EKS-DAR-00043

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00043

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	313.4	2.9E-93	872	1144	273

Status

Unreviewed

Ensembl Protein

ENSDARP00000016852

UniProt Accession

F1R5C7;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

jak1

Gene Synonyms/Alias

jak1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000020625	ENSDARP00000037399	ENSDART00000038990
ENSDARG00000020625	ENSDARP00000016852	ENSDART00000018083

Organism

Danio rerio

Functional Description

Protein Length

1153

Protein Sequence
(FASTA)

MPELAVMDLG RQLCVKMKKQ RKAEMTIPTA MKGLEIHFYL ADTHQLEFFK ACYTAEDLCV 60

EAAKRCRISP LCHNLFALYE ESQDLWYAPN HVFKVTDETS IKLHYRMRFY FTNWHGTSEI 120

ESPVWRHTLS KQKSVLNSQK TTEGTPLLDA ASLDYLFAQG QYDFLRGLSP VRPTQNDEEH 180

HEIENECLGM AVLAITHHAK SNNLPLSGAG AETSYKRFIP DSLNRTIKQR NFLTRIRISN 240

VFKNFLNEFN SKTIQDSNIG LYDLKVKYLS TLETLTQGVG REIFKPKNLK VTGESEGSPA 300

QMLPLGDNGM GYEVQVYGTT GISWRRKPAP NQLILKDKPK SKKIKGDKQW NDKKKDSGWT 360

LFSDFHEITH IVIKDCCVTI YRQDNKTMEL DLFYRDAALS FAALVDGYFR LTVDAHHYLC 420

TDVAPSSVVQ NLENGCHGPI CTEYAIHKLR QEGNEEGTYV LRWSCTEYNF IIMTVVCIEL 480

DLCESRPVPQ YKNFQIETSP QGYRLYGTDT FRPTLKELLE HLQGQLLRTD NLRFQLRRCC 540

PPQPREISNL LVMTTDREPV PQKKTQVSQL SFDRILKEEI VQGEHLGRGT RTNIYAGILK 600

PKSDDEDDLG GYSQEVKVVL KVLGSGHRDI SLAFFETASM MRQISHKHIA LLYGVCVRHQ 660

ENIMVEEFVQ YGPLDLFMRR QTTPLSTAWK FQVAKQLASA LSYLEDKKMV HGYVCSKNIL 720

VARDGLDGEG GPFIKLSDPG IPITVLSREE CVDRIPWIAP ECVKDTANLS IAADKWSFGT 780

TLWEICYNGE IPLKDKKLTE KERFYAAQCQ LATPDCDELA KLMTHCMTYD PRQRLFFRAI 840

VRDIVMVEKQ NPSIQPVPML EVDPTVFEKR FLKKIRDLGE GHFGKVELCR YDPRGDRTGE 900

LVAVKSLKPE NREEQSNNLW REIHILRELY HENIVKYKGI CNEEGGRSIK LIMEFLPAGS 960

LKEYLPRNKA HINLKTLLNY SVQICQGMDY LGSRNYIHRD LAARNVLVEN EGTVKIGDFG 1020

LTKSIKDNEG YYTVKDDLDS PVFWYAPECL IHCKFYRASD VWSFGVTMYE LLTYCDASCS 1080

PMSVFLKLIG PTHGQMTVTR LVKVLEEGKR LPRPDDCSEQ LYNLMRRCWE ATPEKRIDFK 1140

SLIANFQQML DNL 1153

Nucleotide Sequence
(FASTA)

ATGCCAGAAC TAGCAGTCAT GGATCTGGGC AGGCAACTGT GTGTGAAGAT GAAAAAACAG 60

AGGAAGGCAG AGATGACCAT TCCTACTGCC ATGAAGGGAC TTGAGATCCA CTTCTACCTT 120

GCTGACACAC ACCAGCTCGA GTTCTTCAAA GCCTGCTACA CTGCGGAAGA CCTGTGCGTG 180

GAGGCTGCCA AGAGATGCCG CATCTCACCT TTGTGCCACA ACCTGTTTGC ACTCTATGAA 240

GAAAGCCAGG ATCTCTGGTA TGCTCCAAAT CACGTGTTCA AGGTCACAGA TGAGACCAGC 300

ATCAAACTTC ATTATCGCAT GAGGTTTTAT TTCACAAACT GGCATGGAAC CAGTGAGATT 360

GAGTCTCCAG TTTGGAGACA CACACTCAGC AAACAGAAAA GTGTATTAAA CAGTCAGAAG 420

ACCACCGAGG GAACACCTCT ACTAGATGCC GCATCTCTTG ATTACCTGTT TGCGCAGGGC 480

CAGTATGATT TCCTGAGAGG TCTGTCTCCT GTTCGTCCAA CTCAGAATGA TGAAGAGCAT 540

CATGAGATTG AGAACGAGTG CTTGGGAATG GCTGTTTTAG CTATTACCCA TCATGCCAAG 600

AGCAATAATT TGCCATTATC AGGAGCTGGA GCCGAGACAA GCTATAAGCG CTTCATTCCA 660

GATAGTCTGA ACCGCACCAT TAAGCAACGC AACTTCCTCA CACGCATACG CATCAGTAAC 720

GTCTTCAAGA ATTTCCTCAA TGAGTTCAAT AGCAAGACCA TCCAGGACAG CAATATAGGT 780

CTGTATGACC TGAAGGTCAA GTATTTGTCC ACTCTCGAGA CGCTGACTCA AGGAGTGGGT 840

AGGGAGATTT TCAAGCCCAA GAACCTAAAA GTAACGGGTG AGAGTGAGGG ATCCCCAGCA 900

CAGATGCTTC CCTTGGGGGA CAACGGAATG GGTTATGAGG TGCAAGTATA CGGAACTACT 960

GGGATCTCAT GGAGGAGAAA GCCCGCACCG AATCAATTGA TATTGAAAGA CAAACCCAAA 1020

TCTAAAAAGA TCAAGGGCGA CAAGCAGTGG AATGACAAAA AGAAAGACAG CGGATGGACG 1080

CTTTTCTCCG ACTTTCATGA AATAACCCAC ATCGTCATTA AGGACTGCTG TGTCACCATT 1140

TACAGACAAG ACAATAAAAC CATGGAGTTG GATCTGTTTT ATCGTGATGC AGCCCTGTCT 1200

TTTGCTGCAC TGGTGGACGG TTACTTCAGA TTGACTGTGG ATGCCCATCA TTACCTGTGC 1260

ACTGATGTCG CCCCCTCATC GGTAGTCCAG AATTTAGAAA ACGGCTGTCA CGGACCTATC 1320

TGCACAGAGT ATGCCATTCA TAAACTTCGA CAGGAGGGAA ATGAAGAAGG AACCTATGTG 1380

CTGCGCTGGA GCTGCACAGA ATACAACTTT ATTATCATGA CGGTTGTCTG CATTGAGCTC 1440

GACCTGTGTG AATCCAGACC AGTTCCCCAG TATAAGAACT TCCAGATTGA AACGAGCCCT 1500

CAGGGCTACA GACTGTATGG GACAGACACA TTCAGACCCA CTCTGAAGGA GCTGCTGGAG 1560

CACCTGCAGG GCCAGTTACT GCGCACCGAC AATCTGCGCT TCCAGCTGCG CCGCTGCTGC 1620

CCACCACAAC CCAGAGAAAT TTCTAACCTA TTAGTGATGA CCACAGACCG AGAGCCTGTC 1680

CCGCAGAAAA AAACTCAAGT CAGCCAGCTG AGTTTCGACC GCATTCTTAA AGAGGAGATT 1740

GTACAGGGTG AACATTTGGG TCGAGGCACA AGGACAAACA TCTATGCTGG TATTCTGAAG 1800

CCGAAGAGTG ATGATGAAGA TGATCTGGGA GGATACTCGC AGGAGGTGAA AGTGGTTTTG 1860

AAGGTGCTGG GCTCAGGACA TAGAGATATT TCTCTGGCAT TCTTTGAGAC CGCTAGCATG 1920

ATGCGTCAGA TCTCTCACAA ACACATCGCC CTGCTCTACG GAGTGTGTGT GCGTCACCAG 1980

GAGAATATCA TGGTGGAGGA GTTTGTTCAG TACGGCCCTT TGGATCTGTT CATGCGCAGG 2040

CAGACCACAC CTCTGAGCAC TGCATGGAAG TTCCAGGTTG CCAAGCAGTT AGCCAGTGCC 2100

CTCAGCTATC TGGAGGATAA GAAGATGGTC CATGGATATG TGTGCAGTAA GAACATTCTG 2160

GTAGCTCGAG ATGGTTTAGA TGGAGAAGGA GGACCCTTCA TCAAGCTGAG TGACCCCGGG 2220

ATACCCATTA CTGTCCTCAG CAGAGAAGAG TGTGTGGACA GGATTCCTTG GATTGCTCCA 2280

GAGTGTGTGA AAGACACAGC TAATCTGAGC ATAGCGGCTG ATAAGTGGAG TTTCGGGACA 2340

ACTCTTTGGG AGATATGTTA CAACGGAGAG ATTCCTCTGA AAGATAAGAA ACTCACTGAG 2400

AAGGAGAGGT TTTACGCAGC GCAGTGTCAG TTGGCAACCC CTGACTGTGA TGAGCTGGCC 2460

AAACTCATGA CCCACTGCAT GACTTACGAC CCCCGACAGA GGCTCTTCTT CAGGGCCATC 2520

GTCAGGGACA TTGTTATGGT GGAGAAACAG AATCCATCCA TTCAGCCTGT TCCCATGCTT 2580

GAAGTGGACC CGACAGTGTT TGAGAAGAGG TTCCTCAAGA AGATTCGAGA CCTTGGAGAG 2640

GGTCATTTTG GGAAGGTGGA GTTGTGCCGG TATGACCCAC GTGGAGATCG GACTGGAGAG 2700

CTAGTGGCTG TGAAGTCTCT GAAGCCAGAG AACCGCGAAG AGCAGAGCAA TAACCTGTGG 2760

CGTGAGATTC ACATCCTGAG AGAACTTTAC CATGAGAATA TCGTCAAATA CAAGGGCATC 2820

TGCAATGAAG AGGGTGGGAG ATCCATTAAG CTCATCATGG AGTTTTTGCC TGCAGGCAGT 2880

CTAAAGGAAT ACCTCCCCAG AAACAAGGCT CACATAAACC TTAAAACTCT GCTCAACTAT 2940

TCTGTGCAGA TCTGCCAGGG TATGGACTAC CTGGGATCTC GCAACTACAT CCACAGAGAC 3000

CTGGCAGCCC GCAATGTTCT GGTGGAGAAT GAAGGCACGG TAAAGATTGG AGACTTCGGC 3060

CTGACCAAAA GCATTAAGGA TAACGAGGGA TACTACACTG TGAAAGACGA TCTGGACAGT 3120

CCAGTGTTCT GGTATGCTCC AGAATGTTTG ATCCACTGCA AGTTCTACAG GGCATCTGAT 3180

GTCTGGTCTT TTGGAGTGAC CATGTATGAG CTCCTCACGT ACTGTGATGC TTCATGTAGC 3240

CCCATGTCGG TGTTCCTTAA GTTGATTGGT CCAACACATG GACAAATGAC TGTCACCCGA 3300

TTGGTCAAAG TCCTGGAGGA GGGAAAGAGA CTTCCAAGAC CAGATGACTG CTCAGAGCAG 3360

TTGTACAACC TGATGAGGAG ATGCTGGGAA GCAACACCCG AAAAAAGGAT CGACTTCAAA 3420

AGCCTGATTG CCAACTTTCA GCAGATGCTT GACAATCTGT AA 3462

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv+++r+d++gd t+e va+k Lk e  e++s+++ re+ il++l+h

Q: 872   LKKIRDLGEGHFGKVELCRYDPRGDRTGELVAVKSLKpENREEQSNNLWREIHILRELYH  931

         6899*********************************999999*****************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         e+ivk+kg+c++eg +  +l+me+++ GsL++yL+++k++++l+ ll+++ q++++m+YL

Q: 932   ENIVKYKGICNEEGGRsiKLIMEFLPAGSLKEYLPRNKAHINLKTLLNYSVQICQGMDYL  991

         *************99999******************************************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         ++++++hrd+aarnvLve+e+       vk++d+gl+k ++ +  Yy+v+++ ds+++w+

Q: 992   GSRNYIHRDLAARNVLVENEGT------VKIGDFGLTKSIKDNeGYYTVKDDLDSPVFWY  1045

         **********************......************9999****************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224

         apecl+++k +++asdvWsFgvt+yellt c+ ++sp    l+ ++++       r++++

Q: 1046  APECLIHCK-FYRASDVWSFGVTMYELLTyCDASCSPmsvfLKLIGPThgqmtvtRLVKV  1104

         *********.***************************999988888888999999*****

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         lee++rlp+p+ c ++l++lm++c++++p++r+ F+ ++

Q: 1105  LEEGKRLPRPDdCSEQLYNLMRRCWEATPEKRIDFKSLIA  1144

         ***********************************99875

Domain Sequence
(FASTA)

LKKIRDLGEG HFGKVELCRY DPRGDRTGEL VAVKSLKPEN REEQSNNLWR EIHILRELYH 60

ENIVKYKGIC NEEGGRSIKL IMEFLPAGSL KEYLPRNKAH INLKTLLNYS VQICQGMDYL 120

GSRNYIHRDL AARNVLVENE GTVKIGDFGL TKSIKDNEGY YTVKDDLDSP VFWYAPECLI 180

HCKFYRASDV WSFGVTMYEL LTYCDASCSP MSVFLKLIGP THGQMTVTRL VKVLEEGKRL 240

PRPDDCSEQL YNLMRRCWEA TPEKRIDFKS LIA 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776	; Tyr_kinase_non-rcpt_Jak1.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR01824	; JANUSKINASE1.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013