EPS-DAR-00105

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-DAR-00105

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/PTEN	257.1	2.3E-76	120	290	171

Status

Unreviewed

Ensembl Protein

ENSDARP00000023241

UniProt Accession

F1Q649;

Protein Name

Protein Synonyms/Alias

Gene Name

tns1

Gene Synonyms/Alias

tns1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000020845	ENSDARP00000023241	ENSDART00000015159
ENSDARG00000020845	ENSDARP00000123231	ENSDART00000134480

Organism

Danio rerio

Functional Description

Protein Length

1769

Protein Sequence
(FASTA)

MHSYDHLSII FLVFFLPQPE EFEAVHSHTF RLKTFKKGKH CGVCKQTVNN EGLICRVCRL 60

ACHRKCEVKV SSSCVPVANY ELAPSNELPL KHIETTGSTK SSKSMESRRR PSRSLSLIQA 120

MEENYEVDLV YITERIISVT FPSNAEEPSY SANIKEVANM LRSKHGDNYL LFNLSEKRLD 180

ISKLNPKVLD FGWPDHHAPA LDKICSICKA MDTWMNAGSH NVVVIHNKGN RGRTGVVVAA 240

YMHYSNISAS ADQALDRFAM KRFYEDKVLP VGQPSQRRYV QYFSGLLSGH IKINNKPLFL 300

HHVIMHGIPN FESKGGCRPF LKIYQAMQPV YTSGIYNVQG DSQTSICITI EPGLLLKGDI 360

LLKCYHKRFR SPCRDVIFRV QFHTCAVHDL GIVFGKDELD ETFKDDRFPE YGKVEFVFSF 420

GPEKIQGMDH LENGPSVSVD YNTQDALIRW DSYENFNQRC EDSMEDVIHT EGPLDGSLYA 480

KVRKKESLEG GVTANGLPAA ADHTLPAVDH TLPPVDHALS VSSDSGNSTA SIKTDRTDEA 540

SHQPALVSQP SSQPLSPEEK QELDQLLSGL EAPMHRTGYQ SSPGGGGGGG GGVLHLVPAQ 600

VHVNGHSNID RETDILDDDL PISQEGNSVD SLGTLSSFEG RATPADLYYQ SETVINGQDM 660

PYLEKSVHEK MLEPRVHSSS SVQEHLGAPS GYANQNGNIY RSQSLGATPN TDQKYMPKAP 720

ARTTSSRDAV QRLNVWQQFG VPEVPVTDGV TFNPVLQSHS LPEFPQMASQ QEIEQSIEAL 780

NMLMLDLDPA LTQVPKSHSA PSGESGVVTT QPSFSQTQAR PSYQADTAIH DRGAASSMGF 840

PLTFQQVTGE PSQPTMKQQK PTTTSQHVEF ASEAGGQAPM SQSTVPSSTF GVLQLKPLNI 900

YPSSTTSQSP EPQETQRSYS SSSSPLPKES EPEDSSYKLE GLVAHRVAGL PSGEMSPDEA 960

AVPGRCRTLS EGLSQDESPT RGSSVRSPIR CISPELANTI ALNPGGRPKE RHMHSYREAF 1020

EEMDGGPVSP PPIVGGEVLP QTPAFPVSPQ TPYFNMCRSP PGLAKTPLSF LGLKPHNPAE 1080

ILLNQTGSEP RSYVESVAKA AAVPASPTYD SDSLARPAGP SHAYNAPLSS SSPIQNPDPV 1140

ESTLADSGVG MNSLSQAAVD IFHFQPSEIP YQPPPPPYPT SMLGSYISPS PAEAMQNNTT 1200

TIQPLSGSPG TRHHTILSDM ASVPNFQHRL ANQDGPILGR QQAPANGHVP GIAGSPVQGR 1260

HTMVSQGTQS SPILSRQYPV TQGIQSSPIL SRQPMGQAVQ SSPVLNRQAS LNQANQSSPV 1320

LSRQQSITLP NQGSPVLSRQ SSLSHPSQGS PVLGRHPSLT QGSPSLDRHP MYSGYTTPEE 1380

RHGALSRQSS SSGYQPPSTP SFPVSPAGYI EGAGFRQGSP AFQPQLPEKR RMSSSDRTNG 1440

GLSYGTLNGK MSSPVSSGGS TPSVHFFHTL PDFSKLNMCD GSPETRMNVK FVQDTSKFWY 1500

KPDISRDQAI NMLKDQDPGA FVIRDSHSFR GAYGLAMKVA SPPPTTQPTK KAGDVTNELV 1560

RHFLIETSPK GVRLKGCPNE PYFGCLSALV YQHSITPLAL PCKLVIPTRD PLEESPEIAT 1620

PTNPAADMLK QGAACNVLYI NSVDMESLTG PQAIAKAISE TMNASPAPSA TIVHFKVSAQ 1680

GITLTDNQRK LFFRRHYPIG TVTFCDIDPQ ERKWNKPEGG TAKFFGFVAR KQGSTTDNVS 1740

HLFAEMDPDQ PATAIVNFVS KVMISSQKR 1769

Nucleotide Sequence
(FASTA)

ATGCACTCAT ATGATCACCT CTCTATAATA TTCCTTGTTT TCTTCCTCCC GCAGCCTGAA 60

GAGTTTGAAG CCGTTCATTC GCACACCTTC CGGCTGAAGA CGTTCAAGAA GGGGAAACAC 120

TGTGGTGTTT GCAAGCAGAC GGTCAACAAT GAGGGGCTCA TCTGCAGAGT TTGCCGGTTA 180

GCCTGTCATC GGAAGTGTGA AGTCAAGGTC TCGTCCTCCT GTGTTCCTGT CGCCAACTAT 240

GAACTGGCCC CCAGCAATGA GCTCCCCCTG AAACATATCG AGACCACAGG CTCAACCAAA 300

TCCTCCAAGA GCATGGAGTC TCGACGCAGA CCGTCAAGGA GTTTGAGTTT GATCCAGGCC 360

ATGGAGGAGA ACTATGAGGT GGATCTGGTT TACATCACCG AGCGCATCAT TTCTGTCACC 420

TTTCCCAGTA ATGCAGAGGA GCCCAGTTAC AGCGCCAACA TTAAAGAAGT GGCAAACATG 480

CTGCGCTCCA AACATGGAGA CAACTACCTG CTCTTCAACC TCAGTGAAAA GCGCTTGGAT 540

ATCTCCAAGC TGAATCCCAA AGTTCTGGAT TTTGGCTGGC CGGATCATCA CGCTCCTGCT 600

TTGGATAAGA TCTGCAGCAT CTGCAAAGCC ATGGACACTT GGATGAACGC TGGCAGTCAC 660

AACGTGGTGG TCATACACAA CAAGGGAAAC CGAGGTCGAA CTGGGGTGGT TGTGGCTGCG 720

TACATGCATT ACAGCAACAT ATCAGCGAGT GCCGACCAGG CTCTGGACAG GTTTGCCATG 780

AAGAGGTTTT ATGAAGATAA AGTGCTTCCT GTGGGTCAGC CTTCCCAGAG AAGATATGTG 840

CAGTACTTCA GCGGTCTGCT CTCCGGCCAC ATTAAGATCA ACAACAAACC CCTGTTTCTC 900

CATCACGTCA TCATGCACGG CATCCCAAAC TTCGAGTCTA AAGGAGGTTG CCGCCCTTTC 960

CTGAAGATCT ACCAGGCCAT GCAGCCCGTC TACACATCTG GCATCTATAA TGTCCAAGGA 1020

GACAGTCAGA CTAGTATCTG CATCACCATT GAACCGGGCC TGCTTTTGAA AGGAGACATA 1080

CTGCTAAAGT GTTATCACAA GCGTTTCCGC AGCCCATGCC GTGATGTCAT ATTCAGAGTT 1140

CAGTTTCACA CCTGTGCTGT TCATGATCTG GGTATCGTCT TCGGCAAAGA TGAGCTTGAT 1200

GAAACCTTTA AAGACGACAG ATTTCCAGAA TATGGAAAGG TGGAATTCGT CTTTTCTTTT 1260

GGCCCAGAAA AAATCCAAGG AATGGACCAC CTTGAGAACG GGCCCAGTGT TTCTGTGGAC 1320

TACAATACCC AAGATGCACT AATCCGCTGG GATTCCTACG AGAACTTCAA CCAGCGCTGT 1380

GAAGACTCCA TGGAAGACGT TATTCACACC GAAGGTCCAT TGGATGGTAG TCTCTACGCT 1440

AAAGTTCGTA AGAAAGAGTC TCTGGAAGGA GGGGTTACAG CCAATGGTCT CCCAGCTGCT 1500

GCTGATCACA CTTTACCTGC TGTAGACCAC ACTCTACCAC CAGTTGACCA CGCCTTGTCT 1560

GTAAGCAGTG ATTCAGGCAA CTCCACAGCG TCCATCAAGA CTGACCGCAC TGATGAAGCC 1620

AGCCATCAGC CAGCATTGGT GAGTCAGCCA TCTTCCCAGC CCCTCAGCCC TGAGGAGAAA 1680

CAGGAGCTGG ACCAGTTGCT CAGTGGTTTG GAAGCACCAA TGCATCGCAC AGGTTACCAA 1740

AGCAGCCCTG GTGGGGGTGG TGGTGGAGGT GGTGGAGTCC TACATCTCGT CCCTGCCCAG 1800

GTACACGTCA ATGGACACAG CAACATAGAC AGAGAGACAG ATATCCTTGA TGATGACTTG 1860

CCCATCAGCC AGGAAGGGAA CAGTGTGGAC AGTCTTGGAA CTCTCTCATC TTTTGAGGGC 1920

AGAGCCACTC CTGCGGATCT ATACTACCAG TCAGAGACAG TCATTAATGG ACAAGATATG 1980

CCCTACTTAG AGAAGAGTGT CCATGAGAAA ATGCTAGAGC CCAGAGTTCA CAGCTCATCA 2040

TCTGTCCAAG AGCACTTGGG AGCCCCTAGT GGGTATGCTA ACCAGAATGG CAACATCTAT 2100

CGATCTCAGT CATTAGGAGC AACCCCGAAC ACAGACCAGA AGTACATGCC CAAAGCTCCA 2160

GCACGCACAA CCAGCAGTAG GGATGCCGTG CAGAGACTGA ATGTTTGGCA ACAATTTGGT 2220

GTACCAGAAG TCCCAGTCAC AGATGGGGTC ACCTTCAACC CTGTACTACA ATCCCACAGC 2280

CTTCCAGAGT TCCCTCAGAT GGCATCTCAA CAAGAGATTG AGCAGTCCAT TGAAGCCCTC 2340

AACATGCTGA TGCTGGACCT TGATCCAGCA CTTACTCAAG TCCCCAAATC CCACAGCGCT 2400

CCATCTGGAG AAAGTGGTGT GGTCACCACC CAACCATCTT TCTCTCAAAC CCAAGCACGC 2460

CCATCCTACC AGGCTGACAC TGCTATTCAT GACCGCGGTG CGGCCTCTTC AATGGGATTT 2520

CCTTTGACCT TTCAACAAGT AACTGGAGAG CCTTCACAAC CCACCATGAA ACAGCAGAAA 2580

CCCACAACTA CATCCCAGCA TGTCGAATTC GCTTCTGAAG CAGGAGGTCA GGCCCCCATG 2640

TCCCAGTCCA CAGTGCCTTC CTCCACCTTT GGAGTTCTCC AGTTGAAACC CCTCAACATT 2700

TATCCCTCAA GTACCACATC CCAGTCCCCC GAGCCTCAGG AGACTCAGCG TAGCTACTCT 2760

TCTTCCTCAT CCCCTCTTCC CAAAGAGTCT GAACCAGAAG ATAGCAGCTA CAAATTGGAG 2820

GGTCTTGTAG CTCACCGTGT AGCTGGACTT CCATCTGGTG AAATGTCGCC AGATGAGGCT 2880

GCAGTTCCTG GACGCTGTCG GACCCTTAGT GAGGGCCTTT CCCAAGACGA AAGCCCAACT 2940

CGAGGAAGCT CAGTCCGCTC CCCCATTCGC TGCATCTCAC CAGAGCTGGC CAATACAATT 3000

GCTCTGAACC CTGGGGGGCG GCCCAAGGAG AGGCACATGC ACAGCTACAG AGAAGCGTTT 3060

GAGGAAATGG ATGGGGGTCC CGTTAGCCCC CCTCCAATTG TTGGTGGTGA GGTCCTACCC 3120

CAAACCCCTG CCTTCCCTGT CTCGCCACAA ACCCCTTACT TCAACATGTG TCGATCTCCT 3180

CCAGGATTGG CTAAAACACC ACTGTCCTTT CTGGGCCTGA AGCCCCACAA CCCTGCTGAG 3240

ATCCTGCTCA ACCAGACAGG CTCAGAGCCT CGTAGTTATG TGGAGTCTGT GGCGAAGGCA 3300

GCAGCAGTAC CTGCATCTCC AACATATGAC AGCGACAGCT TAGCTCGTCC TGCCGGACCG 3360

TCCCATGCTT ACAATGCTCC ACTTTCCTCC AGCAGCCCCA TTCAGAACCC AGATCCAGTT 3420

GAAAGCACAT TGGCTGACAG CGGGGTCGGG ATGAATTCTT TATCCCAGGC TGCTGTCGAC 3480

ATTTTCCATT TCCAGCCCTC CGAAATCCCA TACCAACCAC CACCACCCCC CTACCCAACC 3540

TCCATGTTGG GTAGCTACAT CAGCCCTTCT CCAGCAGAGG CCATGCAAAA TAATACCACC 3600

ACCATCCAGC CACTTTCTGG AAGTCCTGGG ACAAGACACC ACACCATCCT TTCTGACATG 3660

GCGTCCGTTC CCAACTTTCA ACACAGATTA GCAAATCAGG ATGGTCCCAT ACTTGGGCGA 3720

CAGCAGGCTC CAGCTAATGG TCATGTGCCT GGAATTGCTG GTAGTCCAGT GCAAGGAAGA 3780

CACACTATGG TGTCCCAGGG TACACAAAGC AGTCCCATAC TGAGCAGACA GTATCCTGTC 3840

ACCCAGGGGA TTCAGAGTAG TCCAATTCTC AGCAGGCAGC CAATGGGACA AGCTGTCCAG 3900

AGCAGTCCAG TCCTCAACCG ACAGGCATCC CTGAATCAAG CAAACCAAAG CAGTCCAGTG 3960

TTGAGTAGAC AGCAGTCCAT TACCCTACCC AACCAAGGCA GCCCGGTCCT AAGCAGACAG 4020

TCCTCGCTTA GTCATCCCAG TCAGGGTAGT CCTGTACTAG GACGCCACCC TTCCCTAACA 4080

CAGGGTAGCC CCAGCCTGGA TAGGCATCCG ATGTACAGCG GTTACACCAC TCCAGAAGAG 4140

CGACACGGAG CTCTGTCACG CCAAAGCAGC TCTTCAGGAT ACCAGCCGCC ATCTACACCG 4200

TCTTTCCCAG TTTCTCCAGC AGGATACATC GAGGGAGCGG GATTCAGACA GGGGAGTCCT 4260

GCTTTCCAAC CTCAGTTGCC CGAAAAGAGA CGCATGTCCA GCAGTGACCG CACCAATGGT 4320

GGCCTGTCCT ATGGGACGCT CAATGGGAAG ATGTCCTCAC CGGTGTCCAG TGGCGGCAGC 4380

ACTCCGAGTG TTCATTTCTT CCACACACTC CCCGATTTCT CCAAACTCAA CATGTGTGAT 4440

GGAAGTCCAG AAACCAGAAT GAACGTGAAG TTTGTCCAGG ACACGTCCAA ATTCTGGTAT 4500

AAACCAGATA TCTCGAGAGA CCAAGCGATT AACATGCTGA AGGATCAAGA TCCTGGGGCC 4560

TTTGTGATTC GGGACAGTCA TTCATTCAGA GGAGCCTACG GCTTGGCTAT GAAAGTGGCT 4620

TCACCACCTC CAACCACTCA ACCTACAAAG AAAGCTGGAG ATGTCACTAA TGAGTTGGTG 4680

AGGCATTTTC TAATTGAGAC GAGTCCGAAG GGTGTGAGAC TGAAGGGCTG CCCCAACGAG 4740

CCGTACTTTG GCTGCCTGTC TGCGCTGGTC TACCAGCACT CCATCACTCC ACTGGCACTG 4800

CCCTGCAAAC TAGTCATACC AACCAGAGAT CCTCTGGAAG AGTCACCTGA GATCGCAACA 4860

CCAACCAACC CGGCGGCAGA TATGCTCAAG CAGGGCGCAG CATGCAATGT GCTGTACATC 4920

AACTCTGTGG ATATGGAGTC TTTGACTGGA CCTCAAGCCA TCGCCAAAGC CATTTCAGAA 4980

ACCATGAACG CCAGTCCGGC ACCCTCAGCC ACCATTGTTC ACTTCAAGGT GTCGGCACAA 5040

GGCATCACAC TCACAGACAA CCAGAGAAAG CTTTTCTTCA GACGTCATTA TCCCATCGGC 5100

ACAGTCACGT TCTGTGACAT TGATCCACAG GAGAGGAAGT GGAACAAACC AGAGGGTGGC 5160

ACTGCCAAAT TCTTTGGCTT TGTGGCTAGA AAGCAAGGCA GCACGACAGA CAATGTCAGT 5220

CACCTGTTTG CTGAGATGGA CCCAGATCAG CCGGCCACCG CCATCGTCAA CTTTGTCTCT 5280

AAAGTGATGA TCAGCTCTCA GAAGCGGTGA 5310

Domain Profile

S: 3     ltedgfdldltyvteriiavsfPaeareevyrnnlrevvrlldskhrnkyklynlcserr  62

          +e+++++dl+y+terii+v+fP++a+e  y +n++ev+++l skh ++y+l+nl se+r

Q: 120   AMEENYEVDLVYITERIISVTFPSNAEEPSYSANIKEVANMLRSKHGDNYLLFNL-SEKR  178

         699****************************************************.****

S: 63    ydltklnakvaefgiedlnaPaleklvsickeldeWlseddenvvvlhckggkgrlGviv  122

          d++kln+kv +fg++d++aPal+k++sick++d+W+++  +nvvv+h+kg++gr+Gv+v

Q: 179   LDISKLNPKVLDFGWPDHHAPALDKICSICKAMDTWMNAGSHNVVVIHNKGNRGRTGVVV  238

         ************************************************************

S: 123   cayllaseisakadealdtfgerrtredkvagvkqPsqrryvsyfsqllkgs  174

         +ay+++s+isa+ad+ald+f+++r++edkv +v qPsqrryv+yfs+ll+g+

Q: 239   AAYMHYSNISASADQALDRFAMKRFYEDKVLPVGQPSQRRYVQYFSGLLSGH  290

         ************************************************9986

Domain Sequence
(FASTA)

AMEENYEVDL VYITERIISV TFPSNAEEPS YSANIKEVAN MLRSKHGDNY LLFNLSEKRL 60

DISKLNPKVL DFGWPDHHAP ALDKICSICK AMDTWMNAGS HNVVVIHNKG NRGRTGVVVA 120

AYMHYSNISA SADQALDRFA MKRFYEDKVL PVGQPSQRRY VQYFSGLLSG H 171

Keyword

Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0046872	; F:metal ion binding
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR011993	; PH_like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR013625	; PTB.
IPR006020	; PTyr_interaction_dom.
IPR000980	; SH2.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF08416	; PTB; 1.
PF10409	; PTEN_C2; 1.
PF00017	; SH2; 1.

SMARTs

SM00109	; C1; 1.
SM00462	; PTB; 1.
SM00252	; SH2; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS51181	; PPASE_TENSIN; 1.
PS50001	; SH2; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013