EKS-DAR-00045
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00045
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak280.23.8E-838721143272
StatusUnreviewed
Ensembl ProteinENSDARP00000124187
UniProt AccessionF1R1F7;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene Nametyk2
Gene Synonyms/Alias tyk2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000020326ENSDARP00000124187ENSDART00000149755
ENSDARG00000020326ENSDARP00000055123ENSDART00000055124
OrganismDanio rerio
Functional Description
Protein Length1165
Protein Sequence
(FASTA)
MMYRRGRSRR SKKAGTSKGQ SEGPGVHVFL FWTKDGERCL SYKKGEVTAE DLTTEAAKAV 60
GITPVCHALF ALYDPASLCW YSPNHNFNAE NQSGLLLHFR LRFYFHKWHG LGENAPEVGR 120
YALRTSAGTQ QATSHLLELS ALEYLFAQAK YDFVNDLVPL NAVSGEEEIG RYQNECLGMA 180
VLHLSYTALQ TGSSLQDVAK QTSFLRCIPL SFSRHIAKQN ILTRFRIRRV FAHFVNTFQQ 240
HTVGVGKLGS QEVMYKYLST LERLAPHFGV ETFPVFHLDL RADGGDSGSY LITSRTQNPP 300
EETINEPTHE IRVSGSDGIW WRKFSAQRSQ SDDYSHSQNK ETAALNEEED WNIFCDFPEI 360
SLIAIQGINV CISRQDNMSM DISLDSSIQA RSLVSLLDGY FRLTTDAHHY LCREVAPPRV 420
VLSESNDLHG PLMDEFVLQK LKREVEEGAF LVRWSALDYH RIILASLSRS KKEGENPVYK 480
QFRIRQNGSL FHLEGWDQDF SSIKELTSSL KTFVLKSGED SFTLKKCCLP KPGELSNLLI 540
IRKGAKSSIK SASETPDLSK LSFNPIKDKE ITKEQHLGRG TRTNIYSGWL KIRGSLEDED 600
DESNNNHCKT KGIRVVLKIL EQSQKDKALA FFETASLMSQ VSHCHLIFVH GLSVKGTENI 660
MVEEFVEFGP LDVFLHRERA HVSPQWKFTV AKQLASALCY LETKRLVHGN VCGKNILVVR 720
KGLEEGTSPF VKLSDPGISL SALSQGERVE RIPWIAPECV ADGTRIGSAA DKWSFGATLL 780
EICNNGDLHV SNSTLSEKQR FYETQSRLAV PSSQELASFI SRCLTYDAAA RPSFRTILRE 840
LTEIQIKNPD ISSECESLPD KDPSVFYKRY LRKIRDLGEG HFGKVMLYVY DPHNDGTGEY 900
VAVKALKQEG DGSSLHVSWM KEIEILKSLY HNNIVKYKGC CTEMGGQVVQ LIMEYVPLGS 960
LREYMPKYGQ GIGQGLLFAQ QICLGMDYLH SKRYIHRDLA ARNVLLENEG VVKIGDFGLT 1020
KYIPEGDIYY RVREDGDSPV FWYAIECLKE SKFSFASDVW SFAVTLYEIL TNCSHRLSPP 1080
SKFSDMMGTV HGQMTVVKLI SLLEKNERLP CPPGCPREVY SLMEQCWDFN PDQRPSFLSL 1140
AESLEEIRGP YKQPSSLQLA QLNHR 1165
Nucleotide Sequence
(FASTA)
ATGATGTATA GACGAGGACG TTCTAGGAGA TCAAAGAAAG CAGGGACGTC CAAAGGACAG 60
AGTGAAGGTC CTGGTGTCCA TGTGTTTCTG TTCTGGACCA AAGATGGAGA ACGATGCCTG 120
TCTTACAAGA AGGGTGAGGT GACTGCTGAA GATCTCACCA CTGAAGCAGC AAAGGCTGTG 180
GGGATCACTC CAGTCTGTCA TGCCTTGTTT GCACTGTATG ACCCTGCTTC ATTGTGCTGG 240
TACAGTCCAA ATCACAACTT TAATGCAGAG AACCAGTCGG GCCTGTTACT GCATTTTCGT 300
TTGAGATTTT ACTTTCATAA GTGGCATGGA TTAGGTGAAA ATGCACCAGA AGTGGGCCGC 360
TATGCATTAC GGACCTCAGC TGGGACACAG CAGGCGACAT CTCATTTGCT GGAGCTGAGT 420
GCCCTGGAAT ACCTGTTTGC TCAGGCAAAA TATGATTTTG TGAATGACTT GGTGCCGTTG 480
AATGCAGTGA GTGGAGAGGA AGAGATCGGT CGCTATCAGA ATGAATGTCT GGGTATGGCT 540
GTGCTTCACC TTTCCTACAC GGCTCTGCAG ACCGGCTCTT CTCTACAGGA TGTGGCCAAG 600
CAGACCAGCT TTCTCCGCTG CATTCCTCTG TCTTTTTCGC GACACATTGC CAAACAGAAC 660
ATCCTGACGA GATTCCGGAT TCGGCGAGTA TTTGCACACT TTGTGAACAC CTTCCAGCAA 720
CACACGGTGG GCGTGGGCAA GCTTGGATCA CAAGAAGTCA TGTACAAATA CTTGTCCACA 780
CTGGAGCGCC TGGCACCCCA TTTCGGCGTC GAGACTTTCC CTGTTTTCCA TCTGGACCTC 840
AGAGCTGATG GAGGTGACAG TGGCTCATAC CTCATCACCT CCCGTACACA AAACCCACCT 900
GAGGAGACCA TAAATGAACC TACTCATGAG ATCAGGGTGT CTGGATCAGA TGGCATATGG 960
TGGAGGAAGT TTTCGGCACA GCGGAGCCAG AGCGATGACT ACAGTCATAG TCAGAACAAA 1020
GAAACAGCGG CACTTAATGA GGAGGAGGAC TGGAACATCT TCTGCGATTT CCCAGAGATC 1080
TCTCTGATTG CCATTCAGGG CATCAATGTG TGCATCAGCC GACAGGACAA CATGTCAATG 1140
GACATAAGTT TAGACTCCAG TATTCAGGCT CGCTCTCTGG TCTCACTGCT CGATGGATAT 1200
TTCCGACTTA CGACCGATGC TCATCATTAC CTCTGTCGTG AAGTGGCTCC GCCGAGAGTG 1260
GTTCTCAGTG AGTCCAACGA CCTGCATGGT CCCTTAATGG ATGAGTTTGT GCTCCAGAAA 1320
CTGAAGAGAG AAGTGGAGGA GGGTGCATTT CTTGTGCGCT GGAGTGCTTT GGATTACCAT 1380
CGCATAATTC TGGCTTCTCT GAGTCGGTCA AAGAAGGAAG GAGAAAATCC AGTCTACAAG 1440
CAGTTCCGAA TTAGACAGAA CGGCTCGTTG TTTCATTTGG AAGGCTGGGA TCAAGATTTC 1500
TCCAGCATAA AAGAGCTCAC CAGCAGCTTA AAAACCTTTG TGCTGAAGTC TGGAGAGGAC 1560
AGCTTCACTT TGAAGAAGTG CTGTCTGCCC AAACCAGGAG AGCTGTCAAA CCTTCTTATA 1620
ATAAGGAAGG GTGCCAAAAG CAGCATTAAA AGTGCCTCGG AAACCCCTGA CCTGAGCAAA 1680
CTGAGCTTCA ATCCAATTAA AGACAAGGAG ATTACAAAGG AGCAGCACCT GGGACGCGGC 1740
ACCAGGACTA ACATTTACTC CGGCTGGCTG AAGATCCGCG GTTCACTAGA GGATGAAGAT 1800
GATGAGTCCA ATAACAATCA CTGCAAAACA AAAGGGATCC GAGTTGTTCT CAAAATTTTG 1860
GAACAGAGCC AGAAGGACAA AGCGCTAGCG TTCTTCGAGA CGGCTAGTTT AATGAGTCAG 1920
GTGTCTCACT GTCATCTGAT CTTTGTTCAC GGACTTTCAG TCAAGGGTAC TGAGAACATC 1980
ATGGTGGAGG AGTTTGTGGA GTTCGGCCCC TTAGATGTGT TTCTTCACAG AGAAAGAGCT 2040
CATGTTTCTC CTCAGTGGAA GTTTACTGTC GCTAAACAGC TTGCTAGCGC TCTTTGCTAT 2100
CTTGAGACCA AGCGTTTAGT GCATGGAAAT GTCTGTGGCA AGAACATCCT GGTGGTCCGG 2160
AAAGGTTTAG AGGAGGGCAC GTCTCCTTTT GTAAAGCTCA GTGACCCAGG CATTTCTCTG 2220
TCAGCTCTAT CTCAAGGAGA GCGCGTGGAG CGAATTCCAT GGATTGCTCC AGAGTGTGTT 2280
GCTGACGGGA CTCGTATAGG AAGCGCTGCA GACAAGTGGA GCTTTGGAGC CACTCTGCTG 2340
GAAATCTGCA ACAACGGTGA TCTTCATGTC AGCAACAGCA CATTATCTGA GAAACAGCGC 2400
TTCTACGAGA CGCAGAGTCG CCTGGCGGTA CCTTCGTCTC AAGAGCTGGC CAGCTTCATC 2460
AGCAGGTGTC TGACATATGA TGCTGCTGCA CGGCCCTCCT TCCGGACTAT TCTGAGGGAG 2520
CTGACAGAGA TTCAGATAAA AAATCCAGAC ATTTCATCGG AGTGCGAGTC TCTTCCAGAC 2580
AAAGACCCAA GCGTCTTCTA CAAGCGTTAC CTGAGGAAGA TTCGGGATCT GGGAGAGGGT 2640
CACTTTGGAA AGGTGATGCT GTACGTCTAT GACCCTCACA ATGACGGGAC GGGCGAGTAT 2700
GTGGCGGTGA AGGCCTTAAA GCAGGAGGGC GACGGCAGCA GTCTCCATGT TTCCTGGATG 2760
AAGGAGATCG AAATCCTCAA ATCGCTTTAC CACAACAACA TTGTCAAATA TAAAGGCTGC 2820
TGTACTGAAA TGGGTGGACA GGTGGTTCAG TTAATCATGG AGTACGTCCC GCTGGGAAGC 2880
CTCCGAGAAT ACATGCCTAA ATACGGTCAG GGCATTGGAC AGGGTCTCCT GTTCGCCCAG 2940
CAGATCTGCC TGGGAATGGA CTATCTGCAC TCCAAGCGCT ATATCCATCG TGATCTGGCT 3000
GCGCGCAATG TTTTGTTGGA GAATGAAGGG GTGGTGAAGA TCGGTGACTT TGGCCTGACC 3060
AAGTACATTC CCGAAGGGGA CATTTACTAT CGTGTTCGAG AGGACGGGGA CAGTCCTGTG 3120
TTCTGGTATG CCATAGAGTG CCTGAAGGAG AGCAAGTTTT CCTTTGCCTC TGACGTTTGG 3180
TCTTTTGCTG TGACCCTTTA TGAGATTTTG ACTAACTGTA GCCATCGACT AAGCCCTCCT 3240
TCGAAATTCT CAGACATGAT GGGAACGGTC CACGGTCAGA TGACTGTTGT TAAACTGATT 3300
TCCCTCCTGG AGAAAAATGA GAGATTACCA TGCCCTCCAG GCTGTCCTCG TGAGGTGTAT 3360
TCACTGATGG AGCAGTGCTG GGACTTCAAC CCTGATCAAC GTCCGTCGTT CTTATCGCTG 3420
GCTGAGTCTC TGGAGGAAAT TCGAGGACCA TACAAACAGC CGTCGTCGTT GCAGCTCGCT 3480
CAGCTCAACC ATCGCTGA 3498
Domain Profile
S: 2     kqiesLgkgtftkvfevredaegdsteeevalkvLkesged..isrdfkreaeilsqlsh  59
         ++i++Lg+g+f+kv ++ +d+++d t+e va+k+Lk+ g+      ++ +e+eil++l+h
Q: 872   RKIRDLGEGHFGKVMLYVYDPHNDGTGEYVAVKALKQEGDGssLHVSWMKEIEILKSLYH  931
         6799********************************776651155789************
S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117
         ++ivk+kg+c++ g +  +l+meyv+ GsL++y++k  + +   + l +a+q++ +m+YL
Q: 932   NNIVKYKGCCTEMGGQvvQLIMEYVPLGSLREYMPKYGQGI--GQGLLFAQQICLGMDYL  989
         *************9999********************8876..57899************
S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176
         ++k+++hrd+aarnvL+e+e+       vk++d+gl+k ++++  Yy vre++ds+++w+
Q: 990   HSKRYIHRDLAARNVLLENEGV------VKIGDFGLTKYIPEGdIYYRVREDGDSPVFWY  1043
         **********************......***************9****************
S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp.........lrsesle.......  219
         a ecl+e+k +s asdvWsF+vtlye+lt cs+  sp                       
Q: 1044  AIECLKESK-FSFASDVWSFAVTLYEILTnCSHRLSPpskfsdmmgT-----Vhgqmtvv  1097
         *********.***************************8886554440.....25556667
S: 220   rklelleekerlpkpk.cpaelaelmtnclsyepsqrpsFrailed  264
         +++ lle++erlp+p+ cp e++ lm++c++ +p+qrpsF  ++e 
Q: 1098  KLISLLEKNERLPCPPgCPREVYSLMEQCWDFNPDQRPSFLSLAES  1143
         ****************************************988776
Domain Sequence
(FASTA)
RKIRDLGEGH FGKVMLYVYD PHNDGTGEYV AVKALKQEGD GSSLHVSWMK EIEILKSLYH 60
NNIVKYKGCC TEMGGQVVQL IMEYVPLGSL REYMPKYGQG IGQGLLFAQQ ICLGMDYLHS 120
KRYIHRDLAA RNVLLENEGV VKIGDFGLTK YIPEGDIYYR VREDGDSPVF WYAIECLKES 180
KFSFASDVWS FAVTLYEILT NCSHRLSPPS KFSDMMGTVH GQMTVVKLIS LLEKNERLPC 240
PPGCPREVYS LMEQCWDFNP DQRPSFLSLA ES 272
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00028
EKS-ANC-00027
EKS-BOT-00034
EKS-CAJ-00031
EKS-CAF-00033
EKS-CAP-00033
EKS-FEC-00030
EKS-GAM-00233
EKS-GAA-00049
EKS-GOG-00031
EKS-HOS-00033
EKS-ICT-00028
EKS-MOD-00031
EKS-MUM-00034
EKS-MUP-00034
EKS-MYL-00034
EKS-NOL-00030
EKS-OCP-00021
EKS-ORN-00049
EKS-ORL-00046
EKS-OTG-00034
EKS-PAT-00030
EKS-PRC-00015
EKS-PTV-00032
EKS-RAN-00033
EKS-SAH-00031
EKS-TAR-00049
EKS-TEN-00053
EKS-XET-00032
EKS-XIM-00047
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR019749; Band_41_domain.
IPR019748; FERM_central.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045; Tyr_kinase_non-rcpt_TYK2_N.
Pfam
PF07714; Pkinase_Tyr; 2.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR01823; JANUSKINASE.
PR00109; TYRKINASE.
PR01827; YKINASETYK2.
Created Date20-Feb-2013