EKS-DAR-00920
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00920
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/BRDN/AN/AN/AN/AN/A
StatusReviewed
Ensembl ProteinENSDARP00000110207
UniProt AccessionF1QW93;
Protein NameBromodomain testis-specific protein
Protein Synonyms/Alias
Gene Namebrdt
Gene Synonyms/Alias brdt; si:dkeyp-85h7.3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000020076ENSDARP00000110207ENSDART00000130916
ENSDARG00000020076ENSDARP00000040705ENSDART00000040706
ENSDARG00000020076ENSDARP00000126131ENSDART00000151660
ENSDARG00000020076ENSDARP00000125744ENSDART00000151136
ENSDARG00000020076ENSDARP00000125966ENSDART00000151422
OrganismDanio rerio
Functional DescriptionTestis-specific chromatin protein that specificallybinds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA (By similarity).
Protein Length913
Protein Sequence
(FASTA)
PPQHFTMNGN PPPPEFKNPK KPGRLTNHLQ YIEKVVIRAL WKHHFSWPFR QPVDAVRLNL 60
PDYYTIIKNP MDLTTIRKRL ENNYYWKAME CVEDFNTMFT NCYVYNRPGD DIVLMAQVLE 120
KLFLEKVAEM PEEEYEISAL TTKGPVKGAR KSTIGLKKRP PSPMSEVVFQ QTVTVIPPDA 180
LHTIPSAPLS AQLTAKLKNG VKRKADTTTP SASSIPSCES SSCVTEPKVL KLFSRRGSGR 240
PIKPPCKDLP ESPPQHQVGR RTKLSERLKY CNAILKEMFS KKHSAYAWPF YKPVDAETLG 300
LLDYHEIIHQ PMDMSTIKKK MEAREYTDAL QFAADMRLMF SNCYKYNPPG HEVVSMARKL 360
QDVFEFRFSK IPDEPKNANP VSSHNRVKKE RARSPSSSES SDSESSSPEN SSDTEEEDEE 420
ERAHRLASLE EQQLKAVREQ LQLLTQTPLS KILKRSSSSK SSGCKVCTMM NSLKKPKFNS 480
VLRRKESRAC DSEEEMNTLP MSYEEKRQLS LDINKLPGDK LGKVVNIIKA REPLLRDTDP 540
EEIEIDFETL KPSTLRALEC YVVGCLRKKK NKPPKKSKIK EKDKDLQHAT GEQNSHKKTK 600
IETDGEIKDT THPSRLSDSS SSSSSSDSSS SDSSSSDSCD SDSGLTEQKT KRKQSKGPGH 660
ANKIKKKKYY PVVPLPEQAL RQANAEVKDS SSASGVMCQS RPSSLVSETG SKDLFASQHA 720
KHPVEDITAI TGIPPLLSPL TSPSAAMPAT GSQSTSSSQF EASSPLCLYK DIVLKHADSW 780
TSLGKLATQT PCTIKSSKES FQQFRKVAME KELTTASRGL VSKHCLTQQP QKAKLECQPS 840
KPEVESAELP LMAAILDTPK APEPSSVLQN SVDREREMAR KREQERRRRE AMSGVIDMTM 900
QRDIMATFEK NLE 913
Nucleotide Sequence
(FASTA)
CCCCCACAGC ATTTCACCAT GAATGGGAAT CCCCCTCCCC CAGAGTTCAA GAACCCCAAA 60
AAGCCTGGCC GCCTCACCAA TCATTTGCAA TATATAGAAA AAGTGGTGAT TAGGGCCCTG 120
TGGAAACATC ATTTCTCCTG GCCATTCAGA CAGCCAGTGG ATGCGGTCAG ACTCAATTTG 180
CCAGATTATT ATACAATCAT CAAAAACCCA ATGGATTTGA CCACCATTAG AAAGCGTCTT 240
GAGAACAATT ACTACTGGAA AGCGATGGAG TGTGTTGAAG ACTTTAACAC CATGTTTACA 300
AATTGTTATG TCTACAATCG GCCTGGGGAT GACATTGTTC TGATGGCTCA AGTGCTTGAG 360
AAGCTTTTTT TGGAGAAGGT GGCAGAGATG CCTGAGGAGG AGTATGAGAT TTCTGCTCTG 420
ACAACTAAAG GTCCAGTTAA AGGCGCAAGA AAGTCTACAA TAGGGTTAAA GAAGAGGCCA 480
CCGTCTCCAA TGTCTGAGGT TGTTTTCCAG CAAACCGTGA CCGTCATCCC TCCGGATGCT 540
CTTCACACAA TTCCTTCTGC TCCCCTGTCT GCACAGCTCA CAGCAAAATT AAAAAATGGC 600
GTGAAAAGAA AAGCAGACAC TACGACACCT TCTGCCTCTT CCATCCCCAG CTGCGAGTCG 660
TCATCTTGTG TAACAGAACC AAAAGTCCTT AAGTTATTCT CCAGACGAGG CAGTGGACGA 720
CCCATCAAAC CTCCATGCAA AGACCTTCCT GAATCCCCAC CACAGCATCA GGTGGGCCGA 780
AGGACCAAAC TCTCAGAGAG ACTCAAATAC TGCAATGCCA TCCTAAAAGA GATGTTTTCC 840
AAAAAGCATT CAGCTTATGC CTGGCCCTTT TATAAACCTG TGGATGCTGA GACACTTGGT 900
CTTCTTGATT ATCATGAAAT CATCCACCAA CCCATGGATA TGAGCACCAT CAAAAAAAAA 960
ATGGAAGCTC GCGAATACAC AGATGCACTG CAGTTTGCTG CAGATATGCG GCTCATGTTC 1020
TCAAACTGCT ACAAATACAA TCCACCCGGC CATGAGGTAG TGAGCATGGC AAGGAAACTC 1080
CAGGATGTTT TTGAGTTTCG CTTCTCCAAG ATTCCTGATG AGCCGAAGAA TGCAAACCCA 1140
GTCTCTAGTC ACAACAGAGT AAAGAAAGAA AGAGCACGCA GTCCATCCAG CTCTGAAAGC 1200
AGTGACAGTG AATCATCGTC TCCTGAAAAC TCCTCTGACA CTGAAGAGGA GGATGAAGAG 1260
GAGAGAGCGC ACAGGCTTGC CAGTCTGGAA GAACAGCAGC TGAAAGCAGT ACGAGAGCAG 1320
CTGCAGTTAC TGACCCAGAC ACCTCTATCA AAAATACTGA AGCGCTCAAG CAGCAGCAAG 1380
TCATCAGGAT GTAAAGTTTG TACTATGATG AATTCTTTGA AGAAACCAAA GTTTAACTCT 1440
GTTCTTAGGC GGAAAGAGAG TAGAGCATGT GACTCTGAGG AGGAGATGAA CACTTTACCT 1500
ATGTCTTATG AAGAGAAACG CCAACTAAGT CTAGACATTA ACAAGCTTCC TGGAGACAAA 1560
CTTGGGAAAG TAGTGAACAT CATCAAGGCA CGAGAACCCC TGTTAAGGGA CACAGACCCT 1620
GAAGAGATCG AAATCGACTT TGAGACTCTC AAACCATCAA CTCTTCGAGC TCTTGAGTGC 1680
TATGTTGTGG GTTGTCTCCG GAAAAAAAAA AACAAGCCCC CAAAGAAGTC TAAAATCAAG 1740
GAAAAGGATA AAGACCTACA ACACGCAACT GGAGAACAAA ACTCTCATAA AAAGACCAAA 1800
ATTGAAACTG ATGGGGAGAT TAAAGACACG ACCCATCCTT CTCGTCTGAG TGACAGCAGC 1860
AGCAGCTCGT CCAGCTCTGA CAGCAGTAGT AGTGACTCTA GCTCCTCTGA TAGCTGTGAC 1920
TCTGATTCAG GTCTTACAGA ACAGAAAACT AAGAGGAAGC AAAGCAAAGG CCCTGGTCAT 1980
GCCAACAAAA TTAAAAAGAA GAAATATTAC CCCGTTGTCC CCCTCCCTGA ACAGGCATTG 2040
CGGCAGGCCA ATGCTGAGGT AAAGGACTCT TCTTCTGCCT CAGGCGTGAT GTGCCAGTCT 2100
CGCCCATCCT CACTAGTCTC AGAGACAGGC TCCAAAGACC TGTTTGCATC ACAACACGCA 2160
AAGCATCCTG TCGAGGACAT CACAGCAATC ACAGGCATCC CACCACTTCT GTCACCTTTG 2220
ACCTCACCTT CTGCAGCCAT GCCTGCCACA GGATCCCAGT CTACCTCCAG TTCCCAGTTT 2280
GAGGCTTCCT CTCCTCTGTG TCTTTATAAG GATATTGTTC TGAAGCATGC TGACTCTTGG 2340
ACGAGCCTTG GTAAGCTGGC TACTCAAACT CCTTGCACCA TCAAATCATC CAAGGAAAGT 2400
TTCCAGCAGT TTCGCAAAGT TGCCATGGAA AAAGAGCTGA CCACAGCCTC CCGTGGCTTA 2460
GTTTCAAAGC ATTGTTTGAC GCAGCAGCCC CAGAAGGCTA AGCTGGAGTG CCAGCCTTCA 2520
AAGCCAGAAG TGGAGTCAGC AGAGTTGCCT CTGATGGCGG CCATCTTGGA CACCCCCAAA 2580
GCCCCTGAGC CCAGTTCTGT TCTGCAGAAC TCTGTTGACC GAGAACGAGA GATGGCACGC 2640
AAGAGAGAAC AAGAGCGCCG CAGGAGAGAG GCTATGTCAG GAGTCATTGA CATGACCATG 2700
CAAAGGGACA TAATGGCGAC CTTTGAGAAG AACTTGGAGT AA 2742
Domain Profile
N/A
Domain Sequence
(FASTA)
N/A
KeywordActivator; Bromodomain; Chromatin regulator; Coiled coil; Complete proteome; Differentiation; Meiosis; Nucleus; Reference proteome; Repeat; Spermatogenesis; Transcription; Transcription regulation.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>
EKS-AIM-00462
EKS-ANC-00491
EKS-BOT-00499
EKS-CAJ-00515
EKS-CAF-00505
EKS-EQC-00481
EKS-FEC-00479
EKS-GAM-00301
EKS-HOS-00511
EKS-ICT-00474
EKS-LAC-00508
EKS-MEG-00409
EKS-MOD-00494
EKS-MUM-00532
EKS-MUP-00490
EKS-NOL-00453
EKS-ORN-00635
EKS-ORC-00475
EKS-ORL-00578
EKS-OTG-00504
EKS-PAT-00473
EKS-PES-00441
EKS-XIM-00625
EKS-SAC-00130
Gene Ontology
GO:0005634; C:nucleus
GO:0070577; F:histone acetyl-lysine binding
GO:0030154; P:cell differentiation
GO:0016568; P:chromatin modification
GO:0001207; P:histone displacement
GO:0007141; P:male meiosis I
GO:0051039; P:positive regulation of transcription during meiosis
GO:0043484; P:regulation of RNA splicing
GO:0007283; P:spermatogenesis
GO:0006351; P:transcription, DNA-dependent
KEGG
InterPros
IPR001487; Bromodomain.
IPR018359; Bromodomain_CS.
Pfam
PF00439; Bromodomain; 2.
SMARTs
SM00297; BROMO; 2.
Prosites
PS00633; BROMODOMAIN_1; 2.
PS50014; BROMODOMAIN_2; 2.
PS51525; NET; 1.
Prints
PR00503; BROMODOMAIN.
Created Date20-Feb-2013