EKS-DAR-00762

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00762

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	309.0	5.3E-92	30	278	249

Status

Unreviewed

Ensembl Protein

ENSDARP00000110960

UniProt Accession

F1QWK9;

Protein Name

Protein Synonyms/Alias

Gene Name

map3k7

Gene Synonyms/Alias

map3k7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000020469	ENSDARP00000107410	ENSDART00000124919
ENSDARG00000020469	ENSDARP00000110960	ENSDART00000130414
ENSDARG00000020469	ENSDARP00000009152	ENSDART00000018545
ENSDARG00000020469	ENSDARP00000006286	ENSDART00000025862

Organism

Danio rerio

Functional Description

Protein Length

602

Protein Sequence
(FASTA)

ASELAMSMPS ADMLETPPMY PFEEIDYVDI EVEEVVGRGA FGVVCKAKWK GRDVAIKTIE 60

SESEKNAFIV ELRQLSRVDH PNIVKLYGSC NNPVCLVMEY AEGGSLYNVL HGAEPLPHYT 120

ASHAMSWCLQ CSQGVSYLHG MKPKALIHRD LKPPNLLLVA GGTVLKICDF GTACDIQTHM 180

TNNKGSAAWM APEVFEGSNY SEKCDVFSWG IILWEVITRR KPFDEIGGPA FRIMWAVHRA 240

GTRPPLIKNL PKAIESLMTR CWSKDPSQRP SMEEIVKIMS HLMGYFPGSE EPLKYPYQYS 300

DEGQSNSATS TGSHLDYTCT SNKNDINMEH TNSPGSNDTI KFPYKPKGIS GQSLSRGSSV 360

ESLPGRSHFQ PSSDSKRMSV ELSELEPRLP FASPARPQYK RGHRKTASHG TILDIPKIIV 420

TATCEPHRRR SVQDLPAIGT DASQDSRNNS RSSSPSFRMI TPDRPTVSLN HHRYTCAHRQ 480

RSLDTNGSDN SIPMAYLTLD HQLQPLAPCP NSKESMAVFE QHCKMAQEYL KVQTEIALLK 540

QRKEELIAEL DQDEKDQQNA CRLAQEQKKL IEENKSLSTY YQQCKKQLEL IRAQQQKRQG 600

TS 602

Nucleotide Sequence
(FASTA)

GCTAGCGAGC TAGCGATGTC TATGCCCTCC GCCGATATGC TGGAAACACC GCCTATGTAT 60

CCGTTTGAGG AGATCGATTA TGTTGATATT GAAGTGGAAG AGGTGGTTGG CAGAGGGGCA 120

TTTGGTGTTG TCTGCAAGGC CAAGTGGAAA GGCAGAGATG TGGCCATCAA GACTATAGAG 180

AGTGAATCTG AAAAAAATGC TTTCATTGTT GAGCTTCGCC AGTTGTCTCG TGTAGATCAT 240

CCCAACATTG TAAAGCTTTA TGGTTCCTGC AATAACCCTG TATGTCTAGT GATGGAATAT 300

GCAGAAGGAG GGTCATTGTA TAATGTGCTG CACGGTGCAG AGCCTCTCCC TCACTACACT 360

GCATCTCACG CCATGAGCTG GTGCCTGCAG TGTTCTCAGG GGGTCTCGTA TCTCCATGGC 420

ATGAAACCAA AAGCTCTTAT TCACAGGGAC CTCAAACCTC CCAATCTGCT CCTGGTTGCT 480

GGAGGTACTG TCCTGAAGAT CTGTGACTTC GGGACAGCGT GTGACATCCA GACTCACATG 540

ACTAACAATA AGGGAAGTGC TGCCTGGATG GCCCCAGAAG TGTTCGAAGG GAGCAACTAC 600

AGTGAAAAGT GTGACGTGTT CAGTTGGGGT ATTATTCTCT GGGAGGTGAT CACACGCCGA 660

AAGCCTTTCG ATGAAATTGG TGGTCCTGCT TTCCGCATCA TGTGGGCTGT GCACCGTGCA 720

GGAACACGTC CGCCTCTCAT TAAGAATCTG CCGAAGGCCA TAGAGAGTCT GATGACTCGT 780

TGTTGGTCCA AAGACCCATC GCAGCGGCCT TCCATGGAGG AGATTGTGAA GATTATGAGC 840

CACCTTATGG GGTATTTCCC AGGATCAGAA GAGCCTCTTA AGTACCCTTA TCAGTATTCA 900

GATGAAGGCC AGAGTAACTC AGCCACCAGC ACAGGCTCAC ATTTAGACTA CACATGTACC 960

AGCAATAAGA ACGACATCAA CATGGAGCAC ACAAACTCCC CTGGCAGTAA CGATACAATC 1020

AAGTTCCCCT ACAAACCAAA GGGCATTTCT GGTCAGTCTC TCTCCAGAGG CAGCAGCGTA 1080

GAGAGTCTTC CTGGCAGGTC ACATTTTCAG CCTTCCTCTG ACAGCAAACG AATGAGTGTC 1140

GAACTCTCCG AATTGGAGCC CAGATTACCC TTTGCTTCTC CAGCACGTCC ACAATATAAG 1200

CGAGGTCACC GTAAAACAGC ATCACATGGC ACCATTCTGG ACATTCCCAA GATCATCGTC 1260

ACAGCAACCT GTGAGCCTCA TAGACGCAGA TCTGTGCAGG ATCTTCCTGC CATTGGTACA 1320

GATGCCAGTC AGGATAGCAG AAACAACAGC AGATCGTCCA GTCCAAGCTT TAGGATGATT 1380

ACACCAGACA GGCCTACAGT TTCCCTCAAC CATCATAGAT ATACATGTGC ACACAGACAG 1440

AGATCATTAG ACACTAATGG CTCAGATAAC TCTATCCCTA TGGCCTACCT GACCCTGGAC 1500

CATCAGTTAC AGCCTCTTGC CCCTTGTCCA AACTCCAAAG AGTCGATGGC AGTGTTTGAG 1560

CAGCACTGTA AAATGGCACA GGAATACCTG AAGGTGCAGA CAGAGATCGC ACTTCTCAAA 1620

CAGAGAAAGG AAGAGCTGAT AGCAGAACTA GACCAAGATG AAAAGGATCA ACAGAACGCA 1680

TGTCGCCTCG CTCAGGAGCA AAAGAAGCTC ATAGAGGAGA ACAAGAGTCT GTCCACCTAC 1740

TACCAGCAAT GCAAGAAACA ACTGGAGCTG ATCCGAGCGC AGCAGCAGAA GAGACAGGGC 1800

ACCTCATGA 1809

Domain Profile

S: 1     ieleeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniie  60

         ie+ee++g+gafg v+kakw++++va+K +++e+e+    +++  e+++ls+++hpni++

Q: 30    IEVEEVVGRGAFGVVCKAKWKGRDVAIKTIESESEK----NAFIVELRQLSRVDHPNIVK  85

         5789****************************8888....9*******************

S: 61    llGvcleepnlllvmeyveggsLsnvlhe.kskreidlevlvswalqiArGmaYLhseap  119

         l+G c+++  ++lvmey+eggsL+nvlh+ +  ++++ ++++sw+lq+++G++YLh ++p

Q: 86    LYGSCNNP--VCLVMEYAEGGSLYNVLHGaEPLPHYTASHAMSWCLQCSQGVSYLHGMKP  143

         *******9..89*****************77899**************************

S: 120   kkiihrdLksknvLlseekktlkicdFGtarelskstkmsaagtlawmaPEvlkeekvse  179

         k++ihrdLk++n+Ll +  ++lkicdFGta++++ +++++++g++awmaPEv++ +++se

Q: 144   KALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ-THMTNNKGSAAWMAPEVFEGSNYSE  202

         ********************************99.9************************

S: 180   ksDvwSygvvLWelltrevPykdlse..laiaykvalkglrlpipsscpeklkkLmkecw  237

         k+Dv+S+g++LWe++tr++P++++    ++i+++v   g+r+p+++++p+ +++Lm++cw

Q: 203   KCDVFSWGIILWEVITRRKPFDEIGGpaFRIMWAVHRAGTRPPLIKNLPKAIESLMTRCW  262

         **********************99765589******************************

S: 238   nedpekRpsfseivks  253

         ++dp++Rps++eivk+

Q: 263   SKDPSQRPSMEEIVKI  278

         *************986

Domain Sequence
(FASTA)

IEVEEVVGRG AFGVVCKAKW KGRDVAIKTI ESESEKNAFI VELRQLSRVD HPNIVKLYGS 60

CNNPVCLVME YAEGGSLYNV LHGAEPLPHY TASHAMSWCL QCSQGVSYLH GMKPKALIHR 120

DLKPPNLLLV AGGTVLKICD FGTACDIQTH MTNNKGSAAW MAPEVFEGSN YSEKCDVFSW 180

GIILWEVITR RKPFDEIGGP AFRIMWAVHR AGTRPPLIKN LPKAIESLMT RCWSKDPSQR 240

PSMEEIVKI 249

Keyword

Complete proteome; Kinase; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0048514	; P:blood vessel morphogenesis
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017421	; MAPKKK7.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013