS VLSLGLCSLL LLSAVAAAQS EERERECAFN DQHQQVDEQS VAGDWHITRE 60

NNTILCSKSS RCYGLWEKTH DGEIRLVKQG CWTYIGDQQD CHDDRCVVTT TPSQIQNGTY 120

RFCCCSTNMC NVNFTENWVP SPTSTANRDQ PPIHRDEAIF IALASVSIVA VLIVALFFGY 180

RVMMGECKQG LHNMDMIEAA PSEPSLDLDS LKLLELIGRG RYGSVYKGSL DERPVAVKVF 240

TYANRQNFVN ERSIYRVPLL EHENIARFIV GDERMTTDGR MEYLLVMEYY PHGSLCRYLS 300

LHTLDWVSCC RLAHSLTRGL AYLHTELLRG DIYKPAISHR DLNSRNVLVK NDGTCVISDF 360

GLSMKLTGNR LVRPGEEENA AISEVGTIRY MAPEVLEGAV NLRDCESALK QVDMYAIGLI 420

YWETFMRCTD LFPGETVPEY QMAFQAEAGN HPSFEDMQVL VSREKQRPKF PEAWKENSLA 480

VRSLKETMED CWDQDAEARL TAQCAEERMA ELLLIWERNK PVSPTINPMS TALQNERNLT 540

HSRRAPKMGS YPDYSSSSYI EDHEGMVKNL PGDVSTSGTS SVGGVGVSGS SGGVAATGEK 600

NRNSINYERQ QAQAQARLPS PETSGTSLST TTTTTGLTPS TIMTTISESG HSEDTGAGGS 660

VPVCLQLTEE DLETTKLDPK EVDKNLKESS DENLMEHSQK QFSAPDPLSS GSTSLLYPLI 720

KLAAEVTGGS GSGGQTDFGV GSSGMSDTPT AMFPLPKQQN LPKRPTSLPL NTKNPGRESS 780

SSRLKFGKHK SNLKQVETGV AKMNTVVAVE PHLATVTNNG PSVRSGAGVV VVNGYGVGNG 840

ASSSDAFGNT NPVGPQGEGG APLLQSQLSG EDSRLNININ SSPDEHEPLL RREQPAARDH 900

SGRTNSNNNN SNIHTTATVC ALTAADAQIE ALTCLSGAPD GRDNGVPLRP PKPRRPERPN 960

SLDLSASSQN SSLLDEAVSQ EGKAGSAEKI KKRVKTPYSL KRWRPSTWVV STDTLDGEVN 1020

NNGHSQQTMM AVSGGGHPSA GQSKSSIAVF LVGGGTATAT LTSDPPDMTC L 1071

Nucleotide Sequence
(FASTA)

ATGAGAGTGC GGATCCTAAA CCGGACATCA GTACTGTCAC TCGGGCTCTG CTCACTGCTT 60

CTGCTCAGTG CTGTGGCCGC TGCTCAGAGT GAAGAGCGCG AGCGGGAGTG TGCTTTTAAT 120

GACCAGCACC AGCAGGTGGA TGAGCAGAGT GTGGCAGGTG ACTGGCACAT CACCAGAGAA 180

AATAACACCA TCCTGTGCAG CAAGAGCAGC CGCTGCTACG GCCTCTGGGA GAAAACACAT 240

GACGGAGAGA TCCGTCTGGT CAAACAAGGC TGTTGGACTT ACATTGGTGA CCAGCAGGAC 300

TGCCATGACG ACCGTTGCGT GGTTACCACA ACGCCATCGC AGATCCAGAA TGGCACCTAC 360

AGATTCTGCT GCTGCAGCAC CAACATGTGC AACGTCAACT TCACAGAGAA CTGGGTGCCC 420

AGTCCCACCA GCACTGCCAA CCGTGATCAG CCGCCTATAC ACAGAGATGA GGCCATCTTC 480

ATCGCCCTGG CCTCCGTCTC CATTGTGGCC GTCCTTATTG TCGCGCTGTT CTTTGGCTAT 540

CGTGTGATGA TGGGCGAGTG TAAACAGGGC CTGCACAATA TGGACATGAT AGAGGCTGCG 600

CCATCTGAAC CTTCGCTGGA TTTAGACAGT TTAAAGCTCC TCGAACTGAT TGGCCGAGGC 660

CGCTACGGTT CCGTCTACAA GGGGTCTCTT GACGAACGGC CGGTTGCAGT AAAAGTTTTT 720

ACCTATGCCA ACCGGCAGAA CTTTGTGAAT GAGCGCTCCA TCTACCGAGT GCCTCTTCTG 780

GAGCATGAAA ACATTGCTCG CTTTATCGTC GGCGATGAGC GGATGACCAC TGACGGACGC 840

ATGGAGTACC TGCTGGTCAT GGAGTACTAC CCTCATGGCT CGCTGTGCCG CTATCTGAGT 900

CTGCACACGC TGGACTGGGT GAGCTGCTGT CGTCTGGCTC ATTCACTGAC CAGAGGACTG 960

GCCTATCTGC ACACTGAGCT CCTGAGAGGA GATATATACA AACCTGCCAT TTCGCACCGG 1020

GATCTAAACA GCCGGAATGT TCTAGTGAAG AACGATGGCA CCTGTGTGAT CAGCGACTTC 1080

GGTCTGTCTA TGAAGCTGAC TGGAAATCGT CTGGTACGGC CTGGAGAAGA GGAAAACGCC 1140

GCCATCAGTG AGGTGGGCAC GATCCGCTAC ATGGCGCCGG AGGTGCTGGA GGGAGCCGTG 1200

AACCTCAGGG ACTGCGAGTC TGCATTGAAA CAGGTGGACA TGTACGCCAT CGGCCTCATC 1260

TACTGGGAGA CCTTTATGAG GTGCACTGAC CTTTTTCCAG GAGAGACAGT GCCAGAATAC 1320

CAGATGGCTT TCCAGGCCGA GGCGGGAAAC CACCCGTCCT TTGAGGACAT GCAGGTGTTG 1380

GTGTCCAGAG AGAAACAGAG ACCCAAGTTC CCAGAAGCCT GGAAGGAGAA CAGCCTGGCT 1440

GTGCGCTCTC TAAAGGAGAC TATGGAGGAT TGCTGGGATC AGGATGCAGA GGCTCGTCTG 1500

ACAGCGCAGT GTGCAGAGGA GCGTATGGCA GAACTGCTGC TGATTTGGGA AAGGAACAAA 1560

CCTGTCAGTC CCACCATCAA TCCCATGAGC ACAGCGCTGC AGAACGAGAG GAATCTGACC 1620

CACAGCCGCA GGGCTCCCAA AATGGGCTCT TACCCAGATT ACTCTTCATC CTCTTACATC 1680

GAGGATCATG AGGGCATGGT GAAGAACCTC CCAGGCGACG TCTCCACGTC TGGCACTTCC 1740

TCTGTGGGTG GTGTGGGCGT GAGTGGCAGC AGTGGGGGCG TTGCAGCGAC CGGAGAGAAG 1800

AACAGAAACT CCATCAACTA TGAAAGACAG CAAGCTCAGG CGCAAGCTCG ACTGCCCAGT 1860

CCTGAAACCA GCGGCACAAG TTTGTCCACC ACAACCACCA CAACAGGCCT CACACCCAGT 1920

ACCATCATGA CCACCATCTC CGAATCGGGC CACTCGGAGG ACACAGGAGC CGGAGGAAGT 1980

GTACCAGTGT GCCTTCAACT CACAGAGGAA GATCTGGAGA CCACCAAACT GGACCCCAAA 2040

GAGGTGGACA AGAACCTGAA AGAAAGTTCT GATGAGAATC TGATGGAGCA CTCGCAGAAA 2100

CAGTTCAGCG CCCCTGATCC ACTCAGCTCG GGCAGCACCA GTCTTTTATA CCCACTGATT 2160

AAACTCGCAG CAGAAGTGAC TGGAGGATCT GGAAGTGGTG GACAAACTGA TTTCGGGGTG 2220

GGCAGCAGTG GAATGAGCGA CACTCCCACA GCCATGTTTC CTCTCCCCAA ACAGCAGAAT 2280

CTCCCCAAGA GGCCCACTAG CTTACCCCTC AACACCAAAA ATCCTGGTAG GGAGTCTTCG 2340

TCGTCTCGAT TGAAATTCGG GAAGCACAAG TCCAACCTGA AGCAGGTGGA GACAGGTGTA 2400

GCCAAGATGA ACACTGTGGT GGCCGTCGAG CCACACTTGG CCACCGTCAC CAACAATGGA 2460

CCCAGTGTGC GCAGTGGTGC TGGAGTGGTC GTAGTAAATG GATATGGAGT GGGCAATGGT 2520

GCCAGCTCCT CTGATGCGTT TGGAAACACG AACCCCGTCG GGCCACAGGG TGAAGGGGGC 2580

GCTCCTCTGC TGCAGAGCCA ACTGAGCGGA GAAGACAGCC GACTCAACAT CAACATCAAC 2640

TCCAGCCCTG ATGAACACGA GCCCCTGCTA AGAAGAGAGC AGCCGGCCGC GCGGGATCAC 2700

TCCGGTCGCA CCAACTCCAA CAACAACAAC AGCAACATTC ACACCACTGC CACGGTTTGT 2760

GCGCTCACCG CTGCAGACGC CCAGATAGAG GCTTTAACCT GCCTGTCGGG AGCGCCAGAC 2820

GGAAGGGATA ATGGGGTTCC ATTGAGGCCA CCTAAACCCA GAAGACCAGA GCGGCCAAAC 2880

TCACTGGACC TGTCAGCCTC TTCCCAGAAT TCTTCTCTTT TAGATGAGGC CGTGTCGCAG 2940

GAGGGAAAGG CCGGATCAGC TGAGAAGATT AAAAAACGTG TGAAGACTCC TTATTCGTTG 3000

AAAAGATGGC GTCCTTCCAC ATGGGTCGTC TCCACTGATA CACTAGATGG AGAGGTGAAC 3060

AACAACGGGC ACAGCCAGCA GACGATGATG GCAGTAAGTG GAGGTGGTCA CCCAAGCGCT 3120

GGCCAATCAA AGTCCAGCAT CGCCGTGTTT TTGGTCGGCG GAGGAACAGC AACAGCTACT 3180

CTGACCTCCG ATCCTCCAGA TATGACCTGC CTGTGA 3216

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         lkllelig+Gryg+V+k++l+++ vAvK+f++++++++++E+ iy+++ll+heni +fi+

Q: 211   LKLLELIGRGRYGSVYKGSLDERPVAVKVFTYANRQNFVNERSIYRVPLLEHENIARFIV  270

         6899********************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119

          d+ +++d ++e+llv+ey+++gsL+ yL+ +tld+ +++rla+sl++Gla+LH+e+

Q: 271   GDErMTTDGRMEYLLVMEYYPHGSLCRYLSLHTLDWVSCCRLAHSLTRGLAYLHTELLRG  330

         **999***************************************************8654

S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175

          + +Kpai+HRDl+s+N+lvk+d+tc+i+D+GL++kl+ ++ +    +++aa+s+vGt R

Q: 331   -DIYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMKLTGNRLVrpgeEENAAISEVGTIR  389

         .57**********************************999987777788999********

S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvg  232

         YmaPEvle+a+nl+d+e a+k++D+Y++gL++WE ++Rc++  ++e+v+ey+++f+++ g

Q: 390   YMAPEVLEGAVNLRDCEsALKQVDMYAIGLIYWETFMRCTDlfPGETVPEYQMAFQAEAG  449

         *****************99*****************************************

S: 233   sdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkrl  291

         ++Ps+e+m+ +v ++k+rPk+peawk+++ a+++l++++e+cWd+d+eaRlta++ ++r+

Q: 450   NHPSFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETMEDCWDQDAEARLTAQCAEERM  509

         ***************************9999*************************9987

Domain Sequence
(FASTA)

LKLLELIGRG RYGSVYKGSL DERPVAVKVF TYANRQNFVN ERSIYRVPLL EHENIARFIV 60

GDERMTTDGR MEYLLVMEYY PHGSLCRYLS LHTLDWVSCC RLAHSLTRGL AYLHTELLRG 120

DIYKPAISHR DLNSRNVLVK NDGTCVISDF GLSMKLTGNR LVRPGEEENA AISEVGTIRY 180

MAPEVLEGAV NLRDCESALK QVDMYAIGLI YWETFMRCTD LFPGETVPEY QMAFQAEAGN 240

HPSFEDMQVL VSREKQRPKF PEAWKENSLA VRSLKETMED CWDQDAEARL TAQCAEERM 299

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Receptor; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR015770	; BMPRII.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013