EKS-DAR-00014
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00014
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph490.81.3E-147663919257
StatusUnreviewed
Ensembl ProteinENSDARP00000041799
UniProt AccessionF1Q4S7;
Protein Name
Protein Synonyms/Alias
Gene Nameepha8
Gene Synonyms/Alias epha8;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000023609ENSDARP00000041799ENSDART00000041800
ENSDARG00000023609ENSDARP00000117349ENSDART00000136107
OrganismDanio rerio
Functional Description
Protein Length1027
Protein Sequence
(FASTA)
MASDPGLLPL LVWTISMQVL GSRGTSNNEV NLLDTTKISG DWGWLTYPSH GWDAINEMDE 60
YFSPIHTYQV CNVMSPSQNN WLRTNWIQRD GARRIYIEMK FTLRDCNSMP GVLGTCKETF 120
NLYYYETDRD VGTSIWESQF SKIDTIAADE SFTNVDLGVR RLKLNTEIRG VGPLGKRGFY 180
LAFQDIGACI AIVSVRVYYK RCTGMARNLA IFTDVVTGAD SSSLVEVRGQ CVDHAEERDT 240
PKMYCSAEGE WLVPIGRCVC SAGFEEHRDN CIACEVGFYK PVAGDQQCGK CPLHSHSETR 300
AALSCPCDAN FYRSSTDPPS SPCTRPPSAP VNIISSVNGT SVSLEWVSPL DTGGRSDVIY 360
DVLCQKCDKD GLQCEDCRVG VGGGNGVVNS NVNGASGDTS GAAGGTVGAL NGLVVARSGA 420
ALVRFIPQRT GLTEPWVTVL NLAAHANYTF RIMALNGVTH LSNEQPQSVM VNITTNQAAP 480
SEVMAVRQEN ASQNSVTLFW HEPAQPNGVI LEYDIKYYEK DNEQQSYATL KSKNTSAKVS 540
GLKPGTSYIF QIRARTSAGC GRFSQSVEIQ TGKAPPLRNT NVTIIWICMA SVTGLVTFLA 600
VVICRKRRCG YSKAFQDSDE EKMHYQNGHV SFPEARFYID PHTYEDPCQA VHEFAREIEA 660
SRIKIEKIIG SGEFGEVCYG RMKLPGKRDV PVALKTLKAG YTEKQRRDFL AEASIMAQFD 720
HPNVIHLEGV VTRSKPVMII TEYMENGSLD SFLRRHDGQF TIIQLVGILR GIAAGMTYLA 780
DLGYVHRDLA ARNVLVNSNL VCKISDFGLS RVLEDDPDAA YTTSGGKIPI RWTAPEAIAY 840
RKFSSSSDVW SYGVVMWEVM SYGEQPYWNL TNRDVIKSVE EGYRLPAPMG CPGALHTLML 900
DCWQKDRNER PKFCQIVTVL DKLIRTPETL KSVETLCRLN SPLMNRSIPD FTSCRSVDEW 960
LDTIKMGRYK DHFAAGGYRT LGHVMSMKQH DIQRLGVTLM GHQKKIMTSV QVMRAQVLNQ 1020
SVPSVHI 1027
Nucleotide Sequence
(FASTA)
ATGGCATCAG ATCCAGGGCT GCTGCCCCTC TTAGTGTGGA CTATATCAAT GCAGGTCCTG 60
GGATCCAGAG GAACATCCAA TAATGAAGTG AATCTCCTTG ACACAACTAA AATATCAGGA 120
GACTGGGGCT GGCTCACATA TCCTTCACAC GGGTGGGATG CGATCAATGA AATGGACGAG 180
TACTTCAGCC CCATCCACAC ATACCAGGTG TGCAATGTGA TGAGCCCAAG TCAGAACAAC 240
TGGCTGCGCA CCAACTGGAT CCAGCGGGAC GGTGCGCGAC GGATCTACAT TGAGATGAAG 300
TTCACCTTGC GCGACTGCAA CAGCATGCCG GGCGTCCTTG GCACCTGCAA AGAGACCTTC 360
AACCTCTACT ACTACGAAAC AGACCGGGAC GTGGGCACCA GCATCTGGGA GAGCCAGTTC 420
TCTAAAATCG ACACCATCGC GGCAGACGAG AGTTTTACCA ATGTGGATCT GGGAGTGCGG 480
AGACTCAAAC TTAACACTGA GATCCGTGGT GTCGGGCCGC TGGGAAAACG TGGCTTCTAC 540
TTGGCCTTCC AGGATATCGG AGCGTGCATC GCCATCGTGT CGGTGCGGGT GTATTATAAA 600
CGCTGCACGG GAATGGCGCG CAACCTGGCC ATCTTCACCG ATGTGGTGAC GGGCGCAGAT 660
TCGTCCTCAT TGGTTGAGGT TCGGGGTCAA TGTGTGGATC ACGCTGAGGA AAGAGACACG 720
CCCAAGATGT ACTGCAGCGC TGAGGGGGAG TGGCTTGTTC CTATTGGACG ATGCGTGTGC 780
AGCGCTGGCT TCGAAGAACA TAGAGACAAC TGCATTGCGT GTGAGGTGGG TTTCTACAAG 840
CCTGTGGCAG GAGATCAGCA GTGTGGAAAA TGTCCTCTGC ACAGTCACTC TGAGACTCGA 900
GCAGCTCTGT CCTGTCCCTG TGATGCCAAC TTCTATCGCT CATCTACAGA TCCACCTTCT 960
TCTCCCTGCA CAAGACCTCC ATCAGCCCCA GTGAACATCA TTTCATCAGT GAACGGGACG 1020
TCGGTCAGTC TGGAGTGGGT TTCCCCTCTG GACACCGGAG GCCGCAGTGA TGTGATCTAT 1080
GACGTCCTCT GCCAGAAGTG TGATAAAGAT GGGTTACAGT GCGAGGACTG TCGGGTGGGT 1140
GTGGGTGGAG GTAATGGGGT GGTTAATAGT AATGTTAATG GAGCTTCAGG AGACACCAGT 1200
GGAGCTGCTG GCGGGACAGT GGGAGCCTTG AATGGGCTTG TAGTGGCCAG GTCAGGAGCT 1260
GCTCTGGTGC GCTTCATCCC ACAGCGAACA GGACTTACTG AACCATGGGT GACTGTGCTG 1320
AATCTCGCCG CTCATGCTAA CTATACCTTC CGAATTATGG CGCTAAACGG AGTCACGCAT 1380
CTGAGCAACG AGCAGCCGCA GTCTGTGATG GTCAATATCA CCACTAACCA GGCAGCTCCA 1440
TCTGAAGTGA TGGCCGTCCG GCAGGAAAAC GCCAGTCAGA ACAGCGTCAC TCTTTTCTGG 1500
CATGAACCAG CGCAGCCTAA CGGAGTCATA TTAGAGTATG ACATCAAATA TTACGAAAAG 1560
GACAATGAGC AGCAAAGTTA TGCTACACTG AAGTCAAAGA ACACCAGTGC TAAAGTGTCC 1620
GGTTTGAAGC CTGGAACGAG TTATATCTTC CAGATTCGGG CCAGAACCTC GGCCGGCTGT 1680
GGACGCTTCA GTCAGTCAGT AGAGATACAG ACGGGCAAAG CACCTCCCCT GCGAAATACC 1740
AACGTGACGA TTATCTGGAT CTGCATGGCT TCGGTAACAG GACTGGTGAC ATTTCTGGCC 1800
GTTGTCATCT GCAGAAAACG ACGCTGTGGG TACAGCAAAG CTTTCCAGGA CTCAGACGAG 1860
GAGAAAATGC ACTACCAAAA TGGCCACGTA TCATTTCCAG AAGCCAGATT TTATATTGAT 1920
CCCCACACAT ATGAGGACCC CTGCCAGGCT GTCCACGAGT TTGCCAGAGA AATTGAAGCA 1980
TCCAGGATCA AAATAGAGAA AATCATTGGT TCAGGAGAGT TTGGGGAAGT GTGTTACGGC 2040
CGGATGAAGC TGCCGGGGAA ACGTGACGTC CCGGTGGCTC TGAAGACTCT TAAAGCCGGA 2100
TACACCGAGA AGCAGAGGAG AGATTTCCTG GCTGAAGCCA GCATTATGGC ACAGTTCGAC 2160
CACCCAAACG TCATCCACCT CGAGGGGGTG GTTACTCGCA GCAAACCGGT AATGATCATC 2220
ACAGAGTACA TGGAGAACGG CTCCTTGGAC TCTTTCTTGA GGAGACACGA CGGTCAGTTC 2280
ACCATTATTC AGCTGGTTGG GATTCTGCGT GGCATCGCGG CTGGCATGAC TTACTTGGCT 2340
GATCTGGGTT ACGTCCACCG GGATTTGGCC GCCAGAAACG TTCTGGTCAA CAGTAATCTG 2400
GTGTGCAAGA TCTCAGACTT CGGGCTTTCA CGAGTGCTGG AGGACGATCC TGATGCAGCG 2460
TATACCACCA GCGGAGGGAA GATCCCCATC CGCTGGACAG CACCGGAGGC CATCGCCTAT 2520
CGAAAGTTTT CCTCCTCCAG TGATGTGTGG AGTTATGGAG TGGTGATGTG GGAAGTGATG 2580
TCATATGGAG AACAGCCATA TTGGAACTTG ACCAACAGAG ATGTGATCAA GTCCGTAGAG 2640
GAGGGTTACC GTCTCCCAGC CCCCATGGGC TGCCCCGGGG CCCTCCACAC CCTCATGCTG 2700
GACTGCTGGC AGAAAGACCG CAACGAAAGA CCCAAATTCT GCCAGATCGT CACAGTCCTG 2760
GACAAACTGA TCCGCACTCC TGAAACACTC AAATCAGTGG AAACATTGTG CAGACTAAAC 2820
AGTCCTTTGA TGAACAGAAG TATTCCTGAT TTCACCAGCT GCAGATCGGT GGACGAGTGG 2880
TTGGACACCA TTAAAATGGG CCGCTATAAG GACCACTTTG CCGCAGGAGG GTATCGCACA 2940
CTTGGACATG TGATGAGCAT GAAACAACAC GACATCCAGC GGTTGGGCGT CACGTTAATG 3000
GGCCACCAGA AGAAGATCAT GACCAGCGTC CAGGTGATGA GAGCGCAAGT ACTGAACCAG 3060
AGCGTGCCCT CCGTGCACAT ATAG 3084
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         +kiek+iG+GefGevc Gr+klpgkr+++va+ktlkag+tekqrrdfl+easi+ qfdhp
Q: 663   IKIEKIIGSGEFGEVCYGRMKLPGKRDVPVALKTLKAGYTEKQRRDFLAEASIMAQFDHP  722
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         n+i+leGvvt+skpvmi+teymeng+ldsflr++dgqft+iqlvg+lrGia+gm yl+d+
Q: 723   NVIHLEGVVTRSKPVMIITEYMENGSLDSFLRRHDGQFTIIQLVGILRGIAAGMTYLADL  782
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarn+lvnsnlvck+sdfGlsrvledd++aayttsggkipirwtapeaiayrk
Q: 783   GYVHRDLAARNVLVNSNLVCKISDFGLSRVLEDDPDAAYTTSGGKIPIRWTAPEAIAYRK  842
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         f+s+sdvwsyG+v+wev+syGe+pyw+++n+dvik++eegyrlp+pm+cp al+ lmldc
Q: 843   FSSSSDVWSYGVVMWEVMSYGEQPYWNLTNRDVIKSVEEGYRLPAPMGCPGALHTLMLDC  902
         ************************************************************
S: 241   wqkdraerpkfeqivsi  257
         wqkdr+erpkf qiv++
Q: 903   WQKDRNERPKFCQIVTV  919
         **************987
Domain Sequence
(FASTA)
IKIEKIIGSG EFGEVCYGRM KLPGKRDVPV ALKTLKAGYT EKQRRDFLAE ASIMAQFDHP 60
NVIHLEGVVT RSKPVMIITE YMENGSLDSF LRRHDGQFTI IQLVGILRGI AAGMTYLADL 120
GYVHRDLAAR NVLVNSNLVC KISDFGLSRV LEDDPDAAYT TSGGKIPIRW TAPEAIAYRK 180
FSSSSDVWSY GVVMWEVMSY GEQPYWNLTN RDVIKSVEEG YRLPAPMGCP GALHTLMLDC 240
WQKDRNERPK FCQIVTV 257
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00010
EKS-ANC-00008
EKS-BOT-00009
EKS-CAF-00011
EKS-CAP-00008
EKS-EQC-00011
EKS-FEC-00008
EKS-GAG-00009
EKS-GAA-00013
EKS-GOG-00010
EKS-HOS-00010
EKS-ICT-00010
EKS-LOA-00011
EKS-MAM-00008
EKS-MEG-00008
EKS-MOD-00010
EKS-MUM-00011
EKS-MUP-00011
EKS-NOL-00010
EKS-OCP-00001
EKS-ORN-00013
EKS-ORC-00010
EKS-ORL-00016
EKS-OTG-00011
EKS-RAN-00010
EKS-SAH-00010
EKS-SUS-00008
EKS-TAG-00007
EKS-TAR-00021
EKS-TEN-00009
EKS-XIM-00014
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR020691; EphrinA_rcpt8.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013